Combinations - Benzodiazepines and Oxycodone

[lulz]

According to this piece of research, opiates antagonise GABA responses:

http://www.ncbi.nlm.nih.gov/sites/en...&dopt=Abstract

That would achieve the opposite effect of benzodiazepines, which improve GABA responses.

I've read that benzodiazepines are sometimes prescribed to opiate addicts during withdrawal, there may be some relevence.

This is confused by the fact that I've also read opiates induce euphoria through GABA-mediated dopamine release in certain parts of the brain. Hmm.

Reputation Comments on this post:

good find

[Henfer]

yes it will. some benzo/opiate combos are not even addiciive, they are MULTIPLICATIVE.

SWIH's doctor told him that a high dose of lorazepam can potentiate the effects of alcohol by up to 10 times, depending on tolerance and general state of health.

benzos and opiates go well hand in hand and benzos make opiates even better. however, this is also a great way to kill yourself easily if you overdose, and with the multiplicative thing, that can go VERY fast. please be careful what you do, and never do this combo home alone, only if a friend is there.

if you're nodding away too much and your heartbeat goes down very much as well as your blood pressure, call the ambulance and tell them what you took. it'll save your life. and doctors are not allowed to report you to the police, at least here where SWIH lives. they're bond by their professional discretion.

[cheetahwhisker]

Back when swim used to I.V. heroin he almost died because he took his usual dose of H but did'nt think the two bars he took earlier mattered. Swim woke up with paremedics standing over him, having just given him narcan to reverse the OD. If swim was alone and not with other people when he booted he would have died according to the paremedics. Swim say that benzos do intensify the effects of opiates but it depends on the desired effect that you are looking for. Everybody is different so everybody might not like the slow euphoric combination. Just be very carefull, and try not to do it alone.

[mbrooksbsc]

Originally Posted by Henfer

yes it will. some benzo/opiate combos are not even addiciive, they are MULTIPLICATIVE.

SWIM think you mean that they are not additive, they are synergistic. This means that the effect is greater than the sum of the parts.

SWIM takes clonazepam daily and have been for nearly a year. SWIM has no idea how someone could even stand after having taken 10mg. The most SWIM has ever taken in one session is 2mg, and SWIM was out in about an hour. It also killed SWIM's short-term memory as clonazepam is an anterograde amnestic. SWIM wouldn't be too worried about the 10mg of oxycontin even if it were chewed or crushed. 10mg of oxycodone shouldn't be a problem even for someone with no tolerance. Dentists/Doctors would prescribe percocets 2 tabs (10mg) x 4 times daily.
SWIM has high tolerance to oxy (using up to 400mg IV/daily) and clonazepam yet when SWIM mixes 80mg of oxy with 2mg of clonazepam, SWIM is out. Can't imagine adding alcohol to the mix!

[carousel]

if someone swim knows took .5 mg of k-pin in morning after taking 2.5 mg's the day before would it be safe to take 10-20 mg of hydrocodone later that day?

[Jatelka]

Please always include the chemical name of pharmaceutical drugs in your posts. This can be easily obtained from Google or other search engine. Doing so will avoid confusion on this international forum.

From the rules:

• Use descriptive Topic Subject. This will help others find what they want to read. Topics with bad Topic subjects may be deleted! - there's nothing more annoying than looking at all those stupid "A stupid question" subject lines. I mean, I'm damn lazy, but how hard is it to type "A stupid question about (insert something here)"? As a rule of thumb, most thread titles should include the full name of the drug discussed.

A rule many tend to forget will cause a mass of warnings soon...


Thank you

Thread title edited

[SpaceCadetGlow]

your friend will be fine, as long as he isn't allergic to either drugs. one of my friends takes .5-1mg clonazepam (klonopin) every day and uses hydrocodone frequently; his dose is usually about 30 mg (hydrocodone). Really the only potential downside to the combination would be excessive sedation.

[Jatelka]

Something that should always be stressed is that mixing downers can be extremely dangerous: Extreme caution is advised

Excessive sedation and amnesia are one end of the spectrum, depressed respiration and being unable to protect one's airway the other.

Please also bear in mind that tolerance to the drugs will also play a part, and a perfect dose for some flamingos could well kill another.

[carousel]

Is it O.K. to take a 10 mg lortab if swim's friend takes 1.0 ativans every morning?

[Kushtronics]

SWIM was wondering if 10 - 20 mg of oxycontin and 4 mgs of alprazolam would be considered a dangerous dosage? Grapefruit juice could also have been involved. I read the guy also has a mediocre tolerance to alprazolam- 4 mg definitely makes him feel good.

Kushtronics added 20 Minutes and 23 Seconds later...

Correction: SWIM read the case-study incorrectly. The fictional man in question is on a 2mg of Alprazolam recreational dosage level. SWIM has searched around the forums for answers and has found a few, but would still like further feedback from those who have read or heard of this combination.
The next section in this case study is the fictional man nasally ingesting 15mg of oxyconting.

Will post the rest of this case study when I've finished reading it.

P.S. If this post has been worded incorrectly or in a confusing manner please let me know via PM.

[Boca Bitch]

DO NOT mix hard depressants!!!!!!! Mixing different depressants such as alcohol, benzodiazepines, and opiates GREATLY increases risk of fatal overdose resulting in respiratory failure.

[Jatelka]

^^^ I couldn't agree more. And adding grapfruit juice (which potentiates Alprazolam for certain, although I don't know about Oxycodone) would make the mix even more dangerous.

[EndlessKnight]

A friend of mine once did 1 or 2 mg of Alprazolam (he doesn't remember which), 10 mg of Oxycodone (Percocet) and a couple of drinks (just 1 or 2 rum and colas). He eneded up blacking out for only the second time ever, his whole memory of the night is just a bunch of disjointed scences.

[100mg Methylphenidate]

2mg of alprazolam would make swim melt into his bed for a while.
30-40mg insufflated/oral oxycontin by itself would blow swim out of the water and have him not moving for several hours.

Swim usually only mixes uppers and downers when he mixes pills...which isn't exactly great either.

That mix is pretty dangerous. Although swim has done similar things several times before. It's not smart. And even if that wasn't so, it'd be hard for us to dose swiy for himself. We don't know how big he is or what kind of tolerance he has, or how slow his heart rate is in the first place or any of that.

But if this combination is inevitable, the person doing it would be wiser to start much smaller than that. SWIM has ingested 20mg oxycodone nasally and 1mg alprazolam orally about 45 minutes before hand and be fine...but swim won't recommend it.

[ryanc]

Sorry for the very old thread bump, but didn't decide to make a new thread if this is here.

Anyway, SWIM plans on taking 30mg of oxy and wants to combine it with valium.

SWIM has no tolerance to oxy, and not much of a tolerance to valium. SWIM has experience with the two though, especially with valium.

So SWIM wants to know, would 30mg oxy and 10 mg valium be a safe dose, but also very euphoric at the same time? SWIM was at first thinking 20mg valium with 30mg oxy, but after reading up on it SWIM thinks respiratory depression may come into play.

[Matt The Funk]

Originally Posted by ryanc

Sorry for the very old thread bump, but didn't decide to make a new thread if this is here.

Anyway, SWIM plans on taking 30mg of oxy and wants to combine it with valium.

SWIM has no tolerance to oxy, and not much of a tolerance to valium. SWIM has experience with the two though, especially with valium.

So SWIM wants to know, would 30mg oxy and 10 mg valium be a safe dose, but also very euphoric at the same time? SWIM was at first thinking 20mg valium with 30mg oxy, but after reading up on it SWIM thinks respiratory depression may come into play.

Respiratory depression most likely wouldn't be a problem at that dose for SWIY unless they already have a history of problems with it, or have noticed it on other depressants. Most people also don't find benzodiazepines euphoric, those that do normally have pre-existing anxiety conditions. The dose is safe if SWIY hasn't had bad reactions to either alone, although since SWIY has no tolerance it might be a little too sedating. It depends on what kind of experience SWIY is looking for. Opiods and Benzodiazepines are synergistic as well and each will potentate eachother so keep that in mind. Also keep in mind the addiction potential. SWIM would start slow, try 5mg diazepam + 15mg oxycodone, and slowly increase once SWIY starts to reach near the peak till they are where they want to be. Better safe than sorry. Good luck, and enjoy, a great combo in SWIM's opinion, although Daizepam is a boring benzo to him.

[OsCarwild]

Taking benzos with opiates slows your heart-rate down significantly. When throwing alcohol in the mix it makes your heartbeat even more sporadic... If SWIY has a tolerance to any of the drugs, the risk goes down slightly, but it is still a very bad idea... 10 mg of clonazepam is a very high dosage for anyone and is EXTREMELY dangerous when mixed with other things, especially other downers. SWIM would advise to never take a dosage that high of clonazempan again.

[This is bat country]

SWIM used to mix vicodin, xanax, and booze (mostly booze) on a regular basis- one night as he was lying in bed about to drift to sleep/passout, he realized his lungs weren't working and immediately got out of bed and popped a half caffeine pill. This was the last time he used booze and opiates together- he didn't stop booze and benzos til later and will still occasionally use a low dose of one to complement the other. He enjoys the affects of benzos more than the euphoria I suppose.

[Enlightenme]

If she has no tolerance to benzos, 10mgs of klonopin by itself is dangerous. Mixing alcohol on top of that is bad news. This doesn't sound like experienced drug use from either SWIY or SWIY's girl. An experienced, and smart, user can get away with mixing certain things because he knows about dangers, effects, and doses; not to mention lots of experience with the drugs. Lucky this wasn't a newbe OD story... that would have been tragic. Glad things are well. BE CAREFUL.

[Enlightenme]

SWIM isn't even a big fan of the feeling you get from mixing the two. Adding benzos just seems to make you feel numb and less euphoric, and to feel good on it, you have to get to the point where you're nodding heavily enough to waste the high and pass out. Or you can struggle to stay awake, which isn't that fun either.