Combinations - Whats going on? Why is SWIM not feeling anything with their polypharmacy?

[kritikal]

Well SWIM just took.

5mg Oxycodone Insufflated
10mg Temazepam Insufflated
10mg Temazepam Oral

10mg Diazepam Oral
60mg Propoxyphene
10mg Diazepam Oral

5mg Diazepam Insufflated
10mg Temazepam Insufflated
10mg Temazepam Oral

The effects can only be described as Mildly Sedated and drowsy. No Euphoria whatsoever.

Anyone know what is going on? The last time SWIM had diazepam was about 6months ago with about 60mg and a large amount of alcohol. He cannot recall the rest of the night and the following days were a complete blur.

SWIM should have absoloutely no resistance but i dont see how this amount could have only minor effects.

[Jatelka]

SWIJ is unsure how she missed this post yesterday: First Off she always worries about polypharmacy. Mixing drugs that have additive effects (ie: 2 sorts of downers) is asking for trouble in her opinion, especially when those drugs can potentially cause respiratory depression. Therefore polypharmacy is definitely NOT recommended.

SWIJ has no personal experience of opiates. However a quick look at this thread:

http://www.drugs-forum.com/forum/showthread.php?t=12351

Seems to suggest that the oxycodone and propoxyphene doses were on the low side. (Although combined with the benzos this was almost certainly a good thing!)

With regards to the benzos: Insufflating is an ineffective means of administration for most because they aren't water soluble. Therefore any absorption will be via post-nasal drip (Yummy!). SWIK likely therefore got a lower dose than they anticipated. (Again: probably a good thing!)

Be safe: Know the drugs you're taking, don't poly-medicate.

[kritikal]

The 5mg Oxy was SWIMs last one. Each dosage of drugs has been divided into groups upon when they took them. The first was taken at 3pm the next at 5:30pm and the next at around 7-8. All the medications were prescribed although the Oxy and Propoxyphene were the only ones taken AS prescribed :P

However the next day swim did some more experimentation. He had 180mg Propoxyphene, 25mg Diazepam , 10mg Temazepam, 120mg Codeine and felt some effects but not special. They smoked some cannabis a few hours after injesting the pills and could definently feel the effects of the other drugs which was weird. They later had a few strong drinks and insuflated 30mg of Temazepam which bought on an interesting feeling as well as smoking a joint.

SWIMS first night with Diazepam was absoloutely intense but great. SWIM could have died and wouldnt have known. SWIM has had 30mg of Oxazepam many times and the feelings have been much better than as described from the past few days.

As an added note, i believe SWIM has gained a huge tolerance to Opiates from taking 80mg of Oxycodone daily for a week. I cannot see at all how tolerance from opiates could give SWIM tolerance to benzos though?

Please if anyone Knows what is wrong with SWIM can they please answer as SWIM loves to get blissed on Benzos.

[MrJim]

You probably wouldn't get a "huge" tolerance to opies for a week of 80mg OC. I also don't think that the there is a cross-tolerance between the opies and benzos. I'm sure if there is Jatelka will set us straight.
But tolerance does build to benzo's on their own.

[Jatelka]

Originally Posted by MrJim

I also don't think that the there is a cross-tolerance between the opies and benzos.

SWIMJ is indeed correct. Benzos act at GABA receptors, opiates at opiate receptors.

[788.4]

Originally Posted by kritikal

10mg Temazepam Insufflated

I thought temazepam was only available in gel caps?

[Nagognog2]

For one thing: Propoxyphene is a mild narcotic antagonist. It's chemically related to methadone - distantly. So there is a good possibility that it would block some of the effects of oxycodone. Other than that, you should consider your monkey to be lucky. I suggest that you read Jatelka's post to your chimp again. Mixing mutually cross-potentiating depressants is begging for trouble. Of the permanent variety.

[jduba]

temaz is available in caps filled with a white powder. As for not feeling to euphoric or fucked up...you took a lot of diff meds but not very large quantities of each one therefore getting a slight buzz off each one but not enough accumulative effect to really get you to lift off.

[kritikal]

The temazepam pills here come in 10mg tablets, absoloutely minute. smaller than 5mg benzo pills. i assumed that both benzos mixed would combine as one benzo type high as swim has found Opiates do.

SWIM was on Panadeine Forte (Tylenol 3) for 2 weeks and found 4 would bring him to a decent state of euphoria. SWIM was then given Tramadol which did not react well with The Aropax he was taking for anxiety. SWIM was then given Oxycodone (Oxynorm) it was suggested to take 6 a day. They were 10mg Capsules with about 40mg of filler otherwise pure. SWIM found these to ease his pain but the effect diminished relatively quickly. He found that 10mg of OC and 150mg of Codeine bought on the effect of about 10mg of Codeine when he had no tolerance.

The doctors would not give him Oxycodone because of its addiction potential. So was given Temazepam to sleep. The virus had got terribly worse and SWIM went back to the doctors upon receiving Diazepam and Proproxyphene. The suggested amounts did nothing.

SWIM always being For recreational uses of drugs tried to take what was considered recreational amounts but never experienced much at all. He became somebody totally different it seemed to intoxicate him on the outside but not on the inside.

The propoxyphene was not bad apparently though. Different opiate high very drowsy, heavy eyes, and happy/very talkative.

Benzos really did mess SWIM up made him a total zombie although feelin completely sober

SWIM is now off all Benzos + Opiates and has had terrible withdrawls.

[jduba]

next time with such a low dose of opiods take an hydroxyzine to boost the opiod effect! that may help to

[kritikal]

It was not trying to enhance effects for a trip it was trying to relieve the pain SWIM had.

I knew about the receptors and how each one attaches to different ones, therefore giving you a different high with different drugs.

SWIM is on Paroxetine which i have heard inhibits the CYP2D6 enzyme which is what converts MethylMorphine to Morphine in the brain. To swim the effects of Codeine have been the same none the less.

He has tried Benzos before and had Typical effects. Except on this Occasion it seemed as though they took effect Many Hours upon Administration. Only slight effects when he would smoke a few cones before bed time.

I am curious as to whether or not the Paroxetine effected the nature of the Benzos. He was at the point where he was way too friendly. He would ask somebody to do something for him and be declined upon continuosily nagging that person for the favour. He felt like his typical self, but according to everyone else he was not. They said it was like talking to a brick wall.

SWIM ended up taking about 360mg daily of Propoxyphene during all this time as well. Could this have someway counteracted the Benzos? In four days he had taken 215mg of Diazepam and 250mg of Temazepam. He thought he was sober all the time with this stuff.

I have heard that there are some Contrications with Flouxetine (Prozac), and Diazepam.