hydrocodone tolerance

[csharpprogrammer]

I was wondering if anyone could tell me about the details of hydrocodone tolerance. SWIM started taking two Vicodin ES (7.5-750) to feel a buzz, and in a matter of months, he went to 20 Vicodin ES via CWE. Is it possible for SWIM's tolerance to decrease so that he can feel nice on less than five again? If so could someone please estimate how long it would take to lose the tolerance. All input on tolerance is welcome... thanks in advance.

[Forthesevenlakes]

This question has been asked before, but it takes a month or two of no opiates for the tolerance to go down. If its taking SWIY 20 vicodin to catch a buzz, SWIY would have to lay off for, perhaps, 3 months even. But tolerance can and will go down as long as SWIY doesnt use any opiates during this time.

[Hlucn8]

I hope swiy was extracting the apap befor taking such a dose!?! Swim got hurt in combat and was perscribed 120 count 10mg hydro a month, plus duragesic patches; before he kicked he would take 150+ mg at a time just to feel normal. Took months and months to where four reg vic. (5/500) would buz him. If swiy wants to preserve the magik, it is a once or twice a week endevour, not for every day.

[Forthesevenlakes]

Hlucn8, he was, he said he was using the cold water extraction to remove the APAP. But you bring up a good point, that it takes a while to extinguish tolerance, and its best not to use opiates every day.

[Hlucn8]

Ah! CWE, duh. I thought # was refering to some obscure form of administration. As a well versed somniphile, youd think swim would have picked up on that. Some people arent well versed on internet speak as others. BTW, what doews your sig say? I tried an on-line translation, but could'nt find one.

[Forthesevenlakes]

Ohh, yeah CWE is commonly used around these parts as an acronym.

My signature is from Dante's Purgatorio and is the following in parenthesis of the larger excerpted translation:

"(Now you can understand the quantity of love which warms me to you), when our vanity is forgotten, treating shadows as a solid thing."

[Hlucn8]

Solubility... what a blessing from the gods. to someone who isn't csharpprogrammer, take your time,... take a break. O's are a wonderful lover, a horibble task master.
To Sevenlakes, a proffesor once told his class "Dante spent three days in hell,... were going to spend the next six weeks there...".

[Forthesevenlakes]

HAHAH I love that professor already.

And to SWICsharp...hlucn8 is right. Take a break or taper down with that kind of tolerance. If swiy has trouble taking a break, check out our "recovery and addiction" forum for tips on kicking the habit.

[csharpprogrammer]

Thanks for the replies... but it seems like SWIM is already a little bit ahead. See when SWIM noticed his tolerance increased so much he stopped cold turkey. SWIM hasn't taken any opiates since sometime in May-June. Now this leaves SWIM to wonder, what should he start at if and when he decides to dose again. SWIM is thinking perhaps three Vicodin ES(22.5mg)? Thanks for the feedback.

[Hlucn8]

Depends, what kind of high does swiy want?

[csharpprogrammer]

SWIM really wants the equivalent of what he was experiencing at 20 Vicodin ES.

[csharpprogrammer]

The reason SWIM wants to start low is because he does not want to overdose.

[Hlucn8]

Even before swims tolorence developed, swim found that it took four orally to get a decent buzz. What route of administration does swiy use?

[allyourbase]

you wont OD. youll OD on aceto before you od on hydrocodone. if youre having tolerance problems, its time to hit the grapefruit juice. remember 100 ml of ACTUAL JUICE half an hour before dosing.

[csharpprogrammer]

SWIM takes his drugs by mouth. Grapefruit Juice?? Does that potentiate opiates? I thought that was only with benzos? Or does it stimulate your digestive system?

[Forthesevenlakes]

Grapefruit juice potentiates opiates as well. It potentiates many drugs!

[allyourbase]

it acts as a cytosome inhibitor. cytosomes create the mitochondrial enzymes that break down "drugs". its a mild and natural cytosome inhibitor which is why its preffered over others which, chemically at least, may act to better inhibit the specific cytosomes responsible for breaking down a specific substance.

[kevip7]

Some swim I know wants to know the cold water extract thing. Swim is taking high dosage and would like to protect the liver..

[Hlucn8]

Look to the codiene faq on the net, swiy!

[kevip7]

Acetp floats right? is this the water thing swim was talking about.. not that this swim would do this, its nice to be informed and knowledgable.

[Hlucn8]

Originally Posted by kevip7

Acetp floats right? is this the water thing swim was talking about.. not that this swim would do this, its nice to be informed and knowledgable.

No, APAP is only very slightly soluble in H2O, so, you get a super saturated solution, and all the APAP precipitates, (falls like rain from a heavy rain cloud), out of solution. When the H2O is chilled, the solubility of APAP, (and aspirin as well), drops even lower. It is then filtered off, usually with coffee filters. A further refining can take place with sub-micron filtration for more,... intimate forms of administration Do do this is illegal of coarse, and anybody caught doing so would be guilty of a felony, so SWIM does not recommend this. For future reference, swim suggests that any and all prescription meds be taken as prescribed by swiy's Dr. And do not accept or transfer any prescribed meds, as this would also be in direct violation of federal law. And, as always, treat Os with Respect!

[monkeygone2heaven]

swim always feels the need to control her intake of opiates ad make sure she is not develping tolerance too fast and recommends such attention to all...

swim is prescribed opiates for chronic pain and occasioally used them recreationally, say going through 60 hydrocodone apap 7.5 mg in 4-5 days instead of a month like prescribed.

20 pills is a lot and swim hates to give advice but recommends controlling intake! swim knows how fast tolerance develops for these as she seems to have been one of thoe "sensitive/lucky" ones who actually felt effects with 1/2 or even 1/4 of a pill when she started. this does not last long.

daily use is a no no. swim is one of those "proud" pain patients who can grit teeth and bear pain until next refill if she's been "bad" by taking her pills for recreation. swim recommends coming up with some such system of control, otherwise opiates can be a slippery road.

swim actually crushes and snorts pills too but this is absolutely not recommended. really!! unless one is ready to mess up nose and is OK with inhaling some nasty stuff... swim has read this method of administtation is not supposed to work as well for narcotic pills. because most of what she's getting is not even the opiates etc. despite all such arguments (and given she won't inject) swim enjoys this process and for swim it's been waaay more effective than oral admin. maybe it's swim's extremely slow digetsive system...

swim also always mixes hers with alcohol to potentiate but again this is swim, she is a bit reckless, you gotta be more sane..

NOTE NOTE NOTE: swim really does not condone any of this! be careful with alcohol and know how your body works.. swim knows how to stay alive in hers, doesn't mean the same doses work for you!

if inhaling, be prepared for nose to hurt! swim has inhaled different combinations of stuff (e.g. bad mix of meth) which other people complained was harsh-- but to her, it has felt like pure air compared to some of the stuff she's inhaled.

pps: swim knows she needs to cwe more often but is often lazy. don't do this, be better...

[kevip7]

Wow, thanks for the info.. this swim I know was prescribed to take 10 10/325 per day and 40mg of oxy twice daily.. personally I think this is alot and swim has not followed this. Swim is worried about liver as swim does have to drink to be able to sleep. Swim has to take a benzo from time to time as well. Thanks for the info.. so far swim is managing and is finally happy with meds as swim has had trouble with fently and morphine. Seems w/d from both even with the other drugs seems to happen no matter what.. Swim is now getting stabilized and will gradually cut down on all. Nice to know the information though. Swim is not a newbie but can feel that way to some members who know so much more..

[monkeygone2heaven]

hi! wow, glad swiy is feeling more stabilized! if swiy drinks too (swim does as well!) liver health is really an issue, so is stomach and general health etc . swim recommends continuing keeping an eye on things. and come for support here if swiy needs.

[kevip7]

Swim didnt get good news at doc office as the radio isotope or whatever you call it test confirmed a new problem which swim has already been feeling the pain from.. Swims body is just going down hill. Swim spends the weekends resting as the week of work "sitting behind a desk" wears the swim out. Anyway swim is stabilizing meds but is having to deal with physical pain that is increasing and has nothing to do with meds. Swim is young; driving a car, sitting in chair a certain way, standing to long, lifting anything heavy all irrate swims conditions. Swim doesnt see an end to this.. swim was wanting to cut down and quit but this seems all impossible..