Drugs-Forum  
Home Wiki Studies Forum Groups Blog Video Images News
Go Back   Drugs Forum > VARIOUS DRUG RELATED TOPICS > The euphoric body > Pharmacology
Mark Forums Read
Register Tags

Notices

Pharmacology How drugs affect the workings of the human body.

 
Thread Tools
  #1  
Old 09-02-2013, 23:55
antizero antizero is offline
Silver Member
 
Join Date: 07-01-2005
Male from United States
Posts: 87
antizero is learning how to become a psychonaut.
Points: 232, Level: 2 Points: 232, Level: 2 Points: 232, Level: 2
Activity: 0.2% Activity: 0.2% Activity: 0.2%
How long does Tyrosine take to turn into dopamine?

How long does it take for L-tyrosine to be turned into dopamine? I took 2g about 10 minutes ago.

Post Quality Evaluations:
Posted in wrong forum, should not be in the MDMA forum. Moving thread.
Good thread starter.
  #2  
Old 10-02-2013, 10:19
methylman251 methylman251 is offline
Titanium Member
 
Join Date: 29-10-2011
24 y/o Male from Australia
Posts: 313
methylman251 must live here.methylman251 must live here.methylman251 must live here.methylman251 must live here.methylman251 must live here.methylman251 must live here.methylman251 must live here.methylman251 must live here.
Points: 1,714, Level: 6 Points: 1,714, Level: 6 Points: 1,714, Level: 6
Activity: 21.4% Activity: 21.4% Activity: 21.4%
Re: How long does Tyrosine take to turn into dopamine?

As a direct answer to your question I don't think it has ever been measured in terms of from ingestion to dopamine synthesis, but once tyrosine is in the cells which convert it to dopamine would do it pretty quickly like the two conversions would both happen in less than a second.

In terms of what your going for though that 2g unless you had a severe deficiency in tyrosine wouldnt do much if anything at all since the enzymes which actively transport tyrosine into the brain are already saturated so any more tyrosine would just float around untill other enzymes in the rest of your body convert it into miscellaneous molecules. Even if it were to get into the brain tyrosine hydroxylase which is the first step converting tyrosine to dopamine is also pretty much working at full capacity so taking additional tyrosine won't cause any signifcant change in dopamine levels anyway.

If hypothetically somehow there was a severe tyrosine deficiency and it would make a difference then its the time it takes to be absorbed into the blood stream, cross the blood brain barrier and enter the dopamine neurons so the tyrosine would be being taken up into the CNS and being converted as fast as it could after around an hour. I would have no idea as to how many mg (or more likely ug) can cross the blood brain barrier at any given time given that it relies on active transport.
  #3  
Old 28-02-2013, 18:04
Maranatha Maranatha is offline
Banned
 
Join Date: 08-01-2013
38 y/o Male from United States
Posts: 215
Maranatha is an unknown quantity at this point
Points: 292, Level: 2 Points: 292, Level: 2 Points: 292, Level: 2
Activity: 11.7% Activity: 11.7% Activity: 11.7%
Re: How long does Tyrosine take to turn into dopamine?

Tyrosine also has to be taken on an empty stomach, because if it's taken with food, it will bind to the protein in the food and not cross the blood-brain barrier. The same applies to dl-Phenylalanine.

In my opinion, dl-Phenylalanine is much better than Tyrosine. Tyrosine, for me, makes every single muscle and joint in my body hurt for hours. It's totally miserable. Dl-Phenylalanine actually is an effective painkiller because it stimulates endorphin production.

Here's some interesting info about tyrosine:
Quote:
Precursor to neurotransmitters and hormones

In dopaminergic cells in the brain, tyrosine is converted to levodopa by the enzyme tyrosine hydroxylase (TH). TH is the rate-limiting enzyme involved in the synthesis of the neurotransmitter dopamine. Dopamine can then be converted into the catecholamines norepinephrine (noradrenaline) and epinephrine (adrenaline).The thyroid hormones triiodothyronine (T3) and thyroxine (T4) in the colloid of the thyroid also are derived from tyrosine.

[edit]Precursor to alkaloids

The latex of Papaver somniferum, the opium poppy, has been shown to convert tyrosine into the alkaloid morphine and the bio-synthetic pathway has been established from tyrosine to morphine by using Carbon-14 radio-labelled tyrosine to trace the in-vivo synthetic route .

Mescaline producing cactus bio-synthesize tyrosine into mescaline when injected with it . [6]

Tyrosine does not seem to have any significant effect on mood, cognitive or physical performance in normal circumstances.[21][22][23] A daily dosage for a clinical test supported in the literature is about 100 mg/kg for an adult, which amounts to about 6.8 grams at 150 lbs.[24] The usual dosage amounts to 500–1500 mg per day (dose suggested by most manufacturers; usually an equivalent to 1–3 capsules of pure tyrosine). It is not recommended to exceed 12000 mg (12 g) per day. In fact, too high doses result in reduced levels of dopamine.[21] Tyrosine may decrease the absorption of other amino acids in high or chronic doses. It decreases absorption of l-dopa.
  #4  
Old 28-02-2013, 19:00
NeuroChi NeuroChi is offline
is not his mind
 
Join Date: 18-12-2007
Male from Earth
Posts: 4,631
Blog Entries: 5
NeuroChi is a true resource and beyond reputeNeuroChi is a true resource and beyond reputeNeuroChi is a true resource and beyond reputeNeuroChi is a true resource and beyond reputeNeuroChi is a true resource and beyond reputeNeuroChi is a true resource and beyond reputeNeuroChi is a true resource and beyond reputeNeuroChi is a true resource and beyond reputeNeuroChi is a true resource and beyond reputeNeuroChi is a true resource and beyond reputeNeuroChi is a true resource and beyond repute
Points: 21,143, Level: 21 Points: 21,143, Level: 21 Points: 21,143, Level: 21
Activity: 8.4% Activity: 8.4% Activity: 8.4%
Re: How long does Tyrosine take to turn into dopamine?

Quote:
catecholamine synthesis within dopaminergic neurons
(i.e. of the nigro-neostriatal tract) does, indeed,
depend on both tyrosine hydroxylase activity and precursor
(tyrosine) availability. When tyrosine levels are
elevated, a transient acceleration occurs in dopamine
synthesis, which, in turn, increases the amounts of
the neurotransmitter that are released into synapses.
Quote:
Animals were killed I hr after the first injection
from:
CONTROL OF BRAIN NEUROTRANSMITTER SYNTHESIS BY PRECURSOR AVAILABILITY AND NUTRITIONAL STATE

However,

Quote:
TH [tyrosine hydroxylase, the enzyme that synthesizes dopamine] activity can also be affected by tissue tyrosine concentrations... The extent to which catecholamine neurons respond to having more tyrosine also depends to a major extent on their apparent firing frequencies: for example, in their resting state, nigrostriatal neurons fail to synthesize or release more dopamine when rats recieve tyrosine, however, when the animals receive a treatment that accelerates nigrostraital firing, the neurons become highly responsive to additional tyrosine.
from: Tyrosine Administration Enhances Dopamine Synthesis and Release in Light-Activated Rat Retina


and, contrasting the above,
Quote:
The results in fact show that while single, or up
to three BCAAs [Leucine, Isoleucine, Valine] lowered tyrosine, they had no effect on
dopamine synthesis in our experiments.
from: Effect of Acute Tyrosine Depletion in Using a Branched Chain Amino-Acid Mixture on Dopamine Neurotransmission in the Rat Brain

rats were killed 1.5 or 3.5 hours after initial injection.

though they do quote,
Quote:
previous animal studies have reported
evidence that individual BCAAs including leucine, isoleucine,
and valine decreased both brain tyrosine levels and
catecholamine synthesis (Wurtman et al, 1974; Carlsson and
Lindqvist, 1978; Tam et al, 1990)

So in short, probably about an hour, if the brain is depleted in the first place, otherwise, no effect.

Post Quality Evaluations:
A Well referenced answer
Solid post. Great to have you back ; )
Great response backed up by several studies.
Thanks for the good answer
  #5  
Old 23-03-2014, 14:17
Lemon3 Lemon3 is offline
Mercury Member
 
Join Date: 02-03-2014
22 y/o Male from United States
Posts: 109
Lemon3 needs to UTFSE some more before posting.
Points: 127, Level: 1 Points: 127, Level: 1 Points: 127, Level: 1
Activity: 14.9% Activity: 14.9% Activity: 14.9%
Re: How long does Tyrosine take to turn into dopamine?

If you want to feel something this is what you do.

Make a omelette, but the main key is to use at least 7 eggs (organic is better)..
Or just drink the 7 eggs.

Well, anyway my point is:
After eating a omelette using at least 7 eggs I feel amazing. I have tried loads of vitamins and all that, but nothing. eat a full omelette or just get 7 eggs into you, and you will feel awesome !!!

Post Quality Evaluations:
This has nothing to do with the topic of the thread.

Share this on:

Tags
dopamine, dopamine precursors, mdma, methylone, neurotransmitter levels, neurotransmitters

Thread Tools


Similar Threads
Thread Thread Starter Forum Replies Last Post
Drug info - Utopian pharmacology: Can long-acting analogues of MDMA be developed? (article) Expat98 Ecstasy & MDMA 5 27-02-2014 06:10
Article: Understanding Addiction: Dopamine - A Sample Neurotransmitter ~lostgurl~ Drug Addiction & Recovery 0 13-02-2007 10:16
Blending Psychology & Neurology: Associative Learning, Sensitization, Memory, Neurons Richard_smoker Drug Addiction & Recovery 0 11-04-2006 00:32


Sitelinks: Information:

All times are GMT +1. The time now is 19:16.


Copyright: SIN Foundation 2003 - 2014, All rights reserved