Originally Posted by JustKeepSwimmin
From a pharmacuetical standpoint, they are all under strict requirements so there is VERY little differnce between them.
This is mostly, but not 100% true. I am desperately trying to find the source for this information, but can't at the moment, so you'll have to trust me until I hopefully can. If I recall correctly (If)
, there is a certain amount of variance allowed between different generics, at least when compared to the brand-name of any medication. I believe it's not in the amount, but rather in the rate of absorption.
My doctor and I spoke about this once and he told me that the absorption rate of a generic pill is allowed to vary up to 10% from the name brand. Let's say 80% of the brand name Roxicodone is absorbed when taken by mouth, even if oxycodone
itself has a potential oral BA of about 87%. Unnamed Generic A has an oral BA of 72% due to fillers and the general composition of the tablet. Unnamed Generic B has an oral BA of 85%. Both of those are within 10% of the name brand (i.e., the original on the market, which is why it's the comparison point), but if you compare Unnamed Generic A to Unnamed Generic B, the latter is going to seem much stronger because a 13% difference in BA is actually quite a bit.
Anyway, I'm not trying to discount what you're saying and I actually completely agree with your post; I'm simply pointing out something I've heard in the past that I am fairly sure is accurate.
I can't really answer this question exactly, as I'm prescribed 5mg oxycodone tablets and not the 30s. Interestingly enough, though, from what I've read about personal preference it seems that the 30mg Mallinckrodts ("Ms" or "M Boxes") are quite popular. However, the 5mg Ms are terrible... I find. I order a specific generic each and every month and it actually happens to not be any of the one you listed. I prefer KVK-Tech's oxycodone, which is imprinted with a K and a number I forget. At the time I switched over, I had a few Mallinckrodt's left. I tried taking my usual dose of those in the morning, and the same dose of the KVK in the evening just to see the difference. The latter worked so much better it's almost indescribable. Whether that was based on biology or a placebo effect, I don't know either, but it's really quite amazing how different two can seem (whatever the reason) given the strict guidelines put on their manufacturing.