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  #1  
Old 19-12-2011, 05:42
Specimen Specimen is offline
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What is bad about Risperidone and what does it do ?

I'm guessing it represses mania or something ? Just guessing. Can it make you less human or something ?
  #2  
Old 19-12-2011, 21:06
Axiom Of Choice Axiom Of Choice is offline
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Re: What is bad about Risperidone and what does it do ?

It is an atypical antipsychotic. It antagonizes various Dopamine receptors, especially D_2. It also (due to its atypical nature) antagonizes 5-HT receptors and to a lesser extent, adrenergic and histaminergic receptors.

It is used to control symptoms of Schizophrenia, Bipolar Mania, and extreme Aggressive behavior in certain populations.

It is not inherently 'bad', but it certainly doesn't have any recreational value. It doesn't make you "less of a human" but in higher doses over long periods of time, it can cause emotional blunting and apathy due to its harsh effects on the Dopamine receptors.

Some psychiatrists argue it is less 'emotionally blunting' than the old "typical" antipsychotics since it antagonizes 5-HT2C which causes the increase of Dopamine and Norepinephrine in certain areas of the brain.

Compared to the other atypicals, Risperidone is a bit more harsh with regards to Extrapyramidal effects and Prolactin release. But it isn't as sedating as Olanzapine, Quetiapine, and Clozapine. However, in SWIM's experience, it is not that great of a drug. The extrapyramidal effects occur way to close to the therapeutic dose. It feels more like a 'typical' antipsychotic than Olanzapine and others.

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An excellent synopsis of this medication, comparisons with others, and it's effects.
good precis of effects, based on own experience & theory
  #3  
Old 19-12-2011, 21:39
chibi curmudgeon Gold member chibi curmudgeon is offline
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Re: What is bad about Risperidone and what does it do ?

Well, you knew it was an antipsychotic, or you wouldn't have posted this thread in the antipsychotic subforum. If you were prescribed it, you should have received a short, layperson-friendly description of the drug and its potential side effects.

Failing that, there's always the search engine here and at PubMed.

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Very good directions to more knowledge.
  #4  
Old 30-12-2011, 22:16
cocaman cocaman is offline
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Re: What is bad about Risperidone and what does it do ?

You might not be able to ejaculate when you're on it other than that I noticed no side effects.

cocaman added 3 Minutes and 2 Seconds later...

I just noticed you're female so that won't matter

Last edited by cocaman; 30-12-2011 at 22:16. Reason: Automerged Doublepost
  #5  
Old 08-01-2012, 09:08
sputnik sputnik is offline
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Re: What is bad about Risperidone and what does it do ?

I've been taking a prescribed 1mg daily for bipolar disorder since October. I've gained weight because I'm ALWAYS hungry, thus always eating, and my face is having horrible acne break outs. I feel really shitty about myself because of these two things. I hope you can avoid having it prescribed to you by your doc.
  #6  
Old 19-02-2012, 08:06
oceansurf oceansurf is offline
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Re: What is bad about Risperidone and what does it do ?

Antagonizes? Can someone please explain to Swim what this means? He is just learning these kinds of things. Thankyou

oceansurf added 9 Minutes and 33 Seconds later...

Does it provoke dopamine flow or counteract with it?

Last edited by oceansurf; 19-02-2012 at 08:06. Reason: Automerged Doublepost
  #7  
Old 19-02-2012, 13:27
Mindless Mindless is offline
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Re: What is bad about Risperidone and what does it do ?

Quote:
Originally Posted by oceansurf View Post
Antagonizes? Can someone please explain to Swim what this means? He is just learning these kinds of things. Thankyou

oceansurf added 9 Minutes and 33 Seconds later...

Does it provoke dopamine flow or counteract with it?
First of all there are synapses, which allow a chemical or electrical message to pass to another cell or neuron. Neurons are the nerve cells that process and propagate chemical or electrical signals. The signal that is passed, via the synapse, to a neuro-receptor as a chemical messenger can also be called a neurotransmitter. A drug may inhibit a neurotransmitter, in which case it is referred to as an antagonist. Alternatively, it may enhance or increase neurotransmission, which makes it an agonist.

The attachment at the bottom of this post is a diagram from wikipedia of a neuron passing an electrical signal to synapse, which is then passed across the synaptic cleft to receptors. In this case Risperidone is a dopamine antagonist; it blocks the effects of dopamine. This blockade of dopamine is what makes drugs like risperidone useful in the treatment of psychosis. It is also the mechanism which gives rise to the extra-pyramidal effects of some anti-psychotic drugs like risperidone. These include features of Parkinson's disease, abnormal face and body movements, restlessness, and "rhythmic, involuntary movements of tongue, face, and jaw." Source: British National Formulary 62 September 2011.

This explanation is simplified and gives only a general idea of these concepts to get you started. For example, Serotonin receptors are also antagonised by risperidone as discussed by Axiom of Choice. Agonists and antagonists work in various ways, for example they may block receptors, or increase the availability of neurotransmitters. For those who want a more detailed explanation risperidone "is a dopamine D2, 5-HT2A, alpha1-adrenoceptor, and histamine-1 receptor antagonist." Source: BNF 62 September 2011
Attached Images
File Type: jpg 350px-Chemical_synapse_schema_cropped.jpg (56.5 KB, 6 views)

Last edited by Mindless; 19-02-2012 at 14:50. Reason: added source
  #8  
Old 19-02-2012, 14:27
Billy_Shears Billy_Shears is offline
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Re: What is bad about Risperidone and what does it do ?

Do one of you guys know something about stopping LSD-trips oder other trips on psychedelic drugs? What's about MDMA?
It's a dopamine-antagonist, right? So it could help people with a cocain-overdose?

Thanks a lot!
  #9  
Old 19-02-2012, 16:14
chibi curmudgeon Gold member chibi curmudgeon is offline
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Re: What is bad about Risperidone and what does it do ?

Quote:
Originally Posted by Billy_Shears View Post
Do one of you guys know something about stopping LSD-trips oder other trips on psychedelic drugs? What's about MDMA?
It's a dopamine-antagonist, right? So it could help people with a cocain-overdose?

Thanks a lot!
Are you asking if risperidone can stop an LSD trip or cocaine overdose? This was really hard to read.
  #10  
Old 19-02-2012, 16:20
Billy_Shears Billy_Shears is offline
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Re: What is bad about Risperidone and what does it do ?

Yeah, sorry if it sounds strange to you

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when someone asks for a clarification, you might try wording things differently or explaining yourself in a different manner. This is not a useful response to someone trying to help you
  #11  
Old 19-02-2012, 16:27
Mindless Mindless is offline
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Re: What is bad about Risperidone and what does it do ?

That's a difficult question to answer as you're talking about a lot of different drugs. Additionally, some of these drugs will have an impact on more than one type of neurotransmitter. Amphetamine sulphate is an example; it acts on serotonergic and dopaminergic systems (amongst others). An overdose of amphetamine or MDMA could lead to serotonin syndrome or toxicity, which would require it's own specific interventions. Individuals who overdose may present with different symptoms and effects, which means that treatment might vary in each case. As far as I know, there are no specific antidotes for overdoses in most cases, and the same goes for bad trips.

Risperidone would not be a suitable first-line (no pun intended) treatment for cocaine overdose, or for other drugs which stimulate the sympathetic nervous system (sympathomimetics). The first step would be close monitoring and intensive support in hospital. Problems could include volume depletion (as in hyponatremia), cardiac arrhythmias, tachycardia, seizures, high blood pressure, agitation, and hyperthermia. All of these are treated symptomatically; for example benzodiazepines can be used to treat tachycardia, agitation, seizures, and hypertension. IV isotonic saline can be used to treat volume depletion, and rapid cooling is a treatment for hyperthermia. Source: British Medical Journal Best Practice, Cocaine Overdose.

As for stopping LSD trips or trips on other psychedelics, I would not recommend risperidone or any other antipsychotic drugs without medical supervision. These drugs have their own potential adverse effects as well, including neuroleptic malignancy, and should not be used unless they have been prescribed. Atypical antipsychotics have been implicated as precipitating factors in serotonin syndrome, when given in combination with other serotonergic agents. This means that risperidone combined with drugs such as antidepressants, Cocaine, MDMA and Amphetamine could be quite dangerous.

In short, if you overdose on a stimulant or hallucinogen, don't treat yourself with risperidone. Instead, call emergency services or go to hospital. If you have a bad trip do not self-medicate with risperidone. For better ways of dealing with bad trips see this wiki; The Psychedelic Crisis: Bad Trip.

Sources:
Serotonin Syndrome in Elderly Patients Treated for Psychotic Depression with Atypical Antipsychotics and Antidepressants: Two Case Reports. Izchak Kohen, MD, Marc L. Gordon, MD, and Peter Manu, MD. CNS Spectr. 2007;12(8):596-598.

Recognition and treatment of serotonin syndrome Christopher Frank, MD FCFP Can Fam Physician. 2008 July; 54(7): 988–992.

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Very informative, thanks!
A well-researched post, great contribution!

Last edited by Mindless; 19-02-2012 at 17:11. Reason: punctuation
  #12  
Old 19-06-2012, 03:36
nevergoback nevergoback is offline
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Re: What is bad about Risperidone and what does it do ?

It can increase prolactin levels, in woman causing your period to stop and long term possible infertility, and increased prolactin can put you at risk for some sort of bone or cancer disease.

Thats what it did to me... people who take it under medical supervision (I was in a psychiactric hospital) have to have blood tests every week to monitor prolactin...
my periods stopped and my prolactin went through the roof so i had to be taken off it
also made me gain like 30 pounds.

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antipsychotic, antipsychotics, dopamine, drugs, ecstasy, neuroleptic, risperdal, risperidone

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