Ecstasy & Anti-Depressants - Any Dangers?

[Vanchatron]

I was just wondering if taking Ecstasy whilst on Anti-Depressants is dangerous. I'm on Anti-D's at the moment and I took Ecstasy the other day with no ill side affects but now people are telling me I shouldn't take them if I'm on Anti-D's.


HK

[Abrad]

Depnds on what anti-depressants SWIY is on. It is potentially dangerous combined with MAOIs but less so with SSRIs although SWIM still would not advise it. SWIM believes that taking MDMA while being treated for depression is a bad idea anyway.

[Vanchatron]

I don't understand all this SWIY + SWIM stuff sorry, can you run me through it please


HK

[Abrad]

SWIM = Someone Who Isn't Me
SWIY = Someone Who Isn't You

[Vanchatron]

Originally Posted by abrad84

SWIM = Someone Who Isn't Me
SWIY = Someone Who Isn't You

Thanks pal

Dya mind reading the thread I made below this one please


HK

[addicted2hc]

Say SWIM has recently been prescribed effexor as an Anti-depressent... Would that be a red flag?

Other then the obvious fact that taking E while being treated for depression is stupid, is there anything else to look for?

[Abrad]

Nobody said it is stupid, IIRC the OP had another another thread about how pills weren't working for him, this was probably because of the SSRI blocking the effects of the MDMA. All SWIM said was there is no point in taking pills and getting none of the positive effects and all the negatives. Considering he made his last post about 3 weeks ago and never came back don't be surprised if he doesn't answer.

[Dogears]

Im not sure what real world data shows but any anti-depressant that increases serotonin levels sounds like it could cause problems with MDMA and it's analogues as these drugs cause a sharp increase in serotonin levels and activity while under it's influence. Greatly increased seritonin levels can cause a type of poisening that in extreme cases can be fatal.

[Boyv]

Originally Posted by Dogears

Im not sure what real world data shows but any anti-depressant that increases serotonin levels sounds like it could cause problems with MDMA and it's analogues as these drugs cause a sharp increase in serotonin levels and activity while under it's influence. Greatly increased seritonin levels can cause a type of poisening that in extreme cases can be fatal.

You're right for about half of it.

SSRI's and MDMA do not combine. The SSRI already binds to the serotonine transporters (SERT), so it's already taken. Because of this, the MDMA cannot use the SERT and the effect will be little to none.

MAOI's and MDMA are dangerous indeed. The MDMA will increase the concentration of serotonine in the synapse, while the MAOI prevents your MAO's to break it down. This can result in the serotonine syndrome, caused by a too high concentration of serotonine.

[glitterfly]

ok swim was just reporting what her psychiatrist told her and what she has found through research herself ciao