MDA cross tolerance to any PEA or Tryptamine

[primal440]

hello, swim was wondering if there's any cross tolerance between MDA any any other psychedelic (LSD, RC's, mushrooms..) and if there is, how long would it last?
Also swim was wondering about intravenous use of MDA, he's read a report claiming succesful but has read a topic on IV MDMA and a lot of people may think its stupid, but if swim recalls exactly, that guy was IV'ing a pill, plus SWIM is aware of he risks involved and the not-so-desirable side effects from this route. If swim had a pure batch of MDA, how much would it take to feel the desired effects (including those given by courtesy of IV)? Thanks in advance.

[Nagognog2]

If you are really in Chile, there is a book you would be interested in. It is (Anglais) The Healing Journey - by Dr. Claudio Naranjo of Chile. He administered MDA to patients by the I.V. route. These sessions (some of them) are written in this book.

I know of no direct study with MDA and cross-tolerance. But one would GUESS it would be cross-tolerant with other entactogenis amphetamine that dump serotonin. eg: MDMA, MDE, etc. Regards cross-tolerance with LSD or PEA's like mescaline - I do not know, but it is likely to an extent. Tolerance likely is of the MDMA-type. At least a month would be optimal to wait.

[WrtngCocaineTutorial]

Originally Posted by Nagognog2

I know of no direct study with MDA and cross-tolerance. But one would GUESS it would be cross-tolerant with other entactogenis amphetamine that dump serotonin. eg: MDMA, MDE, etc.

Alexander Shulgin conducted a study of MDMA and MDA cross tolerance:

It showed they do not make cross-tolerance

Tolerance studies also support differences in mechanisms of action. In one study, MDMA was consumed at 9:00 AM each day for almost a week (120 milligrams the first day and 160 milligrams each subsequent day) and by the fifth day there were no effects from the drug except for some mydriasis. And even this appeared to be lost on the sixth day. At this point of total tolerance, there was consumed (on day #7, at 9:00 AM) 120 milligrams of MDA and the response to it was substantially normal with proper chronology, teeth clench, and at most only a slight decrease in mental change.

[enquirewithin]

Originally Posted by primal440

Also swim was wondering about intravenous use of MDA, he's read a report claiming succesful but has read a topic on IV MDMA and a lot of people may think its stupid, but if swim recalls exactly, that guy was IV'ing a pill, plus SWIM is aware of he risks involved and the not-so-desirable side effects from this route. If swim had a pure batch of MDA, how much would it take to feel the desired effects (including those given by courtesy of IV)? Thanks in advance.

If one IVed MDA, presumably the onset would be very rapid (one or two minutes, at a guess) and the experience would be of a shorter duration. A problem could be that one would be tempted to redose to keep experiencing the initial 'rush'-- doubtless a significantly unpleasant hangover would ensue. The dosage would a fraction of that for oral administration.

A fatal overdose is possible:

There was one case in 1953, involving MDA and a psychiatric patient named Howard Blauer that proved fatal. The army had contracted with several physicians at the New York State Psychiatric Institute to explore new chemicals from the Edgewood Arsenal and one of these, with a chemical warfare code number of EA-1298, was MDA. The last and lethal injection into Blauer was an intravenous dose of 500 milligrams.

--Shulgin, PHIKAL, #100

Somewhat related, Karl Jansen reports on the case of someone being addicted to IVing MDMA (pure). MDMA addiction is very rare.

[nanobrain]

while numerous reports of iv admin ranging from 'extacy pills triple stack, dude' to pure pharma grade compound exist, the majority of partakers would not repeat.

please avoid iv if you are only after bypassing 1st pass metabolism, there are options.

while the limited Shulgin studies showed no crosstolerance, the heft of anecdotal evidence gathered since points to definite crosstolerance with most 5HT/DA releasers, some with said transmitter reuptake inhibitors.

crosstolerance of most sorts, btw, may be negated at will with one-time pyrolytic administration of 3-[2-(dimethylamino)ethy]indole at sub-breakthrough dose.

[primal440]

Yeah, me and SWIM are indeed in Chile, Ive been looking out for the book, found it in english which really isnt a problem but im currently banned from the library from where I found it, as well as SWIM fro at least a couple of months more. It is pretty enervating to not be able to find something a compatriot did, especially being so succesful. If Nagognog or any member here does have a copy of the book, SWIM would really appreciate the help if they could put the pertaining help on the dosage of the sessions by dr. Naranjo (cant order books either and doesnt have much time). SWIM really is at odds since he's already tried the experiment both times, with 40-50 mg aprox and only on one of those found an (in)significant experience, the only noticeable effects where obviously, the dilated pupils and teeth-clenching. I and SWIM have searched about IV on forums and sites but has only found one report on erowid, ocncerning pure MDA but unfortunately the experimenter had already high tolerance to the stuff and injected 75 mg, so SWIM is uncertain (http://www.erowid.org/experiences/exp.php?ID=16619). SWIM wouldnt want to waste more precious MDA especially now that the source is dead.
Both past experiments were most likely unsuccesful because of SSRI activity blocking the path for MDA (once he abstained 5-6 days and the other a week, now he's abstained 2 weeks to be certain). The SSRI was Tramadol, and from a knowledgeable person and his experiments he's gathered that it takes a week to clear up all SSRI intrusion on the experience.

SWIM is already experienced on the IV route and is aware of the intensity of both the positive and negative effects of this novel compund, but he is stubborn and curiosity (plus 2 weeks of abstination) will lead him to do that route, as he will most likely do it just once if its a success. Its not at all a thing about bypassing 1st pass metabolism, please understand.

Again, if anybody has the info SWIM is looking for, please post and help. thanks in advance.

[Nagognog2]

Found a few copies of The Healing Journey on Amazon. This book is way out of print. All are used. Better move quick. This is rare.

http://www.amazon.com/exec/obidos/se...=amd-google-20

[primal440]

Yeah I checked that out too Nag, thanks for caring and taking the time but actually SWIM nor I can order online; I know, its a mere 4.79 but plus mailing and the time it would arrive at this latitude I'd rather get a quick answer from the wise overe here. Its not that SWIM is an MDA or a Tramadol fiend, but he's been already preparing and abstaining for 2 weeks, 2 weeks more (which is usually what it takes to get things here in my experience) would be too much. Again, there's nobody pointing a gun to SWIM's face to do this, but he's really eager and would appreciate an anticipation if you have it (or any knowledge gathered from other sources). As for myself, Im def getting that book when I get my check, as for now, Im impotent.
Take note that Tramadol has been prescribed this time and not just used recreationally, if that brings any tears to your eyes.