Adrenochrome report

[genaro]

Body weight: 67 kg

Compound used:
D,L-Adrenochrome freebase (synthetic, 99,98% purity)
CAS: [56-06-8]

synonyms:
Adrenochrome (freebase)
3-Hydroxy-1-methyl-5,6-indolinedione,
2,3-Dihydro-3-hydroxy-1-methyl-1H-indole-5,6-dione

Note: D,L means it is a racemate, which means it is an equimolar mixture of two of enantiomers: the D-Adrenochrome and the L-Adrenochrome (also called (-)-Adrenochrome et (+)-Adrenochrome respectively)

Adrenochrome has been described as a hallucinogen or psychotomimetic and a cholinesterase inhibitor. It has also haemostatic properties (meaning that it is something that stops bleeding.

Description of the powder: a close-up of the adrenochrome crystals shows a dark red color but the powder seems just like dried blood to the naked eye, meaning some slightly orangy brown color. But if I dissolve some crystals into a few drops of water I will get a blood red to bright red solution (depending on the concentration), exactly the same color as Mercurochrome. It has a slightly metallic chemical taste which somewhat reminded me of the taste of blood but it was much more tasteless (less bitter).

Price:
Most labs sell D,L-Adrenochrome(CAS:56-06-8) at 70 to 100euros for 250mg. But I recently found another chemical supplier selling a product named 'Adrenochrome' at 110euros for 50g, the price difference is so huge that I first though it couldn't be the same compound that other suppliers were selling, but CAS number was 56-06-8 so it was definately the same Adrenochrome. Such a price difference seems strange to me, I thought maybe it could be one of the two enantiomers (instead of the D,L form) but this wouldn't be logical as separating two enantiomers is complicated and therefore one enantiomer alone should be more expensive than the DL form, and certainly not cheaper.

Note:
Adrenochrome is quickly oxidised and should be kept away from air, light, humidity and heat. Therefore it is kept in an airtight container which is put in the freezer.
Even this way, it will slowly decompose so it should not be kept for too long before use.


My experimentations with Adrenochrome:

I had acquired D,L-Adrenochrome freebase (the one sold at 70euros for 250mg)

first trial: I held 100mg under my tongue for 1 minute and then swallowed. Fast onset (about 5 minutes)

second trial: I snorted 50mg. Onset: a few seconds.

third trial : I smoked 25mg (vaporised in a crack pipe). Onset is almost instant.

Note that I waited a few days between each trial.

The three trials gave me the exact same effects, which were very light and really uninteresting (I wouldn't even call it a high).

First, it's wasn't hallucinogen nor psychedelic. I had a feeling of warmth through my body, I felt a numbness in my hands and my head (possibly linked to the haemostatic effect), there was some slight sedation, and a very slight short lived euphoria (the euphoria was a slightly more pronouced when smoked, but still very short lived)
There's also some minor visual change (no visuals, just that I would see the room slightly differently than usual, but honestly that was some really minor change, a joint of hashish would have done the same, nothing really noticeable). There might be some slight myosis too (=little pupils), not really sure.

To sum up, effects were extremely weak, absolutely not fun nor psychedelic in anyway, and short lived (I would say the slight initial euphoria is gone within 4-5 minutes, and the few strange feelings that I experience from the stuff are gone within about 1 hour (I couldn't say the exact duration as I didn't really checked my watch)
Needless to say I was very disappointed by this uninteresting compound.

The effects I had from it were flimsy, there was a definite effect on my vision and my mental state for sure but I would definitely not call it 'hallucinogenic'.

SO, I might have wanted to try higher dosages just in case this could intensify any effects (let's say 250mg orally, 100mg snorted and 100mg vaporised), or I might have wanted to try the other adrenochrome (the one sold at 110euro/50g) just to make sure it is the same...but I didn't as I had better things to do with my money and I was pretty sure that even if this would give me some more effect, that would still be of poor recreational/spiritual interest.

Also, about possible secondary effects of adrenochrome: as it is an haemostatic compound (prevents capillary bleeding during injury) it is not impossible that excessive use would end up causing blood circulation troubles, furthermore some scientists seem to say that adrenochrome is known to cause cardiovascular troubles.

To conclude I would say that this is an uninteresting substance to my opinion, and furthermore it's possibly a dangerous one.

Reputation Comments on this post:

Interesting, thanks for posting this.

[nanobrain]

hmm, i prefer smoking the dried extract of the human pineal gland myself, harvested from 1000 nymphomaniac virgins.

interesting read, nontheless.

[hh339]

are u sure it is adrenochrome? it supposedly causes schitzophrenia... maybe it could have been adrenochrome semicarbazone(not sure if thats the exact name but something like that anyway)?

[Nagognog2]

That sounds very similar to what Bongo experienced on adrenolutin, only without the flush of warmth.

[fatal]

adrenachrome semibicarbazone if memory serves... makes you wish people used a search engine for such simple tasks as finding the real name for a chemical before making a potentially wasteful post... by the way if you are going to be saying that adrenochrome causes schizophrenia then you may as well also point out the fact that in fact that is a baseless asshatted urban myth with no particular scientific data backing it whatsoever. just because it was in fear and loathing does not make it true... also i believe in fact that there have been inquisitions into the possible role of several compounds and their potential role in schizophrenia... if a direct causality were to be established between any single brain chemical and schizophrenia you can be god damn sure that it would not exist as a real disease in our society any longer because it is a very severe risk factor for an individual and anyone around them when one is schizophrenic. the whole paranoia not making sense possibly acting out violently thing seems like a definitely negative thing... one that would necessitate a quick fix of some kind... i might be behaving like an asshat myself and if in fact this urban myth is not asshatted at all and has some sort of legitimate backing please someone feel free to post this information here and may a moderator strike this post dead where it stands

(apologies for overusing the term asshat here... its kinda late... if i got carried away im sorry)

Reputation Comments on this post:

[hh339]

Originally Posted by fatal

adrenachrome semibicarbazone if memory serves... makes you wish people used a search engine for such simple tasks as finding the real name for a chemical before making a potentially wasteful post... by the way if you are going to be saying that adrenochrome causes schizophrenia then you may as well also point out the fact that in fact that is a baseless asshatted urban myth with no particular scientific data backing it whatsoever. just because it was in fear and loathing does not make it true... also i believe in fact that there have been inquisitions into the possible role of several compounds and their potential role in schizophrenia... if a direct causality were to be established between any single brain chemical and schizophrenia you can be god damn sure that it would not exist as a real disease in our society any longer because it is a very severe risk factor for an individual and anyone around them when one is schizophrenic. the whole paranoia not making sense possibly acting out violently thing seems like a definitely negative thing... one that would necessitate a quick fix of some kind... i might be behaving like an asshat myself and if in fact this urban myth is not asshatted at all and has some sort of legitimate backing please someone feel free to post this information here and may a moderator strike this post dead where it stands

(apologies for overusing the term asshat here... its kinda late... if i got carried away im sorry)

it SUPPOSEDLY causes schitzophrenia, cant u read?

got damn what a snotty guy, must take a lot of energy. adam gottlieb has written in one of his books that adrenochrome causes temporary schizophrenia while its semicarbazone (OR some similar name) does not.. so mr. bitch about whatever: fuck you and have a nice day.

Reputation Comments on this post:

	flaming
	completely unecessary flaming

[fatal]

Originally Posted by hh339

it SUPPOSEDLY causes schitzophrenia, cant u read?

got damn what a snotty guy, must take a lot of energy. adam gottlieb has written in one of his books that adrenochrome causes temporary schizophrenia while its semicarbazone (OR some similar name) does not.. so mr. bitch about whatever: fuck you and have a nice day.

right and adrenochrome supposedly causing schizophrenia is an asshatted urban myth as was stated earlier. the point wasnt to be insultory. the point was that even mentioning it as a supposedly makes it sound true but unconfirmed. it has in fact been discussed in this thread that it in fact has been shown scientifically NOT to do that. as far as any real data shows it is not a psychomimetic in any capacity worth noting. sorry if anyones feelings got hurt. even though i already had apologized for my verbosity and beligerance in my preceding post on this topic. sorry guys didnt mean to make anyone upset over it. lets all join hands and sing peace rally songs... come on people now... smile on your brother... everybody get together... try to love one another right now...

Reputation Comments on this post:

good response to flamebait

[hh339]

lets all join hands and sing peace rally songs... come on people now... smile on your brother... everybody get together... try to love one another right now...

[/QUOTE]


ok lets sing: SWEET HOME ALABAMA!! no but seriously isn´t the semicarbazone the one with less side effects and the "best" high?

[genaro]

yess I'm sure it wasn't the semicarbazone (aka carbazochrome) as adrenochrome semicarbazone CAS number is 69-81-8 and adrenochrome thiosemicarbazone is 113185-69-6 and adrenochrome oxyme sesquihydrate is 6055-73-8. While the CAS number of the product I had was 54-06-8 which does correspond to "Adrenochrome"

Adrenochrome semicarbazone and thiosemicarbazone arn't hallucinogenic, "true" adrenochrome was clearly not hallucinogenic...unless "adrenochrome oxyme sesquihydrate" is the good stuff...

[fatal]

well then it looks like we're gonna need some of this sesquihydrate stuff... sounds good... if you were skittish about psychedelic drugs making you go crazy before then take a step back... research into chemically ionduced schizophrenia has now begun.... too bad hes dead or we could ask hunter about it... too bad no one thoought of that when the time was right eh? maybe i just need a whole pineal gland to chew on... eat a handful... see what happens to me

[Nagognog2]

It was a firmly entrenched "theory" among the psychiatric community in the late 1950's - early 60's that oxidized adrenaline MIGHT be causitive for schizophrenia. While this idea was tossed in the dumpster, interest in other indolic compounds continued. And then arrived Dr. Timothy Leary at Harvard and his early research into psilocybin (another indolic molecule) - which he used on prisoners at the Concord Reformatory (now MCI-Concord) in a study to diagnose personality traits.

After the psychiatric research community gave up on indoles (and the good Doctor Leary), the next concept was taraxein - a protein complex containing copper that was isolated from the blood of schizophrenics. This theory also was abandoned. Mostly. I'm sure that out there exists a good doctor Gumblestains, Phd - who still supports the theory.

Anywho - this connection between adrenochrome and schizophrenia was what initially catapaulted the substance into prominence in medical journals back then. And into the interest of many a psychedelic pioneer.

[genaro]

well I made quite a few searches about adrenochrome oxime sesquihydrate (CAS: 6055-73-8) with absolutely no results...even official & legit "fine chemicals" suppliers from all around the world don't have it in their catalog (they have D,L-adrenochrome, semicarbazone and thiosemicarbazone but not the oxime sesquihydrate)... I think SWIM is not gonna find any source for this one.

[fatal]

its understandable that this is a hard one to find. fairly exotic by any standards. you definitely could have it custom synthesized if you really wanted some badly enough. not a hard service to find. worth the time? maybe (probably) not.

[Nagognog2]

Pure adrenochrome is very simple to synthesize. The main problem is keeping it. It breaks down very quickly and must be stored under vacuum preferably in liquid nitrogen temperatures. Adrenolutin is more stable and also very simple to synthesize. The 7-Iodo derivative has much the same subtle effects as it's parent compound and is much more stable.

All of these are pretty much a waste of time for those seeking a psychedelic experience though. I don't know what Hunter S. Thompson was doing in Las Vegas - but I can tell you that, beyond a doubt, it was not adrenochrome. Made for a great myth that still persists to this day. But likely Hunter S. fell victim to the same sort of advertising that one sees when they are offered a tiny purple pill being called mescaline. It just ain't so.

[MadShroomer]

Originally Posted by Nagognog2

Pure adrenochrome is very simple to synthesize. The main problem is keeping it. It breaks down very quickly and must be stored under vacuum preferably in liquid nitrogen temperatures.

I don't know what Hunter S. Thompson was doing in Las Vegas - but I can tell you that, beyond a doubt, it was not adrenochrome. Made for a great myth that still persists to this day. But likely Hunter S. fell victim to the same sort of advertising that one sees when they are offered a tiny purple pill being called mescaline. It just ain't so.

SWIM disagrees...
a HIGH ORAL DOSE (especially from a concentrated solution) would produce those effects and SWIM has experienced this first hand...
:Note that the original 10ml viles had "Epinephrine 10:10000" or some such insanly small amount (sorry its been 3 or 4 years and SWIM has lost them):

SWIM experience with Adrenochrome...
the only thing SWIM has ever injected was some Vetrinary Epinephrine (same chemical as human adrenaline) a while ago and it was just Intra Muscular (in left shoulder). This game SWIM increased energy and SWIM had to run around outside to get it used up.
SWIM other experience...
SWIM drank 3 viles (10ml each) and feeling just like Mr. HST in Fear and Loathing, crawled into bath tub but only mild relief followed by 18 hours sleep (SWIM doesn't remember much except being DELIERIOUS and not being able to tell if the lightning flashes in the room were real or not, plus feeling all shaky and on fire, did feel the way it was shown in the movie...most unpleasant b/c SWIM "Took to much man, too much").
The way SWIM made this was a very interesting chemically. SWIM found that pouring the vile of epinephrine into a small plastic circular container, then setting that container on back porch after sunrise where it would be exposed to direct sunlight, it was also cool outside (~70 degress F). The timing was very tricky to get it right when it was "PINK" as possible. It slowly started turning a pink color and there is a point when its as pink as possible b/c SWIM found out that leaving it too long in direct sunlight caused it to go from PINK to Orange/brown (oxidized too much?). So the 3 viles SWIM drank where all of previously oxidised epinephrine that was stored back into the vile and refridgerated (also the epinephrine came in a styrofoam cooler with chemical ice packs inside to keep cold, SWIM put it in FRIDGE just to be safe). Anyone have any PLEASEANT experiences b/c SWIM does not think they exist...
Exept in Clock work orange,
"In the book and film A Clockwork Orange, the presence of a drug whose street name is "drencrom" is possibly a reference to adrenochrome."
and
"The Sisters Of Mercy's second single Body Electric has a song called Adrenochrome on the B-side, the lyrics of which contain apparent references to the drug's psychedelic effect: High tide / Wide eyed / Sped on adrenochrome"

[enquirewithin]

If I remember correctly it was his Samoan attorney who had the so-called adrenochrome. I think Hunter Thompson was so drunk most of the time, he wouldn't know what he was doing. Are we going to read about pineal gland extract next? Interesting report though!

[nanobrain]

^play nice as of now.

taraxein, now there's a weird one. Brimblecombe / Pinder wrote it up well in Hallucinogenic Agents. 1975.

[nanobrain]

i love the word 'asshat.' has anyone ever actually made a hat for the ass? hmmmm.

[fatal]

I think people should really try to use the word asshat as much as humanly possible.

[napoleon in rags]

Not a suprise, it's been known for quite a while that adremochrome is mostly inept.

YOU TOOK TOO MUCH MAN, TOOK TOO MUCH

[genaro]

well I think all the 4 varieties of adrenochrome have some haemostatic properties and very weak effects so better not fuck around those compounds for too long

[fatal]

plus it does seem unappealing that it supposedly is causative for schizophrenia... not that its true but still... personally wouldnt want to be the one to trying to prove something like that... schizophrenics are not happy people most of the time...

[The Mad Hatter]

man you wouldn't believehow many times i've heard some ignorant little kids saying,"man i want to try some of that adrenochrome shit in fear and loathing". then when I try to tell them that that is a myth and that adrenochrome has no hallucinogenic properties i always hear the reply " o ok mr. smarty pants, i think hunter s. thompson knows more about drugs then you do" AHHHH STUPID PEOPLE!!!!!

Reputation Comments on this post:

lol yes the ignorant are everywhere lol

[BeatTakeshi]

yes its just a myth created by that film, people asking me about it everywhere i turn now, driving into the walls, MAD bastards

[Female]

SWIM was wondering if anyone had any information on "adrenochrome". SWIM know it was popularized in Fear and Loathing, and quite honestly that is were SWIM heard of it. SWIM is not exactly sure if it is a real drug. SWIM has looked it up on Wiki and Erowid and got some confusing results. One, it refers to two things, a natural occuring substance already within the body (thus the whole cutting out of the adrenaline gland thing) and some pharmaceudical synethisized stuff.
They also call it "pink adrenaline".
So..is it pure adrenaline, oxidised? Or is it epinephrine(SWIM is not even sure what that is, except that it's used to treat bee stings, antihistamine maybe? correct SWIM if wrong).
SWIM has heared that it causes hallucinations and Erowid's said it wasn't a controlled substance. Has SWIY tried it? Where could SWIY get it? Is it an ingrediant in a drug? Or is it just freaking adrenaline?