How Long Do Opiates Stay in One's System?

[Vali-yum]

If swim takes oxycotin or morphine, how long will it stay in swim's system for?

[Forthesevenlakes]

Originally Posted by Vali-yum

If swim takes oxycotin or morphine, how long will it stay in swim's system for?

swim believes they'll be detectable on drug tests for about 2-4 days (assuming its a urine test). however if swiy has been taking alot of opiates, they may be in the system for up to 7-10 days...and swiy will know when its out of the system because their withdrawals will be over =]

[skeeber]

Are you asking because you have to take a drug test for a job? I am on a significant amount of Percoset daily for a bad back and I recently passed two drug screens with no problems. One was a hair test and the other was a urine test. They must not have checked for opiates. All I take is oxycodone, no illegal drugs. I'm not guaranteeing that you'll pass, just sharing my experience.

[Citizen Kane]

Originally Posted by Vali-yum

If swim takes oxycotin or morphine, how long will it stay in swim's system for?

Morphine is typically out of swiy's blood between 1 and 2 days, and out of swiy's urine between 2 and 4, depending on the dose.

Originally Posted by forthesevenlakes

and swiy will know when its out of the system because their withdrawals will be over =]

That's a misunderstanding. Withdrawals continue even after all opiates are long gone from swiy's system. Most opiate withdrawal symptoms occur because of hyperactivity of the locus coeruleus. Opiates depress this area of the brainstem, and once they are gone, it becomes hyperactive.

[Forthesevenlakes]

swim is not sure that oxycodone is converted into morphine in the body. he'd like to see swiy's source on that. to his knowledge its codeine, morphine, and heroin that would show up on most six panel drug tests. he has actually passed one with oxycodone in his system as well. in fact, according to rxlist.com...

"A high portion of oxycodone is N-dealkylated to noroxycodone during first-pass metabolism. Oxymorphone, is formed by the O-demethylation of oxycodone. The metabolism of oxycodone to oxymorphone is catalyzed by CYP2D6. Free and conjugated noroxycodone, free and conjugated oxycodone, and oxymorphone are excreted in human urine following a single oral dose of oxycodone. Approximately 8% to 14% of the dose is excreted as free oxycodone over 24 hours after administration. Following a single, oral dose of oxycodone, the mean ± SD elimination half-life is 3.51 ±1.43 hours."

so it should not test false positive for morphine.

swiy is right that withdrawals last longer than the length of time that opiates would stay in the system, but he was more advising that to be on the safe side, not to take the drug test until withdrawals from heavy use were over, just to make sure there were not any opioids remaining in the system. he should have been more clear on that point.

[Citizen Kane]

Originally Posted by forthesevenlakes

swim is not sure that oxycodone is converted into morphine in the body. he'd like to see swiy's source on that. to his knowledge its codeine, morphine, and heroin that would show up on most six panel drug tests. he has actually passed one with oxycodone in his system as well. in fact, according to rxlist.com...

"A high portion of oxycodone is N-dealkylated to noroxycodone during first-pass metabolism. Oxymorphone, is formed by the O-demethylation of oxycodone. The metabolism of oxycodone to oxymorphone is catalyzed by CYP2D6. Free and conjugated noroxycodone, free and conjugated oxycodone, and oxymorphone are excreted in human urine following a single oral dose of oxycodone. Approximately 8% to 14% of the dose is excreted as free oxycodone over 24 hours after administration. Following a single, oral dose of oxycodone, the mean ± SD elimination half-life is 3.51 ±1.43 hours."

so it should not test false positive for morphine.

Very good. I retract this statement. I looked for a scientific source for this claim, but couldn't really find one. That's the nice thing about this forum, one always learns something new. On the contrary, it seems that the morphine tests are rather unsuited to detect the metabolites of oxycodone:

Analytically, even though oxycodone is an opiate, oxycodone does not cross-react well in most urine immunoassays. Thus, another technique or an alternate immunoassay that is specific for oxycodone must be employed in order to detect oxycodone’s presence in urine. DSI employs an oxycodone-specific CEDIA (Cloned Enzyme Donor Immunoassay) test. The assay is designed to pick up oxycodone as a single drug.

[Source]

Even though oxycodone, noroxycodone, and oxymorphone are all opiates, they do not cross-react well in the standard opiates assay (vide infra). Due to the poor cross-reactivity of oxycodone and its metabolites in a standard opiates immunoassay, the initial test for oxycodone and its metabolites is performed on its own channel with its own separate antibody, calibrator (100 ng/mL), and controls.

[Source]

Oh well, it proves once more that one shouldn't trust drug rehab.

Reputation Comments on this post:

good point on the drug withdrawal outlasting opiates in the system!

[Forthesevenlakes]

swim definitely understands where rehab and administrators of drug tests would lie about that! they dont want to reveal that their tests are often inadequate, and would rather people avoid drug use out of fear, even if they cant detect everything that people use. but swiy brings up a good point that certain opiates MUST be avoided at all costs right before tests, and that the opiates leave the system faster than withdrawals last.

there are certain tests that detect synthetic opioids too, but theyre not as widely used. so, if anyone reading this is concerned about an upcoming test, do your best to find out what kind of test it will be, and what its capabilities are!