Mdpv

[fatal]

so what does this mean for potency and activity? has anyone ever heard of this before? or even possibly tried it?

[Abrad]

MDPV, it is supposedly active at 5mg. It is more of a stimulant than an empathogen from what I've read. I too would be interested to see if anybody has tried it.

[GDxCAT]

SWIG has tried this.
He went through 1/2 gram just smoking it.
The doses were never measured accurately, just match head sized bumps put into a tweak pipe.

For a short time SWIG felt pretty addicted to it. The high from smoking reminded him of another drug.

Orally he found it great for studying and concentrating in school.

[Abrad]

How would SWIY compare it to meth or speed?

[GDxCAT]

MDPV does not have any euphoria what so ever.

It reminded SWIG of another drug, when smoked it gave a rush and then a little later SWIG was fiending for more.

SWIG doesnt like stimulants much but would prefer meth and amph over MDPV anyday.

[Abrad]

Would SWIY say it would be worth trying? From what I read it doesn't seem very exciting.

[fatal]

is there any reliable information on dosage?------

[Nagognog2]

From the literature, there seems to be a ceiling at around 10mg. Any higher then this, e.g. 15mg, and the comedown appears really hellish and not worth it at all. So this one seems to be a case where less is distinctly better.

[turkeyphant]

The interesting thing about 1-(3,4-methylenedioxy-phenyl)-2-pyrrolidin-1-yl-pentan-1-one is that is appears not to be covered by the UK's Misuse of Phenethylamines act. What's more, some vendors are starting to stock this compound.

SWIM would be interested in obtaining it even though it seems as though it does not hold much scope for research.

[fatal]

so long as by research you mean .... then yes... it has quite the scope for research...

[fatal]

swim would suggest that UK researchers stay away from thsi... dont buy it just because its what you can get... you still have benzodifurans and AMT and thats pretty good. on another thought why has this extension on the phenethylamine family been wasted with the ever so unmagical methylenedioxy substitution? it still enhanced the potency of the parent compound by 30-50x. ok think about this then... if we hold DOTFM-DFLY to be active at a likely 100ug then if you were to add the PV then it would be on the measure of 2-3 ug. DOTFM-PV-DFLY...

[fastandbulbous]

Originally Posted by fatal

swim would suggest that UK researchers stay away from thsi... dont buy it just because its what you can get... you still have benzodifurans and AMT and thats pretty good. on another thought why has this extension on the phenethylamine family been wasted with the ever so unmagical methylenedioxy substitution? it still enhanced the potency of the parent compound by 30-50x. ok think about this then... if we hold DOTFM-DFLY to be active at a likely 100ug then if you were to add the PV then it would be on the measure of 2-3 ug. DOTFM-PV-DFLY...

Despite the 3,4-methylenedioxy substitution it has negligable entactogenic activity as it's an almost exclusively dopamine reuptake inhibitor. In terms of effect, doses in the 2-5mg range produce a very clean CNS stimulation not unlike say methylphenidate or even 4-MAR. At that dose it has none of the distracting CNS properties that detract from amphetamines, but all of the benefits. Go over 10mg though and the excessive dopaminergic activity will make you crazy, coke style (I inadvertantly rectally administered 20mg about a year and a bit ago when I was intending only 5mg and required 5ml of GBL to stop me turning into a total fruit-loop - normally 1.5ml of GBL will knock me out).

The 2,5-dimethoxy-4-whatever substituted phenylpentanones will be devoid of any psychedelic activity

Reputation Comments on this post:

	Informative response as usual.

[fatal]

Originally Posted by fastandbulbous

Despite the 3,4-methylenedioxy substitution it has negligable entactogenic activity as it's an almost exclusively dopamine reuptake inhibitor. In terms of effect, doses in the 2-5mg range produce a very clean CNS stimulation not unlike say methylphenidate or even 4-MAR. At that dose it has none of the distracting CNS properties that detract from amphetamines, but all of the benefits. Go over 10mg though and the excessive dopaminergic activity will make you crazy, coke style (I inadvertantly rectally administered 20mg about a year and a bit ago when I was intending only 5mg and required 5ml of GBL to stop me turning into a total fruit-loop - normally 1.5ml of GBL will knock me out).

The 2,5-dimethoxy-4-whatever substituted phenylpentanones will be devoid of any psychedelic activity

are you sure about that? if not psychedelic then what? cause their could be a whole shitload of different ones and they would all be very potent... 2,5-dimethoxy-4-propylthio-phenylpentanone 2,5-dimethoxy-4-trifluoromethyl-phenylpentanone 2,5-difuranyl-4-propyl-phenylpentanone etc... several of those seem to fit right in with extremely potent activity. is there any reason to believe that 2CPDflyPV for example would be without activity? actually i suppose that at this point it becomes easier to tinker with the naming here for simplicity. instead of 2CP-DFLY-PV or 2c-t-7-PV it be easier to open up a whole new nomenclature for these compounds (theoretically at this point). PK-T-7
PK-T-2
PK-P
PK-E
PK-B
PK-GN
PK-G5
PK-TFM-DFLY

for example... isnt there an alternate naming for the PV? like a PK... ill have to check i might use that instead...
this is a whole new world of psychedelic chemistrythat is yet to be really explored. i would let the MDPV frighten you off honetly. its a whole hell of alot more potent than MDMA ever could imagine. the methylenedioxy group is lacking of any really interesting things as far as psychedelic activity and thus it is hard to find interest in them(for most). it is still a very active drugs... just not necessarily the same as mdma more on the speedy rush side of it... there is no reason to believe that the pentanone-2C-B (PV-B/PK-B) would lack psychedelic activity... is there?



edit: Pk is more catchy

[enquirewithin]

Someone on an other board (not SWIM) said it was their favourite drug of all time and that 30mg produced great euphoria, but please don't take that as safe dose! This could be complete nosense-- it's second-hand information. SWIM would start with a much lower dose.

Others say they have enjoyed smoking it and that it has a brief rush, making it compulsive like crack (but presumably not as euphoric).

[fatal]

Originally Posted by enquirewithin

Others say they have enjoyed smoking it.

and now lets see how long that particular characteristic takes to get this compound scheduled around the world... and you thought the foxy boom got them angry... well... just you wait...

[radiometer]

I think you can call it a Pyrrolidin Ketone, or PK. I tend to trust f&b on these things, as he seems to sort of specialize in SAR. Of course no one really knows, unless the compounds are made and tested.

[fatal]

not about not trusting F&B and his vast array of knowledge in this area... just saying that they have to be active somehow so what would their nature be? its obvious that the potency should be way way up from the parent compounds...

[fastandbulbous]

The alpha propyl group prevents the molecule interacting with the 5HT2a receptor as anything bigger tham a methyl group is too big to let the molecule 'get in the right place' (it's a region of steric hinderance, as Nichols calls it).

MDPV is more potent as a dopamine reuptake inhibitor, but that's very different from any activity at the 5HT2a (or any serotonogic) receptor. There's a lengthy post I made on another forum entitled 'Acid, dragonflies & the 5HT2a receptor' (Bluelight, if that's allowed) that explains why anything bigger than an alpha methyl group removes all psychedelic activity, along with other aspects of SAR with respect to the 5HT2a receptor (ie psychedelic activity)

Reputation Comments on this post:

	another karma-worthy response
	Thanks for great information as usual.

[fatal]

we should all take a moment to appreciate the fact that the member who posted above me knows as much as anyone else in this field. kudos f&b. what would we ever do without you?

[fatal]

so what then of my theoretical compounds fastandbulbous? how would they act as it seems they should certainly be active. just different types of stimulants with insane potency or something more(less?).

by the way is your name from the fastandbulbous from rocket pierre?

[fastandbulbous]

Nah, it's from the babbling bits from 'Trout Mask Replica' (Captain Beefheart)!

Not really sure about the substituted phenylpentanones; the 3,4-methylenedioxy might end up being the most potent because it has oxygen atoms at the same position on the ring as dopamine, so is more likely to interact with the DAT (dopamine transporter responsible for uptake). They might be decent reuptake inhibitors, but the chances of any other activity seem very slight.


Without me you'd get less of the sarcastic fat hippie comments in some threads!


Oh, BTW I tried recrystallizing some from ethanol & making up a sterile soln with a micron filter for the purpose of trying a parenteral dose. 2.5mg IM produced an amazing libido stimulating effect (which is much more noticable as you get older!) that lasted a few hours & was on a par with the best that amphetamine could offer in that field; it was still an incredibly clear thinking state of mind. A few days later I tried the same along with a small amount of cannabis and sex was like being 18/19 years old again. Wouldn't recommend anything over 4-5mg by this route though

Reputation Comments on this post:

the fact that you dont have the highest rep on this board speaks for the lack of appreciation and intelligence of averag...

[nostawk]

Originally Posted by fastandbulbous

Not really sure about the substituted phenylpentanones; the 3,4-methylenedioxy might end up being the most potent because it has oxygen atoms at the same position on the ring as dopamine, so is more likely to interact with the DAT (dopamine transporter responsible for uptake). They might be decent reuptake inhibitors, but the chances of any other activity seem very slight.

I wish I could read this article.


http://pubs.acs.org/cgi-bin/abstract...jm050797a.html

[nanobrain]

it is a very fine line between clearheadedness and insanity with this compound. please exercise much caution as:

a. very easy to overdose, which may produce a long lasting panic attack.
b. hygroscopic. material exposed to air in the scoop on the milligram scale gained weight right before the observer's eyes. thus, it clumps forming very dense chunks. do not eyeball.
c. it has lasting conseqences on your cognitive function and emotional stability.

[Frogster]

I’m following the Discussion for some Time now, as i'm using MDPV for several weeks daily now. Therefore I’d like to make some Comments...

Originally Posted by nanobrain

it is a very fine line between clear-headedness and insanity with this compound. Please exercise much caution as:

a. very easy to overdose, which may produce a long lasting panic attack.

It has lasting consequences on your cognitive function and emotional stability.

I completely agree with Nanobrain on these points, and I don’t doubt that his later posts concerning MDPV are at least a realistic assessment.

Here is my report

-First use: 10mg orally for waking up at 6 in the morning after 2 hours of sleep. Approx 30min till first effects are noted: Wakefulness, then strong motivation for physical tasks, and a slight odd feeling of entactogenic properties (MDMA like but only an euphorialess little touch of it). Effects fading off approx. 5 hours after ingestion.

-After three more similar applications: Similar effects!

-First insufflation use: Wanted to drive to a (very druggy) music Festival in Belgium 200km away: No Sleep before or after work! Needed an Upper to not fall asleep while driving. Drank a Cup of Coffee plus 300mg Adrafinil. No effect! I will fall asleep in a few seconds. Stop at the borderline. 5mg MDPV are insufflated. Wide Awake, plenty of mental and physical energy. Driving easy to the Festival

-First heavy Use: On the Festival 6am, Metylone hang-over, don’t wanna sleep, need an upper! 15-20mg MDPV isufflated, similar Dose for a Friend. I can only describe the effect as a very strong constant energy Push. The Street name "Pusher" would be perfect for MDPV. Again, some entactogenic effects thus not strong or even euphoric. But that constant energy Push is much more long lasting than any Energy Push from Speed or Coke. Couldn’t sleep till 4pm...

-Daily use: Beginning with 15mg insufflated over the day (2-3 Doses). Felt like I could handle MDPV now easily and use it for all kind of tasks that require wakefulness. False! False! False! After redosing I experienced the first Panic Attack on MDPV. It seemed that the overdose Limit is not reduced on redosing, even by waiting at least 3 hors after being on baseline. The third dose of 5mg can initiate the Panic Attack after 8 hours after the first Dose. These Attacks (i’m quite sure they are related to overdose, more than to come-down) are quite bad. Anxiety, Tremor, physical agitation, irritability, dry mouth, fast heartbeat-rate. Obviously too much Adrenaline/noradrenaline/dopamine floating around. Good advice: Always have some beta-blockers and Benzos nearby. BB's fix the heart rate and the Benzos save you out of hell after 30min. So I reduced the dose constantly (10mg a day taken orally now). Effects: Desirable effects shorter and reduced to simple Wakefulness. Baseline after 2 hours. My body seems to begin hating MDPV. Even after a smaller redose like 3mg it can still provoke those bad PA's. Glad to have the Benzos (a real Lifeguard). Side effects seem to worsen: Kidney pain, Headaches, Tinnitus, Skin prickles, diharrea. Seems to be related to Hypertonia. (Again, Beta-Blockers to fix this).

I wanted to dump the rest of my 500mg batch into the toilet several times after I needed 30mg Diazepam to come down, but despite all this bad side effects, MDPV was a still perfect Tool for me for many Occasions: Wakefulness on Parties till very late, extremely reduced Alcohol consumption (health benefit ), easy for getting up early with physical energy, and still cool, Cigarettes seem to restore the wakefulness even after a Panic attack. So happened on a party where I managed to handle the side effects as late as 3am, but than I felt like the evening was just starting.

Another bad thing is that I smoke more (same effect than on regular Coke use)

Conclusion: MDPV is a useful tool and belongs definitely to the "stimulant" class drugs and not in the "entactogen" class drugs. As the side effects seem to worsen over time, the dangers of regular use seem very realistic (like Nanobrain thinks too). There is just one Report on Erowid, and no one knows what MDPV really does apart from DA/NA reuptake inhibition. Therefore I think that I will not order MDPV too soon again.

Always note that MDPV is a very potent Stimulant and very easy to Overdose. This Stuff is for adults and experienced Psychonauts. Taking a Line of MDPV thinking it is Coke say 70mg, could easily lead, without a lot of Benzos, directly to Hospital.

Reputation Comments on this post:

	thank you for your input
	good info
	very useful information
	USE SWIM AND WATCH THE SELF INCRIMINATION!!
	May be a bit biased, but that is what I needed to hear: an honest to goodness experience report of this compound.
	thanks for the report
	Great post, mucho gracias.
	excellent post whatch self incrmination ie SWIMMING like a SWIM
	informative

[Nicaine]

Originally Posted by Frogster

After redosing I experienced the first Panic Attack on MDPV. It seemed that the overdose Limit is not reduced on redosing, even by waiting at least 3 hors after being on baseline. The third dose of 5mg can initiate the Panic Attack after 8 hours after the first Dose. These Attacks (i’m quite sure they are related to overdose, more than to come-down) are quite bad. Anxiety, Tremor, physical agitation, irritability, dry mouth, fast heartbeat-rate. Obviously too much Adrenaline/noradrenaline/dopamine floating around.

Eegads... this happened to SWIM for the first time tonight, completely out of the blue (i.e. not immediately after a redose). He thinks it may be related to a combination of factors such as caffeine use, kratom use and a dose of L-Tyrosine earlier today.

It really is bad enough to want to throw away the rest of the stuff and never touch it again. It doesn't feel like a "normal" panic attack with certain thoughts connected, it feels like a physiological reaction that builds and builds and builds. SWIM is going to hit the benzos, despite concerns of respiratory depression in combination with other meds (the symptoms really give a person no choice at all).

SWIM is going on a prolonged sabbatical from all recreational substances .