New Research Chemicals for 2006-2007 ?

[genaro]

well I'm getting a bit bored with tryptamines and phenethylamines, these are very valuable compounds but there's not gonna be much novelty there (unless maybe around Fly and dragon-fly derivatives which havn't been that much explored yet, and 4ho/4aco derivative of amt which I'm also curious about), but let's say their effects always has somewhat of the same "touch", which is what I'm bored of, I'd like something feeling completely different.

So Here's are some new perspectives that would get all my attention:

Dissociative DXM related compounds

Dissociative Arylcyclohexylamines analogues (= ketamine and pcp related compounds)

Beta-carbolines analogues

Mitragynine & related compounds

Iboganes analogues & related compounds

Oxazoles (muscimol & analogues and such)

Salvinorine-A (any possible derivatives for this one?)

Rare & uncommon ethnobotanicals active principles and their analogues (caleicine, mesembrine, lagochiline and such to name a few)

..not to add that there are so many ethnobotanicals which active principles are still unknown and unexplored (and that could be interesting to be discovered)


So as you can see I'm searching for stuff that would have some unusual effect compared to most of the drugs we've been through until now, something really new (especially something "feeling" new)

...but of course, we need highly qualified chemists to explore such ways and discover new drugs with real psychedelic potential, any shulgin incarnation around ?

So now, you bet on new RCs for year 2006-2007, what new would you wanna try (including new tryptamines and phens)

[no0b]

yea i was just thinkin to myself a while ago if there were any ketamine analogs.. some salvia ones would be pretty cool too., i think it'd be cool to get ahold of some strong rc nootropics

[raven3davis]

SWIM knows little but wat thinking of some new lsd analogs and maybe some more varations of dimethyltryptamine although there are already several.

[snapper]

2006 seems like its going to be a bad year for rcs (so far).. SWIM hopes for new tryptamine and phenethylamine substitutions as well as expansion on the fly and dragonfly skeletons. However, SWIM is not waiting for dissociatives. Dissociatives are easy to OD on, can be used as date rape drugs, and certain flavors can cause people to act very dangerously. They are also usually more dose dependent than more classic hallucinogenics. SWIM thinks any source out there would avoid this type of product due to these issues..
Beta carboline analogs have been easily available in the past and seemed very similar. They are also easily acquired from natural sources. Unlikely anyone would go to the trouble to synth.
Salvinorin is not worth the effort to modify (in terms of making to sell) with parent compound already effective.

Mostly, this year may be good for emerging ethnobotanicals. There are already some interesting new things out there on the horizon, but SWIM thinks pure chemicals will become even harder to find and assure reasonable quality.

Snapper

[no0b]

^
we're just posting ideal suggestions, realistically it probably more than likely wont even happen, but i don't think it'll be as bad as u say it will. u just have to know where to look that's all. for every vendor that turns sh't, there's always an even better one out there to replace it..
- companies have even more custom synthetic projects going on right now, as we speak

[radiometer]

The way things are going, we'll be lucky if there's any chemicals available at all.

[snapper]

Hope you-re right No0b.

Snapper

[no0b]

yea, i see the future turning into the hands of email vendors

[Dreeker]

Im waiting for something with a quick peak, then slow come-down and that gives euphoria and dissasociation

my closest experience was on an empty stomach 400mg DXM then start eating, then about 2 hours in, drink ~6 shots and then smoke weed for a bout an hour

Real nice, but itd be amazing to have that into 1

With diss. i never really have whole body euphoria, i just get real nauseaus and my head is in a different state.

Ive heard some nice things from a friend in TX about cyclohexylamines

[kemistudent]

The way things are going, we'll be lucky if there's any chemicals available at all.

10/4 on that one. I remember a time when a google search would turn up legit places that had quality rc's, now I think theres one, and it's product line up is so sketchy that I don't know if it's even worth checking out.

SWIK, likes dissociative compounds, and has played with ketamine analogues, however he has found a trip could also be very unpleasant, in the wrong state of mind, or the wrong enviorment.

[fatal]

There will always be someone who will supply these chemicals as long as there is a demand. thats how economics works guys... supply and demand

[fatal]

tihkal 1 12 28 51

pihkal 2-7 65 66 70 71 81 85 91 92 99 140 150 151 156 170 171 172 174

DOTFM 2C-TFM anything fly... theres still lots of reasearch to be done here... no need to abandon hope on phenethylamines and tryptamines just yet

[fatal]

or any of these

-2C-T-3 Methallyl
-2C-T-16 Allyl
-2C-T-19 Butyl
-2C-T-21.5 2,2-Difluoroethyl
-2C-T-22 2,2,2-Trifluoroethyl (these 5 have already been assigned by Shulgin)
-2C-T-25 Isobutyl
-2C-T-27 Benzyl
-2C-T-28 3-Fluoropropyl
-2C-T-30 4-Fluorobutyl
-2C-T-31 (4-Trifluoromethyl)benzyl
-2C-T-32 Pentafluorobenzyl
-2C-T-33 3-Methoxibenzyl

or

2C-T-26: 2,5-dimethoxy-4-(1,3-difluoroprop-2-yl)thiophenethylamine (difluoro analogue of 2C-T-4)

2C-T-29: 2,5-dimethoxy-4-(propyn-3-yl)thiophenethylamine

4-fluoromethyl-2,5-dimethoxyphenethylamine
4-trifluoromethyl-2,5-dimethoxyphenethylamine (2C-TFM)
4-(2-fluoroethyl)-2,5-dimethoxyphenethylamine (2C-EF)
4-(2,2,2-trifluoroethyl)-2,5-dimethoxyphenethylamine
4-pentafluoroethyl-2,5-dimethoxyphenethylamine.

credit to nanobrain for the original post to be found here http://www.drugs-forum.com/forum/sho...ighlight=dotfm

[fatal]

and by the way to respond to a questionin the original post yes there are derivatives of salvinorin starting with salvinorin B

[Hyperreal]

Salvinorin-B probably isn't psychoactive, though there are some who dispute this.
But salvinorin analogues do hold promise for future drugs, as Sasha explained here:

"There has been many chemical modifications made of LSD. Most of these have dropped potency or even eliminated any activity at all, but some have led to compounds that are of equal or greater potency. But consider the structure of Salvinorin A, the active component of Salvia divinorum. It presents a treasure house of sites just begging to be chemically modified. There is an acetic acid ester that has been removed by hydrolysis and successfully replaced. What about other esters such as a formate or a propionate? There is a carboxylic acid methyl ester there. Maybe the ethyl or the propyl ester homologues might be interesting. Remember that the parent compound is active in man at less than a milligram total dose -- these minor modifications might very well change both the potency as well as the nature of its effects."

[genaro]

ok guys, fukin drop what you're doing right now and just hassle every chemical suppliers to synthetise salvinorin-a analogues !!!!!!!!! I just can't wait for bioassaying those !

[illuminati boy]

These references might be of interest… The first outlines some synthesized salvinorin A derivatives that are considerably more active at kappa. The second talks about some additional diterpenoids that have been isolated from salvia. If I recall most of the more potent salvinorin A derivatives begin with salvinorin as a starting point.

Props to C6H6, for pointing out this data last year.

Bioorg Med Chem Lett. 2005 Jun 29; [Epub ahead of print]

Synthesis and in vitro pharmacological studies of new C(2) modified salvinorin A analogues.

Lee DY, Karnati VV, He M, Liu-Chen LY, Kondareti L, Ma Z, Wang Y, Chen Y, Beguin C, Carlezon WA Jr, Cohen B.

Bioorganic and Natural Products Laboratory, McLeanHospital, HarvardMedicalSchool, 115 Mill Street, Belmont, MA02478, USA.

Salvinorin A is the most potent naturally occurring opioid agonist yet discovered with high selectivity and affinity for kappa-opioid receptor. To explore its structure and activity relationships, a series of salvinorin A derivatives modified at the C(2) position were prepared and studied. These salvinorin A derivatives were screened for binding and functional activities at the human kappa-opioid receptor. Compound 4, containing a methoxymethyl group at the 2-position, was a full kappa-agonist with an EC(50) value at 0.6nM, which is about 7 times more potent than salvinorin A.

PMID: 15993589

Bioorg Med Chem. 2005 Aug 3; [Epub ahead of print]

New neoclerodane diterpenoids isolated from the leaves of Salvia divinorum and their binding affinities for human kappa opioid receptors.

Lee DY, Ma Z, Liu-Chen LY, Wang Y, Chen Y, Carlezon WA Jr, Cohen B.

Bio-Organic and Natural Products Laboratory, McLeanHospital, HarvardMedicalSchool, 115 Mill Street, Belmont, MA02478, USA.

Bioactivity-guided fractionation of the leaves of Salvia divinorum has resulted in the isolation of three new neoclerodane diterpenoids: divinatorin D (1), divinatorin E (2), and salvinorin G (3), together with 10 known terpenoids, divinatorin C (4), hardwickiic acid (5), salvinorin-A (6), -B (7), -C (8), -D (9), -E (10), and -F (11), presqualene alcohol (12), and (E)-phytol (13). The structures of these three new compounds were characterized by spectroscopic methods. All these compounds were evaluated for their binding affinities to the human kappa opioid receptors. In comparison with divinatorin D (1), divinatorin E (2), and salvinorin G (3), salvinorin A (6) is still the most potent kappa agonist.

PMID: 16084728

I B

[fatal]

just a thought... a salvinorin analogue that is 7 times more potent would be roughly active at about 30 - 40 micrograms... is that safe? these compounds are safe as far as we know... as far as smoking salvia and direct toxicity(or lack there of) have shown us it is pretty safe but still... thats very potent... swim wants some...

[Alfa]

As a pure compound that is not safe, but most compounds can be diluted to proportions where dosing is easier. However with such potence, that does bring the absolute need for a capable professional diluting that into a homogenous mixture. Any failure in producing a homogenous mixture could result in a full blown disaster.

[radio879]

I don't care for salvia myself anymore.. (but i'll smoke DMT all day long), but, thsi molecule can probably be modified to kill the salvia trip part but still be of interest as a kappa-opiate agonist, i dunno what the kappa sites are responsible for (pain at all or what, too lazy to look it up), but who knows.. some people report anti-depressant effects from low dose salvia.

Reputation Comments on this post:

self incrimination

[genaro]

arghhhh how can u babble such a monstruosity, killin the salvia space, what da fuck !?

Due to its shocking content to happy psychonauts your post shall be removed LOL

[nanobrain]

^i'm w/Radio on this one. happy psychonauts in Salvia space, hmmm...

[fatal]

ok well there is a very similar thread on another forum that has been much more active than this one so... without further ado... let the cross posting begin

[fatal]

jaw clenching wrote:
Hell yeah man. My feelings exactly.

Based on the information found here I thought up some analogs based off of AMT and DOC.

The 4-position on the DOC analogs could be replaced with so many different things, the possibilities are so numerous!

The ones that interest me the most are the "cyclo" analogs. I've heard that Shulgin's new Psychedelic Index will feature some of these.

I also have a reference showing that the MDA "cyclo" analog has similiar effects and dosage and may possibly non-neurotoxic. I'll post an image of the structure when I get a chance.



These names might be wrong. If anyone has any corrections or suggestions please let me know!!

001. AMT
002. AET
003. Cyclo-AMT
004. pyrrolidinyl AMT analog

005. 4-HO-AMT
006. 4-HO-AET
007. pyrrolidinyl 4-HO-AMT analog

008. 5-MeO-AMT
009. 5-MeO-AET
010. 5-MeO-Cyclo-AMT
011. pyrrolidinyl 5-MeO-AMT analog

012. dihydropyrano AMT analog
013. dihydropyrano AET analog
014. dihydropyrano pyrrolidinyl AMT analog

015. dihydrofuranyl AMT analog
016. dihydrofuranyl AET analog
017. dihydrofuranyl pyrrolidinyl AMT analog

018. furanyl AMT analog
019. furanyl AET analog
020. furanyl pyrrolidinyl AMT analog

================================================== ========

Does anyone have any info on Shulgin's Psychedelic Index? I thought for sure I saw a post by someone also talking about the "cyclo" analogs (is that an appropriate term?). They also said something about some of the new compounds caused seizures, etc. I can't find the post anywhere.....

[genaro]

"happy psychonauts in Salvia space, hmmm.."

LOL right, "happy" doesn't fit the salvia space that's for sure, let's say fuckin terrorised psychaunauts...now I'm still thinking that everyone would agree that this ruthless & terrorising twisted space is precisely what makes salvia so "magic" and unique (no matter whether or not you like it), therefore I really feel like it would be a waste to synthetise any salvinorin analogue that would lack this magic

...but an orally active one would be fuckin great