Drugs-Forum  
Home Wiki Studies Forum Groups Blog Video Images News
Go Back   Drugs Forum > DRUG-FORUMS > Opiates & Opioids > Oxycodone
Mark Forums Read
Register Tags

Notices

 
Thread Tools
  #1  
Old 20-09-2011, 12:52
Snipez Snipez is offline
Newbie
 
Join Date: 17-07-2011
33 y/o Male from United States
Posts: 14
Snipez should review received reputation comments.
Points: 25, Level: 1 Points: 25, Level: 1 Points: 25, Level: 1
Activity: 0.2% Activity: 0.2% Activity: 0.2%
Bioavailability of oxycodone IR intramuscular injection vs oral

I know the bioavailability of oral oxycodone IR is pretty high (something like 60% to 87%), but what is the bioavailability of the same oxycodone IR if crushed, mixed with water in a spoon, sucked up in a syringe through a tiny cotton ball, and injected intramuscularly? Would SWIM get more of the active ingredient since it is bypassing the liver (which would destroy a lot of it) or would SWIM get less of the active ingredient because essentially pills are made to be swallowed and not intended for injection? SWIM definitely feels euphoria from both methods but it's hard to tell which ROA has a higher BA and lasts longer. Thanks in advance for your knowledgeable and valuable answers.
  #2  
Old 20-09-2011, 17:33
LostControl LostControl is offline
Silver Member
 
Join Date: 10-03-2010
Female from Canada
Posts: 278
LostControl is a decent psychonaut.LostControl is a decent psychonaut.
Points: 313, Level: 2 Points: 313, Level: 2 Points: 313, Level: 2
Activity: 0.5% Activity: 0.5% Activity: 0.5%
Re: Bioavailability of oxycodone IR intramuscular injection vs oral

Wouldn't the best way be to inject directly into your veins? Usually IM injections are things in an oil solution, because they are released slowly from the muscle. I'm going to take an educated guess, and say that IM is probably similar to oral - it's not going to be as quick as sniffing, or intravenous, but it's still getting into your body - so you'll get the same effects over time, as it's released from the muscle. You probably have pretty good bioavailability - similar to sniffing or oral - which, if I recall correctly, are pretty high (over 80% if I recall correctly). Still, if you're going to all the trouble of doing the crushing, injecting, etc., why not just do straight into a vein and get the full-on effect?
  #3  
Old 21-09-2011, 16:13
Snipez Snipez is offline
Newbie
 
Join Date: 17-07-2011
33 y/o Male from United States
Posts: 14
Snipez should review received reputation comments.
Points: 25, Level: 1 Points: 25, Level: 1 Points: 25, Level: 1
Activity: 0.2% Activity: 0.2% Activity: 0.2%
Re: Bioavailability of oxycodone IR intramuscular injection vs oral

I've used insulin needles to do IV a couple times and I find it so uncomfortable. Then it leaves behind a very noticeable bruise. I'm probably not doing it right. Since I've done cycles of steroids before, I am used to intramuscular injections. But maybe I'm just not doing the IV correctly.

Snipez added 1 Minutes and 18 Seconds later...

i mean SWIM! dammit

Last edited by Snipez; 21-09-2011 at 16:13. Reason: Automerged Doublepost

Share this on:

Tags
benzedrex, bioavailability, injecting, injecting oxycodone, injection, iv oxycodone, oxycodone, oxycodone ir, oxycodone iv, oxycodone roa, oxycontin, pharmacokinetics, roxy

Thread Tools


Similar Threads
Thread Thread Starter Forum Replies Last Post
Oxycodone Nnizzle Drug Articles 8 16-03-2014 19:39
The pharmacokinetics and metabolism of oxycodone after intramuscular and oral administration to healthy subjects (1992) Jatelka Pharmacology 0 04-05-2008 08:53

» New Threads
A quick question about tapering...
Last post by Roaddoggy
66 Replies, 2,151 Views
is it good to wean off heroin with...
Last post by Solinari
5 Replies, 295 Views
Coming off heroin using low dose...
Last post by Solinari
23 Replies, 582 Views
Loperamide getting the better of...
Last post by Roaddoggy
385 Replies, 14,895 Views
Take Heroin Get Anxious? UK Users...
Last post by Solinari
3 Replies, 146 Views
Methadone (p.a.w.s) help :(
Last post by methadon
0 Replies, 1 Views
Strangest withdrawal relief ever...
Last post by Ellen042
17 Replies, 1,172 Views
AMT - is it worth it?
Last post by mandy23
4 Replies, 102 Views
Can anyone explain how to plug a...
Last post by TexasPlate288
0 Replies, 1 Views
Please Help Me! How should I taper...
Last post by Capo
10 Replies, 438 Views
» New Wiki Articles
GHB
NET

Sitelinks: Information:

All times are GMT +1. The time now is 15:47.


Copyright: SIN Foundation 2003 - 2014, All rights reserved