Drug info - Buspirone

[miller77]

Has any one heard of BuSpar ? If you have is it any good.

[moldie]

it sucks.


It's used mostly as an anti-anxiety drug. I've seen it given to people on ritalin a lot. I deffinately wouldn't classify it as much of a downer though. Unless you have anxiety problems you probably won't be interested in buspar. It has no affnity for benzo receptors and does not effect gaba binding. This pretty much eliminates any benzo-like effects.

[Alfa]

Buspar works on serotonine.

[camiroquai]

I hate buspar. The only effects I got in up to 5 pills (unknown mg) was a weird feeling in my face. I didn't like it.

[miller77]

Originally Posted by Alfa

Buspar works on serotonine.

what is that?

[Alfa]

Serotonine is a neurotransmitter(a substance which your body uses in the process of transmitting signals to cels.f.e. in your brain) 80% of your serotonine is in your bowels, 10% in your blood and 2% in your brain. Serotonine affects sleep, mood, hunger, dreams, hallucinations, bloodpressureand much more. There are various kinds of serotonine. All with different functions. For example: MDMA (the substance which should be in XTC) has a primairly effect on serotonine, uplifting your mood, making you dreamy, etc. Edited by: Alfa

[moldie]

The odd thing is buspar's action is not entirely understood. Saying that it works on seratonin is pretty nondescript, but it is all one can really say. Well, it does has some affinity for d2-dopamine receptors as well - as if that is saying much. All that can really be said is the buspar is not in any way a recreational drug.


Have you looked at the structure for buspar? theCAS is something like 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-aza-spirodecane-7,9-dione monohydrochloride, depending of course on which ring you start your naming from.

[miller77]

thanks you have been very help full

[miller77]

has any one here heard of topamax? and is t any good?

[Alfa]

BusPar Vs Topamax

[Gahaba22]

I would not suggest taking BuSpar for recreational purposes. The exact mechanism of BuSpar's action is unknown

[young poppa]

this drug is fu(king wild, snort one of them and u feel lke u got hit by a truck, terrible taste when snorted but no burn, ive only done the white bars, which i beleive is the highest dosage pill, they are sold sometimes as zanax

Reputation Comments on this post:

misinformation

[kfoot73]

BusPar treats anxiety and Topomax is used to provide long term relief to
treat migraine headache patients.

[luckyatl13]

i only took one pill of buspar(not sure wat mg)but it made me dizzy and me head feel like it had alot of pressure on it. like if u go underwater realy deep.

[Mike177]

I was on Buspar for several months, it works well for anxiety but takes about 2-5 days to take full effect. Buspar has no recreational value to it and even when used at doctor perscribed doses can have side affects thats are unplesent and anoying. stear clear of this drug unless your looking for long term anxiety relief

[quinone]

Its Serotonin not serotoninE ... hehe

[raven3davis]

Originally Posted by young poppa

this drug is fu(king wild, snort one of them and u feel lke u got hit by a truck, terrible taste when snorted but no burn, ive only done the white bars, which i beleive is the highest dosage pill, they are sold sometimes as zanax

You got xanax mixed up with buspar man. I think you are referring to the slang name for xanax, which is bars, and yea, bars are quite powerful little puppies.Edited by: raven3davis

[twilex]

Originally Posted by raven3davis

You got xanax mixed up with buspar man. I think you are
referring to the slang name for xanax, which is bars, and yea, bars are
quite powerful little puppies.

actually, the highest dosage buspar [buspirone] pill does come in bar form also.


personally, i'm not so sure buspar has recreational value. my doc
has me taking 2 of the bars every night for anxiety. i actually
tried tapering off of them because i felt they weren't doing much, but
i felt so horrible that i just went back on again and all was
okay. anyhow, this is just my own personal experience.

[Emperiorjack]

I think buspar works better has an anti-depressant then an Anti-anxiety
med. I remember I took six of the 30mg bars just to see what would
happen and it made my anxieties worst.

[jesusfreak666er]

buspar is a crappy antianxiety medication, it is only ever effective for people i refer to as "benzodiazapine virgins"... not only is it extremely weak the only way to abuse is to crush and snort... ooo and believe me u will feel it... u will wish u hadn't it. It makes u feel like shit, sick, tired but not in a pleasureable way... u will count the seconds till it goes away.

[pharmapsyche]

I came across 15 buspirone (the generic name for BuSpar) 15mg bars once. I decided to take them as directed, 1 bar a day. I was anxious to see what kind of anti-anxiety effect I would experience. Of course, I was also curious to see whether buspirone had any abuse potential (at the recomended dosage.) I have mild anxiety and after 5 days I hadn't noticed anything different. There was a mild sensation of anxiolytic-like action, but I wondered then just as I wonder now if it was just placebo. I didn't experience any side effects personally, although I wouldn't be surprised if many people did since this drug seems to be somewhat a mystery. Buspirone works on the serotonin receptor 5-HT1a receptor, and also has dopamine D2 antagonist/agonist properties. These properties usually result in the release of prolactin. All in all, my asessment of buspirone is that in a theraputic setting, it might have mild to substancial benefits but as a drug of abuse, none whatsoever. I'd like to note, however, that after about 7 days of taking buspirone, I was driving in my car and felt much more cheerful then normal. This is what I mean when I say 'placebo' vs. buspirone's effects.

[Herbal Remedy]

Swim recently came across a few pills (oval shaped, white, "658" engraved on one side, "watson" engraved on the other-double stacked shape).

Swim's research concluded that the pills are Buspirone Hydrochloride, a drugs used to treak anxiety. But that is all the info swim could obtain, and he thought this was the best place to bring his questions. He was wondering if anyone had any experience/insight/knowledge about this drug and the best method of using it recreationally. Any responses would be appreciated, thanks, peace...

[pharmapsyche]

The pill you mentioned is indeed buspirone hydrochloride 10 milligrams. Buspirone has a potent anti-anxiety effect that usually becomes apparent within 3-5 days of treatment. Buspirone is different from other anxiolytics, such as the benzodiazepines, meprobamate or the barbiturates because instead of acting on GABA receptors it acts on serotonin receptors (specifically, it is a 5-HTP1A receptor agonist.) It also indirectly influences dopamine receptors. I'll write more later.

[Herbal Remedy]

Im worried that the way the pill works will make it hard for me to feel the effects of regular xanax or other drugs so right now im holding off on it. I might be wrong though, thanks for the reply (and any future replies!), peace...

[pharmapsyche]

Good news, Remedy: cross-tolerance to benzodiazepines, barbiturates, and alcohol does not exist with buspirone: GABA-mediated effects are lacking. It works by interfering with the activity of serotonin in the brain, acting as a 5-HT1A receptor partial agonist. Additionally, it acts as a mixed agonist/antagonist on post-synaptic dopamine receptors. So there could be some interactions with serotonin or dopamine agonist/antagonists but not with the GABAergic drugs.

Buspirone is such an interesting compound. Pharmaceuticals never fail to amaze me with their unique properties and theraputic potentials.