Increasing Speed n Meth potency using acetic anhydride

[roidboy]

So anyways iv been thinking that since meth is just amphetamine with a lipophillic meth group added on which increases its brain permability,
and since heroin is just morphone heated with acetic anhydride to increase its brain permability aswell.
Would heating speed with acetic anhydride create an amphetamine with greater permability then meth due to the larger lipophillic sub group?
as Meth is only CH3 and Acetic Anhydride is significantly more lipophillic being C0CH3...
Im not too sure if anyone has done this, but if it would be possible to attach an acetic subgroup to speed instead of methyl im pretty sure, That if the molecule is still active it would be alot stronger since it would be entering the body alot more easily and redily.. making a stronger more potent amphetamine. think Speed, then think Meth then think Acetlyated Speed!! Have i hit on something here or not, does anyone know of anybody trying this?

thats just my too cents, what do you guys think??

[Paracelsus]

NEVER heard of anything like this, roidboy. But it could work. It could be a new discovery, just like heroin was...
SWIY could give it a try, but he should get as much info as possible...(meth is a phenylethylamine, heroin is an opiate)

[Darksanity]

N-Acetyl-Amphetamine? =P

or even

N-Acetyl-N-Methyl-Amphetamine !!! O.o

[roidboy]

see what i mean!??! we'r talking about a molecule thats going to cross the cell meembrain ALOT MORE efficiantly then meth or plain amphet is EVER going to be able to accomplish..
If it works.

[Paracelsus]

deleted because nothing was added.

[allyourbase]

youre conjecture is interesting. but the problem with a dialkyl amphetamine is a rather simple one - it would only last a fraction of the average duration of amphetamine. dealkylation occurs by mitochondrial enzymes created by the cytosomes. when done with an amphetamine molecule this activates other cytosomes thus metabolizing the molecule much faster. one might even conjecture that it would take much more of the molecule in question to be an effector as it would be consumed faster by each pass through the liver.

Reputation Comments on this post:

good info

[Paracelsus]

hmmm..interesting point allyourbase.
so this would work only a couple of times and give stronger and shorter effects? like a rapid tolerance...but can this be reverted through abstinence?

or is there any other way to bypass this problem?

.

[allyourbase]

more complicate chemistry. something tougher to metabolize by the liver.

[allyourbase]

the more I consider this the more interesting it becomes to me. what if for example, one were to put something entirely unconsumable by the human body on this nitrogen. take AU for example. nontoxic, heavy metal. has only one high energy ion in its very outermost rotational sphere, so that this one particular ion is the only one by which the molecule of the AU reacts to its surroundings. since this would of course be the ion having to be bonded and shared at the nitrogen it would be relatively unreactive at cytosome points and at the BBB. of course I know of no chemicly formulaic way of achieving a gold molecule bonded on the end of amphetamine. just food for thought. think well.

[Nagognog2]

I can see the DEA trying to make gold a schedule II metal. And meth cooks chasing people with pliers to extract their fillings.

[allyourbase]

lmao geeked out cooks beating down people to steal tooth amalgam for amphetamine synthesis. I could very much see that happening in arkansas...

[izzy31]

Over complicated and filled with words I spent 3 minutes to say correctly, this method is detering to anyone who'd try it.....might just be easier and perhaps more potent methamphetamine, packaged in tiny bags impossible to find in most stores, garanteed highly potent with just looking at it, and NO assembly required.

[Paracelsus]

ayb, you are right that if the acetyl/meth/amphetamine thing molecule would contain gold, it would be non-metabolizable. but as far as i know it is not very reactive, so it would be difficult to create the conditions for a reaction, especially in a clandestine lab.

Another thing about gold:
"The human body does not absorb gold very well, thus compounds of gold are not normally very toxic. Liver and kidney damage has, however, been reported for up to 50% of arthritis patients treated with gold-containing drugs. Gold used in dentistry is widely regarded as the safest form of restorative material, as well as the most successful. As has recently been discovered, solutions containing special sugar-coated gold nano-particles can be used as toxin-indicators.[8]
Aurum metallicum (metallic gold) is also used as a homeopathic remedy, claimed to be helpful for people with a depressive nature." (from Wikipedia).

But of course there are other solutions for the metabolizing problem. We have to look for something that can not be metabolized by the liver (or at least metabolized harder), but is still brain-penetrable.

Originally Posted by allyourbase

youre conjecture is interesting. but the problem with a dialkyl amphetamine is a rather simple one - it would only last a fraction of the average duration of amphetamine. dealkylation occurs by mitochondrial enzymes created by the cytosomes. when done with an amphetamine molecule this activates other cytosomes thus metabolizing the molecule much faster. one might even conjecture that it would take much more of the molecule in question to be an effector as it would be consumed faster by each pass through the liver.

would other ways of ingesting the drug change something about that? [smoking, IVing, insufflation, etc.]

.

[allyourbase]

no but more complex carriers will make it harder to break down. as shulgin notes in his pikhal.