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  #1  
Old 05-08-2011, 19:34
weenerlongchino weenerlongchino is offline
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How long is a life span of cocaine after it is dissolved in 90% alchohol solution?

How long can cocaine be disolved in about 90% alchohol or water it before the coke is ruined ? Thanx
  #2  
Old 05-08-2011, 20:12
Wanderer Wanderer is offline
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Re: How long is a life span of cocaine after it is dissolved in 90% alchohol solution

With water, there is only some anecdotal evidence of experimentation, though especially with tap water, there are minerals, chlorine, flourine, and more in there which could react with anything in the water. Some instability issues could also arise from adulterants which become reactive in solution.

In alcohol, who knows, probably indefinitely. The hamster knew a physician who had a small bottle of cocaine solution for many, many years. It was still quite active when the hamster's friend had to clean out the physician's office when he died and found the bottle there and evaporated the alcohol. Very nice crystals resulted, he might add.

In the hamster's opinion, the instability issue is a bit overrated as he's been known to experiment with solutions once upon a time. Never had a problem.

Read more here:

Saline Nasal Spray and Optional Dosage Delivery Calculation

Be well...
  #3  
Old 05-08-2011, 20:44
weenerlongchino weenerlongchino is offline
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Re: How long is a life span of cocaine after it is dissolved in 90% alchohol solution

Thanx Wanderer - alway very informative.... What is the fastests and safest way to evaporate the alchohol? Is it heated?
  #4  
Old 05-08-2011, 20:53
Wanderer Wanderer is offline
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Re: How long is a life span of cocaine after it is dissolved in 90% alchohol solution

Mr. Hamster would suggest a bit of UTFSE because these questions are not new.

The hamster knows that alcohol evaporates at room temperature. However, if a heat source is used, don't allow to boil, make sure the area is well ventilated, and there are no potential sources of ignition - open flame, sparks from a motor, etc...

Mr. Hamster says use a bit of common sense on this one.

Be well...
  #5  
Old 06-08-2011, 00:10
Ghetto_Chem Ghetto_Chem is offline
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Re: How long is a life span of cocaine after it is dissolved in 90% alchohol solution

Swims friend would beg to differ on its stability in water. Pure cocaine (95%+) dissolved in distilled water for 2 weeks in temperature of 80F, the vial it was contained in had never been used before and rinsed quickly with acetone. Seemed like junk when it was recovered. Doctors that use cocaine solutions make them immediately before use because of it degrading. If kept cool could probably last a few months but 80F isn't too hard of a temperature to reach.

Swims friend has also dissolved his yayo in a saline nose spray bottle. It worked great but this was winter, and it only lasted three days so who knows about any extended times in solution.

So if cocaine and alcohol make cocaethylene in the body what is to say its not going to be created in the alcohol solution? Cocaine is best to stay in its crystal form.

Peace
  #6  
Old 06-08-2011, 00:55
weenerlongchino weenerlongchino is offline
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Re: How long is a life span of cocaine after it is dissolved in 90% alchohol solution

Quote:
Originally Posted by Ghetto_Chem View Post
Swims friend would beg to differ on its stability in water. Pure cocaine (95%+) dissolved in distilled water for 2 weeks in temperature of 80F, the vial it was contained in had never been used before and rinsed quickly with acetone. Seemed like junk when it was recovered. Doctors that use cocaine solutions make them immediately before use because of it degrading. If kept cool could probably last a few months but 80F isn't too hard of a temperature to reach.

Swims friend has also dissolved his yayo in a saline nose spray bottle. It worked great but this was winter, and it only lasted three days so who knows about any extended times in solution.

So if cocaine and alcohol make cocaethylene in the body what is to say its not going to be created in the alcohol solution? Cocaine is best to stay in its crystal form.

Peace
If the coke gets ruined by changing forms then all these people wouldn't have any success smuggling it by saturating their clothing and other materials with it to later recover it and putting cocaine into melted platic and then get it back somehow and I imagine that hot plastic or fiberglass is a lot worse for coke than some alchohol solution.....
  #7  
Old 06-08-2011, 14:13
Wanderer Wanderer is offline
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Re: How long is a life span of cocaine after it is dissolved in 90% alchohol solution

Quote:
Originally Posted by Ghetto_Chem View Post
Swims friend has also dissolved his yayo in a saline nose spray bottle. It worked great but this was winter, and it only lasted three days so who knows about any extended times in solution.
Mr. Hamster used to do this all the time in saline solution and ethanol. He never had a problem when he did such things.

He's requested a research paper on this be added to the archive. So, the jury is out until we can see some evidence from some controlled experiments.

Not that the hamster is doubting, but he'd like to see it backed up a bit more with an experimental study with controls and empirical evidence.

The paper is:


STABILITY OF COCAINE IN AQUEOUS SOLUTION
  1. John B. Murray,
  2. Hasan I. Al-Shora
Article first published online: 28 JUN 2008
DOI: 10.1111/j.1365-2710.1978.tb00096.x

Quote:
Originally Posted by Ghetto_Chem View Post
So if cocaine and alcohol make cocaethylene in the body what is to say its not going to be created in the alcohol solution? Cocaine is best to stay in its crystal form.
Cocaethelyne is a product of an enzymatic methyl transcripterase which performs tranesterfication in vivo in the liver. Ethanol must be present in the body when this occurs. It's not something which spontaneously occurs in solution.

Medical cocaine solutions are 5-10% cocaine in alcohol. They last a very long time.

Agreed, it's best to stay in crystalline form as there would be a possibility of a reaction between any number of things which might be mixed in as adulterants. The only time one might want to use a solvent or reagent would be for cleaning or purification, then back into a solid.

Be well...

wanderer added 726 Minutes and 8 Seconds later and the research is in...

While the research paper only examined cocaine solution in an opthalmic preparation, it does highlight a couple of things. It confirms that cocaine does indeed degrade in water solution. This is due to several things, the pH of the solution and the storage temperature. This was also done with distilled, sterilized water.

From the research paper: STABILITY OF COCAINE IN AQUEOUS SOLUTION (Please refer to the document for the tables indicated in the text.)

Quote:
Originally Posted by STABILITY OF COCAINE IN AQUEOUS SOLUTION
PHARMACEUTICAL APPLICATIONS

The main application of the work has been the determination of the stability of Cocaine Eye Drops BPC and a comparison with buffered cocaine solutions. The results are shown in Tables 3 and 4.

Cocaine Eye Drops BPC are unbuffered sterile solutions, the stability of which after autoclaving or steaming in 5-ml glass ampoules is shown in Table 3.

At pH 6.8 in Table 4 and 25C the predicted t10% was 24.5 h + 1 .l, -1.06 (P = 0.95) and the experimental f was in the range 23.4-22.7 h. However, at 5C the predicted and experimental t10% was not in close agreement, the difference being possibly due to the difficulty in control of the storage temperature at 5C. At pH 5.0 good agreement was found at 25C between the experimental and predicted t10%. The predicted t10% was 102.1 + 39.4/- 30.0 days and the found t10% was 87.0 f 1.9 days. Storage at 5C for pH 5.0 showed only a 4% loss after 6 months.

Cocaine eye drops buffered at pH 2.2 were very stable losing only 5% after 6 months storage at 25C. Although cocaine hydrochloride solutions buffered at pH 5 and at pH 2.2 exhibit good stability they may cause irritation before the eye can adjust the pH to 7.4. As cocaine is absorbed and acts as the free base, and with a pKa of 8.6 the quicker the pH increases the better for the anaesthetic properties of the solution.

In conclusion we consider that the formulation and methods of preparation recommended by the BPC 1973 are acceptable in respect of the chemical stability of the alkaloid: the assay outlined above should replace the BPC assay and the eye drops should be stored
at 5C with a time limit of 6 months.
So the hamster concedes that there is degradation, but it doesn't appear to be as rapid as some critters believe, though environmental factors are a consideration. The faster degradation in water shown in anecdotal evidence could be due to several factors, the pH of the water, storage temperature, and any potential reactants in the water in the case of nondistilled unsterilized water. Ultimately, water is not that good a long term storage medium, but it's not altogether terrible if it's done under the right conditions, and a six month shelf-life is indicated as it only loses 10% concentration over that period in a solution with pH of 5.5. Although, the higher the pH, the less degradation occurs.

Now, the hamster hasn't found anything on storage in alcohol which would be the case for a topical solution, or for internal use in anesthetizing and/or cauterizing the sinuses or other topical applications where alcohol concentration is not as great a factor as it would be in the case of an opthalmic application such as a surgical procedure. The hamster would like to find some experimental data on pure alcohol as a medium and see what its conclusions are.

The hamster hopes that settles the debate regarding an aqueous solution, and helps to confirm SWIGhetto_Chem's hypothesis based on his critter's experimental observations. The hamster would also like to thank SWIGhetto_Chem's critter for bringing this subject to light and helping to explore it in a bit more detail.

Be well...

Last edited by Wanderer; 06-08-2011 at 14:31. Reason: Added follow-up research and conclusions regarding storage in aqueous solution.
  #8  
Old 09-08-2011, 16:51
Ghetto_Chem Ghetto_Chem is offline
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Re: How long is a life span of cocaine after it is dissolved in 90% alchohol solution

Thanx to the hamster.

Appreciate the clarification on everything. That paper was a nice read to get a more in-depth understanding of how cocaine fares in water. This will make swims foaf feel a little better next time he has some dissolved in water for whatever reason. Just gotta treat it with care, keeping it cool and light free will probably greatly reduce degrading product.

Peace
  #9  
Old 09-08-2011, 16:58
Shampoo Shampoo is offline
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Re: How long is a life span of cocaine after it is dissolved in 90% alchohol solution

From an experimental perspective: I work in a lab where we use cocaine on a regular basis. When we prepare cocaine for administration, dissolved either in Saline, EtOH or DMSO depending on the preparation, the cocaine is used within 48hr. Once made, the solution is kept in a 4˚C storage unit in light-free containment. Having witnessed a diminished effect in animals after only 5 days of storage, I can say with great assuredness that cocaine is not stable in solution for prolonged periods, especially at room temperature or with light exposure.

This may not be as applicable to a recreational user who may not notice a 10% degradation when consuming large amounts, but for the sake of accuracy, it should be noted that significant degradation does occur somewhat rapidly.
  #10  
Old 15-08-2011, 07:38
Wanderer Wanderer is offline
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Re: How long is a life span of cocaine after it is dissolved in 90% alchohol solution

Quote:
Originally Posted by Shampoo View Post
I work in a lab where we use cocaine on a regular basis.
This had the hamster rolling on the floor. He wonders if they might be hiring...

Off topic, but couldn't resist. The other info provided by Shampoo is excellent.

Be well...

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