Combinations - LD50 for Klonopin

[kemistudent]

According to a few wib sites I have looked at, the LD50 for humans would be incredibly high, as for rats it looks pretty high.

Here is some data from one thread:

First Post

Something else interesting regarding the safety of benzos is that Klonopin's LD50 for rats and mice is 4,000mg/kg, and in rabbits it's 2,000mg/kg. Even though animal LD50's aren't necessarily a great indicator of what may be a fatal dose for a human, if we use the rabbit LD50 as an example, it would take around 145,000mg of Klonopin to kill a 160-pound person; using the rat/mouse LD50, it would be 290,000mg!! So, in essence, it's pretty much impossible to OD on the stuff for two reasons:

1 -- Where the heck would you get that much Klonopin?? And if you *were* somehow able to procure it, surely thoughts of suicide would quickly be replaced with thoughts of selling the darned things and becoming filthy rich, lol!
2 -- If the LD50's listed above are similar to the LD50 in humans, one would need to ingest anywhere from 72,500-145,000 2mg pills.
As a side note, just a thought I'm having... First of all, each pill weighs more than the amount of clonazepam in it due to all the fillers. I'd be interested to find out exactly how much one 2mg pill weighs, but for argument's sake, let's just say that a 2mg Klonopin weighs about half as much as a regular paperclip, 250mg. Then 72,500 pills would weigh 18,125 grams. Now, if memory serves me correctly, it takes about 14 liters (14,000g) of water to kill a person of average weight. That would make the pills themselves less toxic than water!
I must reiterate though, the LD50's listed above are just for the sake of example; the human LD50 for clonazepam is not known (for obvious reasons).

Second Post

I once took 100mg klonopin with a pint of vodka and some beers, --I slept for a couple of days, but that was about it. Sounds pretty safe to me. (relatively of course, NOT recommended.)
-thomas-

Third Post

My pdoc told me that one of his other patients took over 100 mg of Xanax in a suicide attempt. Apparently, she was fine (although sleepy). He did add that, thankfully she didn't add alcohol. My impression is that it's almost impossible to OD on benzos unless other CNS depressants are involved.

Fourth Post

I'm always pretty surprised when I read about people who suffer no adverse effects after mixing benzos with alcohol. I had always thought that that combination of CNS depressants would almost surely be fatal. What's the word on this? (maybe I'm thinking of the old barbiturate drugs and alcohol)

Fifth Post

> I'm always pretty surprised when I read about people who >suffer no adverse effects after mixing benzos with alcohol. I had >always thought that that combination of CNS depressants >would almost surely be fatal. What's the word on this? (maybe >I'm thinking of the old barbiturate drugs and alcohol)

This happens to be one of those cases where individual variability in genetic factors is the major determinant of the outcome. There is no way to predict what will be a lethal dose, a priori. Alcohol and benzos combined can kill. What dose will kill a particular individual can only be determined by experiment, which will unfortunately, render that knowledge moot.
BTW, what proves lethal is the suppression of respiration. It's not toxicity that kills. It's the lack of oxygen.


So has anyone ever taken a bunch of benzo's, and if so, what benzo and about how much? EtOH involved? Does EtOH make that much of a difference when determining the LD50 of Klonopin?

Reputation Comments on this post:

good info on the pausible ld50 for humans, which is astronomical, provided other cns depressants arent precent.

[jesusfreak666er]

Why bother wondering the ld50 of clonazapam, people very rarely die of a kpin od but more likely mixing benzos and alc.