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Beta-Ketones Mephedrone, Methylone, Butylone, Methedrone, Ethcathinone, 3-fluoroMethCathinone (3FMC), Methylenedioxypyrovalerone (MDPV)

 
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  #1  
Old 16-01-2012, 03:34
Terrapinzflyer Terrapinzflyer is offline
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α-PVP Drug Info

Can anyone add information about alpha-Pyrrolidinopentiophenone a-pvp

  • names / synonyms
  • molecule
  • dose
  • duration
  • side effects
  • legal status
  • have there been any reported incidents with this compound?
  • since when has this research chemical been available?
  • stability of the molecule / compound



Names: Alpha-pvp, a-pvp, alpha-Pyrrolidinopentiophenone , 0-2387


IUPAC Name: 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone
CAS Number: 14530-33-7 , 5485-65-4 (HCl)
Formula: C15H21NO
Mol. Mass 231.333 g/mol

This substance was patented in 1967 by a German company. It is a stimulant drug related to pyrovalerone. Pharmacology is unknown, but theorized to be a NDRI (norepinephrine-dopamine reuptake inhibitor)

Current legal status unclear. In the US it would be criminalized federally by the pending HR 1254. Could potentially be prosecuted under analog laws.




Experiences with a-pvp should be discussed here: a-pvp Experience Reports


These documents are in the Archives:
a-pvp patent


Research Chemicals Index - Phenethylamines
Research Chemicals Index - Tryptamines
The Research Chemical Index
Research Chemicals Index - Beta-Ketones
Research Chemicals Index - Synthetic Cannabinoids
Research Chemicals Index - Piperazines
Attached Images
File Type: png 200px-APVP_structure.png (6.4 KB, 1714 views)

Last edited by Terrapinzflyer; 16-01-2012 at 03:40.
  #2  
Old 20-01-2012, 19:55
Tech House Tech House is offline
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Re: a-pvp Drug Info

Quote:
Originally Posted by Terrapinzflyer View Post
Pharmacology is unknown, but theorized to be a NDRI (norepinephrine-dopamine reuptake inhibitor)

Current legal status unclear. In the US it would be criminalized federally by the pending HR 1254. Could potentially be prosecuted under analog laws.
It must be a releaser of NE and D as well as an NDRI based on another site's experience reports, which tell of fairly immediate effects upon insufflation, combined with fairly short experiential (as opposed to serum concentration) half-life. Moab, or "Man on a bus" who I see occasionally, ordered some of it and I'll report back about his experience after I see him.

As for legal status, I looked that up because I worry about Moab's online buying behavior, and it seems that a-pvp is already technically illegal in many states such as Texas. However, I find it very difficult to decipher legal status of new RCs because the laws are too complex for my concussion-addled brain to comprehend unless there is an explicit statement that Chemical X is illegal. If I don't see Moab again, I'll have to conclude that things didn't go well with his delivery.
  #3  
Old 28-01-2012, 03:50
snapper Gold member snapper is offline
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Re: a-pvp Drug Info

alpha-pvp is almost as much of a disappointment as alpha-ppp and mdppp for the lab manager but if the ferrets had to pick their favorite, it would be this one. The effects are, like the other two, short acting and relatively mild. Of the three it is the only one that is not unpeasant to smoke but it does not really have other effects past a gentle stimulation and motivation enhancement. Euphoria is minimal but is there and when the ferrets first tried it at the tail of an epic (and their last) MDPV binge, it was barely effective. Like all the MDPV analogs, it is a disappointment in that the high is not nearly so intense, but then again neither are the side effects. It did not trigger any psychosis, vasoconstriction was minimal, the stimulation was smooth and lucid, and did not cause confusion or mental burnout that MDPV inevitably dose at higher doses. The ferrets tried IV once but had a massive tolerance and all they could say was that it was underwhelming (probably akin to their feelings about the other two.
The lab manager may acquire a sample of mppp soon and will try that last, but does not expect anything interesting. Note that this trial was actually some time ago; the ferrets are still on their stimulant hiatus and any further experiments will be in the future.
The lab manager is really disappointed with all of these and does not plan to use them again. The one benefit they have is a very short duration of action and minimal side effects and comedown. This of course translates, as expected, to the lack of any high. Meth, cocaine, and PV fans, unless the batch assayed is of poor quality, you are all bound to be disappointed. However, every ferret's biology is different and some may enjoy these...

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good information and opinion. they're all slightly the same but have there little differences. I find PV to be much more rough than a-pvp. but still almost identical.
  #4  
Old 28-01-2012, 19:17
ToastedWasp ToastedWasp is offline
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Re: a-pvp Drug Info

There is a huge difference in batches for this chem. The results from the first batch were really satisfying, the next batch was total garbage. Huge disappointment in the difference.
  #5  
Old 11-05-2012, 01:52
Synesthesiac Synesthesiac is offline
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Re: a-pvp Drug Info

Can anyone comment on the legality of this compound in the UK?

I presume its covered by the same law that covers MDPV, but i'm no expert on UK laws.
  #6  
Old 16-05-2012, 18:26
Synthesised Synthesised is offline
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Re: a-pvp Drug Info

Yes, this would be covered by the cathinone laws as of April 2010
  #7  
Old 16-05-2012, 21:49
m3c420 m3c420 is offline
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Re: a-pvp Drug Info

Can someone post some pictures of a-pvp being vaporized - for comparison
  #8  
Old 08-06-2012, 20:35
Synthesised Synthesised is offline
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Re: a-pvp Drug Info

Comparison to what?

I found 20mg snorted to be an ample dose. Going higher resulted in elevated heart rate, (mild) anxiety and insomnia. the comedown was unpleasant.

Redosing and dosing too high made for an unpleasant comedown too. Like that given to me by ethylphenidate and methylphenidate (ritalin).

There is a good drive to socialise, an increased sex drive and good mood lift, although these only last around 1-1.5 hours. I enjoyed this and would do it again over pentedrone and MDPPP which I have also tried.
  #9  
Old 04-07-2012, 03:41
smark smark is offline
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Re: a-pvp Drug Info

Quote:
Originally Posted by ToastedWasp View Post
There is a huge difference in batches for this chem. The results from the first batch were really satisfying, the next batch was total garbage. Huge disappointment in the difference.
I agree the first batch i had was rocketfuel, the secoond utterly useless, im at the point of finishing a g just to see what happens as im around 300mg in and not amused with the lack oif quality

smark added 1 Minutes and 21 Seconds later...

Quote:
Originally Posted by m3c420 View Post
Can someone post some pictures of a-pvp being vaporized - for comparison
I dont have photos but on tinfoil it turns a yellow oily colour and leaves no trace(the batch i had anyway)

Last edited by smark; 04-07-2012 at 03:41. Reason: Automerged Doublepost
  #10  
Old 04-07-2012, 05:02
syntheticdave syntheticdave is offline
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Re: a-pvp Drug Info

Quote:
I agree the first batch i had was rocketfuel, the secoond utterly useless, im at the point of finishing a g just to see what happens as im around 300mg in and not amused with the lack oif quality
Sounds like you had a pretty bunk batch i defiantly agree with Synthesised that 20mgs is a sufficient dose.
  #11  
Old 04-07-2012, 17:20
smark smark is offline
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Re: a-pvp Drug Info

Quote:
Originally Posted by syntheticdave View Post
Sounds like you had a pretty bunk batch i defiantly agree with Synthesised that 20mgs is a sufficient dose.
I actually resorted to vaping some on tinfoil and it was much more active but still had to do a fair bit, got to sleep no problem as well.

As i stored the foil and straw in the same box as the apvp i did notice after snorting a line of apvp there was an odour of the vaped residue so maybe storage in cheap baggies by vendors may be an issue
  #12  
Old 16-08-2012, 14:32
psychedelaholic psychedelaholic is offline
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Re: α-pvp

I found a-PVP to be quite nice. Snorted few lines but much preferred vaping it. Strongish rush and nice buzz. Much shorter lasting than MDPV but doesn't make you go instantly insane like PV does. No voices in your head, no conspiracy theories, no one out to get you lol. Once it wears off I found I became uber tired, like being able to fall alseep at my work desk whilst my eyes were still open.
  #13  
Old 20-08-2012, 19:52
Synesthesiac Synesthesiac is offline
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Re: α-pvp

I would describe this as a mild version of MDPV, without as much paranoia or psychosis. Warning to all users: If you re dose with this chemical for more than a few hours you will get cravings when it wears off. If you re dose for more than 12 hours you will get paranoia cravings and anxiety when it wears off. More than 24 hours and when it wears off expect psychosis level paranoia.

This is judging from posts on another forum, and some users recurrent habit of doing too much of this chemical whilst not having benzodiazepines to hand to help the after stimulation. Starts off good and positive with productive posts, but usually ends with a day or two of "The shadow people are still after me" type posts.

Dosage Intranasally: Varies from 5mg threshold, 10mg weak, 15-20mg average, 25-35mg strong.
Duration: 30-90 minutes. After stimulation can last an hour or two.
  #14  
Old 21-08-2012, 10:15
Neurosees Neurosees is offline
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Re: α-pvp

Quote:
Originally Posted by Synesthesiac View Post
More than 24 hours and when it wears off expect psychosis level paranoia.
I know someone who smoked about 30mg of α-pvp and went from baseline straight to psychosis-level paranoia within 20 minutes. It was not a panic attack, it was real paranoid psychosis that lasted for about 12 hours with transient delusions persisting about 48 hours. This individual is more inclined to paranoid thoughts to begin with but this is a very potent stimulant nonetheless.
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Old 17-09-2012, 01:13
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Re: α-pvp

Does anyone know of any literature that details alpha-PVP's mechanism of action in the human body? Or even rat models?

I don't think the information exists. But I could be overlooking it.
  #16  
Old 17-09-2012, 21:15
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Re: α-pvp

Quote:
Originally Posted by Neurosees View Post
I know someone who smoked about 30mg of α-pvp and went from baseline straight to psychosis-level paranoia within 20 minutes. It was not a panic attack, it was real paranoid psychosis that lasted for about 12 hours with transient delusions persisting about 48 hours. This individual is more inclined to paranoid thoughts to begin with but this is a very potent stimulant nonetheless.
Could you please share more information about this?
  #17  
Old 08-10-2012, 10:06
asloan471 asloan471 is offline
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Apvp hcl?

I recently recieved what is said to be APVP HCL Cas #5485-65-4. What I have is a white crystals but when vaped on tin foil burns and turns into a nasty smoke, Nothing like thje APVP ive had in the past, would this be correct for the hcl? If so what method would i use to convert to FB?
  #18  
Old 25-10-2012, 19:03
Subflow22 Subflow22 is offline
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Re: α-PVP Drug Info

Get glass eye dropper tubes from Walgreens. Break / chip / melt the tip so that the narrow dropper portion of the glass tube is removed. Get some poly tubing (heat resistant) which is available at Home Depot, or the type of tube you buy to replace the one on marijuana vaporizer. Cut the tip off of the rubber squeeze bulb, create just enough of a hole to firmly fit your tubing.

You now have a very efficient and cost effective portable vaporizing tube that allows you to easily see the material you are trying to vape. This is priceless with a-PVP, as it easily burns if heated too much or too quickly. A 1$ tube should last you though an entire gram with practice. If you burn the material and the tube becomes opaque, so what? Throw that 1$ tube away and replace it.

This method works equally well for the tan, powdery material as well as the chunky / rocky material. Just make sure you apply enough heat to melt the material in the tube before you pull.

VERY little material is lost this way. Seriously, FUCK FOIL. Make your PV last!
  #19  
Old 06-11-2012, 15:26
Subflow22 Subflow22 is offline
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Re: α-pvp

Quote:
Originally Posted by Neurosees View Post
I know someone who smoked about 30mg of α-pvp and went from baseline straight to psychosis-level paranoia within 20 minutes. It was not a panic attack, it was real paranoid psychosis that lasted for about 12 hours with transient delusions persisting about 48 hours. This individual is more inclined to paranoid thoughts to begin with but this is a very potent stimulant nonetheless.
I assume you are quite certain that this person vaped pvp and not mdpv? I trust you are.

I, personally, have gone on binges as long as 5 straight days, vaping (cleanly) as much as a gram a day. I have gone through extended binges of the white powdery, the redish rocky and tan powdery varieties. I have indeed noticed some increased paranoia, particularly with the white varieties, though never anything unmanageable.

The only time I have EVER experienced psychosis on a-PVP was when I took a double dose of Ambien CR and, rather than sleep, I blacked out. Just wanted to add 2c here, as it appears that prevalence of psychosis is largely contingent upon the individual.
  #20  
Old 13-11-2012, 11:32
drwoood drwoood is offline
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Re: α-PVP Drug Info

Like MDPV, alpha-PVP inhibits the reuptake of dopamine and noradrenaline, and is significantly stronger at inhibiting the reuptake of dopamine. Its IC50 for dopamine reuptake is 52 nM; it's IC50 for noradrenaline uptake is 200 nM - lower numbers mean that it is stronger. See Meltzer et al (2006) '1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (pyrovalerone) analogues: a promising class of monoamine uptake inhibitors' J Med Chem, 49, 1420-1432.

Both a-PPP and MDPV are significantly more selective for the dopamine transporter vs the noradrenaline transporter than dexamphetamine or methylphenidate.

drwoood added 95 Minutes and 47 Seconds later...

Quote:
Originally Posted by drwoood View Post
Like MDPV, alpha-PVP inhibits the reuptake of dopamine and noradrenaline, and is significantly stronger at inhibiting the reuptake of dopamine. Its IC50 for dopamine reuptake is 52 nM; it's IC50 for noradrenaline uptake is 200 nM - lower numbers mean that it is stronger. See Meltzer et al (2006) '1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (pyrovalerone) analogues: a promising class of monoamine uptake inhibitors' J Med Chem, 49, 1420-1432.

Both a-PPP and MDPV are significantly more selective for the dopamine transporter vs the noradrenaline transporter than dexamphetamine or methylphenidate.
I made a mistake in the post above - the IC50 for NE uptake is 56, rather than 200 (I read the wrong column in the paper I cited) - making alpha-PPP less selective for the dopamine transporter than I thought.

Last edited by drwoood; 13-11-2012 at 11:32. Reason: Automerged Doublepost
  #21  
Old 15-11-2012, 06:53
Rob Cypher Rob Cypher is offline
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Re: α-PVP Drug Info

Had a few friends get delusional and paranoid on this after a week or so of vaporizing it (one got to the point of being hospitalized in a psych ward for weeks); would not recommend.
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Old 15-11-2012, 21:22
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Re: α-PVP Drug Info

I was convinced all these folks complaining of psychosis with a-PVP were predisposed or had some latent psychological issues. I was mistaken.

I have been having some personal issues lately, nothing very serious though definitely on my mind at the time of my last pvp run. What began as the feeling that someone was peeking through my blinds, escalated to throwing several blankets over each window. This was followed by the construction of a barricade, around the perimeter of my bed consisting of anything and everything from office chairs, pillows, blankets and large tupperware totes. I began to see the flashes from cameras through the blankets thrown over the windows. I began to hear voices. Each and every time I took a hit, I heard a helicopter flying over my apartment. The longer this went on, the louder it became, until I could swear it was about to land right outside my window. I could clearly see the shadows of people, moving outside the windows, in the light of the helicopter spotlight.

At this point I took flight to the living room. I covered all the windows in a similar fashion. I pulled a 4-man tent from the storage closet and erected it in my livingroom floor, completely displacing the furniture. As I continued to puff, the people outside my windows began to knock on my windows and rattle my door handles.

It was, of course, the police. They had been investigating me for some time now, avid consumer that I am. For sure they figured me for a dealer. They hadn't busted the door down yet, for <insert psycho reason here> but would do so at any moment. As I continued to puff, I realized that there was no way I could possibly hide / dump / dispose of the para and product in time to avoid arrest. I came to the conclusion that there was nothing to be done for the situation and resolved myself to enjoy my time as best as possible until the door came crashing in. Then it occurred to me that I shouldn't just sit there like a pussy, in my own home, and calmly await my doom.

It was then that I decided to confront the police, and their chopper and their dogs and their robots... wait? Robots? Well, there were robot voices for sure, so hell yeah! I jumped up, pipe in hand, pulled a massive drag, and ran out the door to greet....

...crickets.

The voices, choppers, robots... everything... suddenly vanished, not to return. I proceeded to thoroughly enjoy the reminder of my pvp in the quiet comfort of my home. The fear was gone. i had a wonderful laugh at myself, amazed at the power of the mind and proceeded to clean my apartment as I finished off my stash.

Never have I experienced something like this before. It was really pretty interesting, though I can easily see how it could get out of hand. I can say for sure though, next time those robocops show up at my window, I'll have a much better pillow barricade to greet their prying robo eyeballs. Still not sure what to do about the chopper though....
  #23  
Old 15-11-2012, 21:46
Rob Cypher Rob Cypher is offline
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Re: α-PVP Drug Info

I would stop if I were you; you're going to become more and more sensitive to the paranoia side effects as time goes on if you keep using; if watching some of my (online) friends go downhill is any indication. I wonder if it's a form of 'kindling', a process where the brain gets more prone to overstimulation from repeated exposure to chemicals/seizures.

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Yes I would advise you stop right now, everything Rob^^ is saying true.
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Old 13-04-2013, 16:20
fourtysevenpercent fourtysevenpercent is offline
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Re: α-PVP Drug Info

Quote:
Originally Posted by Subflow22 View Post
I was convinced all these folks complaining of psychosis with a-PVP were predisposed or had some latent psychological issues. I was mistaken.

I have been having some personal issues lately, nothing very serious though definitely on my mind at the time of my last pvp run. What began as the feeling that someone was peeking through my blinds, escalated to throwing several blankets over each window. This was followed by the construction of a barricade, around the perimeter of my bed consisting of anything and everything from office chairs, pillows, blankets and large tupperware totes. I began to see the flashes from cameras through the blankets thrown over the windows. I began to hear voices. Each and every time I took a hit, I heard a helicopter flying over my apartment. The longer this went on, the louder it became, until I could swear it was about to land right outside my window. I could clearly see the shadows of people, moving outside the windows, in the light of the helicopter spotlight.

At this point I took flight to the living room. I covered all the windows in a similar fashion. I pulled a 4-man tent from the storage closet and erected it in my livingroom floor, completely displacing the furniture. As I continued to puff, the people outside my windows began to knock on my windows and rattle my door handles.

It was, of course, the police. They had been investigating me for some time now, avid consumer that I am. For sure they figured me for a dealer. They hadn't busted the door down yet, for <insert psycho reason here> but would do so at any moment. As I continued to puff, I realized that there was no way I could possibly hide / dump / dispose of the para and product in time to avoid arrest. I came to the conclusion that there was nothing to be done for the situation and resolved myself to enjoy my time as best as possible until the door came crashing in. Then it occurred to me that I shouldn't just sit there like a pussy, in my own home, and calmly await my doom.

It was then that I decided to confront the police, and their chopper and their dogs and their robots... wait? Robots? Well, there were robot voices for sure, so hell yeah! I jumped up, pipe in hand, pulled a massive drag, and ran out the door to greet....

...crickets.

The voices, choppers, robots... everything... suddenly vanished, not to return. I proceeded to thoroughly enjoy the reminder of my pvp in the quiet comfort of my home. The fear was gone. i had a wonderful laugh at myself, amazed at the power of the mind and proceeded to clean my apartment as I finished off my stash.

Never have I experienced something like this before. It was really pretty interesting, though I can easily see how it could get out of hand. I can say for sure though, next time those robocops show up at my window, I'll have a much better pillow barricade to greet their prying robo eyeballs. Still not sure what to do about the chopper though....

I'd love it if you we could get the admins to get us these people's IP address just so we can try to get into contact with them. I know most people that get on DF write a horror story and maybe make a couple posts, ya know, it'd just be interesting to see if he's made progress. Like barn....*unknown amount of time later... like an hour at least find this tab open forget about completely...oh yeah, barntard74 or something close enough to that, popular in the cannabinoid forums... idk dude it's been like an hour since I was writing this I'm at my friends house now, opened this tab. later.
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Old 14-04-2013, 19:19
Rob Cypher Rob Cypher is offline
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Re: α-PVP Drug Info

Quote:
Originally Posted by fourtysevenpercent View Post
I'd love it if you we could get the admins to get us these people's IP address just so we can try to get into contact with them. I know most people that get on DF write a horror story and maybe make a couple posts, ya know, it'd just be interesting to see if he's made progress. Like barn....*unknown amount of time later... like an hour at least find this tab open forget about completely...oh yeah, barntard74 or something close enough to that, popular in the cannabinoid forums... idk dude it's been like an hour since I was writing this I'm at my friends house now, opened this tab. later.
I wouldn't like that at all (and an IP address alone isn't really enough to locate someone in that manner, especially if they were using proxies or had one that alternated between logins). I think most D-F users would find that a bit too much like surveillance of some sort and creepy as well, not to mention a gross violation of privacy.

I usually assume that most folks that don't follow up were turned off of using drugs in general for a while and/or ended up doing a stint in psych wards/rehabs; we usually hear about the fatalities when it comes to 'bath salts'-style stuff like this due to the media's sensationalist nature towards 'legal highs' in general (although in this case I think it deserves the negative press it gets).

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