PFPP (Flipiperazine) basics

[Alfa]

PFPP. (p-Fluorophenylpiperazine. Aka Flipiperazine).

Works mainly on the serotonine system and creates changes in sensory perceptions. Effective dose is 20 mg and effects last for around 3 hours. A significant portion of users experience migraines and naussea. Especially when taking over the reccomended dose.

The research done on this compound seems to be very limited:

Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(6):989-1001.

Molecular pharmacology of niaprazine.

Institut de Biologie Physico-Chimique, Paris, France.

1. The pharmacological profile of niaprazine was investigated using in vitro ligand binding techniques. 2. Niaprazine exhibits a low affinity for the vesicular monoamine transporter and for D2, alpha 2, beta, H1 and muscarinic cholinergic receptors. Niaprazine, particularly the (+)stereoisomer, has a higher affinity for alpha 1 (Ki = 77 nM) and 5-HT2 (Ki = 25 nM) binding sites, but is poorly recognized by 5-HT1A and 5-HT1B binding sites (Ki sigma mciroM). In contrast, p-fluoro-phenylpiperazine, a major metabolite of niaprazine, exhibits a higher affinity for the 5-HT1 subclasses than for the 5HT2 class. 3. These results suggest that the pharmacological properties of niaprazine reflect both its non-reserpinic catecholamine depletor effect and its action on alpha 1 and 5-HT2 receptors. A role of p-fluoro-phenylpiperazine via 5-HT1 sites cannot be excluded.
Neuropharmacology. 1982 Feb;21(2):163-9.

The effect of niaprazine on the turnover of 5-hydroxytryptamine in the rat brain.

Niaprazine (60 mg/kg i.p.) increased rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Rat brain 5-hydroxytryptamine (5-HT) levels were unchanged. Niaprazine also produced a short-lasting depletion of rat brain noradrenaline (NA) and dopamine (DA). Pretreatment with alpha-phenyl-alpha-propyl-benzeneacetic acid, 2-(diethylamino) ethyl ester hydrochloride (SKF 525A) (75 mg/kg i.p.) potentiated the increase in 5-HIAA and depletion of catecholamines produced 1 hr after niaprazine, but abolished the reduction in 5-HIAA produced 8 hr after the drug. This suggested that a metabolite might be responsible for the delayed reduction in 5-HIAA levels. A potential metabolite, p-fluoro-phenylpiperazine (FPP) (5-40 mg/kg i.p.) reduced rat brain 5-HIAA and 3,4-dihydroxyphenyl acetic acid (DOPAC), and inhibited 5-HT and NA uptake in vitro. Unlike niaprazine, FPP produced no behavioural sedation, but in large doses produced a behavioural syndrome indicative of serotonergic stimulation. Studies of the metabolism of 14C-niaprazine in rats indicated the presence of a urinary metabolite with the same chromatographic characteristics as FPP. These results suggest that niaprazine itself depletes brain catecholamines and increases 5-HT turnover, while a metabolite, FPP, subsequently reduces the turnover of 5-HT and DA.

[Cuberun]

Do you know which sort of "brand mixes" contain flipiperazine (that sounds so gimmicky).

[Thirdedge]

MASH. 37.5mg per capsule. Its a mildly psychedelic downer, kinda like taking a Benzo and a 2 shrooms at the same time.

Flipiperazine was first synthesised in New Zealand. I didn,t experience a migraine from 2 capsules / 75mg of Mash, but did notice mild nausea, similar to that of approx 50mg of TFMPP.

[Forthesevenlakes]

seems odd to SWIM that piperazines can bind so many types of receptors and have a wide range of subjective effects. SWIM always just assumed every piperazine was somewhat like amphetamine, but maybe thats just BZP. and by odd, i mean interesting. SWIM will definitely have to read up on their pharmacology, even if he has no interest in ever trying any of them.

[JewishNazi]

Why dont you think of amphetamien as an atypical PEA?

[darrinotago]

Any one used this on its own or mixed with anything any comments welcomed thanx

[Thirdedge]

Swim used it once, probably wouldn,t bother again. Similar to TFMPP but with toxic side effects from even a mild dose. Many of these other Piperazines (other than bzp / viagra etc) are pretty crappy really, they give a buzz similar to the nausea stage of a hbwr trip.

[Nagognog2]

This crap is poison and is used to kill intestinal worms in farm animals. Yummy - Yum - Yum!!

Re-Opened by GOD

[stjbm06]

OK, SWIM just got 6 grams of this shit FREE and needs some advice OTHER than "this crap is poison"... SWIM has full intention of trying this first at a very safe dose, then increasing, but wants to know whether he is being the first guinea pig out there and at what dose one could see some actual effects and what to expect so he doesn't freak out.

peace

[Thirdedge]

Originally Posted by stjbm06

. . . but wants to know whether he is being the first guinea pig out there and at what dose one could see some actual effects and what to expect so he doesn't freak out.

peace

No, swiy is not beeing the first guinea pig for this chemical - it is widely available in a commercial product as mentioned above.
Said product contains 37.5mg per capsule, this is what swim tried.
I recomend swiy get some good scales and measure out 20mg for a mild dosage or 40mg for a strong dosage. Higher dosages than 40mg are likely to involve side effects such as nausea and headache.
It is worth noting that in NZ where these sorts of things are widely available, most prefer bzp or bzp with tfmpp. Most try these more novel substances once or twice as an experiment and then move on.

[starboy]

This chemical, like BZP was a metabolite of a medicine which would have gone through trials before being marketed, so you are not going to be the first person to consume it.

The pleasant margin is in the "up to 20mg" dose range, some marketers apply marketing formula to this dosage and produce higher dosage products for a better price hoping to boost sales without realising that the nausea and headaches negate any advantage that may have been gained by the price comparison, and then providing 5HTP pills with them as though 5HTP is a magic bullet for comedowns makes matters worse, in some cases increasing unpleasant side effects.

Less is more.

Headaches respond well to ibuprofen.

[bushman]

Any information on effects when not mixed with other things? Is it worth using as a stand alone substance? SWIM has heard that:

"pFPP has little stimulant effects, with its subjective effects derived mainly from its action as a 5HT1A agonist. Its effects have been described as similar to a cross between Fluoxetine and a very small dose of LSD, both of which have significant actions as 5HT1A agonists in addition to their primary mechanism of action."

SWIM wonders wether pFPP really has mild hallucinogenic qualities?