is it possible to abuse diphenoxylate? (lomotil)

[magic_johnson]

I was prescribed lomotil for after having diharrhea for about a week. I found out that it contains diphenoxylate which is related to some narcotics such as morphine. To prevent abuse they add atropine to cause unpleasant effects. So I was just wondering if anybody has ever used this drug to get high and if so, is it possible to do a cold water extraction to get the atropine out?

[Fantasian]

Diphenoxylate is potentially a recreational opiate and can be used as such, however when combined with Atropine as is the case in Lomotil when taken in high doses the following adverse effects occur. Diphenoxylate is chemically similar to Pethidine (AKA Demerol)

ventricular fibrillation, supraventricular or ventricular tachycardia, giddiness, nausea, blurred vision, loss of balance, dilated pupils, photophobia, and possibly, confusion, hallucinations and excitation. These latter effects are due to the fact that atropine is able to cross the blood-brain barrier. Because of the hallucinogenic properties, some have used the drug recreationally, though this is very dangerous.

The recreational effects of Atropine are similar to using large amount of any of the other anti-chlolegenic drugs that act as deliriants. It should be warned that using these drug for recreational purposes can possibly induce Terrifying realistic Nightmarelike hallucinations.


As to a CWE im not sure and someone else may be able to answer this. FOrtunatly for SWIF he has very easy access to hospital opiates therefore very rarely uses CWE for anything as he can obtain the pure form. If you want to try the CWE and see if it has worked start with a clinical dose and work your way up, the effects of the Atropine should become very obvious even at slightly above clinical dosages without providing too much discomfort or danger.

These effect most prodominantly observed will be blurred vision.

[Forthesevenlakes]

also do a search for the "loperamide: sudafed of opiates" thread...if lotamil doesnt readily cross the blood brain barrier there's a few ideas in that thread which might help things work after swiy has done an extraction. great first post.

[magic_johnson]

does anyone know the solubility of diphenoxylate or if a CWE would get the atropine out?

the fact that diphenoxylate is similar to Meperidine makes me want to try this with atropine

[Nagognog2]

Atropine Sulfate, the usual medical form of atropine, is very soluble in water - 1 gram dissolves in .4ml of H2O.

[magic_johnson]

Originally Posted by Nagognog2

Atropine Sulfate, the usual medical form of atropine, is very soluble in water - 1 gram dissolves in .4ml of H2O.

thanks for the info

do you know if diphenoxylate is soluble in water?

[Nagognog2]

Very slightly soluble in water, so if a monkey had access to extremely fine filter paper, a Buchner funnel, and a vacuum source - it could work. Other wise the monkey should figure that anything over 2mg (milligrams) of atropine will show toxic effects.

Read: Save 'em for when you eat at the cheap place down the street with the cook named Sticky.