Anal use - Benzodiazepines rectally?

[xanned]

Just prepared a 2mg clonazerpam, 3 ml vodka and 10 ml water solution. I will let it sit over night, plug it tommorow morning and post results

xanned added 699 Minutes and 46 Seconds later...

Just plugged the solution...stung my shadow's ass a little but god damn, i have never felt clonazepam with such a quick onset and such potent effects!

(Two 1mg tablets, 7ml water, 3ml vodka, let dissolve OVERNIGHT in an airtight vial and ass it for breakfast)

[ComfortablyNumb]

SWIM just shoved a valium pill up his shaft, he told me he wished he just swallowed it. Its been 20 mins, should he feel anything yet?

[RaverHippie]

Don't force chinchi to attempt this for the sake of reporting back the results. and also to get a real unbiased report it may be good to hold off on the alcohol until the benzo's effects have set in, just to be sure that the method of administration is behind any changes to the effect of the diazepam.

[ganja4girl20]

swim tried alprazolam anally the first time today. swim was hesitant but it actually works! dont know if the buzz is any better, but it did hit much quicker than usual. swim just used water, next time swim will try with alcohol but doesnt know how. any suggestions?

[mbarnes0]

did swianyone else try this and agree with swim that it sucked? swim was terribly disappointed. his lizard's ass just couldn't keep it in. very frustrating for swim's lizard...

SWIM knows for a fact that rectal administration works, he has just never used it for benzos. SWIM would say your lizard doesn't have the syringe in there far enough. SWIM uses a 10ml oral syringe from the local drug store and sticks it in at least to the 7.5ml line. They say that SWIY needs to put it "at least 2 knuckles in". SWIM has never had a problem keeping in 10ml of liquid or even up to 30ml for that matter. Once SWIY gets above 10ml though, SWIM thinks it does get a bit uncomfortable for about 5 minutes just trying to to shit it out.


Some swimmer please correct me if SWIM is wrong...

So benzos for the most part are pretty insoluble in water, which is why snorting is a waste. Crushing them down and mixing with water won't release hardly any of the goods into the water, but the water makes it possible to get your dose up in there and it gets absorbed through the rectal walls?

SWIM guesses he is confused on the part where they aren't water soluble but he always just used water to plug anything he has done so far, which has only been opiates.

[Stimulants]

Pre-dissolved simply hastens absorption,but water or solvent soluble shouldn't make a difference in suitability for pr.

It's well known that Tylenol is not water soluble, however it works as a pain reliever administered pr.

The amount of alprazolam we're talking about is single digit mg, so even if it's sparingly soluble in water, a 250ml of water should be more than enough to be a carrier.

FYI, alprazolam is highly soluble in chloroform, somewhat soluble in 95% ethanol and methanol, very slightly soluble in water and soluble in dilute nitric acid.

Reputation Comments on this post:

There's a reason newbies aren't allowed to post links. Please don't try to get around it!

[PsychoActivist]

Swipa was always under the impression that Benzo's are not absorbed well through the music membranes. Which to him it seems that plugging them would be almost the same as snorting them, as both methods take to the mucrose membrances. Most Benzo's are not water soluble.

This is just waht I have read and understood.

I could be wrong, but can I challenge any of you to help find some reputable resources or these posts?

It is our job here within this community to provide accurate information as well a harm reduction.

Again, I am not saying anyone is particularly wrong here. I would just like to seee some solid proof here.

Thank you and be safe

~PA~

[Stimulants]

Originally Posted by PsychoActivist

Swipa was always under the impression that Benzo's are not absorbed well through the music membranes. Which to him it seems that plugging them would be almost the same as snorting them, as both methods take to the mucrose membrances. Most Benzo's are not water soluble.

One would find that a lot of pills are made with non-water soluble active ingredients.

This is just waht I have read and understood.

I could be wrong, but can I challenge any of you to help find some reputable resources or these posts?

It is our job here within this community to provide accurate information as well a harm reduction.

Again, I am not saying anyone is particularly wrong here. I would just like to seee some solid proof here.

Thank you and be safe

~PA~

This applies to and only to diazepam, but here is a research based findings:

Def: po = oral, pr = plug

Pharmaceuticals:
Roche Valium IV
Roche Valium 10mg pill
Roche Valium PR
privately made PR

Subject: 6 volunteers

No statistically significant differences in po/pr in peak serum conc. or time to peak
n=6
mean po 76%, STD 16.8%
mean pr 81%, STD 13.0%

bioavailabiltiy was concluded to be similar for PR and PO for diazepam.

SWIM finds that the number of volunteers was not great enough (6 patients) to be conclusive, but based on these limited findings, there's no reason to do p.r. in place of p.o. since there's really no conclusive gain.

Source:
Article ID 1402110 from PubMed on US National Institute of Health site.
Br J Clin Pharmacol. 1982 March; 13(3): 427–432.
PMCID: PMC1402110

Bioavailability of diazepam after intravenous, oral and rectal administration in adult epileptic patients.
S Dhillon, J Oxley, and A Richens

Reputation Comments on this post:

	great job bringing some science into this thread! really good post, someone whishes they had more rep pts to give for it
	Valuable information

[pinokio]

Hello SWIMMERs,

would be would be a proper dose of Alprazolam (if any) for SWIM to start with rectal administration. SWIM has already ingested 2mg of Alprazolam oraly, and takes xannies 2x / year, so he is net a very experienced user.

1.5mg Seems ok for SWIM, but better ask more experienced SWAT.

Thank you.
Thank you.

pinokio added 0 Minutes and 44 Seconds later...

*WHAT would be .. krist.

[double trouble]

SWim has tried Diazepam rectaly for the first time today and by reading other swimmers posts he has come up with his own way to benefit from "plugging" Diazepam.

Please note:Swim was comming down from rectally administered methylone before his experiment.(so results probably differ when sober).

Firstly Swim read through ALL of this thread to gather as much knowledge and info as possible(plus googling it).

Swim Read that Diazepam isn't very water soluble but is soluble in Alcohol and fats(oils)or lipids ,so here's how he did it........
using a 5ml liquid medicine measuring syringe(NO needle) to measure.

1) swim took two 10mg diazepam tablets and crushed them down to a fine powder in the bottom of a shot glass.

2)Swim then Added 5 drops of vegtable oil to the powder and mixed well.

3)he then added 2ml of alcohol(vodka) 37% to help dissolve any remaining diazepam and mixed well again(at this point when left to settle the oil still floats to the top of liquid)

4)Then Swim added 2.5ml's of warm water to the mixture stirring constantly and then sucked it up into the medicine syringe.

5)swim then put a bit of lube on the tip of the syringe and went for it!
Knees up to shoulders.....swiy gets the picture!!

6) WOW! swim doesn't know whether it's a psychosomatic thing or not but it felt like it started working within 30 seconds.

7)After 5 minutes swim was feelin well chilled out and bearing in mind that he was still a bit high on methylone,the results were fantastic!

8)SWim noticed that the effects of the Diazepam climbed in strength up to about 30 minutes after administration.Then seemed to have leveled out.

So there you go swiy's ,this is deffinately swims new way to get chilled out
it worked fantasticaly!

Remember mixing drugs is bad and potentially harmful even fatal.
Swim does things(drugs) in moderation but likes to push it a little too far sometimes.
DON'T do as Swim does just cos Swim likes it....he isn't medically trained.

BUT this is just a novel way to take Diazepam and IT WORKS!

Have fun but BE CAREFUL!

[killagorilla187]

What kind of product do you need to administer anything rectally, please advise swim. What Im thinking or seen are these big things that look like turkey basters. Those would seem useless and waseful since there so big.

Please post link or tell swim what to get. thanks

[kapten]

SWIM had previously tried rectally administering ativan and diazepam after mixing with water and wasn't too impressed.

Recently SWIM thouroughly mixed diazepam with an oil (propylene glycol) and alcohol (80% grain liquor) and then filtered out the binders etc from the pills.

SWIM was very impressed in the difference. Not an expert, but SWIM assumes the extra solubility and removing the binders would make for much better absorbtion.

Care to comment ?

FYI SWIM was doing this to research IM injections. See here if interested:
See this post if interested: http://www.drugs-forum.com/forum/sho...4&postcount=48

[fiveleggedrat]

Swim has become accustomed to rectal use after using hydromorphone in this way to potentiate it, which worked VERY well.

Swim's going to take 2mg lorazepam, and dissolve in a, oh, say 10% ethanol solution for better/faster absorption, after "cleaning" the admin site very well, which makes a BIG difference. Usually, 2mg would provide a buzz. 4mg is blackout, while 2 1/2-3 1/2 depending on random biological factors, is usually the sweet spot. All in all, lorazepam sucks vs. other benzos, even with alcohol OR opioids.

Avoiding first pass metabolism has to give the lorazepam some more "oomph" to it. Hoping this 2mg will go decently far, Swim needs to be able to sleep and relax, being out of pot, his lovely crutch.

Swim'll be back later