Does rectal admin of morphine increase bioavailibility??? - Page 2

26-08-2006, 09:48

Wyborowa

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Location: Buffalo, NY USA

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Does rectal admin of morphine increase bioavailibility???

How does rectal administration of morphine increase bioavailibility when taking it orally is only 30% bioavailible? Rectal would be similar to insufflation, right? Wouldn't the morphine turn into gell in the enema bottle? Swim is using the 30mg MS contin xtd release....would swim have to take the coatin off then crush it? or just crush the whole pill, mix with more water than necessary and bum boot it?
THANKS!

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