New Research Chemicals for 2006-2007 ?

[fnord]

id like to see more of the 2-c's personaly,and some ibogaine realated stuff. oh yeah salvaa reminds me of huffing gas when i was like 13

[MadShroomer]

These aren't "new" rc's but this is what SWIM did for the first time the other day.

first experience with DOI:
3:30pm dosed 2.5mg doi with friend (we each ate 2.5mg).
6:30pm dosed 10mg 2c-e with friend (10mg each).
7:30pm smoked AMT hcl out of home made "freebase" pipe using hollowed out clear lightbulb. (~2 hits or 2-4mg each)
This was the ticket, the AMT suddenly pushed the visuals from the other two phenethylamines/amphetamines to increadible hights! Full bending/warping of reality was amazing, the AMT helped to increase feelings of happiness/euphoria along with fits of uncontrollable laughter that made SWIM and SWIM's friend's faces hurt!

The full blown visuals lasted until ~5:30am when they subsided enough to where SWIM and SWIM's friend dosed 1mg ativan each, then snorted 1mg apiece. After drinking a beer swim was able to sleep at around 7:00am (15.5 hours after initial dose) and awoke after 6 hours of sleep still feeling effects. This was felt until around 6:30pm (27 hours after initial dose). An side note, the DREAMS WERE INCREDIBLY LUCID and crazy!

[MadShroomer]

SWIM's friend said that when his imaginary cat had taken DOI then 2c-e 3 hours later the visuals were incredible!
an example of what everything looked like is:



Also, having seen an animated ".gif" version of this picture, SWIM and SWIM's friend were convinced that this regular .jpg below was MOVING LIKE CRAZY! OMG LOL

if ya want to see a pic of the animated version (its a flash embeded image) i'll post it .. or try

we'll here's a link
http://five.flash-gear.com/water/wat...30&w=512&h=395

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Reputation Comments on this post:

	off-topic posts
	wow, visons like that. good post!

[Nagognog2]

And for American Politicians and Pentagon Officials: The Time-Released Capsule! SalvinirON & ON & ON XC.

[glogga]

I'd like to try DOPR.

[GDxCAT]

Is that the amphetamine of 2c-p?

[Mo0dy]

Yes it is. It can be a good compound but the duration is far too long imo : 20h - 30h

Aleph-2, the amphetamine version of 2c-t-2 looks interesting. Also the synthesis is in pikhal and the chemist have already made the 2c-t series, so it shouldn't be a problem to make this one unlike the fly series which seems harder/more expensive to make

[glogga]

is that the amphetamine of 2c-p?

Yes. Shulgin said it had character similar ketamine, which was why he didn't like it. But I figure I might like that.

[enquirewithin]

But there is a nagging suggestion of the out-of-body, out-of-center character that is the hallmark of the anesthetic and delusional drugs such as scopolamine or ketamine

This is what Shulgin said about DOPR. I'm not sure that really means it's like ketamine. I think Shulgin is mistaken lumping drugs such as scopalamine (ie, belladonna,etc) which are delirogens and ketamine which is a dissociative anesthetic. (Shulgin was uneasy about out-of-body experiences but also about cannabis.)

[illuminati boy]

Oh what the heck… I will toss one out there… how about something like a Mescaline hemi-FLY?

I B

[fatal]

Originally Posted by illuminati boy

Oh what the heck… I will toss one out there… how about something like a Mescaline hemi-FLY?

I B

or how about a ganesha hemi-FLY?

[fatal]

oo00oo thats a good one^^^

[fastandbulbous]

As long as you stick to the short acting dissociatives I don't think there's that great a danger from them; that's basically ketamine analogues (the ketone group on the cyclohexyl ring) as the direct PCP analogues will also have the lengthy duration of action as well as a real OD potential. Ketamine has been around a while now and I don't think there has been much about ketamine fatalities or other such bad press - it's lethal dose is something like 7000mg - so the low OD potential will def attract vendors. You could possibly see the appearance of one or two analogues from vendors; something like 2-phenyl-2-ethylaminocyclohexanone is very similar in terms of its pharmacology and pharmacokinetics, but is 4x the potency of ketamine (ketamine is 2-(2-chlorophenyl)-2-methylaminocyclohexanone). There are reports about another analogue (tiletamine) on Erowid, it wasn't reported as being as pleasant as ketamine (although fairly similar), but that is most probably due to a couple of things:

1) Tiletamine has a 2-thienyl group instead of a phenyl group as the aromatic ring. This is reported to make the PCP derivatives with a 2-thienyl group (eg TCP) noticably different in effects.

2) The only source for tiletamine is a vetinary anaesthetic containing it, but it comes as a solution already mixed with a benzo. Things like diazepam are usually given to people receiving ketamine as a surgical anaesthetic to prevent the mind-expanding effects (emergence phenomena as they like to call it in medical papers - no sense of humour in some medical people!)

God knows I've gone on about it to just about anyone who'll listen in the hope that somebody will consider it a viable RC - here's hoping...

Reputation Comments on this post:

Good info.

[enquirewithin]

The idea of alternatives to Ketamine is a fascinating, but it's hard to find much out about tiltemine.

http://www.erowid.org/experiences/su...letamine.shtml
There are three reports on Erowid.

One says that two kids got strung out on it for three months, so it can't be unpleasant, if the report is true. They also describe it being not psychedelic (no "T-hole").

Another says: 'It blows K away. Give this shit a try all.'

These two are with telazol.

The other report, apparently with pure tiletamine, decribes it as 'vile.'

I can't see why mixing a dissociative with a benzo which relieves anxiety would make it unpleasant, just less memorable. Just a thought...

Perhaps it is more dangerous that ketamine? Telazol has at least one death attributed to it.

The jury is not out on whether it could be a good RC, but the evidence so far is not promising.

It would be highly interesting to read more of people's experiences.

Reputation Comments on this post:

Good post. Embedded links are always appreciated.

[illuminati boy]

Originally Posted by fastandbulbous

You could possibly see the appearance of one or two analogues from vendors; something like 2-phenyl-2-ethylaminocyclohexanone is very similar in terms of its pharmacology and pharmacokinetics, but is 4x the potency of ketamine (ketamine is 2-(2-chlorophenyl)-2-methylaminocyclohexanone)...

God knows I've gone on about it to just about anyone who'll listen in the hope that somebody will consider it a viable RC - here's hoping...

That has to be the one of the more interesting suggestions in this thread. Do you have additional data on this particular compound?

I B

[fastandbulbous]

Originally Posted by illuminati boy

That has to be the one of the more interesting suggestions in this thread. Do you have additional data on this particular compound?

I B

Yep a fair bit - apparently it's been detected twice in street samples. It's not just that one though that's interesting; the N-ethyl version of ketamine - 2-(2-chlorophenyl)-2-(N-ethylamino)cyclohexanone will be about twice the potency of ketamine, as would 2-phenyl-2-(N-methylamino)cyclohexanone.

According to the SAR studies I've dug up on arylcyclohexylamines, the point of the 2-chloro group on the aromatic ring is to increase analgesic activity of ketamine (but this halves it's potency compared with the unsubstituted aromatic ring). One way of retaining (actually increasing) analgesic activity would be the use of 3-hydroxy or 3-methoxy phenyl compounds. These have a fair bit of affinity for the mu opiate receptor without a decrease in potency as a dissociative; the logical target compound would be 2-(3-hydroxyphenyl)-2-(N-ethylamino)cyclohexanone, which should also be 4x the potenct of ketamine, but with an affibity for the mu receptor which isn't much less than that of morphine. While it would, no doubt increase the abuse/euphoric potential of the drug, it also increases respiratory depression an equal amount - for that reason alone, I don't think the RC people would want to touch it for fear of it being responsible for an OD death (and we all know what happened when 2C-T-21 caused the death of the quadraplegic in Louisiana!)

[Nagognog2]

How about a furanyl derivative of a beta-Carboline? Harma-Fly? Seriously. 5,6-furanylharmaline/harmine. Anyone ever attempt such? I know that altering the position of a MeO on these can greatly change the potency in chimps - like us. Upwards.

[genaro]

as suggested illuminati boy, mescaline derivatives would be great

[grandbaby]

From PIHKAL entry on DOEF:

"And I'll bet you dollars to doughnuts, that if one were to make the two-carbon analog 2,5-dimethoxy-4-(2-fluoroethyl)-phenethylamine, it would be every bit as much a treasure and ally as is 2C-B or 2C-I. In fact, I am sure enough about this prediction that I am willing to name the stuff 2C-EF. It will be easily made from 2C-B by the same reaction scheme that was used above for DOEF. And I will even guess that its activity level will be in the 20-30 milligram area."

I'd like a piece of that...

[fatal]

how about 3,4,5,6-difuranyl-2-methoxy-amphetamine?

[Iggypoop]

Ehh fatal, i'm not a genius, what would be the profile of such a compound?

[fatal]

picture a G-5 hemi-FLY. it would be similar to that but witha nother furanyl ring instead of the norbornyl ring. pihkal 84

[Iggypoop]

Thanks, sounds fairly interesting

http://www.erowid.org/library/books_...ihkal084.shtml

linked for everyones easy access

I wish we knew more about the fly series, 2c-b-fly seemed not so good to many :/ . Fairly erratic stuff it would seem. Expectation plays a role i suspect.

[fatal]

ALEPH-21
2,5-dimethoxy-4-(2-fluoroethylthio)amphetamine

[fastandbulbous]

Actually, now it's been mentioned, I do remember wondering about the amphetamine version of 2C-T-21. A lot of people seemed to think 2C-T-21 to be not worth the bother, but along with several others that have been passed by, I thought that they were really quite potentially useful compounds so seeing Aleph-21 would be interesting. On the downside, it might be quite dissimilar to 2C-T-21 in the same way the subjective descriptions for Aleph-2 & 7 are quite dissimilar to 2C-T-2 & 2C-T-7. Also, it'll be stupidly potent - the effect on the aromatic ring electrons is greater for 2-fluoroethylthio than it is for say a chloro group, and there seems to be a quite good correlation between electron withdrawing effect and human potency (the strongest electron withdrawing group, trifluoromethyl - CF3 - is the group present in the most potent 2C-x/DOx series. 2C-TFM is reported active at 3-5mg & DOTFM at under a milligram). Aleph-21 might be active at a 1mg dose; nearly twice the potency of DOC.

Another one passed by, IAP could well be modified to 3-methoxy-5-(2aminopropyl)indan - the MMDA positional equivalent, but using a trimethylene ring rather than a methylenedioxy. It may be as unique as MMDA seems to be in it's psychoactivity (well, we can live in hope!). You could also see it as a derivative of G-3 (PIHKAL #82), with the 2-methoxy group removed (G-3 is actually the IAP/trimethylene ring structural equivalent of DMMDA/methylenedioxy ring, so there might well be hope of something good)