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Cocaine & Crack Cocaine & Crack Cocaine

 
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  #1  
Old 16-10-2006, 22:12
kailey_elise Gold member kailey_elise is offline
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Cocaine a better pain reliever than opioids?!?

Hi there. I'm mostly a lurker, though I do post occasionally when I think I might have an answer better than those already posted or a question not currently asked - like today.

A friend of mine ("SF") suffers with a chronic pain condition and is prescribed opiates (methadone & dilaudid) for the pain. Apparently, the pain has gotten much worse as of late; I was IMing with "SF" last night as many things were tried in an attempt to alleviate the pain: an additional 10mg methadone on top of the usual dose (I think it was 100mg in all by the end), 6mg Dilaudid orally, 1 frozen mudslide drink (vodka & Kaluha w/milk & coffee ice cream), 1 screwdriver drink (vodka w/oragne peach juice), then 10mg Dilaudid plugged (crushed, dissolved in water, then administered via enema), 30 minutes later another 6mg Dilaudid plugged, 1 hour later a final 4mg Dilaudid plugged, for a total of 20mg Dilaudid plugged & 6mg orally. "SF" intimated that no more was taken out of fear.

Apparently, not only was the pain still, well, painful, "SF" reported no real buzz - just a slight one for about 2 minutes after finishing the screwdriver.

Flash forward to this morning, pain is reported to be the same (even after "SF" took the normal morning dose of methadone, 30mg), but a friend came over in the early afternoon with some cocaine. "SF" partook of the cocaine and felt better - said the pain wasn't totally removed or anything, but it helped - MUCH more than the opiates.

Any ideas on how this could be? What chemicals/parts of the brain would cocaine hit that opiates wouldn't/didn't? Could the cocaine actually just be potentiating (sp?) the opiates and making them work better? And although this isn't the correct forum, anyone know why 20mg of Dilaudid plugged didn't work (not even a buzz to at least forget about the pain!), but 2 lines of cocaine did?

Man, I felt (and continue to feel) so bad for "SF", and I worry too, with the large doses of narcotics seemingly needed to make the pain subside. :'(

Thanks in advance for any help anyone can provide!

~K.Elise

Last edited by Benga; 22-09-2007 at 10:40.
  #2  
Old 19-10-2006, 14:44
monkeygone2heaven monkeygone2heaven is offline
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Re: Cocaine a better pain reliever than opioids?!?

cocaine does NOT act on the central nervous system pain centres, only is a local anesthetic. one of the main confusions. your friend may not get relief from opioids, not all chronic pain conditions (unfortunately) are relieved with narcotics, i'll be the fist to tell you as a) chrronic pain patient, b) neuropharmacologist!

NO basis whatsoever in using cocaine other than recreation. period. the only pain relief is topical anesthetic (e.g, numbing of your gums when you administer orally etc). is not effective in any known chronic pain condition. sorry!
  #3  
Old 22-10-2006, 01:06
stoneinfocus stoneinfocus is offline
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Re: Cocaine a better pain reliever than opioids?!?

I´m, suffering of chron. pain, also, and when I took the Line 1 to mirror, it really helped alleviating the pain.

Maybe some dopaminergic or any other neuronal synergy within opiates or pain perception that cocaine alters?.. swim wonders how medics can be so sure about most of their wisdmom and applications? -maybe they have to, to justifiy a sometimes useless and ethically cruel treatment, cause there has to be a landmark, when life has to take its toll

Usually, when one substance is a nightmare to some it might be gold to another and patients perception often are very distinct and exact, if the patient has to deal with a chron. condition.

And recreation -in its etymological meaning, is something very useful in regard to chronic pain management.

It might me depression, which would be alleviated, that worsen painperception?
  #4  
Old 22-10-2006, 03:09
kailey_elise Gold member kailey_elise is offline
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Re: Cocaine a better pain reliever than opioids?!?

Quote:
Originally Posted by co-incidence View Post
I´m, suffering of chron. pain, also, and when I took the Line 1 to mirror, it really helped alleviating the pain.
That's exactly what SF said, & was totally amazed by that fact.

Quote:
Originally Posted by co-incidence View Post
And recreation -in its etymological meaning, is something very useful in regard to chronic pain management.

It might me depression, which would be alleviated, that worsen painperception?
I wonder about the depression as well; SF doesn't seem depressed (and I've seen SF through some depressive episodes!), but in my research it seems that many (most? perhaps even all?) chronic pain patients suffer some degree of depression, and that it can sometimes appear different than, er, "traditional" clinical depression. So perhaps SF & I are both missing the signs of depression, because we're looking for the traditional signs of past episodes? Who knows...

It would be so lovely if SOME company out there could come out with a drug that acted on the same (or at least many of the same) receptors as cocaine, without (or without many of) the negative side effects. *sigh*

I know that cocaine isn't solely a "topical anesthetic", that it works in the brain. I was wondering what exactly about it might be hitting the areas that interpret pain in the body. Perhaps the previous commentor doesn't understand the nature of chronic pain & how pain is felt/interpreted by people who are ALWAYS in pain.

Sadly for SF, cocaine isn't something you can take on a regular basis like other medications! *LOL* But, I'm pleased that SF found something that might work to help on those, well, not rare, exactly, but not common, either, situations when the prescribed treatments just aren't doing what they're supposed to do. Too bad it's illegal - I really hope SF finds SOMETHING legal that will help the condition!

Thanks for the feedback, everyone!

~K.Elise
  #5  
Old 22-10-2006, 11:06
psyche psyche is offline
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Re: Cocaine a better pain reliever than opioids?!?

Cocaine does have analgesic effects on central nervous system, altough I have no idea if it helps in chronic pain. Waddell and holtzmann(1999) found that alone cocaine produces analgesia in the hot-plate, but not the paw-pressure test. It has synergestic analgesic effect with mu- and kappa opioid receptor agonists. Studies show that these interactions are involved with noradreneric mechanisms, supraspinal mu and delta receptors and spinal mu receptors. So it surely does alleviate pain especially with such large doses of opiates.
  #6  
Old 29-10-2006, 11:23
monkeygone2heaven monkeygone2heaven is offline
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Re: Cocaine a better pain reliever than opioids?!?

could swiy post a link to those studies? swim is very interested.

there have been studies trying to link cocaine(dopamine) and opiate receptor up/down regulation and addiction and there may well be common substrates to those but most are a bit obscure, and in any case the links are not well-understood nor direct.

http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_DocSum

http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_DocSum (just title)

the simple fact swim was trying to point out but probably was too short in her reply, is cocaine does not (is not known to) bind to any opiate receptors and cause direct pain relief. cocaine, swim is sure, not a "better" pain reliever than opiates. but if we bring subjectivity into it, there is no point to talk about it. what is "better" for swiy, may not be beter for swiy2... etc...

one has to keep in mind there are various kinds of pain and this should be discussed with your doctor. - e.g, arthritis pain is very different from neuropathic pain. for example neuropathic pain iwll often not respond well to opiates.

now, that doesn't mean when patient pops a few pills they don't feel better. they can still feel the pain but might not care much about it -- if we are calling that pain relief than sure, anything under the sun can be a pain-reliever depending on person! but is that a good reason to become dependent on opiates?

the point made about "perception of pain" is a valid one. back to cocaine, when one is under a certain euphoric, good feeling, pain perception is improved. but one can achieve the same (decrease in felt pain without improvement in condition) with meditation and self-hypnosis. so swim would be surprised if any sane medical practicioner would instead propose trying cocaine. it's expensive, potentially addicting, not good for health. and it is not acting directly on the pain system. if we are talking about a terminal cancer patient, and cocaine is the only thing that helps them, maybe. but it is not a default pain drug.

swim is not trying to be "holier than thou" - she uses cocaine herself!! what she thinks is important is separating causes from effects, choices from wanting to believe. swim has known people taking opiates for pain relief and by the time they realise they've been abusing them, they're addicted. swim has avoided this by being brutally honest with herself. same goes for cocaine i think. one needs to be honest to herself about why the substance is being used. for pain relief? swim will be open minded and say, OK. but swim knows and loves cocaine -- its one hell of a drug ya know!!



ps: if someone is depressed, probably the worst things they can do is play around with dopamine drugs like cocaine and amphetamines. they may make a person feel good! but for how long? there is a "down" to these things and they make long term changes in the brain! this is nother topic but really important:

http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_DocSum

http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_DocSum

http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_DocSum
  #7  
Old 06-11-2006, 11:28
stoneinfocus stoneinfocus is offline
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Re: Cocaine a better pain reliever than opioids?!?

While swim has now the ability to use meth instead of opiates, or with opiates and he must say, that it not only alleviates depression and pain better, it also adds to flexibility and physical constitution and he´s now awake, when he´s awake. Before, he was in pain taking opiates and maybe sleeping the half of the day, having periods of maybe 3 hours where he´d be nearly awake, but then being too exhausted and having to get a nap, with amphetamines he´s now up to 6-8 hours straight through awake, physically active and less in pain than with opiates.

He´s using cocaine sometimes and never came across a major tolerance to stims in his whole life, where he´s been using those at will, so he´s very optimistic, that it would stay this way, and even if not, it were already worth it and would be!

I can´t see what´s so diabolic on cocaine, at lease 1/2 of South America is on it and the sides are phyiscally less dramatic than abusing aspirine or paracetamol, resp. acetaminophen - imho losing the kidneys and going to dialysis every other day for a few hours, for the rest of your life, is worse than max.3 months of depression from the most sever and longest cocaine abuse?

Most of the links you´ve posted are mostly conducting tests of an animal model of addiction for parallels in humans.. swim can´t tell how worse an addiction could get, cause he never really had a bad one, except for mj and cigarettes, which he overcame and thereby reducing any risk of dependence to less then 99%, but there´re always some extremes: extreme users of a substance with no sides or only few and heavy users with all the sides, even short term users being in a from all sides overdramatized and so exacerbated mess.

I could give an exmaple where one would go through all the clinical sings of an addiction to neraly all conrtolled substances, with a slight amphetamine psychosis for a month and after a self-chosen 3 years off-period, returning to a yearlong controlled non-addicitve use of those, beside anything that is smokable , since statistical numbers indicate, that habitual cigarette smoking might be the curse and reason of all heavy addictions and intoxication problems, or so to say, an additcive behaviour, that would lead to the latter.

I couldn´t say that a doctor, thinking of cocaine as a pain remedy, would be insane, -let´s be clear about the fact, that, a chron. pain patient has no way -he´s either addicted to his pain, leaving himself and his life in a mess, or he´s addicted to take a remedy, i.e. opiates, or anti-depressives, or -you name it, any substance with a numbing or synergistic effect.

As swim came across this kind of logic he radically adapted to it over a few years and he couldn´t be more honest to himself or responsible for what he´s doing and finally, climbing across some narrow minded law-related borders and doctors opinions and limits, he might now be a criminal to some extent, but he´s got more of a life than before, and this is all that counts!

Cocaine shouldn´t be short ot expensive if it´d be exstensively marketed, relating to one of your arguments, not should the sides be too detrimental, if some would use clean stuff for what he might think has a purpose in his life.
  #8  
Old 06-11-2006, 12:33
Alicia Gold member Alicia is offline
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Re: Cocaine a better pain reliever than opioids?!?

No way! a numbing sense maybe for throat and mouth and possibly eye surgery but no way in the way opiates work and feel..
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Old 06-11-2006, 14:13
psyche psyche is offline
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Re: Cocaine a better pain reliever than opioids?!?

I don't have links to aforementioned studies. The information is from the Psychopharmakology of herbal medicine by Marcello Spinella.
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Old 08-11-2006, 06:25
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Re: Cocaine a better pain reliever than opioids?!?

SWIM was (is?) addicted to heavy duty dosages of opiates for 6 years & of course went through terrible WDs when said person ran out. Cocaine completely *stopped* the WDs during the time of cocaine use. In fact, that person now has a prescription for suboxone and hasn't needed to take it because s/he has cocaine. S/he is hoping that when the supply of coke runs out, the opiates will have been out of the body long enough to not even need the suboxone, at least from a physical sense.

So yes, although it may not make sense scientifically (I didn't read all the responses), coke works VERY well as a substitute for opiates for that SWIM that I mentioned.
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Old 08-11-2006, 12:04
Alicia Gold member Alicia is offline
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Re: Cocaine a better pain reliever than opioids?!?

Quote:
Originally Posted by lipglass View Post
SWIM was (is?) addicted to heavy duty dosages of opiates for 6 years & of course went through terrible WDs when said person ran out. Cocaine completely *stopped* the WDs during the time of cocaine use. In fact, that person now has a prescription for suboxone and hasn't needed to take it because s/he has cocaine. S/he is hoping that when the supply of coke runs out, the opiates will have been out of the body long enough to not even need the suboxone, at least from a physical sense.

So yes, although it may not make sense scientifically (I didn't read all the responses), coke works VERY well as a substitute for opiates for that SWIM that I mentioned.

Yeh perhaps, but duration is crap with cocaine and not to mention the possiblity of a due addiction
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Old 08-11-2006, 12:08
Nicaine Nicaine is offline
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Re: Cocaine a better pain reliever than opioids?!?

Opiate receptor agonists also seem to have the ability to stop the symptoms of a cocaine crash (depletion of neurotransmitters)... SWIM has used kratom before and noticed that all depression/anhedonia went away. However, it returned when the kratom wore off.
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Old 23-11-2006, 23:24
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Re: Cocaine a better pain reliever than opioids?!?

'X' also suffers from severe chronic pain since his early teens. Many painkillers came and went, even morphine based ones didn't do the trick. Finally, methadone proved to be the best painkiller, but still, there's always a certain amount of pain.

Fact is that cocaine does work as a painkiller in 'X's case as well. Even stranger perhaps is the fact that 'X' always wakes up in pain and in need of his meds 1st thing, except if he has had a few lines the night before... In that case there's hardly any pain the next morning, and he can even take his meds a little later.

Somehow it seems that cocaine not only 'boosts' the painkillers, but also lengthens their effect. And if it'd be psychological, it wouldn't work the next morning.

It's not sure how and why, but it does work. (It also helps against depression, but that's another story).

Your friend SF might want to take up with his physician to increase the level of methadone to a plane that works, and drop the rest of the meds. It's possible the other - lesser - painkillers block (or occupy) the receptors where one would want the methadone to be. For instance, if one mixes methadone and codeine, the latter will decrease the effectiveness of the first, thereby diminishing the painkilling potency overall. ‘More’ isn't necessarily better, and methadone on it's own is often more effective as combined with other painkillers (incl. alcohol).

NB: in order to prevent habituation and an increasing need for methadone, it’s advisable to reduce the amount whenever possible (i.e. when the pain is ‘doable’), only to increase when necessary. It’s good that it exists, but it still remains a ‘necessary evil’.

HTH
  #14  
Old 27-04-2011, 01:41
Tony Williams Tony Williams is offline
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Re: Cocaine a better pain reliever than opioids?!?

SWIYs body probably thinks it's endangered or something and needs to use it's own pain killers as dopamine is being released.
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Old 27-04-2011, 14:38
kailey_elise Gold member kailey_elise is offline
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Re: Cocaine a better pain reliever than opioids?!?

Quote:
Originally Posted by Tony Williams View Post
SWIYs body probably thinks it's endangered or something and needs to use it's own pain killers as dopamine is being released.
Huh? I don't understand what you're trying to say.

Also, you realise it's been 5 years since this thread was last active, right?

~Kailey
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Old 29-04-2011, 02:06
Tony Williams Tony Williams is offline
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Re: Cocaine a better pain reliever than opioids?!?

How the fuck did I end up in this thread!!! haha!! Sorry!!! Speaking of bringing back the dead!!!!

The point I was making do you think our body are killing the pain as they think we need pain relief for dangerous situations? because the Cocaine is artificially putting us in that situation,
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Old 29-04-2011, 05:11
Herbs&Hopes Herbs&Hopes is offline
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Re: Cocaine a better pain reliever than opioids?!?

Firstly, I am well aware it is a very old thread but I can relate my friends personal experience with an acute injury turned chronic, and cocaine use for pain relief.

Injury:
Anterior displacement of vertebrae due to physical trauma. Skeletal alignment was pristine prior the injury; both legs within 1/8th of an inch every assessment at the chiropractor, hips and shoulders always aligned and level.

Anyways, post-injury he felt a strong opposition to becoming addicted to opiates. Around December and January '07/'08 he was unable to get he preferred pain reliever and was given an ounce of coke instead. He was unhappy with this and unloaded enough to purchase moreof his preferred reliever and snorted the rest out of desperation and to his surprise he obtained pain relief. He noted 25-35 minutes of pain relief from a single line. He was very surprised as he thought the stimulant nature of the drug should be tightening his muscles around his damaged skeleton and causing more pain due to being all tight and knotted to begin with. The inflammation around the knots in the muscles around his spine were suddenly percieved as being far-less painful than prior the insufflation as well as the pain directly in his skeleton become far more managable.

This continued for a couple weeks until he was able to get some more of his preferred pain reliever at the time. He was seeing a doctor from month 1 of the injury and specifically stated his opposition to opiates. Months later when he was getting off his DOC due to tolerance and inefficacy of pain relief after months of use for that application he tried over 10 other medications for pain relief before finally being given codeine. He requested several times to try a narcotic after trying about 5 meds and the doctor continually refused, later he found out it was because there was 'drug-seeking-behavior' on his medical file. Sorry im getting off track; he suspects the dopaminergic quality of cocaine has something to do with the perception of pain - it may not block the signal of the pain on a cellular basis like an antinociceptive effect, but it does indeed alter the threshold for perception, and affect inflammation somehow. When the cocaine wore off, he would find himself incredibly tight in the core of his body, feeling incredibly stiff and sore on top of the feeling of the spinal fracture and slip. A line though and the feeling was gone, I think the 'numbing' effect is much more than simply a topical property. He never thought he would snort coke with a skeletal injury - continually rejected by GP's in town and not referred to a chronic pain clinic or for diagnostics even though the spine was clearly affected, deducible simply by removing my shirt and looking at my back, pain will drive one to insane lengths - to insanity itself unfortunately at times.

Unlike you, he had no opiates in his system at the time, perhaps maybe some Cannabis sp., but I am quite certain that was during the 2-3 months which he had stopped cannabis consumption because it hurt to cough WAY TO FUCKING MUCH!

Pain relief is probably directly correlated with the adrenalin and dopamine release.... just a thought.


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Herbs&Hopes

Last edited by Herbs&Hopes; 15-07-2011 at 14:19.
  #18  
Old 22-01-2012, 04:27
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Re: Cocaine a better pain reliever than opioids?!?

I realize this is an old thread and I NEVER thought I'd sign up for this website because of the name but when and if people search for what I have and end up here they should know my story...24, extremely bad chronic pain - 3 bulging discs, 1 ruptured, moderate arthritis, degenerative disc disease, neuropathy, sciatica and carpal tunnel. My life ended years ago...I didn't even work long enough to get decent disability, I get pain medication (180 oxycodone 15, somas) but I craved to feel normal again, the screaming at night, can't get out of bed, people not understanding or even willing to sympathize with you, think your an addict.......I have taken extra, drank, just to try and get my pain below what it can never go past - a 6-7. It's bad, I got an itch because I had done c-c before (C C is short for...whatever, you get it) thought I'd do it once, get it out of my system then go back to my screwed up life. But for the first time in THREE years, my pain was non-existant...I cried I could DO things again not rub and punch my legs because I forgot to take a pill and starting to go into withdrawal.....don't do it. Because when it's gone, you hurt worse....your pain tolerance is lowered and you get the worst snap back to reality imaginable because you realize you can't stay on it 24/7 and you will never be like other people. I feel worse knowing it takes away my pain, if I had known it would numb my pain, I'd have never done it. Please if you have the will, don't go looking for it like I did........you'll regret it. Build a pain tolerance, and accept the fact that it hurts, all the time....doing it will make you mentally and physically weaker to handle it, it took me a long time to build the tolerance I didn't know I had, I thought I had to work on it for several more years....now it...it sucks. So please, don't do it. If your like me, you will do it anyway, I'm stubborn and angry at the world for this and running in f*ck it mode....I figured..hey, living in hell, going to hell I might as well enjoy the ride....it makes your pain SO much worse...omg it's bad.

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