Potentiating Amphetamine

[Nahbus]

To swallow a few pills?
SWIM says 5-HTP is good for you anyway..
Sounds like something SWIM will try.

[AchaeaPerson]

Would it be a bad idea for SWIA to mix several different Amphetamine potentiators mentioned in this thread? For example; ingesting .5tsp baking soda, one Alka-Seltzer tablet dissolved in water, and 100mg of caffeine, then a half hour later taking another 100mg of caffeine, and another Alka-Seltzer tablet, then taking however much Amphetamine is desired a half hour after that? SWIA normally wouldn't go to such lengths, but he plans to enjoy the last of his current stash of d-Amphetamine on Friday or Saturday, and he told me that he wants to be sure it's a memorable experience to hold him over until he's able to purchase more. If this plan could possibly be dangerous, he'd appreciate suggestions as to what combination of potentiators he could take to get the most out of his d-Amphetamine without putting himself at risk.

[logicbomb666]

Swim always takes amphetamine on an empty stomach and sometimes changes his stomach or urinary pH to either increase potency or increase duration, respectively.

When swim wants potentate effects swim takes 3-4 Tums Ultra 1,000's about twenty minutes before taking the amphetamine. Sometimes an hour or so in swim will take another tums.

Swim also puts a small spoonful (not heaping, sometimes less) of baking soda in to 4 oz. water, swishes it around and downs it..... for swim, this can make the amphetamine last up to twice as long.

Sometimes Swim takes a protien pump inhibitor with the amphetamine, this seems to help ("reduce gastric acid secretion by up to 99%" wikipedia: Proton_pump_inhibitor)

swim read on wikipedia that acute doeses of sodium bicarbonate (baking soda) can make one dose of amphetamine last up to 24 hours. swim wants to figure out what these "acute doeses" are

[dark12]

SWIM would like to know if "basifying your body" with antacids prior to consuming amphetamines will potentiate them even if one chooses to insufflate them rather than swallow them?

[Sloop]

yes dark 112, it doesnt matter how you put the amphetamines into your bloodstream (snorting dropping plugging shooting etc) if your blood is a bit more alkaline it slows down the kidneys filtatration rate of the amph molecule, but dont take too much baking soda and make yourself too alkaline, 24hrs cranking is not always nice unless your driving your big truck a long way.

Reputation Comments on this post:

thanks for the advice!

[dark12]

haha thanks for the info sloop!

Reputation Comments on this post:

he answers and has sense of humour

[jj_redick_stud4]

Swim takes one zantac 30 minutes before taking his adderall. It increases the absorbtion rate and how much is absorbed, so it increases the effects and makes it last longer. It works great for SWIM but everyone is different so just because it worked for SWIM doesn't mean it will work for SWIY.

[sknkv2]

With the bi-carb soda method, does it matter which way the drug is ingested to be effective? Say you eat some bi carb, like a teaspoon or something, and then smoked or snorted the amphetamine instead of taking it orally, would it still have a potentiating effect?

[dark12]

Originally Posted by insert_username_here

With the bi-carb soda method, does it matter which way the drug is ingested to be effective? Say you eat some bi carb, like a teaspoon or something, and then smoked or snorted the amphetamine instead of taking it orally, would it still have a potentiating effect?

I asked this question a few posts up.
SWIsloop said it does indeed potentiate the effects. In SWIM's experience he would be correct.

[gmeziscool2354]

Somebody yelled into my neighboors window that a good way to break time release on xr's is to open the pill and crush the contents in prefered method. add the powder to several ounces of water. it is highly soluble in water, so if there is any undisolved material it is most likely binder, but since it no longer encapsulates anything it is basically innert. a small amount of baking soda can be added to the mix which can serve as potentiator. The man yelling into my neighboors window told them that a by product of the reaction of the baking soda/stomach content acid base reaction, roughly NaHCO3+HCL CO2 gas is given off which produces bubles in the stomach allowing for faster absorbtion (carbonation). He also reccomened eating a tums or a rolaid ahead of time and going light on the Bicarb in the final mixture because it can upset the stomach. by making the substance aqueous before injestion and destroying the time release binders

[chronman]

swim was wondering if prescription drugs like nexium, prilosec, or reglan have an effect on amphetamines? the first 2 are used to treat acid refulx and reglan is for the same but it also has anti-psychotic properties. it says it inhibits dopamine receptors, so does this mean reglan will weaken the high from drugs like amphetamines? what about opiods?

[doggy_hat]

Originally Posted by chronman

swim was wondering if prescription drugs like nexium, prilosec, or reglan have an effect on amphetamines? the first 2 are used to treat acid refulx and reglan is for the same but it also has anti-psychotic properties. it says it inhibits dopamine receptors, so does this mean reglan will weaken the high from drugs like amphetamines? what about opiods?

It would be a bad idea to mix a dopamine inhibiting anti psychotic with amphetamine. Mixing drugs with opposite effects on the same neurotransmitter should never be done. In addition to weakening the high there can be more serious effects. Maybe someone that has more knowledge in pharmocology could elaborate as to why. It's usually a good idea to always obey the golden rule: Don't mix uppers and downers.

[dark12]

Hello.

I have done a bit of research and found a study relating to the combination of Reglan(metoclopramide) and amphetamines:

Metoclopramide potentiated the effects of all doses of d-amphetamine on both measures; peak effects occurred in the second or third hr after d-amphetamine injection.

Clinicians are advised that metoclopramide, which is presently extensively for gastrointestinal and other disorders, may interact adversely with drugs that affect dopaminergic function.

Source

In short, Reglan will potentiate the effects of amphetamines, but it is not known to what degree. SWIM would advise to stay away from this combo.

Hope this helps.

[chronman]

Originally Posted by dark12

In short, Reglan will potentiate the effects of amphetamines, but it is not known to what degree. SWIM would advise to stay away from this combo.

Interesting, swim talked with swims pharmacist and she just checked her computer for drug interactions with reglan, nothing came up. swim asked her how sure she was since reglan inhibits dopamine receptors. She said it probably inhibits one that the amp doesn't affect, but just to be safe take the amp 3 hours before the reglan.

[doggy_hat]

Originally Posted by dark12

Hello.

I have done a bit of research and found a study relating to the combination of Reglan(metoclopramide) and amphetamines:
Source

In short, Reglan will potentiate the effects of amphetamines, but it is not known to what degree. SWIM would advise to stay away from this combo.

Hope this helps.

I stand corrected. I would've thought a Dopamine Inhibitor would negate the effects of a drug that increases Dopamine levels.

[doggy_hat]

SWIM's tried sodium bicarbonate to increase potency for his 27mg concerta(methylphenidate) prescription. The pill is plenty potent enough but wears off too early, and sodium bicarbonate seems to be somewhat effective.

But he was wondering if there are any side effects from daily taking sodium bicarbonate? Surely the body's Ph is at a certain level for a reason.

[sknkv2]

Would just like to say cigarettes also do a great job of potentiating the effects for 5-10 minutes. SWIM knows this from personal experience, it can even bring him back up for a while if he is coming down.

[UberDouche]

SWIM has found the baking soda method to prolong the durration of effects, but not increase them, as was stated earlier above. Prilosec seemed to make no difference whatsoever, for SWIM.

SWIM DOES NOT recommend the following. It is only presented for informational purposes:
SWIM has, in the past, mixed:
50mg metoprolol (beta blocker to lower blood pressure),
2mg Abilify,
150mg buproprion (also a stim, albeit a crappy one),
2500mg Depakote
and 250mg Adderall XR to no ill effect.
The Adderall was the only non-prescribed drug in the batch. It was taken in two doses of 125mg spaced four hours apart. Spent the next 24 hours gaming, tweeking, and generally being very non-productive.

The experience with the same amount of Addreall but without the other Rx's (done even longer ago by SWIM) was essentially the same. It just had more euphoria to it and was a little 'brighter'.
Everyone is different. Livers are not all the same. What gets one SWIY high will kill another and vice versa.
Plenty of time to experiment, no hurry. Start slow and low, if SWIY starts at all (mixing up the Adderall).

[PitfromGreece]

SWIM read the following on line.

About 45 minutes ago as of the time I am writing this, I and two of my friends decided to crush up a 75 mg capsule of Effexor along with 20 mg of Dexedrine. I know from past experience that snorting 20 mg of Dexedrine all by myself would barely get me high, let alone splitting it with two other people. But with the combination of snorting dex and Effexor, even at such a low dose, I feel like I’ve got wings. The rush is awesome, I am happier than I have ever been, and I have enough energy to wrestle a bear.

As I sit here writing this experience report, I am in the clearest state of mind imaginable, but it feels like I'm zooming along through the clouds the whole time. I can't help but grin like an idiot because absolutely everything makes me happy right now.

I'm like superman, faster than a speeding bullet, stronger than a locomotive, and able to leap tall buildings in a single bound. Okay, maybe not literally, but I am so buzzed, so empowered, that it really feels that way. I could run a two minute mile and still have energy to spare. I cannot stress this point enough, I feel superhuman, logically, I know that I'm not, but my body keeps telling me that I am and it is getting easier and easier to believe it all the time.

I've been a speed freak for a long time, but this is different than any speed high, I don't crave any more, and the body sensations are just so much better.

[gmeziscool2354]

any one have any experience with combining amphetamine with an acid reducer such as ratadine or cimetidine?

swim has never tried this but will have is amp connection back later today and is interested

[Grey Sky]

Swim recommends a healthy diet with lots of fruit and veg and good quality protein as the first step towards amphetamine potentiation. Besides the obvious benefits, the mineral content of such a diet will have a natural alkalising effect on the body, and avoids the problems of excessive sodium or aluminium consumption that come with using baking soda or antacids, although organic acids in the fruit and veg may still inhibit intestinal absorption if taken around the same time as oral amphetamines. Swim takes his sublingually to avoid this, since he likes to eat fruit in the mornings.

Swim also takes a 2:1 calcium/magnesium supplement with his dexamphetamine meds in the morning, a general vitamin & mineral supplement later in the day with a meal, nibbles at a vitamin C supplement at various points through the day (which inhibits absorption and may increase elimination of amphetamines, but Swim values his health), and sometimes takes melatonin at night to improve his sleep, especially when his circadian rhythm is out of kilter, though his dexamphetamine meds have actually stabilised his sleep patterns lately, so he doesn't need the melatonin so much these days.

Swim has tried piracetam in the past, but it gave him a headache, so he shelved it after a few tries. He's never used it with dexamphetamine, and has decided to give it another chance, since he still has a couple of packs of it. Swim also drinks tea, so he gets moderate amounts of caffeine, but he can't tell what effect it has on the dexamphetamine. Swim recently experimented with taking 2.5mg of yohimbine hydrochloride along with 35mg of dexamphetamine, taking the yohimbine sublingually in small increments so that he could stop if there were any adverse effects, since yohimbine is an MAO inhibitor and could be dangerous to use with amphetamine, but he didn't notice anything at that dose, and the next day he woke up feeling hung-over, so he hasn't tried it again since then, though he doesn't know if the hang-over was due to the yohimbine or if it was just generally a bad morning.

[Boca Bitch]

There are three main factors that decide amphetamine potency:

1) Stomach Acidity: As it's been said a low pH in stomach acid considerably weakens absorption of amphetamines. One could use antiacids such as baking soda or calcium supplements, however this is known to cause stomach bleeding on occasion. In my opinion, it's better to by-pass the stomach if one wishes to avoid this situation. Sub-lingual absorption works, but usually amphetamines don't taste too good.. so nasal insuffulation may prove to be the best method as a replacement to oral.

2) Inhibitatory Neurotransmitters: Amphetamines cause a flood of stimulatory monoamine neurotransmitters (i.e. dopamine, serotonin, and norepinephrine), however the brain continues to issue inhibatory signals to (attempt to) regulate the levels.
Caffeine works by slowing the release of the body's main inhibatory neurotransmitter, GABA and increases levels of glutamate, the body's main excitatory neurotransmitter. So its presence acts two-fold on the amphetamine's effects: it A) stops some of the signals that slow monoamine release, and B) directly potientiates amphetamines by further exciting the cell to release more monoamines.

3) Monoamine Oxidase: The brain releases enzymes to metabolize all neurotransmitters almost as soon as they are released; when this happens to monoamines, this process is called monoamine oxidation. A monoamine oxidase inhibatior (MAOI) stops the brain from releasing enzymes, allowing the neurotransmitters to remain in use for a longer duration. Nicotine naturally contains two weak MAOIs, and can be used to extend the length of the amphetamine's effects and may increase its strength.

DO NOT use a prescription MAOI in combination with ampetamines (or any other stimulants). These are too strong and can result in a potentially life-threatening condition, known as serotonin syndrome.

Boca Bitch added 424 Minutes and 4 Seconds later...

Originally Posted by Sloop

yes dark 112, it doesnt matter how you put the amphetamines into your bloodstream (snorting dropping plugging shooting etc) if your blood is a bit more alkaline it slows down the kidneys filtatration rate of the amph molecule, but dont take too much baking soda and make yourself too alkaline, 24hrs cranking is not always nice unless your driving your big truck a long way.

That's interesting... I would have guessed no, because of the bypassing of the stomach. But that makes sense.

Now I'm curious... could slowing down kidney filtration have any potential adverse effects (other than simply potentiating the psychoactive effects of amphetamines)?

[gmeziscool2354]

a few things. firstly, correct dosing of antacids can decrease the amount of amphetamine excreted to virtually none. this means that all of the amphetamine is broken down into its metabolites, theoretically prolonging the experience. This may not be the case for everyone since some pharmokinetic testing has indicated that in certain individuals the 'peak' of a dose if felt after the plasma levels peak.

seccondly, ranitidine is a strong amphetamine potentiator, as it greatly slows its metabolism. I'm not sure how, but swim knows from repeated experience that this is the case. There are several studies done on this, but i'm to lazy to reference them. try a google search.

thirdly, with spansules (XR) the plasma levels are all over the place due to the way the beads break down in the gut. Swim's best advice for oral users who wish to 'remove the time release' is to crush the pills as best as on can and add them to water. shake the mixture for a while prior to drinking, preferably until there is only powder or gunk on the bottom. this will esseintially destroy the time release and possibly increase the bioavailibility

insuflation has its ups and down, it has a higher bioavailbility, but there are limits to how much the nose can absorb. They formulate these pills to be as un-abusable as possible, so they add sugars which 'gunk up' in the nose and prevent absorbtion.

Rectal absorbtion of aphetamine is probably the best way to use it other than injection. THis method hits quick, hard and with out many of the side effects of insuflation.

gmeziscool2354 added 1 Minutes and 43 Seconds later...

oh also, tobacco contains several mono-amine oxidase inhibitors. i don't know if they are weak or just in low quanities, but this will greatly potentiate its effects

[Dreamland]

SWIM was thinking abou taking amino acids & supplements with amphetamine to boost it up. the amino acids that SWIM has in mind
is- Acetyl-carnintine, l-tyrosine, DLPA, & ginseng.. acetyl-carnitine is a nootropic, and may increase the focus part of amphetamine, ginseng is a natural stimulant, and can boost the energy part of amphetamine, and
tyrosine and phenylalanine are precurser supplements to encourage the dopamine & noradrenaline, which could increase and potentiate the uplifting mood enhancing of amphetamines.

SWIY think it would be a good combo? SWIM will try it sometime, and report back if it did potentiate SWIm's adderall. SWIM also always takes
a gram of l-arginine before taking adderall.

[gmeziscool2354]

It's proven that supplements will reduce the feelings of a 'crash' so theoretically it may help the overall exp quite a bit. Swim likes to avoid debilitating crashes and assumes swiy does too