Opiate Bioavailabilities

[nate81]

couldn't bioperine be used to increase bioavailability? More bang from SWIYour opiate buck..

[Laudaphun]

Something rather interesting regarding one of SWIM's earlier posts and perhaps applicable to other substances considered to be effective subligually such as some benzos... Since the availability of buprenorphine is supposedly much higher when administered as a solution with alcohol as the solvent as opposed to tablet form, SWIM has come to believe that rinsing your mouth out with plain old mouthwash prior to suboxone administration increases it's availability since the alcohol would soak into the tissue in your mouth a bit before you spit it out, taking suboxone immediately thereafter would be very similar to having an alcohol based solution. It should be noted that DO NOT swallow mouth wash as it contains methanol which is poisonous... as opposed to ethanol which SWIM assumes would have been the alcohol of choice for use as a solvent when preparing a suboxone solution. SWIM is still fairly certain that rinsing your mouth out with mouthwash (methanol) or some people even use vodka (ethanol) as mouthwash... SWIM has never really looked into much literature other than what she already posted, so just using herself as a lab rat tested this out and found there to be some truth to it. However, she still has not yet attempted to concoct an alcohol based suspension from the tablets... just prepared the mouth with different substances prior to administration, looking at pH differences using differnent natural acids found in juices and thoroughly rinsing the mouth out prior. SWIM has found better result from an alcohol rinse than by trying to create a more acidic environment via fruit juices as suggested by her dr. While a little extra acidity may help, it's not really noticable. Anyone else that feels like trying some form of an alcohol rinse, SWIM would be pleased to hear your results and opinions... As well as any other pre-administration techniques you feel increase absorption or have no affect.

It is also interesting that while most benzos are not water soluble, sparingly soluble at best, this may also assist in sublingual administration of benzos as well... Not tested, just a hypothesis.

[lostribe]

Originally Posted by Laudaphun

Something rather interesting regarding one of SWIM's earlier posts and perhaps applicable to other substances considered to be effective subligually such as some benzos... Since the availability of buprenorphine is supposedly much higher when administered as a solution with alcohol as the solvent as opposed to tablet form, SWIM has come to believe that rinsing your mouth out with plain old mouthwash prior to suboxone administration increases it's availability since the alcohol would soak into the tissue in your mouth a bit before you spit it out, taking suboxone immediately thereafter would be very similar to having an alcohol based solution.

How are the subs being directly effected by said mouth rinsing method? SWIM is curious as to method of injestion. Is SWIY sucking on pill? Dissolving under toung?

[Laudaphun]

just dissolving under the tongue as normal
with the idea that there are lingering amounts of alcohol remaining after you spit out your alcohol, or even swallow it if ethanol, especially under the tongue more would get stuck there afterwards... SWIM used to drink a beer before taking a suboxone... and you could tell from the lingering taste of he alcohol that some was still presentin the mouht

[somniferic]

SWIM thinks from about 20 years experience with buprenorphine that the increase in bioavailability SWIY's would gain would not be substantial enough beacuase of the kind of buzz that bupe creates, which is not really a sharp ascending 'high' as such, rather a reasonable 'elevation', followed by many hours of very steady feelings of, well...niceness, oh, and usually a fair bit of the ol' opioid motivation.

Messing about with the form is next to pointless almost in SWIM's opinion.

[pipolito]

What would be the intramuscular BA of oxycodone ?

[Vagisil]

hmmm, i really don't think there are many.

[Panthers007]

Do more research before jumping to a conclusion. Benzodiazepines, for instance, show greater bio-availability taken orally than by insufflation - most of them. Keep looking.

[Oneiros]

IV = 100% bioavailability

[RadioHead]

Most codeine potentiators also potentate APAP.

[ninjaned]

woulda been nice to see more smoked bio-availabilities. other than that, nice post.

[Toela65]

Snorting should not be done with DHC, something to do with a massive histamine release or pulmonary endema or something. Basically it isn't safe so shouldn't be done. I could be wrong though.

[Bajeda]

From a paper I recently uploaded -----> Oral diacetylmorphine (heroin) yields greater morphine bioavailability than oral morphine: bioavailability related to dosage and prior opioid exposure


Apparently, once addicted to opiates, your body not only craves them, it also becomes more efficient at absorbing them.


• In opioid-dependent people, bioavailability of morphine from oral doses of diacetylmorphine is also 37% higher than that of oral morphine.

• Morphine bioavailability is two and 1.5 times higher in chronic users than in opioid-naive subjects after low oral doses of diacetylmorphine or morphine, respectively.

• Oral absorption of morphine from diacetylmorphine is dose dependent, i.e. bioavailability increases with diacetylmorphine dose.



"Morphine bioavailability was considerably higher in chronic users [diacetylmorphine 45.6% (95% confidence interval 40.0, 51.3), morphine 37.2% (30.1, 44.3)] than in naive subjects [diacetylmorphine 22.9% (16.4, 29.4), morphine 23.9% (16.5, 31.2)] after low oral doses (48.5 µmol) of either diacetylmorphine or morphine. Morphine clearance was similar in both groups. Moreover, oral absorption of morphine from diacetylmorphine was found to be dose dependent, with bioavailability reaching 64.2% (55.3, 73.1) for high diacetylmorphine doses (1601 µmol)."



This basically suggests that if a person was opiate dependent and going to consume a relatively large dose (likely considering effect of tolerance), it would be much more worthwhile to orally consume heroin than it would be for someone with little history of opiate use consuming a smaller dose. Also, it would be more advantageous for the latter person to take morphine sulfate, whereas for the opiate dependent person the heroin would actually be more bioavailable orally than the morphine would be, so they would be better off trading any morphine tablets they have in exchange for heroin (assuming they can get relatively pure diacetylmorphine and assuming they wish to take it orally).

I don't know if these findings hold for other opiates or other methods of consumption (now that would be quite interesting). If the increased bioavailability resulting from experience level and/or a larger size dose only applies to oral consumption, then it would appear that you might actually get more bang for your buck with oral consumption than with smoking. Of course the onset and duration of effects differ to a large extent between the methods of ingestion, so personal preference will probably still be a deciding factor. Its something people may want to consider though.