4-ho-met

[Abrad]

Please post info about 4-HO-MET here.

Can anyone add information about:

• names / synonyms
• molecule
• dose
• duration
• side effects
• legal status
• have there been any reported incidents with this compound?
• since when has this research chemical been available?
• stability of the molecule / compound

Experiences with 4-HO-MET should be posted here: Experiences - 4-HO-MET experiences

Names: N-ethyl-4-hydroxy-N-methyltryptamine, 4-HO-MET,
IUPAC: 3-[2-(ethylmethylamino)ethyl]-4-indolol

These documents about 4-HO-MET are in the file archive
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Has anyone any experience with this chemical, SWIM is having trouble finding much info on it outside of TIHKAL.

[GDxCAT]

That is because it has not been made widely available yet so not many people have tried it out.
Be the guinea pig and let us know what u think, your information will be greatly appreciated.
Also just a few threads below this one you will find this thread (http://www.drugs-forum.com/forum/showthread.php?t=16490) which is asking almost the same thing.

judging by tihkal it should be similar to miprocin and psilocin .
Start your dosage off at the lower end of the spectrum and work your way up.

be safe, be smart and take it sleazy.

peace

[trptamene]

Please post info about 4-HO-MET here.

Can anyone add information about:

• names / synonyms
• molecule
• dose
• duration
• side effects
• legal status
• have there been any reported incidents with this compound?
• since when has this research chemical been available?
• stability of the molecule / compound

Experiences with 4-HO-MET should be posted here: Experiences - 4-HO-MET experiences

Names: N-ethyl-4-hydroxy-N-methyltryptamine, 4-HO-MET,
IUPAC: 3-[2-(ethylmethylamino)ethyl]-4-indolol

These documents about 4-HO-MET are in the file archive

[trptamene]

21. 4-HO-MET
TRYPTAMINE, N-ETHYL-4-HYDROXY-N-METHYL; 4-INDOLOL, 3-[2-(ETHYLMETHYLAMINO)ETHYL]; N-ETHYL-4-HYDROXY-N-METHYLTRYPTAMINE; 3-[2-(ETHYLMETHYLAMINO)ETHYL]-4-INDOLOL

SYNTHESIS : A solution of 0.50 g 4-acetoxyindole (see under 4-HO-DET for its preparation) in 5 mL Et2O was stirred and cooled to 0 °C with protection from atmospheric moisture. There was then added 0.5 mL oxalyl chloride. The reaction mixture was stirred for an additional 30 min, and the yellow crystalline solid was removed by filtration and dissolved in 10 mL of anhydrous THF. This was treated with a 40% solution of methylethyl amine in anhydrous Et2O, dropwise, until the pH was >10. The solvents were removed under vacuum and the residue dissolved in 200 mL CHCl3. This was washed first with 50 mL 0.1 N HCl and then with 50 mL of saturated aqueous NaCl. After drying with anhydrous MgSO4 and filtration, the solvent was removed under vacuum. The residue was recrystallized from Et2O to give 0.60 g (yield 73%) of 4-acetoxyindol-3-yl-N-ethyl-N-methylglyoxylamide with a mp 179-180 °C. Anal: C,H,N.

To 10 mL of a stirred solution of LAH (1 M in THF under N2), there was added dropwise a solution of 0.57 4-acetoxyindol-3-yl-N-ethyl-N-methylglyoxylamide in 10 mL anhydrous THF. When the addition was complete, the reaction mixture was brought to a reflux for 15 min. After cooling to 40 °C, sufficient water was added to decompose both the reaction complex and the excess hydride. After filtration through Celite (under an N2 atmosphere), the solvent was removed under vacuum, and the solid residue recrystallized from EtOAc/hexane to provide 0.18 g (41%) N-ethyl-4-hydroxy-N-methylindole (4-HO-MET) with a mp 118-119 °C. Anal: C,H,N.

DOSAGE : 10 - 20 mg, orally

DURATION : 4 - 6 hrs

QUALITATIVE COMMENTS : (with 20 mg, orally) "Qualitatively a lot like psilocin. I started within the first half-hour, and at the max, I felt the same alteration of color and form, and times, sound was felt. As with psilocin, the experience was wave-like, with an alteration of effects between near-normal perception at one minute, only to be swept up in a swirl of altered concept the next minute.

EXTENSIONS AND COMMENTARY : First, an apology for just a single entry in the comments section. This, and several other of these substituted hydroxy and methoxy tryptamines, had had earlier evaluations, but the notes are not at hand and cannot be used. Much will have to come back from memory, and there must be an appropriate fuzziness allowed for the concluded generalization as to dose and duration. With this particular compound, some of the original observations suggested that it was more potent than psilocin, certainly more dramatic. But at the bottom line, I doubt that this ethyl homologue, or the isopropyl homologue 4-HO-DIPT for that matter, could be distinguished from the methyl counterpart psilocin in any blind clinical study.

What's to choose between them? From the view-point of synthesis, the cost and availability of the secondary amine will certainly be a factor. Both methylethyl amine and methylisopropylamine are available, but are quite expensive. Dimethylamine, on the other hand, is dirt cheap but it is a recognized precursor to DMT and thus is difficult to find. In any events, the dimethyl compound is widely available in the mycological arena, and I suspect it would be simplest to stay with nature.