I have wondered the same, as I am currently on 40mg Vyvanse daily for ADHD. Sulbutiamine seems like it would have a very strong synergistic effect with amphetamine
. Here's my understanding:
Sulbutiamine up regulates the reticular activating system, which is the center of arousal and motivation. Hyperactive children (Those with ADHD…) are thought to have a poor reticular activating system which is responsible for activating the appropriate part of the brain when stimuli are absorbed. I.E. When somebody asks you a question and you have to make a decision, this system sends those stimuli to the prefrontal cortex.
Amphetamines do a decent job at simulating this by stimulating the entire brian overall. The idea being that a poor reticular activating system does a weak job at arousing the brain, so if the brain is already at a higher level of arousal, activation of those areas would be easier. Taking these two together would therefore be synergistic. A more powerful reticular activating system + a more active brain = more overall attention, focus, and most importantly, better performance.
Sulbutiamine also decreases the density of glutamate receptors in the prefrontal cortex to increase activity. At first, this seems contradictory. But as I understand, this means that transmission becomes more centralized and less likely to stimulate the 'wrong' receptors. Much like trimming the hedges, Sulbutamine gives your brain a 'haircut' so that things don't get tangled up and you come to false conclusions or make bad choices. Each signal goes exactly where it is meant to go, and transmission becomes easier.
Amphetamine stimulates the prefrontal cortex, so the effects of Sulbutamine would be sped up. Increased transmission would induce LTP, a type of learning that 'hard wires' pathways in your brain so that you don't have to think about things so much in the future. It creates shortcuts that allow you to build off of what you know and succeed further in life. If you have trouble remembering people's names, you could either have ADHD, or just not have a reason to remember them. When you ask a hot girl for her name, you get aroused, and your memory pathways get fired when she tells you. These happen independently. However, LTP only occurs when memory is linked to a state of arousal. LTP would occur in this situation and you would learn that it is important to remember names because forgetting her name would be embarrassing and decrease your chances of having sex (primally: less arousal in the future.)
General arousal from amphetamine + improvement in transmission from sulbutamine = more LTP, more learning, better memory, and more success.
So final check-list here:
Stimulates the brain, causing connections to occur faster, and heightening mental ability.
Up regulates the reticular activating system, causing it to become more active and increase arousal of the brain which aids concentration.
Decreases the density of glutamate receptors in the pre-frontal cortex to create more efficient transmutation and better learning.
ALSO (didn't touch on this), decreases dopamine
in the pre-frontal cortex, which leads to an increase in dopamine receptors in the area to compensate. More dopamine pathways in the prefrontal cortex enables us to feel more complex emotions and make more complex decisions.
The combination of the two would create a hyper rewiring of the brain. Sulbutamine would set the infrastructure of what to do (increase motivation, trim the hedges to improve learning, increase dopamine receptors in the prefrontal cortex), which Amphetamine would speed those mechanisms along by stimulating the pathways required to make those effects happen. Sulbutamine is the car, Amphetamine is the gas.
I am actually about to order Sulbutamine to aid the therapeutic effect of Amphetamine. The only reason I stumbled upon this was some to read some accounts of others who have used it.
Don't take this as complete fact or to persuade you to make a decision. I have finished a semester of Introductory Psychology at my current liberal arts college and have spend about a year casually researching drugs
and how they work when I realized I may have ADHD. How much you want to respect my opinion is completely up to you.