Drugs-Forum  
Home Wiki Studies Forum Groups Blog Video Images News
Go Back   Drugs Forum > DRUG-FORUMS > Downers and sleeping pills > Benzodiazepines
Mark Forums Read
Register Tags

Notices

Benzodiazepines All about benzodiazepines (downers)

 
Thread Tools
  #1  
Old 15-11-2012, 01:45
biggpri biggpri is offline
Silver Member
 
Join Date: 26-08-2007
28 y/o Male from United States
Posts: 184
biggpri is a decent psychonaut.
Points: 91, Level: 1 Points: 91, Level: 1 Points: 91, Level: 1
Activity: 2.5% Activity: 2.5% Activity: 2.5%
Why does smoking make alprazolam less effective?

I used th search engine, but had no luck. I'm wondering why, in a pharmocological or biological sense, smoking makes xanax less effective. What does it do chemically? I read that it prevents the absorbtion of xanax. Is this true and can anyone shed some more light on this?
  #2  
Old 20-11-2012, 07:50
zerozerohero zerozerohero is offline
Titanium Member
 
Join Date: 11-10-2010
Male from France
Posts: 373
zerozerohero probably knows what they are talking about.zerozerohero probably knows what they are talking about.zerozerohero probably knows what they are talking about.zerozerohero probably knows what they are talking about.zerozerohero probably knows what they are talking about.
Points: 545, Level: 3 Points: 545, Level: 3 Points: 545, Level: 3
Activity: 0% Activity: 0% Activity: 0%
Re: Why does smoking make alprazolam less effective?

Benzodiazepines are uneffective or less effective when smoked - the bioavailability of most benzos (their ability to penetrate the human bloodflow and the ability to cross the blood-brain barrier) is highest when used orally (eg. swallowed). Very few benzos can be injected for higher efficiency and this requires very special preparations - just crushing benzo pills and trying to dissolve and inject them can very easily lead to death.
There is a LOT of litterature on that matter on the forum, take time to do a new search, you'l find many answers. Also do consult wikipedia for specific benzos. You'll find the bioavailability values right on top of the article usually.
  #3  
Old 20-11-2012, 23:02
biggpri biggpri is offline
Silver Member
 
Join Date: 26-08-2007
28 y/o Male from United States
Posts: 184
biggpri is a decent psychonaut.
Points: 91, Level: 1 Points: 91, Level: 1 Points: 91, Level: 1
Activity: 2.5% Activity: 2.5% Activity: 2.5%
Re: Why does smoking make alprazolam less effective?

Perhaps i should've worded my post a little better. What i meant to ask was why smoking cigarettes before taking a xanax dose makes it less effective. One time when i was prescribed xanax, i read in the accompanying pamphlet that smoking while taking this medication prevents up to 50% of its absorbtion into your system. Is this true just with cigarettes? Or also marijuana? And why is it absorbed less effectively?
  #4  
Old 21-11-2012, 01:00
Kratomlucida Kratomlucida is offline
Newbie
 
Join Date: 14-11-2011
22 y/o Male from United States
Posts: 1
Kratomlucida is an unknown quantity at this point
Points: 6, Level: 1 Points: 6, Level: 1 Points: 6, Level: 1
Activity: 0.1% Activity: 0.1% Activity: 0.1%
Re: Why does smoking make alprazolam less effective?

Swim has never heard of this. Usually people state smoking kicks in substances faster and better. Can swiy please explain why he/she is under the impression that smoking makes it less effective?

Post Quality Evaluations:
Please do not use SWIM http://www.drugs-forum.com/forum/showthread.php?t=197306
  #5  
Old 21-11-2012, 03:46
JJ1234 JJ1234 is offline
Silver Member
 
Join Date: 22-06-2010
38 y/o Male from United States
Posts: 335
JJ1234 is captain of the psychonauts.JJ1234 is captain of the psychonauts.
Points: 286, Level: 2 Points: 286, Level: 2 Points: 286, Level: 2
Activity: 0% Activity: 0% Activity: 0%
Re: Why does smoking make alprazolam less effective?

【Melting Point】230 - 231

【Boiling Point】509

Maybe the heat destroys it and changes it chemically before it gets to the point of vaporization. Or perhaps 509 degrees may be way too hot too reach with a butane lighter. Even if it was possible who would want that hot as smoke in their lungs? Not to even mention who knows what chemicals are produced by igniting the fillers in the pill?

If you really want it to hit faster than the 15-30 minute it takes and you can handle the taste, try it sublingually. It is completely gross enough for me just to swallow them though. It is truly the best ROA and most people with agree with this.


I am not sure of any of this so anyone sees something wrong with it feel free to clear things up. This is my best guess as to why smoking it sucks though.

Melting/boiling point info from: http://www.chemicalbook.com/ProductM...6141398_EN.htm

-Edit: WOW, I don't even remember posting that! Kind of funny but i guess i should lock myself away from my PC better while blacking out.

Sorry for off topic post. I seriously can't believe i did this.

Last edited by JJ1234; 29-11-2012 at 00:26.
  #6  
Old 21-11-2012, 05:13
Kid Cudi Kid Cudi is offline
Titanium Member
 
Join Date: 20-01-2012
Male from United States
Posts: 418
Kid Cudi really adds to the discussion.Kid Cudi really adds to the discussion.Kid Cudi really adds to the discussion.Kid Cudi really adds to the discussion.Kid Cudi really adds to the discussion.Kid Cudi really adds to the discussion.
Points: 863, Level: 4 Points: 863, Level: 4 Points: 863, Level: 4
Activity: 0% Activity: 0% Activity: 0%
Re: Why does smoking make alprazolam less effective?

Quote:
Originally Posted by JJ1234 View Post
【Melting Point】230 - 231

【Boiling Point】509

Maybe the heat destroys it and changes it chemically before it gets to the point of vaporization. Or perhaps 509 degrees may be way too hot too reach with a butane lighter. Even if it was possible who would want that hot as smoke in their lungs? Not to even mention who knows what chemicals are produced by igniting the fillers in the pill?

If you really want it to hit faster than the 15-30 minute it takes and you can handle the taste, try it sublingually. It is completely gross enough for me just to swallow them though. It is truly the best ROA and most people with agree with this.


I am not sure of any of this so anyone sees something wrong with it feel free to clear things up. This is my best guess as to why smoking it sucks though.

Melting/boiling point info from: http://www.chemicalbook.com/ProductM...6141398_EN.htm
The OP wasn't referring to smoking the alprazolam; rather, smoking cigarettes before ingesting alprazolam.
  #7  
Old 21-11-2012, 10:18
zerozerohero zerozerohero is offline
Titanium Member
 
Join Date: 11-10-2010
Male from France
Posts: 373
zerozerohero probably knows what they are talking about.zerozerohero probably knows what they are talking about.zerozerohero probably knows what they are talking about.zerozerohero probably knows what they are talking about.zerozerohero probably knows what they are talking about.
Points: 545, Level: 3 Points: 545, Level: 3 Points: 545, Level: 3
Activity: 0% Activity: 0% Activity: 0%
Re: Why does smoking make alprazolam less effective?

yep, post wasn't clear at first - i've read that smoking makes benzos less effective for some reason somewhere already, probably here on DF, a search wouldn't harm.

As for smoking benzos vs ingesting: utfse! The issue is more than well documented on DF.
  #8  
Old 22-11-2012, 04:06
RoK Krawler RoK Krawler is offline
Silver Member
 
Join Date: 21-02-2011
32 y/o Male from United States
Posts: 51
RoK Krawler is learning how to become a psychonaut.
Points: 63, Level: 1 Points: 63, Level: 1 Points: 63, Level: 1
Activity: 0.1% Activity: 0.1% Activity: 0.1%
Re: Why does smoking make alprazolam less effective?

Never had that problem. I have the, Did i just smoke one...? Oh well, Ill have another lol. So my almost two pack a day habit leans to a elevation of some sort. But all people are differnt, But if you dont smoke and take part in smoking before hand, It might be the stimulant in the cigarette thats stronger.

Share this on:

Tags
alprazolam, nicotine

Thread Tools


Similar Threads
Thread Thread Starter Forum Replies Last Post
Movies about drugs dillydude Drug culture 254 13-12-2013 05:27
Alprazolam Nanashi Drug Articles 18 27-12-2012 18:33
Pharmacology - Alprazolam Jatelka Benzodiazepines 0 16-08-2007 18:20

» New Threads
Should i come off suboxone?
Last post by figgy
4 Replies, 74 Views
Tramadol use after prescribed for...
Last post by detoxin momma
2 Replies, 21 Views
Hallucinations on MDMA comedown?
Last post by Jozi Gold
8 Replies, 280 Views
Stopped for 6 days now
Last post by M0RPH3US
9 Replies, 96 Views
LSD and prescription drugs
Last post by BigDiggerNick
1 Replies, 75 Views
LSD is LSD is LSD, difference in...
Last post by polio vaccine
13 Replies, 392 Views
Getting Pets or Animals High
Last post by detoxin momma
48 Replies, 3,745 Views
Euphoria: Reaching the new setpoint
Last post by Andrewk3n
2 Replies, 170 Views
Yolanda's journey: hydrocodone...
Last post by YOLANDA70
15 Replies, 343 Views
mixing different bags together
Last post by polio vaccine
5 Replies, 236 Views
» New Wiki Articles

Sitelinks: Information:

All times are GMT +1. The time now is 16:41.


Copyright: SIN Foundation 2003 - 2014, All rights reserved
"Wiki" powered by VaultWiki v3.0.20 PL 1.