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Beta-Ketones Mephedrone, Methylone, Butylone, Methedrone, Ethcathinone, 3-fluoroMethCathinone (3FMC), Methylenedioxypyrovalerone (MDPV)

 
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  #1  
Old 30-10-2006, 01:31
Nicaine Nicaine is offline
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Methylenedioxypyrovalerone (MDPV) Experience Reports

MDPV (methylenedioxypyrovalerone) Experiences

Please add your experiences with MDPV ( methylenedioxypyrovalerone, 1-(benzo[d][1,3]dioxol-5-yl)-2-(pyrrolidin-1-yl)pentan-1-one ) here. Please add dosage, route and duration to the top of your post like this:

Quote:
Originally Posted by EXAMPLE
Dosage: 5 mg in one glass juice
Route: Orally
Duration: 2 hours
When posting a experience, please describe:
• body weight & gender
• dose taken
• route of administration
• Setting: in what environment it was taken.
• duration of main effects
• main effects
side effects
• after effects
• rating of the experience
• addictive qualities / abuse potential
• any other valuable information
• information on heart rate / blood pressure effects if available

Information about this substance, other then experiences, should be discussed here: Methylenedioxypyrovalerone Drug Info

Research Chemicals Index - Beta-Ketones
Research Chemicals Index - Phenethylamines
Research Chemicals Index - Tryptamines
Research Chemicals Index - Synthetic Cannabinoids
Research Chemicals Index - Piperazines
The Research Chemical Index

(end mod edit)
_______________________________________

Substance: MDPV (1-(3,4-methylenedioxyphenyl)-2-(pyrrolidin-1-yl)-1-pentanone HCl).
Structural similarities: Methylphenidate (Ritalin), cocaine.
Nature: Potent stimulant, dopamine (DA) reuptake inhibitor in humans.
Typical human dosage: 0-5mg (low), 5-10mg (moderate), 10+ mg (high).
Approximate number of doses per gram: 200.
Form used: Dissolved in distilled water, 1ml per mg of powder supplied.
Anticipated methods of admin: Intranasal (via atomizer), oral or rectal.
Anticipated after-effects: Mild depression/anhedonia (dopamine depletion).
Harm reduction (during): Antioxidants, beta blocker, sedative, food, continuous fluids.
Harm reduction (between): L-tyrosine, vitamins, minerals, hydration, food, sleep, time.
Main MDPV thread: http://www.drugs-forum.com/forum/showthread.php?t=19972

Experience Report #1

After a decent stretch of sleep (and some food) SWIM feels much better today and got the urge to experience this reputed "clear headed stimulation" fully, so he loaded 3ml (=3mg) into his nasal pump atomizer. After around 2mg intranasal, SWIM noticed some irregular heartbeats consistent with mild stimulation, plus a sudden urge to empty his bowels. He's at around 2.5ml (=mg) and once again it feels like a couple cups of coffee to him. SWIM has decided to take it up to 5mg and will load another couple ml into his nasal pump. He feels that <=5mg of this drug represents a low dose and is probably pretty safe, at least given the way he feels on it.

SWIM likes this technique of administering small amounts at a time and watching as it takes effect. He is not going to tangle with either >5mg doses or rectal admin until more experience reports have been posted, nor does he plan to use this stuff regularly (particularly if he's still awake in 12 hours!). Note that SWIM has something of a general stimulant tolerance, if there is such a thing.

+ ~00:30 - solid 3mg ingested, SWIM finally notices a little euphoria! This is much better... He will go slow on the last 2mg.
+ ~00:45 - (~4mg) feels something like a couple solid lines of coke to SWIM in terms of both degree of stimulation and general enjoyment. He should probably just stop here, but dunno. In any case, SWIM is much happier with this stuff today and highly recommends that it's used when the body is well fed and rested, which is a good general reco. for enjoying oneself on any stim.
+ ~01:00 - SWIM has slowed down/backed off at ~4.5mg... except for the degree of intestinal activation he's very, very happy with this substance. Final post here will be when it appears to be wearing off, barring any unforseen events.
+ ~02:05 - SWIM is craving a boost and will give into it ONCE, as in 1mg. Note that he considers it a duty to report any fiending and subsequent "giving in" where dopamine reuptake inhibition is concerned.
+ ~02:35 - That's enough... although fiendish, the substance gives a clear warning sign SWIM has learned to heed/obey or pay the price (propylhexedrine gives this too, strangely M1 does not and he could abuse himself to death on it).
+ ~02:45 - Peak seems to have come/gone, last 1mg didn't do much and was a waste of time. SWIM will (with some regret) let this go.
+ ~03:00 - Main effects are gone (and badly missed), aside from some residual energy. SWIM doesn't sleep for another 8 hours or so, hopefully he'll have no problem then. Great, 8 hours to mull over how nice it would feel to do more. Resisting must be a rite of passage into the official RC-er's club... next SWIM will get a scale and join all the way .
+ ~03:15 - 2.5mg zolpidem + 0.75mg clonazepam taken rectally as a relaxant. An antidepressant is really what was needed. Doing/coming off of MDPV is like winning a Mercedes and being told at the last minute they got your name wrong. Uggh. In the future SWIM will have to reserve kratom for the aftermath, but being so close to his recent "O.D." + severe stomach issues he doesn't dare use any for at least a couple days... that was far too traumatic to risk again so soon.

+ ~05:00 - Ahh! SWIM is craving a redose and is this close --> <-- to giving in. SWIM thinks he will redose once with 4mg (intranasal atomizer again), as he has to find out if it can be done without the "panic attacks" others have noted. Total dosage is still <10 mg so it should be possible. Given the brevity of effects, he should still get to bed more or less on time tonight as well.
+00:30 since redose - on the way back up, bowel stimulation noted right away. If same level is not reached at ~4mg as last time, SWIM will give up completely and absolutely not push the bounds of this stuff (and next time he'll go rectal for improved bioavailability, and probably duration of effects too). SWIM likely has yet to find the optimal (for him) way to administer this stuff.
+00:38 since redose - Entire 4mg administered, SWIM will wait and see if peak occurs at 60-90 min. as before, and what that peak looks like. Still nothing even remotely resembling anxiety/panic, just an obvious energy boost.
+01:00 since redose - High is not comparable to the first time. Feels much more jittery and less pleasant. If this changes, SWIM will say so and I'll post about it.
+02:45 since redose - Added a mg or so to nasal atomizer somewhere in there (sigh... at least it's not hit after hit like smoking would be). Nearly at or over personal dosage limit (fingers tingling slightly), but things are currently good. Peak has likely been hit, but no sign of downslide in effects yet. SWIM is frankly about ready for it at this point. A sedative has been prepared on the side in case it's needed.
+03:15 since redose - Very interesting... substance appears to still be fully active, albeit still jitterier than the first dose. Let's hope this doesn't turn into some 6+ hour thing, or whatever. This was unexpected, but if there's a "build up in the system" effect then in retrospect it's not surprising. Others have noted "anxiety attacks" after a couple redoses (despite feeling like they came down in between) and attributed it to overdosage. It appears re-dosing once may be 'necessary' with this substance to fully enjoy it, unless brief effects are wanted for some specific reason (such as a sexual encounter, followed by sleep).
+04:15 since redose - Substance is still fully active in SWIM's system, no sign of comedown yet. He hopes there won't be an ugly crash this time . SWIM is going to pre-emptively go with the sedative, there should still be enough MDPV effect to tell when it's wearing off (and the stimulation is becoming annoying).
+06:00 since redose - Effects definitely on the downswing (SWIM can instantly check sexual responsiveness to see what dopamine's doing in his brain). It may still be a while until he's "completely" down. Feels like the crash is gonna be worse this time, but nothing twisted or evil after this short a period of dopamine depletion. SWIM has been to coke parties where a friend begs him piteously for a single small line, knowing it's the last anyone has for the night. None of that crap around here .
+07:00 since redose - Aftermath. Better than most stimulants, frankly. Better than anything but a short methylone run, better than propylhexedrine, *far* better than coke. SWIM ate something and had a cup of black tea (brand contains only a small amount of caffeine). He feels back to baseline now, no depression and no cravings unless he purposely thinks about the drug. Another hour and a half or so browsing the web, then off to bed. Hope SWIY has enjoyed reading this first report... MDPV requires caution, but appears to reward patience and experience (anyone can get there, but the latter requires the former).

Notes on the high: SWIM's appetite is killed by this stuff, but he managed to force 1/2 a protein bar no problem. Constant fluid intake maintained, as is SWIM's practice on stims. Increased stomach acid (as noted below with snapper's monkey). Periodic muscle spasms (mainly in his face and legs) minor but evident. Some lower back pain/strain, as with any stimulant. Heart rate seems to be boosted very little, likely BP too (minimal peripheral sympathomimetic effects) although he's on a low dose of beta blockers. Boost in sexual interest present = telltale sign of increased dopamine. Periodic 'standalone' euphoria noted, but it's mild compared to some other stimulant substances.

Post Quality Evaluations:
Very good, detailed post
Fantastic report. Thanks.
Very informative post thanks

Last edited by Phenoxide; 13-03-2011 at 17:51. Reason: standardized experience thread header format, unrelated attachments removed
  #2  
Old 30-10-2006, 13:45
Nicaine Nicaine is offline
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Experience Report #2

Condition(s): Insufficient sleep
Method of Admin: Rectal
Rate of Admin: 1mg/~15 minutes
HR since yesterday: 500mg L-Tyrosine, B Vitamins, EGCg antioxidant
Today's reading assignment for researchers : http://tinyurl.com/shj5b

SWIM is in the unenviable position of finding it impossible to sleep (whether from yesterday's fun or not, it's hard to say... he also suffers from chronic insomnia as a condition and has become tolerant to the hypnotic effects of zolpidem) and it looks like he's going to have to wait until this evening and he gets tired enough to sleep.

This opens him to a bit of experimentation for Experience Report #2. This one is riskier than yesterday's; little recovery time is involved. SWIM is not well rested, and he wants to try rectal admin. He plans on proceeding with extreme caution, but some risk is involved anyway (primarily the possibility of minor overdose and the much-feared MDPV panic attack).

+00:00 - 1mg was taken rectally, mixed with 3ml of water. SWIM does not expect much effect from this, so he's going to continue dosing 1ml at a time at 15-30 minute intervals until a hoped-for effect is achieved (or until unpleasantness strikes, whichever comes first).

+00:10 - SWIM feels a small but significant energy boost from the preceding, i.e. like he got a good night's sleep after all. He's going to go eat something before proceeding any further.

+00:30 - SWIM is still eating, etc... there's going to be a delay before he proceeds further. He set aside a rectal syringe with 4mg of clonazepam in case of emergencies, enough to stun a small elephant .

+00:40 - 1mg MDPV taken rectally. Intestinal activation + energy boost noted almost immediately. Very pleasant! Nothing about this substance has struck SWIM yet as the slightest bit negative, unlike a good 50% or so of RC-nauts who have tried it. Could it be that his slow/cautious approach to dosing is paying off?

+00:55 - 0.5mg MDPV taken rectally, something just told SWIM to proceed cautiously.

+01:00 - SWIM is taking a break for a hot shower.

+01:25 - SWIM took ~2mg of enalapril maleate for potential BP issues (he needs to get a cuff). It's funny how the stuff, a common medication for hypertension and heart problems, is potentially riskier than MDPV in that symptomatic hypotension requiring medical attention can develop quite easily. How to explain to a doctor that SWIM took some enalapril he ordered from Europe to protect against a mysterious research chemical from Europe that he injected up his rear end?

+01:30 - 0.5mg MDPV taken rectally, SWIM is off to the store to pick up some food-type supplies. He's feeling very up/positive at the moment. Isn't Wellbutrin also a dopamine reuptake inhibitor, albeit a crude one?

+01:55 - This is not a good stimulant to do on less than a full night's sleep; without a strong norepinephrine component it feels like a forced, tired sort of energy. A jittery sort of drowsiness is possible, albeit hard to describe... this may even be related to the "panic attacks" some people have experienced, as one's emotional stability is compromised without sufficient sleep. For future reference: Don't use MDPV 'standalone' without a good night's rest. SWIM is switching to intranasal dosing for any further usage today, to more finely control dosage. And he's going to bed early tonight; sounds nice right now.

+04:15 - SWIM finds this stuff to be frustrating at times... in particular, the "sexual boost" quality comes and goes, which could be more SWIM's fault for overusing stimulants lately than anything else (he can't get anywhere sexually without stimulants, period... sad, isn't it? ).

Still, something about the MDPV high is too short lasting, and is neither deeply involving nor truly satisfying. It seems SWIM is left wanting for more every time he uses it. Despite the supposedly strong focus on dopamine, SWIM tends not to have more than a couple orgasms per experience (which is nothing for him + stimulants).

This is the last time he's going to use this stuff for awhile -- not because he's satisfied, but because he's frustrated and unfulfilled and there's little point to it beside lost sleep and a depressing comedown. Aside from its extremely inexpensive (actually, dirt cheap) cost-per-dose, SWIM is not too impressed. Maybe he'll try combining a lower dose of it with a lower dose of propylhexedrine, and see how this plays out. AFTER he's taken a break from stimulants for a week, anyway, unless he's about ready to start crashing in graveyards . Escalating dosages, diminishing effects, falling body weight, mood swings, depression, health problems, is this what SWIM wants? He's not sure he's prepared to pay the price to follow this path where he suspects it leads. No, let's cut the bullshit. Where it does lead.

SWIM is going to drop out of the game soon, come down and hope he'll be sleepy enough to go beddy bye. So it's in the middle of the day, f*ck it if they can't take a joke. Better than rolling until evening and being unable to sleep again tonight. Thanks for reading.

+08:00 - SWIM is in the middle of a horrendous crash. If SWIM is drowsy enough to sleep it won't be a big deal, otherwise he could be in for some nastiness.

Last edited by Nicaine; 30-10-2006 at 21:35.
  #3  
Old 30-10-2006, 18:36
nanobrainPlatinum member nanobrain is offline
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Re: MDPV Experience Report(s)

please let us know when you are graced with Morpheus's embrace (sleep)...and more.
  #4  
Old 30-10-2006, 19:04
Nicaine Nicaine is offline
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Re: MDPV Experience Report(s)

Quote:
Originally Posted by nanobrain View Post
please let us know when you are graced with Morpheus's embrace (sleep)...and more.
Unfortunately, SWIM will have to let you know after he re-enters the waking domain, unless SWIY has the ability to enter dreams (in which case, please come on in & try talking some sense into the idiot sitting behind this keyboard).
Quote:
Originally Posted by Psych0naut View Post
Nicaine, what is it with you and rectal administration? It's starting to look like it's your new fetish
It's cost effective and works extremely fast. Honest, there's no other reason (sorry if I disappointed you ).

Seriously, it doesn't seem cool that an Ambien tablet could start working in <10 seconds and take full effect in about 30?

Last edited by Nicaine; 30-10-2006 at 19:11.
  #5  
Old 30-10-2006, 22:48
Nicaine Nicaine is offline
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Experience Report #2, Cont'd

+09:00 - SWIM is in the middle of a fairly unpleasant crash, although lacking the severe anhedonia and other twisted qualities associated with substances that deplete all three neurotransmitters (dopamine, norepinephrine, serotonin) like cocaine and MDMA.

Some of it is obviously related to the sheer idiocy of using stimulants while sleep-deprived and physically exhausted. Strong drowsiness, along with inability to sleep. Lower back pain and difficulty sitting up straight. Random muscle spasms, likely related to prolonged hypertonia and mild electrolyte imbalance. Heart rhythm slightly off, SWIM took 20mg of verapamil (his collection of 'harm reduction' substances has gotten quite big). SWIM is really scared of painful cramps in his calves, which have occurred on occasion after cocaine runs... most often SWIM wakes up yelling in pain, but it's happened while awake before too. Hopefully this symptom is not associated with MDPV use.

As is his custom (most of the time) SWIM will attempt to stay awake through the crash, get some food in his stomach and go to bed properly.
  #6  
Old 31-10-2006, 10:45
snapper Gold member snapper is offline
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Re: MDPV Experience Report(s)

SWIM knows all about the calf cramps. Sometimes they have left SWIM lame.
So far SWIYs lab monkeys confirm what SWIMs opinion of MDPV is. SWIM also started very low and worked up, but has yet to get any truely satisfying effect.
SWIM has often felt that methylone is not worth it - it's a tease. So it seems is MDPV. In this sense, sparing use may be the problem. Like M1, it is possible that the attack dose will have a greater effect than any subsequent boosting. However, given dosage sensitivity, this will require tedious, incremental,increasing dosages to find an ideal point. SWIM is beginning to feel about this like SWIM felt about BZP - not worth the effort or expense.
SWIM has also appreciated strong anorexia with MDPV, though no sexual enhancement (or inhibition) at all.
For the record, SWIM suspects that panic / anxiety was associated with weed - seems there is a negative interaction for SWIM, unlike with almost everything else.
Nicaine, SWIM would recommend staying away from the enalapril - it can be quite toxic to some and should be prescribed by a Dr.... SWIM has known people with hypertension to get some really severe side effects from it. SWIY should find out if SWIY has high blood pressure before taking something with those kind of potential side effects. So far, MDPV has not raised SWIMs BP significantly, but then again, SWIMs monkeys do not have hypertension.
  #7  
Old 31-10-2006, 18:17
Nicaine Nicaine is offline
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Experience Report #2 Conclusion...

+28:30 - SWIM fell asleep without a problem after 5mg of Ambien. He slept heavily and woke up once in the middle of the night (another 5mg Ambien put him asleep again). No calf cramps, thank goodness.

He woke up this morning with an ache in his left side... mild, but not very encouraging. He also began craving MDPV about 2 hours after waking up -- not too encouraging either. Didn't take any (so far) and has no plans to. Given that he's only used it over a 48-hour period, SWIM suspects it's more a general addiction to stimulants, and having some always sitting around is not a very good thing. Given how many doses can be had from even 100mg of MDPV, it's not something a person with addictive tendencies should be ordering.

Snapper, SWIM appreciates the advice on enalapril... he felt similarly after researching the stuff in-depth, and likely will use it rarely or never. Verapamil should serve a similar purpose anyway and its side effect profile seems better. SWIM takes "harm reduction dosages" which he considers to be 50% of the lowest prescribed dose... he usually notices positive effects at those doses, while minimizing the chances of negative ones.

You may also be right about the 'attack dose' of MDPV. The trouble is, it seems like the first dose is short-lasting, and subsequent redoses last longer... so SWIM suspects even a higher attack dose would still last no more than a few hours, albeit more intense ones. SWIM may experiment in this area, as MDPV is so cheap it's tempting even though the high is nothing to write home about.

P.S. Nagognog2, what are you talking about?

Last edited by Nicaine; 31-10-2006 at 18:58.
  #8  
Old 01-11-2006, 04:26
Nicaine Nicaine is offline
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Notes on addictiveness

Although it may be too early to form a legitimate firm opinion, SWIM feels that despite its frustratingly short duration of main effects (or perhaps because of it?) MDPV is psychologically addictive, perhaps highly. SWIM finds it somewhat difficult to have lying around without being on it, not as much as coke but more-so than methylone and many other substances. He felt a craving for it earlier today, planned not to use it but did so anyway. A careful reading between the lines of threads (here and elsewhere) related to this substance suggests that many researchers almost immediately begin to use it often/daily, at least for awhile. Reading between the lines is not required to note that some have also smoked it continuously for extended periods of time and in relatively large amounts, reporting a compulsivity comparable to crack cocaine.

Although it's been repeated a lot already, SWIM thinks it can't be repeated often enough: Anyone wanting to try this stuff should (A) think twice, (B) be *very* conservative with dosing and frequency of use if you do get some, and (C) be prepared for the need to exercise self-control and willpower, and for potential consequences should you fail to.

P.S. for god's sake, don't smoke it. OK, maybe that wasn't called for, but... umm, yeah.

Last edited by Nicaine; 01-11-2006 at 04:35.
  #9  
Old 01-11-2006, 05:49
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Re: MDPV Experience Report(s)

^ SWIM bought a small quantity of this compound well over a year ago, and has so far followed Plan A-B as outlined above - he's never tried the stuff.
  #10  
Old 01-11-2006, 07:06
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Re: MDPV Experience Report(s)

Quote:
Originally Posted by radiometer View Post
^ SWIM bought a small quantity of this compound well over a year ago, and has so far followed Plan A-B as outlined above - he's never tried the stuff.
SWIM has folowed the same course of action. Nothing he has read so far has made him convinced that it is worth the investment in time so far. But who knows?
  #11  
Old 01-11-2006, 13:23
nanobrainPlatinum member nanobrain is offline
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Re: MDPV Experience Report(s)

investment in time - it is the opposite. as the Dead used to sing in Uncle John's Band, 'wo-ho, what i wanna know,
where does the time go?'

the point about self control is critical. have a good lock for your monkeys' cage...
  #12  
Old 01-11-2006, 16:34
snapper Gold member snapper is offline
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Re: MDPV Experience Report(s)

SWIMs toilet is still coming down from all the BZP and other piperazines SWIM flushed a while back. Wouldn't want to OD the toilet. Then the monkeys might start throwing their poop at their lab manager !
SWIM feels that the addictive potential is far less with oral dosing than snorting, smoking, or presumably rectal administration.
SWIM feels the best use is as a general purpose low dose stimulant, though SWIM still wants to push the dose to see what happens. SWIM is not particularly interested in stimulants, but is always willing to lend lab monkey services to the community for the greater good of all lab monkeys. Hence SWIM will press on...
Nicaine - this stuff is most likely unsuitable for SWIY's lab monkeys.
  #13  
Old 02-11-2006, 16:09
Nicaine Nicaine is offline
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Re: MDPV Experience Report(s)

Quote:
Originally Posted by snapper View Post
SWIM feels the best use is as a general purpose low dose stimulant, though SWIM still wants to push the dose to see what happens. SWIM is not particularly interested in stimulants, but is always willing to lend lab monkey services to the community for the greater good of all lab monkeys. Hence SWIM will press on...
Nicaine - this stuff is most likely unsuitable for SWIY's lab monkeys.
You're probably right... the monkeys definitely do better with a specific purpose (i.e. sex boosting), higher dose and longer-acting stimulant. But the stuff may still come in handy as something to use along with something else to boost the effects of that something-else, particularly given the low cost.

Anyway, his monkeys are taking a complete break from stimulants right now.... nothing stronger than black tea, until *at least* Friday night, and probably a lot longer. One of them still has a vague pain in its left side (may be kidney related) mostly noticeable upon waking up in the morning, which SWIM is hoping will just go away without needing a trip to the vet. SWIM is not so reckless to push things until his monkeys suffer severe health problems.
  #14  
Old 02-11-2006, 22:07
Nicaine Nicaine is offline
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Re: MDPV Experience Report(s)

SWIM put 4mg of MDPV in his nasal snifter. His excuse -- he wants to challenge the kidney pain & see if it gets any worse when he uses the stuff. The real reason: He wants to get buzzed on MDPV.
  #15  
Old 03-11-2006, 00:01
snapper Gold member snapper is offline
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Re: MDPV Experience Report(s)

SWIM's labmonkeys are dorks !
Might want to cut of their hands, then lock them into their cage with the teapot !
Well at least this confirms MDPV's ddictive draw - Oh what will the labmonkeys do when the MDPV is gone - switch to crack? Have someone kick them in the back to challenge any ensuing kidney pain ?
Bad monkey.
  #16  
Old 03-11-2006, 01:30
Nicaine Nicaine is offline
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Re: MDPV Experience Report(s)

Quote:
Originally Posted by snapper View Post
SWIM's labmonkeys are dorks !
Might want to cut of their hands, then lock them into their cage with the teapot !
Well at least this confirms MDPV's ddictive draw - Oh what will the labmonkeys do when the MDPV is gone - switch to crack? Have someone kick them in the back to challenge any ensuing kidney pain ?
Bad monkey.
You gotta give SWIM this -- at least he's honest. Or maybe it's a worthless quality compared to his numerous faults (dubious self-control where addictive substances are concerned being a big one).

P.S. as far as the second part of the third sentence above goes... his monkeys will simply convince him to reorder. After all, unlike crack, a dose of the stuff costs a couple candy bars. It seems SWIM may have found a substance cheap enough to really get his @ss into trouble with.
  #17  
Old 03-11-2006, 07:14
GDxCAT GDxCAT is offline
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Re: MDPV Experience Report(s)

SWIG is also very compulsive with this stuff.
He feels a need to redose every couple hours (if smoking he sometimes redoses every 45 minutes or so).
The strange thing is that SWIG doesnt find this substance enjoyable at all. It makes him less sociable, scatter brained, does not help much with studying and makes him feel depressed. And still he redoses the stuff like a fiend.

This is perhaps the weakest and worst stim SWIG has ever tried but still he feels drawn to it in a strange way. After his supply runs out he says he wont be going back to this stuff. A stong cup of coffee and piracetam work much better for focusing and studying.

Oh SWIG told me he experinced a k hole while on MDPV and it was a wild trip. This was SWIGS 1st k hole though so he doesnt know how it would compare to Ketamine without mdpv.
  #18  
Old 03-11-2006, 07:38
Nicaine Nicaine is offline
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Re: MDPV Experience Report(s)

Quote:
Originally Posted by GDxCAT View Post
SWIG is also very compulsive with this stuff.
He feels a need to redose every couple hours (if smoking he sometimes redoses every 45 minutes or so).
The strange thing is that SWIG doesnt find this substance enjoyable at all. It makes him less sociable, scatter brained, does not help much with studying and makes him feel depressed. And still he redoses the stuff like a fiend.
Dopamine has that effect, although it should also contribute a pleasurable aspect of SOME sort. SWIM seems to find MDPV more enjoyable and less compulsive than SWIY, but still relatively compulsive and not-so-great. It's particularly sucky if (A) used when SWIM got a poor night's sleep before, or (B) SWIM has used it more than one day in a row.

It could be that dopamine depletion is SWIY's problem, particularly using the substance more than one day in a row and/or smoking it. There's only so much to go around inside those neurons.
  #19  
Old 03-11-2006, 12:57
fastandbulbous fastandbulbous is offline
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Re: MDPV Experience Report(s)

Quote:
SWIG is also very compulsive with this stuff.
He feels a need to redose every couple hours (if smoking he sometimes redoses every 45 minutes or so).
The strange thing is that SWIG doesnt find this substance enjoyable at all. It makes him less sociable, scatter brained, does not help much with studying and makes him feel depressed. And still he redoses the stuff like a fiend.
And I think therein lies the problem... once you go over a certain amount in a fixed time period (the amount in say one day differs from person to person), then it suddenly loses it's most desirable properties and produces a 'cracked out' feeling with excessive sympathetic activity. Redosing every 45 mins will almost inevitably lead to this state; I've found no less than 4 hours between redoses and no more than 30mg in a 24 hour period (rectally) to be the ideal limit for a dosage regieme.
  #20  
Old 03-11-2006, 20:02
Nicaine Nicaine is offline
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Re: MDPV Experience Report(s)

Quote:
Originally Posted by fastandbulbous View Post
And I think therein lies the problem... once you go over a certain amount in a fixed time period (the amount in say one day differs from person to person), then it suddenly loses it's most desirable properties and produces a 'cracked out' feeling with excessive sympathetic activity. Redosing every 45 mins will almost inevitably lead to this state; I've found no less than 4 hours between redoses and no more than 30mg in a 24 hour period (rectally) to be the ideal limit for a dosage regieme.
30mg in a 24 hour period rectally!! SWIM can't take more than about 3-4 mg per rectal dose, and the notion of 7 to 10 redoses in 24 hours is just too much. He finds 4mg rectal equating to 10-15mg via snorting or oral routes.

SWIM has his own dosing regimen, using a nasal atomizer (i.e. snorting MDPV dissolved in dh2o). Snort ~0.5mg, wait 15 minutes, snort ~0.5mg, wait 15 minutes, so on and so forth. Eliminates the whole "number of redoses" controversy and keeps his blood levels a lot steadier. ISE it's those brief ups & dizzyingly fast comedowns that makes MDPV a frustrating/annoying substance, so SWIM does what he can to keep the high on a fairly even keel.

SWIM ordered another 100mg for his monkeys last night. The combination with propylhexedrine was outstanding, resembling methamphetamine in every aspect (including length of effects, 12+ hours up there followed by a very gradual comedown). It was almost too much... if/when SWIM does it again, he'll be sure to start in the MORNING so he can sleep some time during the following night. Even high dose benzos didn't bring him down much off that combo... it was POTENT. He'd be more than a bit worried if one of those 'panic attacks' struck while he was tweaking out on both substances.

Last edited by Nicaine; 03-11-2006 at 20:22.
  #21  
Old 05-11-2006, 06:22
Nicaine Nicaine is offline
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Re: MDPV Experience Report(s)

SWIM has noticed a lot of influence from 'mental attitude' on the enjoyability of MDPV. Someone in another thread noticed a strong, irresistable 'energy push' at higher doses, and SWIM has noticed this as well. Earlier he caught himself thinking "wish I could relax, this sucks, I want to come down." Needless to say, it DID suck. Later he started thinking "energy.... energy... this rules" and the high was a lot better. Guess this goes for any substance, even psychedelics... if you don't like the head space, it's gonna suck. SWIM thinks this substance could actually help get him off his arse & out doing interesting stuff for the first time in years, provided he's willing to give up the comfort zone he's gotten so fond of.
  #22  
Old 05-11-2006, 16:33
nanobrainPlatinum member nanobrain is offline
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Re: MDPV Experience Report(s)

it is the others' comfort levels that get stretched with the given monkey under MDPV. careful.
  #23  
Old 05-11-2006, 23:25
Nicaine Nicaine is offline
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Re: MDPV Experience Report(s)

Quote:
Originally Posted by nanobrain View Post
it is the others' comfort levels that get stretched with the given monkey under MDPV. careful.
SWIM thinks MDPV is deceptive in that it can certainly cause problems if abused, but he doesn't believe it's somehow "special" or more toxic compared to other stimulants such as meth or coke. It has to be equally respected alongside the classic stims... however, SWIM doesn't think it needs more respect than those. Yeah, maybe there are unknown long-term toxicity factors, but it doesn't seem likely given the subjective effects of the drug. Something that digs deep enough to cause permanent damage to dopamine neurons would very likely be inducing strong euphoria, hyperthermia, seizures, mania, hallucinations, psychosis and extreme anhedonia upon comedown. Brain damage doesn't occur in a vacuum. What SWIM has experienced seems more reminiscent of a moderate reuptake inhibitor along the lines of methylphenidate.

Last edited by Nicaine; 05-11-2006 at 23:57.
  #24  
Old 06-11-2006, 00:44
snapper Gold member snapper is offline
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Re: MDPV Experience Report(s)

Those are dangerous assumptions to make, Nicaine. Chems can damage you through all kinds of mechanisms, and MDPV is new and unknown.
SWIM feels that MDPV is not as friendly as other stims. It is too dose sensitive when it comes to catacholamines. With cocaine or speed, SWIM can push the euphoria way higher with repeated use, but with MDPV, hitting that magic 8mg creates a super unpleasant state of of extreme tachycardia (160-180bpm), sweating, dizziness, numbness of extremities, rapid and weak peripheral pulses with dropped beats, extreme overstimulation, shakes and confusion. This translates to SWIM as 'about to overdose and flop like a fish'. SWIM had this happen twice now, and stopped it quickly with an atenolol and a light dose of a traquilizer SWIM had put away for an emergency. SWIM was fine after that, will all of MDPVs effects gone (SWIM always found propranolol to stop cocaine's high for SWIM too back when SWIM abused it, so go figure...).
Now for an well prepared idiot like SWIM, this is not a big deal. SWIM could recognize and deal with the problem, but this could be deadly to someone else with a higher dose and nothing to control the symptoms with (ie - worse idiot who is not prepared). Now kratom and weed were on board both times and could be contributing factors, kratom as a stimulant and weed as an anticholinergic (increases heartrate), but SWIM has never had this happen with the two latter alone. These reactions have prevented SWIM from pushing MDPV to 10 mg orally, and SWIM is beginning to think that this chem has too short of a duration of effect and is too unpredictable for SWIM to push any further at all.
SWIM supposes that part of the fun is research, but not if it makes SWIM feel like SWIM is about to die.
And no, SWIM is certain that these two episodes were not panic attacks. SWIM was not nervous or had any of the normal thought patterns SWIM has when these occur. In fact, SWIM would not have dealt with them as rationally or quickly had they been.

Post Quality Evaluations:
good advice
  #25  
Old 06-11-2006, 01:15
Nicaine Nicaine is offline
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Re: MDPV Experience Report(s)

Quote:
Originally Posted by snapper View Post
Those are dangerous assumptions to make, Nicaine.
Dangerous how? SWIY should know how careful SWIM is with this stuff, after reading these experience reports. They're educated guesses, that's all. They don't affect SWIM's care in using the substance.
Quote:
These reactions have prevented SWIM from pushing MDPV to 10 mg orally, and SWIM is beginning to think that this chem has too short of a duration of effect and is too unpredictable for SWIM to push any further at all.
It becomes obvious rather quickly that MDPV is not amenable to being "pushed" in dosage, but SWIM is not at all sure why this suggests it may be a dangerous substance at more reasonable doses. Some drugs work with a "more is better" formula applied, some do not. Acetaminophen is supposedly pretty safe, but "push" its pain relief much and you're six feet under. OTOH, opiate dosages can be "pushed" (within limits) for more relief of pain if the current dose isn't doing it.

FWIW, SWIM has pushed meth doses with much worse results than anything reported for MDPV. Extreme paranoia, inability to tolerate light/sound, high temperature, extreme cardiac effects, feelings of insects crawling on the body, and a "panic attack" along with that. Is meth somehow less dangerous than MDPV, or is it just that familiarity breeds.... ahem, trust?
Quote:
SWIM supposes that part of the fun is research, but not if it makes SWIM feel like SWIM is about to die.
Good, SWIY is right... it's not worth it. Try combining stuff like SWIM's been doing... kratom is a good combo (although some really bad jitters can occur), propylhexedrine a better one. There are potentially many others.

Last edited by Nicaine; 06-11-2006 at 01:33.

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