Originally Posted by salgoud
Then Knife, you do truly have ADHD and of course the dextro isomer of methylphenidate
will be stronger than the racemic.
However, in people without ADHD, dextroamphetamine is much stronger than Ritalin
. When I did Ritalin, it did the same to me that dextroamphetamine did to you, after an hour or two, I was asleep. Strange the way certain stimulants
work on people.
In normal people the bioavailability of Focalin is 11-52% and the half-life
2-4 hours. Dextroamphetamine has a bioavailability of 75% and a half-life from 10-28 hours (average 12 hours). However, I sure everyone is different, but for the majority the above is the norm. For you it is the opposite because you have perhaps a severe form of ADHD. I am just surprised that Adderall
(you have been prescribed this drug
, correct) does not last longer that Focalin. Perhaps it is due to the fact that Adderall is not pure dextroamphetamine but also has racemic amphetamine
in it also. I'm sure Focalin helps one concentrated better in the dextro form. However, is it an Extended Release form?
Vyvanse is a prodrug. By itself it is inactive, however when the body metabolizes lisdexamfetamine, it strips off the added L-lysine group and turns the drug into dextroamphetamine. Thus it is no different than Dexedrine, except the time it takes to turn into dextroamphetamine. It also remains the pro-drug, lisdexamphetamine for a little less than an hour, then turns into dextroamphetamine and has a half-life of 12-13 hours. Averaging about the same as Dexedrine. However, the strengths might be different also, I haven't had time to look those up, however I'm sure the dose of Focalin may be greater than 10-20mg. Also, one can get a physical tolerance to amphetamines when taken all the time, and the liver has a way of metabolizing drugs
faster and faster, to get them out of the system. Switching to Focalin can fool the liver, because it is a somewhat different molecular structure. However, once Focalin is taken over a period of time, the same problem may and could happen. IMO.
Ha my ADHD is pretty bad, I sometimes feel like a 5 year old child.. so restless, need to run around the block to "get my energy out" (my mum's made me do that actually, throughout my entire childhood), terrible with deadlines and appointments, you get the point. However, when medicated, I've managed to maintain a 3.9 GPA at university in upper-level courses. I'm 20 by the way, in my last 3 semesters of a 5-year biomedical engineering B.S. program.
I'm actually prescribed (all of the medications I've mentioned here were prescribed to me legally) 10 mg of instant release Focalin (dexmethylphenidate
) 3 times a day. I prefer this over the extended release formulation because the XR was very unreliable. On Focalin XR 30mg (I believe this is the highest dose), some mornings I'd get a huge burst of 15mg of the medication, crash until after lunch when the second 15mg would "kick in". It would only last about an hour or two until I felt nothing at all. I worked at a law firm while I was on this medication.
In my first post, I didn't mention that Focalin lasts longer than Adderall or Dexedrine. The problem with the aforementioned amphetamine-based medications is that they didn't work
well with me. They didn't increase motivation, they didn't produce euphoria
, they didn't improve my concentration. Instead, Adderall induced a craving of Hershey's Sundae Pie (screw that, I don't even remember eating one) and intense need for sleep. My fiancÚ used to call these Adderall naps.
A similar thing happened when I was prescribed Dexedrine (dextroamphetamine) 10 mg three times a day. Instant release. I would take the medication, get ready for school, and lay right back in bed (and fall asleep for a few hours, missing many lectures) if I didn't get out the door and stick myself in my car. Initially, the act of driving improved my alertness, but the dextroamphetamine got the best of me. Vyvanse was actually the most promising of the amphetamines. I know it is essentially dextroamphetamine, but it worked quite well after the 3 hour nap I had to take upon administration of 50mg. I felt like a zombie.. I'd knock out, wake up and have incredible concentration.
I've tried various medications in the past 4 years or so, but I've been on the same dose and frequency of Focalin (dexmethylphenidate) for the past 3 years, with 1 month "breaks" where I tried Vyvanse, Adderall, and Dexedrine due to insurance issues. I haven't noticed a decrease in efficacy whatsoever.
My fiancÚ, who does not have ADHD, responded to Focalin and Adderall in a similar fashion interestingly. Focalin has him concentrated and productive (at 2.5mg - 5 mg, he can't tolerate 10 mg). Adderall has him yawning, scatterbrained, easily distracted, hypersexual (I didn't mind this) if I woke him up by playing along, and overall a very difficult study buddy during finals. Needless to say, we got very little done.
If I want to be random and annoying, and feel driven to tend to various cravings for food, I'll go for the Adderall. If I want to catch up on sleep, I'll take Dexedrine. If I HAD to choose another medication to go on, I'd probably go for the Vyvanse. I could just wake up at 5 am, take the medicine, go to sleep for a few hours and wake up focused.
When one asks which is stronger, Ritalin (methylphenidate) or Adderall, I think it really depends on what you want it to do, what pre-existing conditions you might have.. some people respond in drastically different ways to these two medications. Regardless of bioavailability and half-life. The best way I could answer this question is by stating that they're both