Dose - Benzodiazepine Equivalent Doses

[Jatelka]

Thought this might be useful.

Contributions to it have also come from darkbreed, kareena, Moda00, and WeareStardust

Brand names for these drugs can be found here...
http://www.drugs-forum.com/forum/sho...ht=brand+names

She appreciates that benzos have different sedative, anxiolytic and myorelaxant properties but this is essentially a tool for converting to diazepam (usually for withdrawal purposes)

Benzodiazepine	Half-Life (hours)	Equivalent dose (to 10mg Diazepam)	Indication
Alprazolam	6-12	0.5mg	Anxiety
Bromazepam	10-20	5-6mg	Anxiety
Brotizolam	6-7	0.25mg	Anxiety
Camazepam	6-11	? equivalence	? Indication
Chlordiazepoxide	5-30 (36-200 for active metabolite)	25mg	Anxiety, Alcohol Withdrawal
Cinolazapam	9	40mg	? equivalence
Clobazam	12-60	20mg	Anxiety, Anticonvulsant
Clonazepam	18-50	0.5mg	Anxiety (not in UK), Anticonvulsant
Chlorazepate	36-200 (including active metabolite)	15mg	Anxiety
Clotiazepam	6-7	5-10mg	? indication
Cloxazolam	55-77	1-2mg	? indication
Delorazepam	60-200	? equivalence	? Indication
Diazepam	20-100 (36-200 for active metabolite)	10mg	Anxiety, Anticonvulsant
Doxefazepam	3-4	? equivalence	? Indication
Estazolam	10-24	1-2mg	Hypnotic
Etizolam	3-15	1-2mg	? indication
Fludiazepam	23-48	? equivalence	? Indication
Flunitrazepam	18-36 (36-200 for active metabolite)	1mg	Hypnotic
Flurazepam	40-250 (including active metabolite)	15-30mg	Hypnotic
Halazepam	15-35 (15-100 for active metabolite)	40mg	Anxiety
Haloxazolam	? Half life	5mg	? indication
Ketazolam	30-100 (36-200 including active metabolite)	15-30mg	Anxiety
Loprazolam	6-12	1-2mg	Hypnotic
Lorazepam	10-20	1mg	Anxiety, Anticonvulsant
Lormetazepam	10-12	1-2mg	Hypnotic
Medazepam	36-200	10mg	Anxiety
Mexazolam	70	1mg	? indication
Midazolam	2-6	5mg	Sedation
Nimetazepam	? Half-life	? equivalence	? Indication
Nitrazepam	15-38	10mg	Hypnotic
Nordazepam	36-200	10mg	Anxiety
Oxazepam	4-15	20mg	Anxiety
Oxazolam	10-20 (36-200 for active metabolite)	60mg	? indication
Pinazepam	40-100 (36-200 for active metabolite)	20mg	? indication
Prazepam	36-200 (including active metabolite)	10-20mg	Anxiety
Quazepam	25-100	20mg	Hypnotic
Temazepam	8-22	20mg	Hypnotic
Tofisopam	6-8	100mg	? indication
Triazolam	2	0.5mg	Hypnotic

Non-benzodiazepines with similar effects

Zaleplon (Sonata) 2, 20mg
Zolpidem (Ambien) 2, 20mg
Zopiclone (Zimovane) 5-6, 15mg

Sources: Ashton, pubmed, the lovely folk from df

Reputation Comments on this post:

	Great information!
	Great Information On benzos
	Nice info!
	Very good information!
	Wow nice.
	Nice work J :)
	diamond-esque thread J !
	Nice job!
	good info
	Very useful, thanks
	Good thread, very informative

[Fantasian]

Great info, SWIM is glad to have access to many benzo's and this table helped significantly.

[acexnx316]

If I am not mistaken, you did not include the following Benzodiazepine's (Click on each one for a bit more info):

D03083 Bentazepam (USAN)

D03631 Cyprazepam (USAN)

D01293 Ethyl Loflazepate (JAN); Meilax (TN)

D01286 Flutazolam (JAN); Coreminal (TN)

D01279 Flutoprazepam (JAN); Restas (TN)

Sorry I'm too lazy to report the dosages/mg available in, half-lives, equivalent dosages, etc., but check out http://www.genome.jp/dbget-bin/get_htext?Drug+-f+F+A (1st Level) and/or http://www.genome.jp/dbget-bin/get_htext?Drug+-f+F+E (5th level) for more info (You can also do a text search).
Although all the meds listed on the page are not available in the USA, some are, some can be imported, some are illegal/banned, etc. it is still a great page.

Has information for other types of meds besides benzos as well, such as narcotics, barbituates, etc. too.

Thought you all may appreciate it.

Pz.

Reputation Comments on this post:

	Excellent post. never heard of most of them but here's to research!
	Wow =/ I agree, never heard of them! Thanks for the info!

[jesusfreak666er]

Swim never really understood these charts, equivalency of dose in reference to what? (IE: sedation, anti- convulsive, what)

[Jatelka]

Equivalence is to diazepam, for the purposes of alleviating withdrawal symptoms when detoxing. Therefore 0.5mg Alprazolam equates roughly to 10mg diazepam, which equates roughly to 20mg Temazepam.

[Psychopatic]

I'm working on a list containing all known benzodiazepines. If anyone have information about the substanses in the list (equivalence, half-life & active metabolites), I would be grateful! The substanses in red, I have no info about, the substanses in orange, I only have the half-life , the green is complete already.

But I have the CAS-number for every substanse, if needful!

Benzodiazepines:

• Adinazolam
• Alprazolam
• Arfendazam
• Bentazepam
• Bromazepam
• Brotizolam
• Camazepam
• Carburazepam
• Chlordiazepoxide
• Cinolazepam
• Ciprazepam
• Climazolam
• Clazopam
• Clobazam
• Clobenzepam
• Clonazepam
• Clotiazepam
• Cloxazolam
• Delorazepam
• Diazepam
• Dibenzepine*
• Demoxepam
• Doxefazepam
• Elfazepam
• Estazolam
• Ethyl dirazepate
• Ethyl carfluzepate
• Ethyl loflazepate
• Etizolam
• Fletazepam
• Fludiazepam
• Flunitrazepam
• Flurazepam
• Flutazolam
• Flutemazepam
• Flutoprazepam
• Fosazepam
• Gidazepam
• Girisopam
• Halazepam
• Haloxazolam
• Homochlorcylizine*
• Iclazepam
• Ketazolam
• Lofendazam
• Lopirazepam
• Loprazolam
• Lorazepam
• Lormetazepam
• Meclonazepam
• Medazepam
• Menitrazepam
• Metaclazepam
• Mexazolam
• Midazolam
• Motrazepam
• Nerizopam
• Nevirapine*
• Nimetazepam
• Nitrazepam
• Nordazepam
• Nortetrazepam
• Oxazepam
• Oxazolam
• Phenazepam
• Pinazepam
• Pivoxazepam
• Prazepam
• Potassium chlorazepate
• Potassium nitrazepate
• Pranazepide*
• Premazepam
• Proflazepam
• Propizepine*
• Quazepam
• Ripazepam
• Sarmazenil*
• Siltenzepine*
• Sulazepam
• Tarazepide*
• Temazepam
• Tetrazepam
• Tibenzonium iodide*
• Tivirapine*
• Tofisopam
• Tolufazepam
• Triazolam
• Tuclazepam
• Uldazepam
• Zapizolam
• Zolazepam

* Is unsure if this really counts as benzodiazepines

Non benzodiazepines, but with similar effect:

• Alpidem
• Eszopiclone
• Indiplon
• Zaleplon
• Zolpidem
• Zopiclone

Reputation Comments on this post:

	great goal. I hope you will succeed in completing the list.
	very useful list, thanks

[Jatelka]

Welcome Psychopatic: That would indeed be an astonishing resource!

FYI: Nivaripine and Tivirapine are non-nucleoside reverse transcriptase inhibitors used to treat HIV infection (they stop the virus replicating)

Tibenzonium iodide is an anti infective agent used for oral hygiene

Tarazepide is a cholecystekinin A antagonist (pancreatic enzyme antagonist)

Sarmazenil is a benzodiazepine receptor inverse partial agonist. It has effects similar to flumazenil which is used to REVERSE the effects of benzodiazepines

Homochlorcyclizine is an anti-histamine (H1 receptor antagonist) similar to promethezine with some anti-cholinergic and antibradykinin activity

Dibenzepine is (as far as SWIJ can work out) a tricyclic antidepressant

Good luck in SWIY's quest, and please take some time to read the rules and find out a bit more about how df works!

[Psychopatic]

Thank You!

I these substanses came up when I searched, all of the had "-xxx-benzodiazepin-xxx", in their generic names. But like clozapine, which is a medicine to treat schizophrenia, it's even called a dibenzodiazepin.

[~lostgurl~]

Originally Posted by Jatelka

Zopiclone (Zimovane) 5-6, 15mg

Zopiclone's brand name is Immovane (typo) also SWIM disagrees with the Ashton Manual on the Zopiclone dose, she says 7.5mg of Zopiclone or less would be equivalent to 0.5mg of Clonazepam, definitely not 15mgs. When SWIM first started taking Zopiclone 3.75mg would knock her out.

[Jatelka]

Originally Posted by ~lostgurl~

SWIM disagrees with the Ashton Manual on the Zopiclone dose, she says 7.5mg of Zopiclone or less would be equivalent to 0.5mg of Clonazepam, definitely not 15mgs.

The equivalence is to Diazepam, not Clonazepam. And Zopiclone IS marketed as Zimovane (in the UK anyway)

[pixplzthx]

Just thought I'd add a pretty picture to this thread. I find the following kinds of charts easier to read. I hope it helps:

Chart shows equivalants, onset, peak and half life

Note: Uploaded to archive

[wearestardust]

Further research turns up a more accurate half-life for Rivotril (clonazepam) as between 40 and 150 hours. So it does have a pretty high range and the top end is quite high, which is what I suspected.
Anything with the same figures as diazepam, such as the excellent prazepam (Centraz, Lysanxia 40mg) has the active metabolite nordazepam. I particularly like to use the 15mg nordazepam available in many european countries, especially the excellent NORDAZ, which appears to be on sale in France only now. Calmday is more common, but Nordaz is a higher quality anxiolytic.

[tyranny4u]

the tyrant has done a little research on some missing info, maybe you'd
like to add these to the chart:

Haloxazolam - no info found until now

---
Camazepam - mainly hypnotic
Camazepam (marketed under the brand names Albego, Limpidon, and Paxor) is the dimethyl carbamate salt of temazepam, a metabolite of diazepam. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Compared to temazepam, camazepam has shown greater anticonvulsant properties, roughly equal anxiolytic properties, and less sedative and amnestic properties.
http://jacki.wikidoc.org/index.php/Camazepam

---
Fludiazepam - mainly anxiolytic
http://www.flexyx.com/E/Erispan.html

---
Tofisopam - anxiolytic (has no sedative or anticonvulsant effects!)

---
Doxefazepam is a benzodiazepine hypnotic
equivalence 7,5 mg - 15 mg
http://inchemsearch.ccohs.ca/inchem/...39&Search.y=15


---
Etizolam - hypnotic, anxiolytic
Etizolam has an anxiolytic action about 6 times greater than that of diazepam.
http://en.wikipedia.org/wiki/Etizolam

---
Mexazolam - anxiolytic

---
Nimetazepam - half-life 14-30 hours, equivalence 5 mg
http://en.wikipedia.org/wiki/Nimetazepam

---
Pinazepam - anxiolytic, is a prodrug of N-desmethyldiazepam, equivalence 10 mg
http://www.biomedexperts.com/Abstrac...methyldiazepam

---
Cinolazepam - hypnotic, sedative

---
Delorazepam - half-life ~ 100 hours - equivalence 1 mg, mainly anxiolytic, also hypnotic
http://en.wikipedia.org/wiki/Delorazepam
http://www.torrinomedica.it/farmaci/...he/Dadumir.asp
quote from manufacturers site:
"04.1 Indicazioni terapeutiche -

Disturbi d’ansia.
Insonnia."

[nathan8it]

Ok.. there was so much to read I couldn't even see anything.. but out of curiosity how many milligrams of Diazepam would be considered a dose?

nathan8it added 3 Minutes and 46 Seconds later...

See.. I saw that it said Diazepam 10mg -- but a 10mg valium can't have 10mg's of Diazepam in it.. I know that this confusion is my stupidity.. but it's really bothering me so please help me!

[pixplzthx]

Actually, yes it can! Valium™ is the brand name of a drug that contains diazepam as the main and active ingrediant. You could use the terms interchangeably in the United States but it might provide some confusion, say, in Mexico where the brand name of diazepam is different.

Using the chemical name helps to alleviate (most) confusion on DFF (this website) since it is an international forum.

I don't know if this clears anything up for you but just know this: A "beginners" dose of diazepam (brand name Valium™) can range from 2 mg to 10 mg depending on medical need, age of the patient and other medications that the person is on at the time.

[baron samedi]

Apologies for SWIM's ignorance on the topic, but is 0.5mg Clonazepam and Alprazolam roughly the same strength as 10mg Diazapam?
Also, how does Clonazapam compare to Alprazolam/Lorazepam in terms of onset of action?

[nathan8it]

Originally Posted by pixplzthx

Actually, yes it can! Valium™ is the brand name of a drug that contains diazepam as the main and active ingrediant. You could use the terms interchangeably in the United States but it might provide some confusion, say, in Mexico where the brand name of diazepam is different.

Using the chemical name helps to alleviate (most) confusion on DFF (this website) since it is an international forum.

I don't know if this clears anything up for you but just know this: A "beginners" dose of diazepam (brand name Valium™) can range from 2 mg to 10 mg depending on medical need, age of the patient and other medications that the person is on at the time.

Ya, swim ended up figuring it all out.. Thanks for the info guys..

nathan8it added 3 Minutes and 3 Seconds later...

Originally Posted by pixplzthx

Actually, yes it can! Valium™ is the brand name of a drug that contains diazepam as the main and active ingrediant. You could use the terms interchangeably in the United States but it might provide some confusion, say, in Mexico where the brand name of diazepam is different.

Using the chemical name helps to alleviate (most) confusion on DFF (this website) since it is an international forum.

I don't know if this clears anything up for you but just know this: A "beginners" dose of diazepam (brand name Valium™) can range from 2 mg to 10 mg depending on medical need, age of the patient and other medications that the person is on at the time.

Lots of help man. Thanks a lot.

[jordan sharifian]

Swim is thankful for the information.

[serpentine]

swim found delorazepam pills in his closet...the active principle is delorazepam 1 mg...half life is 80/100 hours...indication: anxiety

Reputation Comments on this post:

Interesting snippet on a lesser known benzo

[joey g.]

every one goese to these equivelency charts on google or wiki......but they are not very accurate. from prsonal exp. i've done (and im not bragging) almost evry benzo...and there are like 60 to85 different benzos. i've done all the subtypes...and even did old soviet union benzos that are illegal here. those charts u need to take w/ agrain a salt.

[Jatelka]

^^^ Very much agreed. As stated this sort of thing is a rough equivalence, for withdrawal purposes

[MisterV]

Some different dose listing SWIM found:

Reference: Diazepam 10mg

Alprazolam 1mg

Bromazepam 4,5mg

Chlordiazepoxide 20mg

Clobazam 20mg

Clorazepat 20mg

Clotiazepam 10mg

Lorazepam 1-2mg

Metaclazepam 15mg

Nordazepam 15mg

Oxazepam 30mg

Oxazolam 40mg

Prazepam 20mg

Brotizolam 0,25mg

Flunitrazepam 1mg

Flurazepam 30mg

Loprazolam 1,5mg

Lormetazepam 1mg

Temazepam 20mg

Triazolam 0,25mg

[pig_iron]

Originally Posted by baron samedi

Apologies for SWIM's ignorance on the topic, but is 0.5mg Clonazepam and Alprazolam roughly the same strength as 10mg Diazapam?

Actually, SWIM would say it's closer to 1mg or .75mg that would equate 10mg of Diazepam. It can be different for everyone.

Originally Posted by baron samedi

Also, how does Clonazapam compare to Alprazolam/Lorazepam in terms of onset of action?

The onset of action of Clonazepam is considerably slower, unless taken in the Klonopin wafer form (sublingual). Start of therapeutic window generally begins .5 hour to 45 mins after ingestion.

[TinfoilxTouch]

Everyone should be aware that the table listed was intended for those trying to switch drugs to taper off them. I find it nowhere near accurate for the therapeutic effects.

20mg diazepam is far more effective for me than 4mg xanax would be, over the course of the day. It’s really hard to compare these things in a chart when the half-lives are so different. I guess if you gave someone 10mg Valium and then .5mg Xanax and asked them how they felt on each after 30 minutes, then it might come out as a wash. I dislike this take because it doesn’t take into account that certain benzos are plasma bound and accumulate in your system while others don’t’, thus making them more potent over time. I also don’t like it because the half-life times listed don’t seem anywhere near the therapeutic range of each drug (I’ve been RX’ed many of them). I won’t get into the obscure ones, but I’ve never had a dose of Xanax last past 6 hours, and Lorazepam can easily last 10+ hours.