Of course remember Tussionex. It is a Schedule III and a wonderful cough syrup. It has 10mg of hydrocodone
per 5ml or teaspoon and chlorpheniramine
, an antihistamine
(which actually adds to the high.) Then Hycodan cough syrup 5mg/5ml and some atropine
to curb abuse (it never curbed abuse for me). Then Dicodid 5mg pure hydrocodone tablet made by Knoll, and was a Schedule II. All the others are Schedule III cough syrups. Tussionex was about the most amount of hydrocodone one could get, and still be a Schedule III for a long time.
I did read somewhere that the most hydrocodone and the least amount of acetaminophen
when compounded into a pain medication and still be a Schedule III: would be 15mg of hydrocodone and 80mg of acetaminophen. This amount was never marketed, however it was compounded by pharmacies and is the most and least amounts prescribed by law and still be a Schedule III.
However, with that SODAS delivery system and if it is fairly tamper proof, the Scheduling may be up in the air. Zohydro is definitely going to be expensive, because it will only be available in brand name for awhile. But why they are just coming about with this now, is beyond me.
's Schedule changes also when it is sold in Codeine Sulfate form without any additives, in the U.S, to Schedule II. Codeine Sulfate for injection is a Schedule II (Howard Hughes' favorite pain killer of choice).
I believe in time, there will be codeine, DHC and hydromorphone
in time released versions. Although not available in the U.S. at this time, I read long ago they had time released versions of these drugs
in other Countries, or were working on them. Opana is in both I.R. and in E.R. formulations (Oxymorphone
). Currently, hydromorphone can be easily extracted and abused the I.M. and I.V. route. I would think it would be less tamper proof in timed release form and I'm sure they will follow the timed release marketing strategy. Zohydro, would not be able to be extracted to an injectable form. Hydrocodone bitartrate has never been an injectable drug
. People do their CWE to get the acetaminophen out, then usually take it orally and I have never heard of people injecting it, like one would OxyContin. I've heard many questions about, "Why can't hydrocodone bitartrate be injected?" I still don't know the answer to this, probably something to do with crossing the Blood Brain Barrier and must have the liver metabolize it first before it is effective (hydromorphone is one active metabolite).
I believe the doctor on Fox News this morning was somewhat misleading when he said, people will figure a way to crush it and snort it or shoot it. A lot of pre-approval propaganda to keep Zohydro off the market. I'm sure the FDA will approve it, because when you know the truth, this medication will have advantages without the liver damaging acetaminophen and 50mg of hydrocodone for a opiate
tolerant person is really not that much, every 12 hours. We will see, soon.