Drugs-Forum  
Home Wiki Studies Forum Groups Blog Video Images News
Go Back   Drugs Forum > VARIOUS DRUG RELATED TOPICS > Drug News > Health (News)
Mark Forums Read
Register Tags

Notices

Health (News) News about drug research, treatment, and health issues.

 
Thread Tools
  #1  
Old 20-02-2013, 17:25
source source is offline
Palladium Member
 
Join Date: 24-04-2010
40 y/o Female from England
Posts: 1,262
Blog Entries: 2
source must mainline Medlinesource must mainline Medlinesource must mainline Medlinesource must mainline Medlinesource must mainline Medlinesource must mainline Medlinesource must mainline Medlinesource must mainline Medlinesource must mainline Medlinesource must mainline Medlinesource must mainline Medline
Points: 5,099, Level: 10 Points: 5,099, Level: 10 Points: 5,099, Level: 10
Activity: 0.6% Activity: 0.6% Activity: 0.6%
Targets For Treatment Revealed By Study Of Cocaine Addiction

Scientists at UC Santa Barbara are researching cocaine addiction, part of a widespread problem, which, along with other addictions, costs billions of dollars in damage to individuals, families, and society. Laboratory studies at UCSB have revealed that the diminished brain function and learning impairment that result from cocaine addiction can be treated - and that learning can be restored.

Karen Szumlinski, a professor in the Department of Psychological & Brain Sciences at UCSB, and her colleagues Osnat Ben-Shahar and Tod Kippin, have worked in the field of addiction for many years. Senior author of a paper on this topic published recently in The Journal of Neuroscience, Szumlinski is particularly interested in the part of the brain called the prefrontal cortex, where the process of "executive function" - or decision-making - is located. This area is involved in directing one's behavior in an appropriate manner, and in controlling behavior.

With her research team, Szumlinski discovered that a drug that stimulates a certain type of glutamate receptor - when aimed at the prefrontal cortex - could restore learning impairment in rats with simulated cocaine addiction.

"Needless to say, this (the prefrontal cortex) is one of the last parts of the brain to develop, and, of relevance to our students, continues to develop through about age 25 to 28," said Szumlinski.

Szumlinski explained that in the prefrontal cortex there seems to be "hypo-frontality," or reduced functioning, in drug addicts, as well as in patients with a range of neuropsychiatric diseases, including schizophrenia, depression, and attention deficit disorder.

Szumlinski calls the prefrontal cortex a late-developing brain area that is critical for making proper decisions, and inhibiting behavior. "You damage this brain region and you lose the ability to self-regulate, you make impulsive decisions like engaging in risky sexual behavior or drug-taking, you basically go off the deep end in terms of function," she said. "So we were very much interested in how drugs of abuse impact the prefrontal cortex, given that human drug addicts show deficits in this brain area when you put them into a scanner. They show hypo-activity." She said this hypo-activity, or hypo-frontality, might relate to a neurotransmitter that scientists know is involved in exciting the brain.

A key question, according to Szumlinski, is this: "Was that hypo-frontality there in the first place, and that's why they became an addict; or did the drugs change their prefrontal cortext, to cause it to become hypo-functioning and thus they're not able to control their drug use? You can't parse that out in humans. So that's why we turn then to animal models of the disorder, and we do have this rat model that we use in the paper."

Szumlinski pointed out a key difficulty in the development of treatments for addiction: There is little money targeted to the study of this disease. Hence, in addition to studying the brain mechanisms that are involved, she is joining forces with researchers who study other neurological diseases that are well-funded, to help find cures. She hopes that government approval of new drugs for these other diseases would eventually make the drugs available for clinical trials to study their effects on cocaine addiction.

Szumlinski cited statistics, calculated by scientists M.K. Bird and A.J. Lawrence of Australia, indicating that addiction can cost up to 3.5 percent of gross domestic product in Western countries, equaling $485 billion in the U.S. in 2007. In that year, addiction research received less than 2 percent of public and private funding of all cancer research.

Medical News Today, 15th February 2013.
http://www.medicalnewstoday.com/releases/256352.php
Attached Images
File Type: jpg cocaine.jpg (47.9 KB, 216 views)

Share this on:

Tags
cocaine, cocaine abuse, cocaine addiction, cocaine addiction research, cocaine addiction treatment, drug addiction news

Thread Tools


Similar Threads
Thread Thread Starter Forum Replies Last Post
Cocaine Dependence And Withdrawal: Neuroadaptive Changes In Brain Reward And Stress.. Nicaine Cocaine addiction 1 24-06-2013 00:28
History of Coca Benga Drug Articles 0 10-05-2007 14:07
Predisposition to Addiction Found in Cocaine Study Each Hit Miscellaneous News 5 13-03-2007 18:50
Drug info - Cocaine addiction could be genetic, new study claims klaatu Cocaine & Crack 9 14-08-2006 23:13
Perspectives on Cocaine Addiction:Recent Findings from Animal Research pharmapsyche Cocaine addiction 2 15-02-2006 23:21

» New Threads
Detoxing off Methadone
Last post by LuLu81
0 Replies, 1 Views
7 days clean from Oxycodone - need...
Last post by Taarna
6 Replies, 196 Views
Heart rate lower after taking...
Last post by V4Vyndetta
0 Replies, 14 Views
sometimes when the hopeless...
Last post by beentheredonethatagain
0 Replies, 14 Views
Homemade enema and cleaning the...
Last post by Name goes here
9 Replies, 284 Views
W-18: Potent new mu-opioid agonist
Last post by Free goldfish
6 Replies, 4,551 Views
How Hard was it for you to get...
Last post by joy rider
19 Replies, 1,207 Views
Oxycontin Addiction: dancing with...
Last post by Polixx
2 Replies, 63 Views
Some of my concerns about...
Last post by kmak
3 Replies, 404 Views
Heroin Withdrawls- Imodium
Last post by purplemolly
1 Replies, 61 Views
» New Wiki Articles
GHB
NET

Sitelinks: Information:

All times are GMT +1. The time now is 08:23.


Copyright: SIN Foundation 2003 - 2014, All rights reserved