Combinations - Xanax (Alprazolam), barbiturates and grapefruit juice: Lethal?

[Aopocetx]

If a man were to ingest 3.0mg alprazolam (Xanax) and 150mg butalbital, chased with a 100% grape juice, would this be lethal? Assuming no tolerance and a weight of 130lbs.

[ClicheName]

If you have to question whether or not it would be lethal you shouldn't be taking that much to begin with. Having never used (or planned on using) benzos or other downers, I wouldn't know, but you should definately do more research before even attempting this.

[Aopocetx]

Too late, already taken. I feel a head ache. Something weird.

[Jatelka]

Originally Posted by Aopocetx

Too late, already taken. I feel a head ache. Something weird.

And todays "Drugs-Forum Darwin Award" goes to... Guess who?

Seriously: 2 respiratory depressants together is asking for trouble: Risks of unconsciousness, inability to protect SWIY's airway and reduced respiratory rate. This is potentially lethal.

3mg Xanax is a large dose for someone with no tolerance. The maximum therepeutic dose of butalbital is 5mg/kg/day.

Grapefruit juice inhibits the cytochrome p450 enzymes which break down benzodiazepines in the liver (theoretically increasing benzodiazeopine concentrations). Barbiturates are cytochrome p450 inducers (although SWIJ has no idea how long it takes before this has an effect) so hopefully SWIY's liver enzymes will be upregulated and this will cancel out the effects of the grapefruit juice!

If SWIY feels weird SWIJ strongly (and somewhat cynically) suggests that they GET OFF THE INTERNET AND SEEK MEDICAL ATTENTION!