Subutex - Drug Addiction Advice

[craiglibertine]

How Subutex works:
Subutex (generic name buprenorphine)is a partial agonist/antagonist at the opiate receptor. That means, it attaches to the same receptor site in the brain and nervous system as does Heroin (and other opiates - morphine, DHC, DF's, codeine. However, there are some important differences in the way that Subutex affects the body, as opposed to Heroin:
1) It is a Partial antagonist. That means, it only has some of the affects that Heroin does. It does not give a great high, but it can make you feel good, and it will certainly stave off withdrawals.
Subutex does not have such a marked effect on the circulatory and respiratory system as Heroin does. Heroin causes heart-rate and breathing rate to slow down, even to stop, which is what happens in overdose. An interesting characteristic of Subutex is that even at higher doses, it does not tend to depress the heart rate or breathing in the same way.

2) It is a partial Antagonist. This means that Subutex will block the effects of other opiates and you will not get a high.

3) Subutex has a very high affinity for the opiate receptor, more so than Heroin. What this means is that Subutex will preferentially bind to the opiate receptor. If there is any Heroin in your system and you take Subutex, the Subutex will displace the Heroin from the opiate receptors in your body, and you will be almost instantly precipitated into withdrawal. Furthermore, Subutex will remain active at the receptor for up to 72 hours. Any further Heroin (or other opiates) that you try to use on top, will not work.

The way that people are induced onto Subutex, after using Heroin, methadone, or other opiates, is to cease using for 48hrs. This means that at 48hrs you would be in active withdrawal. This is the time that Subutex is introduced. The Subutex will attach to the opiate receptor and lessen the withdrawal symptoms. The dose can then be slowly increased over a few days in order to stop withdrawals and stabilise for maintenance therapy, (eg. as an alternative to methadone maintenance); this is often a good way to go, as it gives you time to get the rest of your life together - look after your health, sort out your finances, get a job if you don't have one, get away from the using crowd, put a support network into place...before considering detoxing completely.
Normally, when starting on Subutex with a view to detox-ing straight away, again - you would increase the dose gradually over a few days to a point where you felt comfortable - no withdrawal symptoms, and then start decreasing slowly - it can be done over 10-14 days fairly comfortably, or over a longer period of time if necessary.



DO NOT POST COMMERCIAL LINKS IN THESE FORUMS. READ THE RULES:

http://www.drugs-forum.com/forum/ann...t.php?f=43&a=1

[Subuser]

I just recently detoxed using Subutex and would like to point out that the administration of Subutex/Suboxone is changing rapidly.
Initially, addicts were started with dosing as high as 32mg and titrated to about 16 mg a day.
I was given 8 mg the first day and after 2 weeks I am down to 1 mg daily.
As to the question of when the first dose it administered, that is an important point since many addicts may not seek help if they believe they must endure 48 hours of withdrawal before treatment.
I was given my first dose only 12 hours after my last use and the withdrawals were almost nonexistant.

Before proceeding to post in these forums, you MUST first familiarize yourself with the rules here. Pay close attention to the rules regarding self-incrimination and learn to use SWIM (Someone Who Isn't Me) or equivalent. Proceeding without abiding by our rules can and will get you banned.

The rules can be found here:

http://www.drugs-forum.com/forum/ann...t.php?f=43&a=1

Thank you & Welcome.

[wellhelm]

This swim has nothing but praise for subutex. It was like a miracle drug. No withdrawal symptoms at all. Way less(if at all) addicting than methadone. The only problem is where swim lives methadone clinics are in as abundance as liquior stores but subutex is scarce.