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  #1  
Old 29-11-2011, 04:17
PIPEMACGYVER PIPEMACGYVER is offline
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Effects of fluoxetine (prozac) at high doses

Im aware that fluoxetine is by no means considered a recreational drug, but ive heard crazy stories about people taking 80 mgs and upwards and falling into a manic, delerious state of mind, especially in combination with weed for some reason. All ive managed to find on the internet is a bunch of people just saying "prozac has no recreational value" or "dont fuck with SSRIs retard". Can someone tell me more about this drug? What effects does it cause at doses higher than reccomended?

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a good question ansd asking for evidence
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Old 29-11-2011, 05:30
Mindless Mindless is offline
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Re: Effects of fluoxetine (prozac) at high doses

These are some of the potential adverse effects of SSRIs; Gastro-intestinal effects are quite likely at higher doses. There may also be loss appetite, hypersensitiity reactions and rashes. The latter may be a sign of serious systemic reaction and could be accompanied inflammation of blood vessels. There may be swelling beneath the skin, serious allergic reactions, joint and muscle pain, and photosensitivity. Also dry mouth, nervousness, anxiety, headache, insomnia, tremor, dizziness, weakness, hallucinations, drowsiness, convulsions, milky secretions from the breast, sexual dysfunction, urinary retention, sweating, hypomania or mania. Additionally there may be electrolyte disturbance, movement disorders and dyskinesia, visual disturbances, and bleeding disorders.

Additional adverse effects of Fluoxetine include vasodilatation, postural hypotension, pharyngitis, dyspnoea, chills, taste disturbance, sleep disturbances, euphoria, confusion, yawning, impaired concentration, changes in blood sugar, alopecia, urinary frequency; rarely pulmonary inflammation and fibrosis; very rarely hepatitis, toxic epidermal necrolysis (a severe reaction of the skin) , and neuroleptic malignant syndrome-like even (a life threatening neurological disorder).

Despite that awfully long list, millions of people take SSRIs like Fluoxetine without experiencing any significant or long-term adverse effects. It can be an effective and reasonably safe antidepressant.The maximum daily dose for an adult is 60mg daily, although 20mg would be the initial maximum dose. This can be increased over 3-4 weeks.

If Fluoxetine is taken at higher doses, the chance of adverse reactions multiplies. If Fluoxetine is used at a much higher dose than is prescribed, or if it is taken as a recreational drug, there is also a higher risk of adverse reactions. At the very least a person doing so would feel sick and have an upset stomach, as well as feeling agitated.
When taken with cannabis many of the adverse effects may increase in a multiplicative rather than additive way. For example stomach upsets, dry mouth, headaches, dizziness, confusion, agitation, and increase in blood pressure would be quite possible and may be amplified by taking this combination.

There may be some euphoria, but that would likely be over-ridden by other adverse effects. Those stories are of probably some self-deluded nitwits bragging; it's more likely that the experience was unpleasant.

Source of information British National Formulary (BNF 62 2011)

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Well done on including the source for the first few paragraphs, very nearly gave you negative rep for not naming sources! Keep up the good posts :)

Last edited by Mindless; 29-11-2011 at 05:35. Reason: repetition
  #3  
Old 29-11-2011, 05:46
PIPEMACGYVER PIPEMACGYVER is offline
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Re: Effects of fluoxetine (prozac) at high doses

Thankyou, thats more what i was looking for
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Old 29-11-2011, 12:42
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Re: Effects of fluoxetine (prozac) at high doses

Glad to help. Once I accidentally took a double dose of a similar drug, Paroxetine. I was already prescribed the maximum dose. I felt sick, had a terrible headache, and experienced derealization and anxiety. Zero recreational value.

Last edited by Mindless; 29-11-2011 at 13:11.
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Old 03-12-2011, 00:23
Lethargy Lethargy is offline
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Re: Effects of fluoxetine (prozac) at high doses

One of our close friends once took an entire bottle of prozac. He says he went to the hospital and they said it shouldn't harm him, but had him drink activated charcoal. He only remembers that after a few hours he got incredibly sleepy, fell asleep and felt normal the next day.
  #6  
Old 12-12-2011, 21:14
PIPEMACGYVER PIPEMACGYVER is offline
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Re: Effects of fluoxetine (prozac) at high doses

Im curious as to how that happened lol. "Hooray i got a full bottle of prozac!" *trips and falls, pills fly into air and all manage to land in his mouth* *swallows* "....fuck"

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adverse reaction, antidepressant, drug, drug forums, drugs, drugs forum, drugs-forum, fluox, fluoxetine, pharmaceutical, prozac, ssri, ssris

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