Overdose - ld 50 for coke

[tre2005be]

swim would like to know what the ld50 is for coke

[Nagognog2]

LD50 for cocaine is listed as 17.5mg/kg I.V. in rats. However the calculated amount for a human has been placed at 1.2gm orally.

[tre2005be]

so if swim ingested 1.2 mg of pure coke swim would have a 50% chance of dieing?

[fishinabottle]

Originally Posted by Nagognog2

LD50 for cocaine is listed as 17.5mg/kg I.V. in rats. However the calculated amount for a human has been placed at 1.2gm orally.

Any references for the 1,2gm or can we count this under hearsay?

Everybody doing drugs for some time laughs about this "1,2gm" and if you have a reference I will be happy to do my best to make the author the joke he his.

[Nagognog2]

1.2 GRAMS. Yes - that is considered the LD50 for cocaine in your average size human. When figuring LD50's it is important to know that the other 50% of the mice, rats, dogs, etc. that were used in these "experiments" did not get up and walk away undamaged. The survivors of these stupid tests with various drugs may well have suffered permenant damage.

[tre2005be]

the damage is the less than important part

[markdahman]

Originally Posted by tre2005be

the damage is the less than important part

Wow man, your really brave hope SWIM is planning on doing it cuz if a human like u would be trying it, it wouldnt be very wise...

I also hear cocain is not a active drug if swallowed because it becomes nor-cocain or something of that type!!
50% chance @ Death+Expensive drugs = No buzz? why?

[levdog]

Originally Posted by markdahman

Wow man, your really brave hope SWIM is planning on doing it cuz if a human like u would be trying it, it wouldnt be very wise...

I also hear cocain is not a active drug if swallowed because it becomes nor-cocain or something of that type!!
50% chance @ Death+Expensive drugs = No buzz? why?

ingesting cocaine is a main method if admin, it gives you a buzz lasting longer than snorting, lol. also, i have ingested more than X gramms before

Whoopee! X grammes! Dicksizing: Yeah!

Reputation Comments on this post:

this is a really bad example to set for people!

[Sloop]

Hey 1..2 grams of coke oral i mean swallowed can kill you?
is this correct?

isnt this more a case of injected 1.2 g for the average person? or snorted


some people have survived with busted condoms of coke in their ass etc and i think they pack more than 1.2 grams in these. Swim was once forced to swallow a bit more than this in a police search. Swim forgot he hadnt tied the bag and held it in the mouth hoping the cop would get the frisk over fast, no questions and fuck off. fortunately the cop only asked a few questions and let swim go, it was dark, swim was talking spanish and he doesnt speak that well so the cop probably thought the tourist is stupid anyway and didnt suspect swim had a 3 gram bag in the gob. Swim must of ended up with half of it dissoved in his mouth, as he didnt spit it out until well away. Swim couldnt talk much for an hour, completely numbed his tongue throat etc, but not much of a buzz. Swim thinks the stomach juices de activates the blow, though didnt sleep that night

hence question over 1.2 grams oral a potential killing dose?

[Nagognog2]

So says the medical literature on the subject. I know of no one who has purposely tried to refute this by choice. Any takers? If so, please call this number (USA):

1.800.SUICIDE (784-2433)

[raven3davis]

Anyone see the movie blow?

George: "The official toxicity limit for humans is between one and one and half grams of cocaine depending on body weight. I was averaging five grams a day, maybe more. I snorted ten grams in ten minutes once. I guess I had a high tolerance." If 1.2g is the ld 50 then the quote in blow is pretty accurate.

Street cocaine is notoriously impure though so 1.2 grams of blow wont really be 1.2 grams of blow. Some coke is even below 50% pure. Consider yourself luck if you are getting 80% purity.

[INodHardOhYeah]

Also remember that the LD50 is the amount at which 50% of subjects died. Some most certainly could or did pass from amounts less than the LD50

[Alicia]

Id also say it depends on the user, body build etc, boyo used to do coke and he was fine did it another time and had a seizure which wasn't pretty he stopped coke tried crack a small amount of crack thinking it would a tad safer due to the duration and guess what seizure again.. It has been know to kill out right on single even in regular users. Coke always been unpredictable in some sense. Swia rarely uses it now thou. find the high kinda pointless.

[Bajeda]

I found a research article suggesting that genetic differences may play a large role in a person's suseptibility to lethal overdose of cocaine, as well as some case studies.

It seems like interesting stuff from the abstract, but I have to go now so I'll read over it when I have time and then upload the files and/or post the link here if applicable to this thread. It seems like it will be.

[bman1]

According to a paper published in the journal Pharmacology, Biochemistry, & Behavior, the LD50 of Cocaine when administered IP in Mice was 95.1 mg/kg. The reference for this data is:

Bedford JA, Turner CE, Elsohly HN. Comparative lethality of coca and cocaine. Pharmacol Biochem Behav 1982 Nov; 17(5):1087-8.

More information about the measurement of LD50s for recreationally used psychoactives can be found at:

http://www.erowid.org/psychoactives/...es_ld50s.shtml

[Bajeda]

http://www.drugs-forum.com/forum/loc...d=942&catid=25


Cocaine puts enormous strain on the heart.

You are more likely to die from Cocaine use after you have been using it for a time rather than when you first start using it... i.e. the negative effects of cocaine on the cardiovascular system that may cause lethal effects are cumulative.

This may explain the large variation in ld 50 levels. People die from the cardiovascular problems that cocaine causes much of the time so other factors like overall health, length of cocaine usage, and family history of heart problems come into play.

[nonlinear]

sorry to bump this old thread, but keep in mind that an LD50 is the dose that was lethal for 50% of the subjects, but some subjects died at lower doses and some died at higher doses. if you're going to try this you really need to find out what the distribution of lethal does is, and to be safe you should probablly use a dose below that of the lowest lethal dose.

also, these will probablly be doses of pure cocaine (check the primary report). with street coke, LD50s will be higher (depending on quality).

[xxBMT]

From what a Doctor told me when i went to rehab for Coke...The Lethal Dose is actually 1.5(1 gram and a half) Ive done more than that. Ive done 2.5 in one sitting by myself and nothing happend to me. And Im very small i was a chronic user for awhile. My heart is normal Lungs are normal.But It also depends on the person. Health issues medications your taking and weight.


As they say...Can I overdose on cocaine?...If your Rich enough

[unconditionaldl]

SWIM snorts about 2gs every friday and saturday night, everyone swim knows does about this amount :S so the ld does not make sense :S

[Fight Club]

I think the key factor here is whether it's done all at once or over time. Because it breaks down so quickly in the bloodstream, it makes a big difference whether it hits the system all at once (think IV or smoking here) or over time (snorted or ingested).

Most of NIK's experience is with IV coke use, and he has found that slamming anything more that .4 to point 5. grams at one time would likely cause a seizure, which is tantamount to playing russian roulette. You might come around, but sooner or later it will cause cardiac arrest, and this would happen at doses well below the LD-50 for most people.

BTW, the amounts referred to above are not a safe dose IV.

FC

[beentheredonethatagain]

Originally Posted by Fight Club

I think the key factor here is whether it's done all at once or over time. Because it breaks down so quickly in the bloodstream, it makes a big difference whether it hits the system all at once (think IV or smoking here) or over time (snorted or ingested).

Most of NIK's experience is with IV coke use, and he has found that slamming anything more that .4 to point 5. grams at one time would likely cause a seizure, which is tantamount to playing russian roulette. You might come around, but sooner or later it will cause cardiac arrest, and this would happen at doses well below the LD-50 for most people.

BTW, the amounts referred to above are not a safe dose IV.

FC

True that Fight Club, a 1/2 gram of pretty clean coke will bring the most tolerante user to his knees or much much worse as getting that much coke at once is more than the heart can sometimes handle. I was dreaming with 1/4 gram of very potent cola and it was a ride I wont forget.

[GenaroXVIII]

Several people have said that the LD-50 for street coke will be higher than pure cocaine because it will be cut with stuff. Unless I am way off, couldn't that "stuff" lower the LD-50? Depending on what it is there could be synergistic effects that strain the heart more.

[rxbandit]

Most cutting agents are inert substances used solely to increase the weight. Most of the cuts do not have synergistic effects but are simply inactive. Swim has seen alot of coke that is around 20% in his area meaning one would have to blow 7.5 grams to reach the LD 50. Most coke in the states is no where near pure, even if its say 50 % pure swiy would nead 3 grams within in say an hour to hit the LD50. T

the LD50 is not laughable, the assumption that swiys coke is medical grade is however.

Reputation Comments on this post:

good post