Didn't feel effects of X

[mattinbr]

Swim tried to roll for the first time tonight but he barely felt anything. Swim has been taking 100 mg of Zoloft for anxiety for about a month now and he heard this can block the effects of X. How long would Swim need to lay off the Zoloft to feel the effects of X in the future?

[Unsolved]

Hi, how's it going? Yes, most likely according to what I've been told Zoloft especially can block almost all the effects of MDMA (extacy). At doses over 50mg this becomes more and more likely. Not to mention that in some ways the chemical Zoloft (steraline) is closely related to MDMA so there are issues of cross tolerance as well. Tell your friend to wait at least 2 monthes before trying extacy again to get full effect of the pill. I know this is a long time but certain changes in the brain and serotonin are made in the Brian with any anti depressant medications. Good luck!!!!

[M3th]

The first time SWIM rolled. He didnt feel anything. And yes, if you are taking ANY SSRIs they will DEFINITELY block the effects of MDMA. I suggest stopping them for about a week in advance to rolling.

Here is a thread i made about my pet alligator a week or so back.

http://drugs-forum.com/forum/showthread.php?t=17624

[Nagognog2]

Never mind the other posts. They mean well, but...........

You friend should not just stop taking zoloft, or other SSRI's, cold-turkey. This can make your friend feel like hell. This class of drug needs to be slowly decreased - under the care of a doctor.

Once the zoloft has been stopped, a full 2 months is required for the brain to revert to it's normal chemistry. Then, and only then, can MDMA work it's magic. There are no shortcuts.

Use the search engine here for more information on SSRI's. There is more coming in every day.

[mattinbr]

Thanks for the advice guys. Swim appreciates it.

[xpr´k]

Originally Posted by Nagognog2

Never mind the other posts. They mean well, but...........

You friend should not just stop taking zoloft, or other SSRI's, cold-turkey. This can make your friend feel like hell. This class of drug needs to be slowly decreased - under the care of a doctor.

Once the zoloft has been stopped, a full 2 months is required for the brain to revert to it's normal chemistry. Then, and only then, can MDMA work it's magic. There are no shortcuts.

Use the search engine here for more information on SSRI's. There is more coming in every day.

Nagognog2, does this apply to zyban to ?
Ive been thinking of quitting smoking using zyban, ive done so in the past and that drug really does wonders for me, absolutely no urge to smoke and none of the sideeffects alot of my coworkers seemed to experience (insomnia most mentioned).
I can go a few months without XTC, but if it really takes 2 months after you stop taking zyban this would mean a 5 month no XTC period, there's bound to be at least 1 party i dont wanna miss out on during that time .

[Unsolved]

I have to respectfully disagree with Nagogno2. There is no doubt that for some people Zolfot and other ssri's should be stopped slowly and weaned off of. However a number of people can get away with stopping these ssri's cold turkey such as SWIM. Especially those who did not suffer from depression symptoms in the first place. SWIM and a number of people have stopped taking these ssri drugs cold turkey without any ill effects or minimial bad side effects. For some people weaning off of these drugs just per longs the agony of these bad side effects vs. just stopping them cold turkey.SSRI's are unpredicatable and everyone responds to them differently. Believe me SWIM works in a hospital and has spoken to medical staff about this very issue and done his research. There is just no way to know unless you try it and stop taking the medication. If you do start experincing bad or ill side effects fixing this can be as easy as taking the medication again and waiting for it to kick back in again. Weaning off of these medications will not effect the results of mdma overall vs. instead of stopping the zoloft cold turkey if you wait long enough they will both give you the desired effects again. Hope this helps!!!

[Nagognog2]

Noted. You are lucky indeed. Try this on size:

http://www.drugs-forum.com/forum/showthread.php?t=17736

[Unsolved]

Good read man. Thanks for sharing thats very interesting indeed. Cymbalta is a very, very hard anti-despressant to get off of. SSRI's and mdma research is more of my field of specialties and intrest. In my opinion Cymbalta is one of the very worest medications to get off of and exibits servere withdrawl symptoms. I had a friend that stopped cold turkey with this drug, she had a lot of problems for some time. If I'm not mistaken Cybalata is not just an SSRI that treats very servere depression but also works on other chemcials complicating getting off this drug even more. There for it's not just classified as a anti-depressant but also a drug used to treat psychosis and other servere probelems like Zyprexia. I'm not sure you could compare it to a drug such as zoloft though. Anways stay safe my friend and take care.

[Nagognog2]

I am not familiar with Zyban (bupropion). Though it's structure resembles diethylpropion (Tenuate) - which acts more like an amphetamine-class CNS stimulant than anything else. Was used for weight-loss. What effects is has as an SSRI I do not know. Anyone else?

[Unsolved]

I think I found what you wanted guys. It appears that it doesn't just work on one chemical in the brain but many different chemicals. This is a drug I would definitely consult a doctor about before discontinuing. Hope this helps.

"Zyban is a drug marketed by Glaxo-Wellcome and has been used, very successfully, to treat nicotine addiction directly. In this case it is different to the way other anti-smoking agents work, such as nicotine gum and patches, since these simply supply an alternative source of nicotine other than cigarettes. Zyban works at the neurological level, reducing the craving for nicotine in any form. At the moment it is licensed in the US, but not yet in the UK. It is potentially extremely important, as this discovery could open the door to finding similar molecules for treating much more serious addiction problems, such as cocaine and heroin, etc."

"The active ingredient in Zyban is bupropion, a relatively weak inhibitor of the neuronal uptake of dopamine, serotonin and norepinephrine. Chemically, bupropion is related to phenylethylamines and has a relative molecular weight of 276.2. Although, bupropion was initially marketed as an anti-depressant (Wellbutrin), it is chemically unrelated to tricyclic, tetracyclic, selective serotonin reuptake inhibitors or other known anti-depressants.

"The pharmacokinetics of bupropion is best described by a two-compartment model with a distribution phase (how long it takes for the drug to be absorbed into the body and begin working) having a mean half-life of 3-4 hours, and an elimination phase (how long it takes for it to be metabolised and broken down to inert waste products) which has a half-life of 21 hours. Bupropion is extensively metabolized into three active metabolites. At least one of these metabolites is formed by an enzyme called cytochrome P-450 2B6 enzyme. The terminal half-life of the three metabolites ranges from 21 to 37 hours. This means that it may interact with other drugs which also effect this enzyme, such as orphenadrine and cyclophosphamide. The main known side-effects of zyban are dry mouth and dizziness, although there are a few others."

"The recommended and maximum dose of Zyban is 300 mg/day given as 150 mg tablets, twice daily. Treatment is usually initiated while the patient is still smoking and the target date for smoking cessation is normally within the first two weeks of Zyban treatment. Zyban therapy then continues for 7 to 12 weeks, depending on the effect of the therapy. If the patient has not reduced smoking by the seventh week of Zyban therapy, it is unlikely that he/she will quit during that attempt and Zyban therapy is normally discontinued."

Source data: http://www.chm.bris.ac.uk/motm/zyban/zyban.htm

[xpr´k]

you can add being nervous and insomnia to that main sideeffects list.
At my work alot of people have tried zyban and those 2 get mentioned most by the people who didnt respond well to it.
My docter said it only works good for 1 in 3 persons, the other 2/3 either suffer sideeffects or it doenst reduce their need to smoke.
Guess i was one of the lucky 1/3rd , pitty i started smoking again 5 months after i started zyban.