Drugs-Forum  
Home Wiki Studies Forum Groups Blog Video Images News
Go Back   Drugs Forum > DRUG-FORUMS > Opiates & Opioids > Codeine
Mark Forums Read
Register Tags

Notices

 
Thread Tools
  #1  
Old 22-06-2013, 17:40
fleeman fleeman is offline
Newbie
 
Join Date: 08-06-2013
21 y/o Male from Canada
Posts: 5
fleeman is an unknown quantity at this point
Points: 38, Level: 1 Points: 38, Level: 1 Points: 38, Level: 1
Activity: 0% Activity: 0% Activity: 0%
How much Codeine metabolizes into Morpine?

Hey first post here.

I have looked up and down this forum for an answer but couldn't find anything.

A Buddy of mine was wondering how much codeine actually metabolizes into Morphine?

For example if he were to take 50mg of codeine, how much of that would metabolize into morphine?

thanks in advance for any replies!
  #2  
Old 22-06-2013, 18:18
Millie Platt Millie Platt is offline
Banned
 
Join Date: 22-03-2013
28 y/o Male from France
Posts: 581
Millie Platt probably knows what they are talking about.Millie Platt probably knows what they are talking about.Millie Platt probably knows what they are talking about.Millie Platt probably knows what they are talking about.Millie Platt probably knows what they are talking about.
Points: 746, Level: 4 Points: 746, Level: 4 Points: 746, Level: 4
Activity: 28.4% Activity: 28.4% Activity: 28.4%
Re: How much Codeine metabolizes into Morpine?

i'm sure this has been covered about a million times but the rule of thumb is roughly 10% - give or take depending on metabolism.

some can't metabolise it at all.
  #3  
Old 22-06-2013, 20:53
Mindless Mindless is offline
Straight out of Trumpton
Co-Moderator
 
Join Date: 23-02-2011
50 y/o Male from United Kingdom
Posts: 1,628
Blog Entries: 3
Mindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forum
Points: 7,647, Level: 12 Points: 7,647, Level: 12 Points: 7,647, Level: 12
Activity: 20.0% Activity: 20.0% Activity: 20.0%
Re: How much Codeine metabolizes into Morpine?

The amount of codeine metabolised into morphine can vary. Some individuals appear to be extensive metabolisers, while others may be poor metabolisers. 6%-10% Caucasians, 2%-5% African Americans, and 1% Asians are poor metabolisers of CYP2D6 substrates such as codeine
Quote:
Patients who are CYP2D6 PMs (Poor Metabolisers) will not convert codeine to morphine and will have a reduced analgesic effect from codeine. When patients who are CYP2D6 EMs (Extensive Metabolisers) are administered a CYP2D6 inhibitor, they do not convert much codeine to morphine and have a minimal analgesic response to the codeine.
Ten percent seems to be the usual overall dose of morphine from codeine. Perhaps members of this group occupy points around the middle of a poor metaboliser-extensive metaboliser continuum.

Drug Interactions: insights and observations. Understanding an Important Variable in Patient Response. John R. Horn, PharmD, FCCP, and Philip D. Hansten, PharmD, Pharmacy Times 2006.

It has been suggested that extensive metabolisers may convert codeine into morphine at an 'ultra-rapid' rate. CYP3AF inhibitors and renal insufficiency may lead to an increased risk of codeine toxicity for extensive metabolisers.

Codeine Intoxication Associated With Ultrarapid CYP2D6 Metabolism.

Chen et al (1991) make similar comments:
Quote:
There are several potentially important clinical implications of our findings. In healthy young subjects, there is unlikely to be unpredictable accumulation of codeine and codeine-6-glucuronide with chronic administration. This may not be the case, however, in patients with impaired renal function and in the elderly, in whom plasma codeine-6-glucuronide concentrations may be substantial and could contribute to adverse effects. Poor metabolisers of codeine may not derive any of the pharmacological effects associated with codeine.
Disposition and metabolism of codeine after single and chronic doses in one poor and seven extensive metabolisers.

Post Quality Evaluations:
Interesting data on ethnic variables

Last edited by Mindless; 20-07-2013 at 13:42. Reason: corrected hyperlink

Share this on:

Tags
codeine, morphine

Thread Tools


Similar Threads
Thread Thread Starter Forum Replies Last Post
Cold Water Extraction of Opioids Alfa Wiki Articles 13 26-07-2012 01:09
Drug Info - Codeine trptamene Codeine 0 27-10-2007 01:34

» New Threads
AM I GONNA DIE??? WHAT DID I DO...
Last post by highlikeplanes
7 Replies, 382 Views
Ways to hide/mask meth symptoms...
Last post by rawr161
47 Replies, 100,428 Views
$1,000 Each Hepatitis Pills In...
Last post by TheBigBadWolf
1 Replies, 2 Views
how long will 30mg of diazapam...
Last post by bobes
3 Replies, 130 Views
Coming off heroin using low dose...
Last post by EliteOps1
24 Replies, 615 Views
I tried MG seeds for the first...
Last post by Opiate lover27
1 Replies, 2 Views
MXE and extreme tolerance?
Last post by hookedonhelping
3 Replies, 58 Views
Homemade enema and cleaning the...
Last post by TheBigBadWolf
7 Replies, 209 Views
Molly or meth?
Last post by Opiate lover27
2 Replies, 106 Views
Bupe for Depression with no opiate...
Last post by bobes
4 Replies, 141 Views
» New Wiki Articles
GHB
NET

Sitelinks: Information:

All times are GMT +1. The time now is 19:50.


Copyright: SIN Foundation 2003 - 2014, All rights reserved