Originally Posted by GeographyGeography
slaya would you elaborate on how you came to think this? This is the perfect place for it.
I agree with him. I'll try my best to elaborate my reasoning:
I'm not sure whether it says it on your bags of Bizzaro/sonic zero/Zencense products, but it lists which type of cannabinoids aren't
in the blends. The list covers most types(including two I've actually never even heard of, but are classified as cannabinoids), except the adamantylated structures, like STS-135
. As far as I'm aware, as well, there's not a whole lot of currently existing alternative structures aside from the ones listed on the packages and the adamantylated cannabinoids. Hopefully that helps narrow the scope of what we're looking at.
The reason I bring up these structures, is because of the adamantyl part. Many basic adamantane(most basic form of the hydrocarbon) derivatives have NMDA antagonistic and anticholinergic effects, among others and are widely used as a range of antiviral drugs
. Because of the... 'exotic?' nature of adamantane, I wouldn't find it odd that metabolism takes place there, thus producing another drug
in it's own right. Many of these drugs can stay in the body for quite some time, too.
Having used anticholinergics recreationally, myself, I can definitely say some of the effects of the high(in dark rooms at high doses I see 'lightning flashes,' the way I nod when I smoke a lot which doesn't happen when I first start smoking) and withdrawal
(mainly the mental fog, loss of some muscle rigidity) feel like some of my experiences with anticholinergics. The nod I sometimes get 10 minutes after I've smoked a fair amount is extremely reminiscent of a high dose of Diphenhydramine
(Benadryl). Many people have also said that smoking the newer blends give them diarrhea, which anticholinergics can definitely cause. However, contradictory to that, cannabinoids generally slow
gut motility, so one could assume this would mean the opposite of diarrhea. Endocannabinoids are used to tell your brain you're hungry, stimulating appetite and slowing gut function until nutrients trigger another response in the body that stimulates metabolism and shuts down appetite(to tell you to stop eating, or that you no longer require sustenance). So a marked increase in gut motility during the duration of the 'high' is somewhat unexpected, and as such, raises my eyebrows as to what may cause this.
I'm not a doctor, chemist, pharmacologist, ect. These causes are purely speculative, and relative to my own personal past experiences. However, many people smoking these Zencense products tend to describe the effects quite similarly, so there is a level of regularity in the experiences. I can only speculate on the relation of anticholinergic effects, as I have a great deal of experience with them(it seems most people are unable to enjoy anticholinergics, and so experience in use is somewhat few and far between). If anyone could speculate on NMDA effects in relation, please, as I have limited experience with NMDA antagonists. NMDA antagonists are drugs like Ketamine
, and PCP
. Better speculation comes in comparison to purely NMDA-antagonistic drugs, as many have multiple effects, such as Ketamine binding to opioid
receptors, and PCP binding to dopamine
Bizzaro contains adamantylated cannabinoids, which, when metabolized, gives off semi-simple adamantane derivatives that effect the glutamate(NMDA) and/or cholinergic systems. Many adamantane derivatives have long half lives(usually a few days), and as such could be a major source of the brain fog and other certain 'withdrawal' effects shortly after discontinuing use.
While perhaps not an NMDA antagonist or anticholinergic, most adamantane derivatives usually have some
sort of psychoactive
effect. I speculate this strongly influences the high, and after effects that seem prominent in the gastric area.