HCL, HCI, freebase questions

[pancho]

what do these mean, and is one better than the other?

[Kemikaru_Tenshu]

A salt of an organic compound is formed using an acid in a (usually) one-to-one molar ratio of acid to compound.


The base compound from which each of the salts is formed is called the freebase, as in a "free of acid" basic organic compound. HCL is just an incorrect way of expressing a hydrochloride (HCl) component in the salt. So neither one is better than the other, as the two refer to the same thing.


A freebase is usually not very water soluble, whereas an organic salt of a strong acid usually IS very water soluble. These qualities make the matter of selecting the correct acidic component to use in a certain application entirely dependant on the requirements of that application. Such things as potential duration of action, absorption, method of administration, etc. must be taken into account.





~KT