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Deleriant antihistamines Diphenhydramine, cyclizine and other antihistamines.

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  #1  
Old 17-03-2006, 13:03
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Cyclizine Experiences

Before i begin i realise that other drugs were used here but the profound effects were those of the cyclizine.

Hypothosis: SWIM used 100mg of cyclizine with alcohol previously and noticed some strange effects similar to that of a very very low dose of mushrooms. eg. lights brighter, small tracers. SWIM researched cyclizine on this forum and on other sources to find it was hallucinagenic however in the deliriant catagory. SWIM has had experience with mushrooms and mescaline and wanted to see if there was a differance. His advised recreational dose was 600mg from members of this forum but SWIM preferred to work himself up to that level just to be safe. Hence the experience below.

Setting: Bedroom, lights off very dark, general outline of shapes is visable. SWIM is with his girlfriend who will be referred to as "L". No other people around. L is on no substance and will be sober but is aware that SWIM is on a substance.

T- 0:00
SWIM ingests 200mg of Cyclizine and 180mg Codeine Phosphate (no Paracetamol)
At this point SWIM feels Slight anticipation, expectant of the all too familar opiate warm fuzziness. SWIM notes however that the codeine is not the main experience just to make him a little more comfortable, his recreational doses on this are much higher.

T - 0:25
SWIM begins to feel the tingling sensation of the codeine and that warm fuzz accociated with opiates but no effects that he noticed from the cyclizine.

T - 1:00
Swim feels the full opiated warm feeling combined with lots of iching which he loves. SWIM still has no real effects from cyclizine however the opiate buzz in his head feels a little differant, blurred somehow. SWIM feels very sedated and falls asleep.

T- 2:00 - 2:15
Swim reawakes with a strange cold feeling inside his stomach and his head feels like something is swirling inside of it. SWIM also notices to focus his vision it requires alot of effort other wise his eyes remain out of focus. SWIM turns to see if L is ok, she is quietly sleeping but to his horror her neck is about 40 cetemeters long and her head is at a strange angle. SWIM gets very scared and a huge adrenaline rush and grabs L. The moment he touches L she returns to normal wakes up groggily and asks if SWIM is ok. He replies with a gentle "yeh im alright, the hallucinations have started thats all." L nods and allows him to continue. SWIM notices that the opiated feeling of Codeine is particularly decreased and only just noticable.

T- 2:15 - 3:00
SWIM sees multiple hallucinations, SWIM's middle two fingers meld into one so that he has 3 fingers and a thumb. SWIM looks to the far side of the room to see a very tall slim cloaked figure motionless. SWIM keeps telling himself that this is just a hallucination but the figure is still there, SWIM gets out of bed where he was lying down and caciously touches the figure and it dissappears. SWIM notices at this point he can also making the hallucinations dissappear by focusing his vision on them, although this requires much effort. SWIM keeps seeing differant people around the room however none of them move they are all stationary. SWIM would like to point out that the majority of hallucinations he experienced were of fake people. SWIM turns back to L and notices her arms are huge, and her skin looks plastic like, SWIM is beginning not to enjoy this experience, to begin with he found it very profound and interesting but he is now becoming more and more scared and just wanting the hallucinations to stop. SWIM notices that this 45 minute period seems to last for hours, at this point time distortion is long. At this point the opiated feeling from Codeine is gone as far as SWIM can make out. His head is stll fuzzy but this does not feel like the usual opiate feeling. SWIM would like to add that the hallucinations did not manifest themselves from nothing but rather from objects, for example a lamp next to a hangbaf next to a chair morphed into a crouched cloaked figure.

T-3:00
SWIM closes his eyes and gets no CEV and realises he can escape the hallucinations in this way. SWIM lies cuddled with L with his eyes closed knowing that he is safe there. However SWIM begins to here buzzing noises and humming that L cannot here. SWIM is tired and scared now, he is ready for the experience to end.

T- 3:05 SWIM goes to the toilet and notices that the Hallucinations do not occur in bright light, however he did not remain in the light for long so he cannot be sure.

T-3:20
Swim ingests 20 mg of Diazepam, shorlty after dosing SWIM notices that the experience slows down and is not as frighting. SWIM finds he can cope with the hallucinations a little more. SWIM feels very sedated and is worried about his level of sedation and breathing and tells L this. L promises to watch him carefully.

T-3:45
SWIM falls asleep probably due to the sedative effects of all 3 drugs, cyclizine, codeine and diazepam.

T-8:00

SWIM feels quite ill and hungover but alright, SWIM is glad to have experienced Cyclizines effects.

T- 20:00

Baseline.


Conclusion

Cyclizine causes hallucinations even at the 200mg dosage for SWIM. SWIM is very glad he did not follow others advice and start out at the 600mg mark or SWIM feels like he might have gone to hell and back. SWIM feels like Cyclizine isnt really something he would like to repeat. SWIM also wishes to add that diazepam(valium) was exceptional at calming him down and helping him to cope with the hallucinations. SWIM is glad however that he has L present or felt like he wouldnt have been able to cope and is also glad that he now knows the effects of recreational Cyclizine. SWIM would not reccommend it to others as SWIM felt most of the hallucinations manifested from his fears and worries even though he felt the setting was most posative with his girlfriend.

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  very well written report and nice experience.
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  #2  
Old 06-06-2006, 02:04
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The following was taken from SWIFantasian's Journal after more research was done post this experience. The following does include certain combinations which I consider dangerous and i have marked the ones i feel this way on.

"
Cyclizine (Marezine; Marzine; Emoquil)
This is an antihistamine drug used to treat nausea, vomiting and dizziness associated with motion sickness and vertigo. It does however have certain hallucinagenic effects that are relatively unknown and undiscovered. It also serves as an anti-cholergenic.

Medical dosage - 50mg

Onset oral - 30minutes - 1 hour
Peak oral - 1 hours
Come down oral - 2 hours
Total duration oral - 4 hours

Onset IV - Immidiate
Peak IV - 30 minutes
Come down IV - 2 hours
Total duration IV - 2 hours 30 minutes

Oral dosages:

50mg - After onset a strange sensation is felt that is difficult to describe, a fuzzy head is gained however it is very differant to that of the experiences with Cannabis. The eyes become dry and single objects become difficult to focus on. During a short time in the peak complex visual hallucinations are present such as flickers of light and other such phenomenia. If nausea was present predosing it now is not.

100 mg - Same as above however effects are more pronounced, complex visuals become more paterned and begin to make shapes like circles and squares.

Iv dosages:

50mg IV - Peak is instantanious and effects are stronger than that of 100mg orally. Very complex hallucinations are present such as small walking men and shimmering surfaces.

100mg IV - Sedation becomes present in this and a pressure is felt in the head similar to that of what SWIM would imagine when someones head explodes. It is strangely not unpleasant however not enjoyable either. Sedation overules most effects here however at certain points when SWIM manages to keep his eyes open strong hallucinations are present. People who arn't there, tiny walking men clapping symbols made from pixals. A slight Nausea accompanies this dosage even though this drug is an antiemetic.

Drug combinations:

350mg Cyclizine + 6 shots of alchohol - This experience report is relativly innaccurate due to confusion and memory loss.

SWIM does however remember the feeling that he was incredably heavy and found it very difficult to move. Also multiple hallucinations previously stated were present. In hindsight this was dangerous and irresponsible, i remember feeling phychologically effected from this experience due to terrifying hallucinations.

30mg Morphine + 50 mg of cyclizine - This is probably the best use of Cyclizine. The combing enjoyable effects of morphine with the fuzzy headedness of cyclizine create a most enjoyable chilled feeling.
"

I hope you found this information valuable and enlightening, please PM me with further questions on Cyclizine
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  #3  
Old 28-07-2006, 10:46
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what swim finds interesting is the appearance of the black hooded figure in the trip. swim has met several lab rats who have had similar sightings, but all while sober and in a half asleep state. he believes the term is 'hypnogogic hallucination' and the viewer is generally paralyzed, having had their eyes opened during REM sleep. this is sometimes thought to be the origin of incubus/succubus myths.

anyway, swim is thinking that perhaps the drug-induced appearance of the figure could shed light on why such a figure appears even to sober people. perhaps overactive anticholinergic activity occurs during REM sleep to some?

good report as always!
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Old 12-08-2006, 23:42
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Further on SWIF's Cyclizine experiences.

50mg Cyclizine IV + Entonox (50% nitrous oxide 50% oxygen)

Similar effects to the 50mg IV however the hallucinations are more apparent showing nitrous oxides effects at enhancing other drugs. Several people seen who wern't there, black hooded figure returned.

Sidenote: It is notable that after common recreational use of Cyclizine it begins to show emetic effects rather than antiemetic. SWIF commonly now feels sick when ingesting it. He believes this might be due however to his body being used to having Cyclizine with morphine and therefore pushing him into minor withdrawal even though no morphine is present and he is clean of opiates. In one sense a psychological sickness.
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Old 13-08-2006, 00:13
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that makes sense somewhat with the minor withdrawal. its probably an expectation effect, swif's body expects the morphine to be co-administered with the cyclizine, and starts an opposing effect to what the morphine would have, swim forgets the term for that process at the moment though, its part of pavlovian conditioning though. and since there is no morphine present, a minor withdrawal results.

interesting that the black hooded figure is a reoccuring theme too.
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Old 14-08-2006, 17:03
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does SWIY know if SWIM can buy these over-the-counter? or would he need a presciption, SWIM dosen't want to get them illegally
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Old 16-08-2006, 23:39
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SWIY can only obtain these through presciption although there are other deliriant anti-emetics that can be gained over the counter. I will have to do more research on Buccastem to find out if they are deliriant.

Cyclizine is not hard to obtain through prescription it is commonly prescribed for motion sickness or polypharmacologically with other drugs.

What does SWIY want it for, as an anti emetic or as a deliriant?
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Old 17-08-2006, 02:26
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Quote:
What does SWIY want it for, as an anti emetic or as a deliriant?
SWIM wants it for a deleriant, he's never tried any deleriant apart from Diphenhydramine, which he has a whirlwind romance with. As much as Nytol has always been good to him, he can't help thinking that there's better things out there for him, and this Cyclizine sounds like wonderful stuff.

SWIM has looked for deleriants that are legally obtainable without presription, antihistamines and otherwise, he has found nothing, if SWIY has any info on such a chemical, he would love to hear about it.

Cyclizine does sound like a viable option, has SWIY has ever tried Diphenhydramine? If so, can he compare the two, are there differences in intensity or any other aspect of a trip?
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Old 17-08-2006, 02:34
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The Deleriants SWIF has used are as follows in order of most intense to least:

Cyclizine
Dimenhydrinate (very structually similar to Diphenhydramine)
Prochlorperazine

Cyclizine is more in the head than Dimenhydrinate, SWIF found him commonly believing things were there as you can see above more so with cyclizine. It is notable that when Intravenous Cyclizine is administered there is a massive pleasurable rush present that is not there with oral administration. This also causes a 5 minute rush of visuals that can be quite intense and unnerving.

All in all SWIF would say Cyclizine is about 1.5 times as potent in effects as Dimenhydrinate both taken at significantly higher doses than clincal.

It should also noted that SWIF is not sure of all the negative effects that cyclizine may have on ones body when taken at above clinical dosages so therefore one should be very careful.

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Old 17-08-2006, 02:48
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That sounds very appealing to SWIM, he has experienced visualisations as strong as the ones SWIY expereinced (such as the 5-4 fingers and the cloaked figure), through the use of Diphenhydramine. Possibly more intense, but then it's incredibly hard for anyone to really convey the intensity of an experience, and how convincing or overwhelming it was, so i'm sure neither of us can really say.

From what SWIY has experienced from Cyclizine and Dimenhydrinate, SWIM would deffinately like to try Cyclizine, he thanks you for your take on these drugs and their effects.

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Old 10-03-2007, 00:23
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Re: Cyclizine Experiences

Hmm... SWIM finds himself strangely tempted to venture into the realms of IV drug administration now.

It's a thought that has always filled SWIM with fear, but he says he would try it if he thoroughly knew correct procedure for doing so, dangers of doing so, and most importantly what substances are safe.

SWIM apologises for the vagueness and fairly irrelevant nature of this post, but Delerianyt Antihistamines are his forté, and to hear about SWIY using IV with them makes him feel more tempted. SWIM uses Codeine, but has never really wanted to bother with IV opiates.

SWIFantasian - Is Cyclizine comparable to Diphenhydramine (or Dimenhiydrinate) in as much as the inability to distinguish the real from the unreal?

SWIM has had some unpleasant experiences with antihistamines and has decided to start looking for drugs whose experiences are more controllable.

All info is appreciated. Again, sorry for the ambiguity of this post.

~Dark

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Old 10-03-2007, 18:51
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Re: Cyclizine Experiences

No problem, if SWIY is one of the few to venture to the outer rim that are deleriant antihistamines SWIF wishes him luck. SWIF never wanted to do anything but take a glimpse at that world.

Cyclizine for SWIF was quite a bit stronger and more intense than Diphenhydramine but SWIF must admit that he had many more experience with cyclizine than he had with Diphenhydramine. Cyclizine definately causes Delerium associated with being unable to dintinguish reality with fantasy and vice versa.

Beware with IV administration and definately do not Crush pills and slam them. SWIF's experience were with injectable cyclizine as he had/has access to the such. Also a quick sidenote to say that IV opiates are a very dark path and very few can maintain use and continue what anyone would call a 'Quality' life.
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Old 10-03-2007, 19:37
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Re: Cyclizine Experiences

Very true.

Last edited by Micklemouse; 14-03-2007 at 22:46.
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Old 15-03-2007, 22:31
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Re: Cyclizine Experiences

Just an update: SWIM tells me IV drugs are not going to be added to his list, after all.

He also believes that in general, they deserve the amount of bad press they receive.

~Dark
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Old 14-05-2007, 12:10
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Re: Cyclizine Experiences

I've been reading on prochlorperazine cuz i have some, but its meant to be anti nausea and anti-psychotic, so its hardly a deliriant is it?
I was thinking of taking some anyone have experience?

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Old 14-05-2007, 15:10
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Re: Cyclizine Experiences

Prochlorperazine is an anti-emetic as cyclizine is but as far as SWIF knows it has no deliriant effects, it's anti-psychotic effects are somewhat mild however.

It is known as a first wave anti emetic (the cheapest) to try to stop a patient vomiting. then followed by cyclizine and maxilon then followed by potent anti emetics like ondansatron (Zofran). For some it works for sickness for others it doesnt. In SWIF's experience cyclizine is a better antiemetic however has more side effects.

SWIF would not advice its use recreationally as it has little value in this respect.
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Old 18-05-2007, 23:21
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Re: Cyclizine Experiences

SWIM has had experience with diphenhydramine, and would like to repeat the experience minus a few things. SWIM noticed that on her higher doses, she felt like her arms and face were swelling. This may have been delirium, but SWIM highly doubts it because the feeling of her face swelling lasted much longer than the delirium faze. SWIM also did not like the extreme change in her breathing to very very shallow..SWIM knows these effects are inescapable with diphenhydramine because it goes along with the toxic effetcs of anticholingeric(sp?). SWIM wanted to know if cyclizine would produce the same toxic effects such as the swelling and shallow breathing for SWIM. Any ideas?
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Old 24-05-2007, 16:52
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Re: Cyclizine Experiences

Female - see http://www.drugs-forum.com/forum/sho...749#post263749
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