Viagra with XTC

[Amok]

Has anyone tried it yet, mixing rolls with Viagra? Does it enhance the E effects?

[bowlingforcindy]

i wanan try viagra on its own first. then ill mix it with x, and problably coke, and ket, and base, and whatever i have

[jojotheman]

yes ive dunnit, 1 word: mmmmmmmmmm

[korky8097]

watch out, it is pretty dangerous mixing them. Low doses of the viagra dude.

[sg43]

SWIM has taken viagra on rolls, taken about1 hour after taking his 3rd roll. Took a long time to kick in and didnt seem to fully work untill SWIM was coming down. SWIM beleives the combination of too many rolls made it not as a effective, and for the issue of saftey viagra increases your blood pressure, I beleive reading somwhere that you should not do "whippits" (n20) on viagra/rolls.

[roidrage]

wouldnt it be able to give you a heart attack since its adisved not to take viagra if you have heart probs and e's make you heart beat like mad?

[SLICE]

I've tried it once and i'd definately do it again!i just don't have a girlfriend at the moment

[Hyperreal]

http://www.erowid.org/chemicals/mdma/mdma_health7.shtml

Reputation Comments on this post:

Nothing good to say, but a link?

[sonerer]

Friend of mine is considering doing X and Viagra together so
he can fuck for ... a long time. I’ve heard that if you do Viagra when you are
young it can wreck sexual experiences for the rest of your life + other bad
shit when you do X and V together...

True or False?

[Nagognog2]

Never heard that one. BUT mixing a cardio-stimulant with an amphetamine is about as stupid as it gets. DON'T let "friend" do this.


Now back to my plans to pass out Viagra on Halloween....

[nanobrain]

priapism and cardiovascular issues.

very popular mix in gay clubs.

ps. dont take 1/2 of a Viagra, or you'll go off half-cocked...

[Nagognog2]

Baaaaad!!

[devil]

I have not read anything good about mixing these two

[Expat98]

Originally Posted by nagognog2

Never heard that one. BUT mixing a cardio-stimulant with an amphetamine is about as stupid as it gets. DON'T let "friend" do this.

Do a net search on MDMA and Viagra, and you'll see that this is a very popular combination that many people have tried, and it appears to be relatively safe (at least for those who can tolerate MDMA and Viagra when taken by themselves). Here's what Erowid has to say about the possible heart risks:

"Heart issues
Perhaps the most dangerous possible interaction between Viagra and MDMA is the theoretical risk that Viagra's vascular effects could interact dangerously with MDMA's heart-rate, blood pressure, and body temperature increasing tendencies. MDMA is a strong stimulant, increasing heart rate, blood pressure, and body temperature. Sildenafil, on the other hand, is a vasodilator and reduces blood pressure systemically. Although it is inappropriate to assume that a vasodilator 'cancels out' the effects of a stimulant, there is currently no indication that combining these two substances increase the cardiovascular risk of the other. Both alone provide substantial medical risks to those with heart conditions by themselves."

(See http://www.erowid.org/chemicals/mdma/mdma_health7.shtml)

[Nagognog2]

Oh yeah. Now it sounds much safer. Sure....so do you plan on taking this mixture? My lab ape, Bongo, would feel rather a fool walking about with an erection while trying to interact and talk with people. Sounds like a bad ad on TV about some guy named Bob who lost his shorts in the neighborhood swimming pool. Just ad dilated pupils. As regards heart conditions - the majority of such go undiagnosed. Until you wind up in an emergency room on a gurney. Why push your luck?

[Expat98]

The point is that this particular combination has had a lot of empirical testing in the real world, and from everything that I've read on the subject, there doesn't seem to be much of an increased risk over taking these substances alone. If anyone can find evidence to the contrary, please post it.

As for your point about not pushing your luck because you may have an undiagnosed heart condition, do you also recommend that people stay away from MDMA and Viagra taken alone because of this risk?
Edited by: Expat98

[Expat98]

By the way, one reason I posted in this thread is because I believe you were incorrect in calling Viagra a "cardio-stimulant". If you have any rational basis for claiming this is a risky combination, you haven't shown it.

Just to be clear, I am NOT claiming that it is in fact a safe combination. I'm just saying that there seems to be some empirical evidence that it is safe. I would be willing to risk it.

But I do fully agree that it would be a complete waste to have to walk around and talk to people when you've got a massive hard-on, so that would not be the preferred setting to try this in. Edited by: Expat98

[Nagognog2]

Understand this well: What you say here is taken as gospel by young folks who lack experience and education. PLEASE try to educate the people here to, if they must experiment, do so safely and sanely. What you write here, all of you, is being read by thousands of people. As well as quoted and misquoted.


Get the picture? Good.

[quinone]

For the record, this combo is often called Sextasy (I find that funny
=P), and is yet another indication of the lack of intelligence that
some drug uses have. Fortunately there is little effect between
viagra and MDMA itself to my knowledge (viagra blocks PDE5, a
phosphodiesterase that is responsible for stopping the cGMP cascade
that releases NO across cell membranes to relax smooth muscle.
Fortunately this effect has nothing to do with your hearts function, or
any serotonin related response.



THE PROBLEM</span>, however is that
viagra is meant for people with ERECTILE DYSFUNCTION, aka ppl who for
some reason have a less then adaquate cGMP cascade, or who produce too
much PDE5. If taken by a healthy young man, the erection can last
for HOURS (or EVEN PERMANENTLY). The penis is not meant to remain
erect for so long, and doing so will not only make it very likely that
upon hospital visit you will need to have your PENIS AMPUTATED, but if
you are lucky enough to lose the erection, there is a good chance of
suffering a permanent erectile dysfunction for the rest of your
life. Furthermore, since MDMA results in an increased heart rate
and thus an increased blood flow, the liklihood of these problems
manifesting themselves is even greater with a higher blood flow in your
penis.



The moral of the story? If you're stupid enough to mix viagra and
MDMA without actually having an erectile dysfunction ... at least
theres a very good chance that you will not be able to propogate your
stupid genes to future generations in the gene pool.

[Alfa]

Pfizer has produced extreme amounts of Viagra and released this on the markets since 1998, if I recall correctly. Soon after the release of the product, the product was hyped very well. At one point 'someone' stole over a billion doses from a warehouse in the Netherlands. Yes, you read that right a full warehouse was emptied over night without anyone noticing this. It was all over the news. I very much doubt that it was not sold directly from Pfizer to the underground.This hit the underground market quickly. Because of all the media attention the product sold well. Anyway,extreme amountsof Viagra have been sold world wide. Here in the Netherlands almost every sex shop sells it and it is their money maker. It is sold for recreational purposes, mainly to people without erectile problems. Hospitals do warn for ereections which last to long. I read a article, about someone that needed releave by injection of a medicine against the erection, now and then. But I have never heard anything about amputation. I am not saying that it doesn't occur, but I doubt that it occurs frequently. Damn, that would be a hell of a law suit.

[Expat98]

Alfa, you are right on. There is no need for the unfounded scare-mongering that quinone posted. Viagra and generic sidenafil knockoffs are used around the world for recreational purposes by guys without erectile dysfunction. Priapism can occur, but it is very unlikely unless you overdo it. 50mg or even 25mg should be enough for anyone without erectile dysfunction.

Note, however, that if priapism does occur, then you do need to take it very seriously and get yourself to a hospital, because permanent damage CAN occur. (Quinone is right about that much at least.)

[quinone]

I wasn't trying to 'scare-monger' anything. And my statements were definitely NOT unfounded. As i've stated a few times in these forums, i'm a biochemist.I have done active research on pharmaceuticals and on a class of NO suppressing compounds (a potential class of antibiotics that target bacteria with LPS, which induced NO release). I have an intimate knowledge on the NF-kappa signalling pathway, and its role in NO, iNOS, PGE5, TFT, and MDE1 expression.


I was simply contributing my knowledge to the potential implications of using viagra without need. I am not conceited enough to think that my statements would seriously scare anyone into not taking a drug. If you feel it necessary to take an erectile dysfunction drug when you're erectile system is perfectly healthy ... well thats your gamble to make (such as buying a random pill off the street can be a gamble).


It was my impression that these forums were designed to share knowledge and experience with others, and given my advanced knowledge of Viagra's mechanism of action, and its biochemical implications when combined with a drug known to increse heart rate and blood pressure I thought I could be helpful in shedding some light onto the potential dangers of mixing the two (that is what sonerer was asking was it not?)


If I had simply said 'o its bad for you, you will die' then I can certainly understand you flaming me expat98, but I backed my statements up with credible scientific evidence and specific mechanisms of action ...

[Expat98]

Originally Posted by quinone

THE PROBLEM, however is that viagra is meant for people with ERECTILE DYSFUNCTION, aka ppl who for some reason have a less then adaquate cGMP cascade, or who produce too much PDE5.* If taken by a healthy young man, the erection can last for HOURS (or EVEN PERMANENTLY).* The penis is not meant to remain erect for so long, and doing so will not only make it very likely that upon hospital visit you will need to have your PENIS AMPUTATED, but if you are lucky enough to lose the erection, there is a good chance of suffering a permanent erectile dysfunction for the rest of your life.*

Quinone, sildenafil citrate sees widespread recreational use by healthy young men with no erectile problems. Unless you can produce some evidence that a statistically significant number of men have to have their penis amputated after taking a normal dose of Viagra, I stand by what I said: your post was unfounded scare mongering.

I am new on this forum and not trying to make enemies here, but I just think that's a load of BS.

[Expat98]

Originally Posted by quinone

Furthermore, since MDMA results in an increased heart rate and thus an increased blood flow, the liklihood of these problems manifesting themselves is even greater with a higher blood flow in your penis.

By the way, the problem with priapism is that blood flows into the penis but is unable to flow out. So why do you think higher blood flow in the penis would result in increased risk of priapism? Seems to me that it would reduce the risk if anything. But then I don't have a PhD in biochemistry like you.

"What is priapism?

Priapism is a prolonged and painful erection that can last from several hours up to a few days. The priapismic erection is NOT associated with sexual thoughts or sexual activity. What happens is that blood flows into the penis, but is unable to drain as it would in a normally flaccid penis. Considering that the penis provides little room for blood to circulate, the blood becomes stagnant after a while, acidifies, and loses oxygen. Without oxygen, the red blood cells become stiff, and even less able to squeeze their way out of the penis."Edited by: Expat98

[Alfa]

Originally Posted by quinone

It was my impression that these forums were designed to share knowledge and experience with others, and given my advanced knowledge of Viagra's mechanism of action, and its biochemical implications when combined with a drug known to increse heart rate and blood pressure I thought I could be helpful in shedding some light onto the potential dangers of mixing the two (that is what sonerer was asking was it not?)


If I had simply said 'o its bad for you, you will die' then I can certainly understand you flaming me expat98, but I backed my statements up with credible scientific evidence and specific mechanisms of action ...

Your views are most welcome here. I think the risks of viagra need some light shed on, as they are certainly there. You describe it as it's likely to get a permanent erection or have your penis amputation from taking a dose of viagra. This doesn't comply with what I see around me. Many of my friends take it for fun. I have tried it once, but found it unhandy to go out once you had enough fun and I have found a nicer product. Please provide arguments to your statements. I can see no scientific evidence for them yet. Please do not take expat98's statement as flaming, but as criticism.