Potentiating Amphetamine

[bcStoner420]

I tried searching but found nothing on this. I know that grapefruit juice works for like opiates and dxm and stuff and was wondering, would this also work to potentiate amphetamines? or if not grapefruit juice anything?

[methyl]

Baking Soda is said to potentiate the absorption of amphetamines.


However, I've never tested Baking Soda + Adderall.

[bcStoner420]

After research i have confirmed this is true, thanks!

For anyone else out there wanting to see written proof...


http://www.rxlist.com/cgi/generic/de...etamine_ad.htm

look under drug interactions, it says that any gastrointestinal alkalinizing agents potentiate absorption of amphetamines. One being sodium bicarbonate (baking soda).

It also says, Gastrointestinal acidifying agents (guanethidine, reserpine, glutamic acid HCl, ascorbic acid,fruid juices, etc.) lowerabsorption of amphetamines.

So theres 2 ways to get the most out of your amphetamines, SWIM will have to personally try this.

Well, SWIM tried this taking a small amount of baking soda on a spoon washed down with water, starting about 6 hours before dosing every 2 hours, then 10 minutes just before dosing. He must say he was dissapointed with the results, but due to his very high tolerance lately he hasnt been getting much at all out of amphetamine anyway, he will have to take a month or so off because its definatly alot of fun. If anyone else tries this with better results, please share with us all.

Ooohh, my 300th post

[Aopocetx]

According to Wikipedia caffeine potentiates amphetamines by inhibiting an enzyme.

http://en.wikipedia.org/wiki/Caffeine

[Allex]

SWIM usually takes 100mg caffiene or a strong coffee plus some baking soda when taking amphetamines.
There is another potentiator: a class of drugs called Protease Inhibitors. e.g. Ritonavir (Norvir) is one of the strongest drug potentiators. These are prescription HIV medications and seem difficult to find on the internet as SWIM can't seem to find any online. They inhibit the enzyme CYP3A4 which is the enzyme that metabolizes many drugs (INCLUDING non-prescription meds! overdose more likely!) - so the drug is in your blood alot longer and more concentrated. It is said to potentiate amphetamines 2 or 3 fold (therefore take 1/3-1/2 your normal dose to avoid overdosing). I read somewhere else that it can potentiate MDMA 5-10X though I havent researched or found out properly. Be VERY careful with PIs and also avoid alcohol. They have a strong effect on many other drugs too (but can reduce effects of some) so look it up if you get access to them. Ritonavir - Wiki

[Beeker]

Okay *gets out laser pointer ... and starts blinding people*

Okay, now the scientific hooboo jooboo on this subject is about complete.

Learn about loading and stacking nootropics. It makes SWIMS fun items work about twice as well plus really helps your mood and memory. All legal in the US. These you need, learn to keep a supply with your 00 gels.

Piracetam - Most important and cheap cheap! It took me 8 days to finally get a feeling from Piracetam at 800-2400mg a day. By itself it has some effects but reach out for your Adderall or MDMA!! Weed, all the amphetamines, those 2c-XX chemicals as well as the old tryps.

HA! That's is about all I REALLY know. There are several experts here and a search will tell you more then I could. I've seen al least 20 Nootropics making their rounds. Unlike most herbal pills that we know blow ass and you might assume that this was a joke on you or something. this stuff works, joke later.

Reputation Comments on this post:

informative

[Anabolic Monkey]

Could someone post how much it potentiates the effects of adderall, weed, and mdma?

[old hippie 56]

Try 1/2 teaspoon baking soda dissolved in 4 oz. water, wait about a hour, take your pill or whatever, good results will followed. Swim goldfish tried it with a 30mg XR.

[Beeker]

Originally Posted by old hippie 56

Try 1/2 teaspoon baking soda dissolved in 4 oz. water, wait about a hour, take your pill or whatever, good results will followed. Swim goldfish tried it with a 30mg XR.

Listen to the elders, they lived.

[Nahbus]

Yes, SWIM knows of baking soda. He has recently read that Alka Seltzer Gold blows the baking soda potentiation out of the water.
SWIM wants to know how much alka seltzer to take, and how long before the amphetamine dose (and also how much, roughly, it potentiates amphetamine [to assess the dose])
Or if there are any other tried and true methods. Thanks.

Reputation Comments on this post:

Good topic.

[Forthesevenlakes]

probably just the normal amount of alka seltzer...half an hour to an hour before hand, and then maybe a little bit more co-administered with the adderall should do it.

at least thats how it works for opiates and swim, maybe adderall is a little different but swim thinks itd work here too.

[fishinabottle]

Neither baking soda nor Alka Seltzer potentiate the effects of amphetamine, the just slow down excretion such providing a longer duration for people who are on the acidic side with their bodychemistry.
A much better result might be possible with piperine - a main ingredient of black pepper oil - which is known to block many enzymes responsible for drug metabolisation. Much more then grapefruit juice.

[Forthesevenlakes]

hm, i think the alka seltzer could aid in absorption. you know, make the stomach more basic, so its slightly easier for alkaloid drugs to leave. but the excretion thing, thats interesting, swim will have to pay attention to that next time he uses. how much piperine or black pepper oil would work for potentiating?

[Nahbus]

Hmmm, SWIM is torn. He has one 20mg Adderall left. He is used to snorting them, would it be better for him to get some alka seltzer, or at least baking soda, and try 1/2 teaspoon baking soda (or the alka seltzer) 1 hour before ingesting the adderall, or do you think he would have better effects with snorting it?
SWIM needs to get the most out of this last pill as he can.
Tips for him?
(slightly important he gets the most effects out of this so he can get a lot of work done today)

Overall, the yohimbine alkaloids seem to increase amphetamine effect and toxicity by serotoninergic or dopaminergic mechanisms

Hmmm, SWIM has yohimbine HCl, but one 9mg pill alone makes his heart rate pretty fast, or so it feels. SWIM would be a bit weary of combining these. Does anyone have anymore information on this?

[Forthesevenlakes]

swiy says to potentiate the adderall with alka seltzer. better yet tagmet (cimatidine) might help potentiate it too. it affects cytochrome p34(?) enzymes which would help potentiate some drugs.

also do not combine yohimbine with adderall. that is really dangerous! swim says they are both cns stimulants which could have too much synergy and lead to a dangerously elevated heart rate. plus, yohimbine is a weird drug on its own, it stimulates through ACh pathways (swim THINKS), and leads to orthostatic hypotension rather easily. swim has seen people experience drastic and bizarre changes in body temperature and vascular constriction from 'normal' doses of this drug. plus even though it creates a stimulant effect, it also reliably creates a stress response that triggers the release of cortisol, and stress may not be good for working. plus swim has never heard anyone say that it enhances creativity or motivation particularly, even though it may agitate them.

[daeron]

tsk tsk tsk...NH are you a member of the drug forum or not???
crush-it-plug-it

[Forthesevenlakes]

Originally Posted by daeron

tsk tsk tsk...NH are you a member of the drug forum or not???
crush-it-plug-it

all while performing autofellatio!

[thadj]

Convert your adderal to meth, that will potentiate it. As to the "basifying your body" trick, it slows excretion because a smaller fraction of the amphetamine molecules are in the protonated NH3+ form. The high will last a bit longer.

Is it really worth it?

[hyperlite]

200mg of Caffeine Anhydrous as always for SWIM....

[mspen1018]

Baking soda is better than caffiene because caffiene will make you urinate more and get rid of the amphetamine faster....

[jesusfreak666er]

is there a significant amount of piperine in crushed black pepper (food black pepper), if so can swim fill a capsule, if so how much? when? will it cause gi blacklashes? Some more info on the use of piperine to potentiate adderall would be nice.

Swim knows that pepper is used sometimes by eating spicy or eating a pepper before using a drug that is absorbed through the mouth like gums or under tongue since it increases blood flow in the mouth... such as oral salvia chewing. but adderall he has never heard of such but it sounds very interesting!

there is a thread on addy potentiating (being they r both amps they should be merged if possible) but anyway they mentioned piperine a chemical found in pepper similar to grapefruit juices enzyme blocking effect but far more potent anyone know anything about this, baking soda and such only effects the ph and slows the speed of digestion down... not potentiates.

[azrael2600]

swim takes 100mg's of 5-htp tryptophan, and 1000mg's of L-tyrosine, with a b-complex vitamin everday for a week prior to ingesting amphetamines. mostly MDMA and makes swim have more euphoria and the trip lasts longer.
5-htp tryptophan elevates seritonin levels and L-tyrosine elevates dopamine levels

[Nahbus]

To swallow a few pills?
SWIM says 5-HTP is good for you anyway..
Sounds like something SWIM will try.

[izzy31]

Why couldnt I have read this over and more clearly???

I read basically the same thing on another website the other day and again today on the adderall info paper that came with my adderall the other day, and got mixed up into thinking that acidifying agents was what would increase absorption and took 2 antacid tablets this morning - BIG MISTAKE! Pretty much counteracted and killed the drug from ever taking effect at all!

The real funny (not really) thing is that I realized I was reading it wrong RIGHT AFTER I took it this morning!

Originally Posted by bcStoner420

After research i have confirmed this is true, thanks!

For anyone else out there wanting to see written proof...


http://www.rxlist.com/cgi/generic/de...etamine_ad.htm

look under drug interactions, it says that any gastrointestinal alkalinizing agents potentiate absorption of amphetamines. One being sodium bicarbonate (baking soda).

It also says, Gastrointestinal acidifying agents (guanethidine, reserpine, glutamic acid HCl, ascorbic acid,fruid juices, etc.) lowerabsorption of amphetamines.

So theres 2 ways to get the most out of your amphetamines, SWIM will have to personally try this.

Well, SWIM tried this taking a small amount of baking soda on a spoon washed down with water, starting about 6 hours before dosing every 2 hours, then 10 minutes just before dosing. He must say he was dissapointed with the results, but due to his very high tolerance lately he hasnt been getting much at all out of amphetamine anyway, he will have to take a month or so off because its definatly alot of fun. If anyone else tries this with better results, please share with us all.

Ooohh, my 300th post

[AdderallJunkie102]

anyone tryed tums to potentiate Amphetamines vs baking soda?