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  #1  
Old 07-04-2011, 18:15
pharmycologist pharmycologist is offline
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Xanax XR (alprazolam) thoughts on defeating XR Matrix

Hey folks,

Just some thoughts and questions SWIM had about Xanax XR and attempts to use it recreationally, at least as much as possible.

SWIM got quite a few of them. His first experiment was crushing and letting sit, occasionally agitating the powder, in some lemon juice. SWIM let it sit for about 10 hours the first time, about 12 the second time. Both times definitely gave SWIM a slight euphoria like an IR Xanax would give, but it wasn't as strong although the relaxation lasted much longer.

SWIM would like to get some high proof alcohol soon and test this method with alcohol to attempt to break the gel matrix.

BTW after leaving the powder in the lemon juice there were almost no clumpy gluey globs like one sees when after exposing the XRs to moisture.


This is SWIMS experience in case anyone has XRs and wants to get more out of them.

First question is, does anyone have a solid fool proof method for extracting the good stuff from the matrix? From my research this or the alcohol method seems to be the best.

Second question is does anyone have ideas about the efficacy of plugging XRs? I guess the safety more importantly. Say SWIM crushed up an XR and parachuted up the back end? SWIM knows this would increase the effects but was wondering if any harm could be done from the matrix gel or if it would likely just gel up up in there lol. Probably would be tough but wanted to see if anyone knew much about it as SWIM is trying to conserve.
  #2  
Old 12-04-2011, 07:16
Roads Roads is offline
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Re: Xanax XR (alprazolam) thoughts on defeating XR Matrix

Quote:
Originally Posted by pharmycologist View Post
Hey folks,

Just some thoughts and questions SWIM had about Xanax XR and attempts to use it recreationally, at least as much as possible.

SWIM got quite a few of them. His first experiment was crushing and letting sit, occasionally agitating the powder, in some lemon juice. SWIM let it sit for about 10 hours the first time, about 12 the second time. Both times definitely gave SWIM a slight euphoria like an IR Xanax would give, but it wasn't as strong although the relaxation lasted much longer.

SWIM would like to get some high proof alcohol soon and test this method with alcohol to attempt to break the gel matrix.

BTW after leaving the powder in the lemon juice there were almost no clumpy gluey globs like one sees when after exposing the XRs to moisture.


This is SWIMS experience in case anyone has XRs and wants to get more out of them.

First question is, does anyone have a solid fool proof method for extracting the good stuff from the matrix? From my research this or the alcohol method seems to be the best.

Second question is does anyone have ideas about the efficacy of plugging XRs? I guess the safety more importantly. Say SWIM crushed up an XR and parachuted up the back end? SWIM knows this would increase the effects but was wondering if any harm could be done from the matrix gel or if it would likely just gel up up in there lol. Probably would be tough but wanted to see if anyone knew much about it as SWIM is trying to conserve.
The panda disagrees that the high proof alcohol method is the best way of defeating the time release matrix. Here's why.

Firstly, lets take a look at what this matrix is actually primarily composed of: hydroxy-propyl-methyl-cellulose, or hypromellose. A derivative of cellulose. Acetone would make a better solvent than ethanol, even isopropyl alcohol would be better, but who wants to take a shot of acetone full of xanax? Gross! If such a method were attempted, a coffee filter or some similar straining device would be necessary to catch the alprazolam.

Hypromellose is hydrophilic, meaning it attracts water. In regards to the function of Xanax XR, the outer layer of the pill attracts water in the digestive tract, binds to it and thus causes expansion, or "gelling up" of the of the pill, once that first layer of hypromellose dissolves, the Alprazolam it has bound to it is released and the second layer repeats the same gelling process; so and so forth. Think of a whole Xanax XR pill as a layered spherical type shape, sort of like say, the planet Earth, or an onion, or something like that.

Scientifically speaking, the easiest way to destroy hypromellose would be to heat it up in an oven or over a fire; unfortunately this would likely cause the pill to literally explode into flames, as hypromellose is highly combustible. This would annihilate the Alprazolam in the process.

Alternatively one could attempt to heat water to around say 85-90 degrees celsius, deposit the powder in said water and let it sit for a while and the hypromellose should rise to the top and dissolve; what damage this would do to the Alprazolam molecules is unfortunately unknown, and it may in fact deteriorate or destroy them in the process; rendering the entire endeavor useless.

Unfortunately there is no surefire way of defeating this matrix that the panda knows of, however from everything the panda has studied on defeating time release matrices based on cellulose derivatives, 2 facts the panda has gathered that need to happen if you want to try.

1. The pill has to be cut up, then crushed entirely into a powder. There is a reason the print on the back of your Xanax XR bottle says "Do not chew or crush before swallowing". By simply separating the actual physical body of the pill, you are already bypassing the matrix partially.
2. Hypromellose dissolves faster in acidic solutions.

This is why you're attempted lemon juice extraction worked to some degree: because of citric acid. Lemon juice has a particularly high level of acidity and ranks in at a 2.3 on the PH scale.

So what, can we use that's even more powerful; barring hydrochloric acid of course, - lime juice. Lime juice is usually around a 1.8 to a 2.0 on the ph scale and is probably one of the most acidic substances you could get your hands on and still be able to ingest. In comparison, gastric acid has a ph of 1.

The panda would suggest a lime juice extraction next time over lemon juice due to its greater acidity. Also, filling the stomach with as much acid as possible before ingestion will further help the process of degrading the hypromellose. So yes, chugging lime juice, lemon juice, orange juice and some kind of soda or coca cola in theory may help the process along - possibly all four; why the hell not? Any chemical that increases gastric acid production (caffeine being the most obvious choice), will also help this process.

This is just theory unfortunately, and there is literally no consensus anywhere on the internet about how to successfully defeat celluloid based time release matrices; regardless of what drug they are bound to.

Try the lime juice though. More than 12 hours may be needed for a succesful extraction; maybe give it a full day.

edit: Unless your colon is made out of hydrochloric acid, plugging Xanax XR powder would merely result in a giant blob of gel stuck to the inside of your ass cavity, with very little actual xanax absorption, as the digestive juices are primarily what degrades the preparation. Plugging: not a good idea.

Feel free to send hate mail to Dow Chemicals for their extensive efforts in proliferating this ridiculously annoying polymer; truly a giant cockblock to the drug using community, and not just with Xanax XR but with a number of opioid time release preparations among others.

source: "Direct Compression of Sustained-Release Hydrophilic Matrix Tablets Containing Hypromellose and MCC"
Tim D. Cabelka and Paul J. Shesky, Larkin Laboratory, Dow Chemical Company. 1999

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great read, interesting suggestions, love the cockblock analogy!
Amusingly informative post - good job! :)
Awesome info on the science behind it, thank you!

Last edited by Roads; 12-04-2011 at 08:58.
  #3  
Old 12-04-2011, 11:47
Revolvingdoo Revolvingdoo is offline
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Re: Xanax XR (alprazolam) thoughts on defeating XR Matrix

A quick question? Is this the same time release mechanism as in the new oxycontin 80 mg's?
  #4  
Old 12-04-2011, 12:13
benzup! benzup! is offline
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Re: Xanax XR (alprazolam) thoughts on defeating XR Matrix

the question is, do the pharma's know how to unlock the polymer matrices to regain access to recreational aspects of what inside these XR pills, or is it ones of these 'lock the door then throw away the key' problems, which to the drug world is the equivalent of handing you over free and total access to jessica alba, but only after all her holes have been filled in with reinforced concrete and sewn up with carbon nanofibres. .

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Oh my, that is funny as all.
  #5  
Old 12-04-2011, 17:41
Roads Roads is offline
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Re: Xanax XR (alprazolam) thoughts on defeating XR Matrix

Quote:
Originally Posted by Revolvingdoo View Post
A quick question? Is this the same time release mechanism as in the new oxycontin 80 mg's?
Yes. Hypromellose is indeed a part of the time release matrix of the oxy 80s. In fact, if a pill has a time release matrix and is a solid object, I.E. like Xanax XR, and is not a capsule filled with beads, it's almost safe to assume that it is a polymer celluloid based matrix.

The only time release pills the panda can think of off the top of his head that aren't HPMC based would be Dexedrine Spansules (dextroamphetamine), which uses a multi-bead based time release mechanism, which is easier to bypass, and Vyvanse which is Lisdexamphetamine; or, amphetamine bound to the protein Lysine, requiring metabolism in the liver for the drug to even take effect.
  #6  
Old 13-12-2011, 16:53
Frankd0913 Frankd0913 is offline
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Re: Xanax XR (alprazolam) thoughts on defeating XR Matrix

Afoaf said crush to fine powder and mix with strong hot black coffee, the gel dissipates instantly!!!
  #7  
Old 03-09-2012, 11:25
UseYourIllusion UseYourIllusion is offline
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Re: Xanax XR (alprazolam) thoughts on defeating XR Matrix

Quote:
Originally Posted by Roads View Post
The panda disagrees that the high proof alcohol method is the best way of defeating the time release matrix. Here's why.

Firstly, lets take a look at what this matrix is actually primarily composed of: hydroxy-propyl-methyl-cellulose, or hypromellose. A derivative of cellulose. Acetone would make a better solvent than ethanol, even isopropyl alcohol would be better, but who wants to take a shot of acetone full of xanax? Gross! If such a method were attempted, a coffee filter or some similar straining device would be necessary to catch the alprazolam.

Hypromellose is hydrophilic, meaning it attracts water. In regards to the function of Xanax XR, the outer layer of the pill attracts water in the digestive tract, binds to it and thus causes expansion, or "gelling up" of the of the pill, once that first layer of hypromellose dissolves, the Alprazolam it has bound to it is released and the second layer repeats the same gelling process; so and so forth. Think of a whole Xanax XR pill as a layered spherical type shape, sort of like say, the planet Earth, or an onion, or something like that.

Scientifically speaking, the easiest way to destroy hypromellose would be to heat it up in an oven or over a fire; unfortunately this would likely cause the pill to literally explode into flames, as hypromellose is highly combustible. This would annihilate the Alprazolam in the process.

Alternatively one could attempt to heat water to around say 85-90 degrees celsius, deposit the powder in said water and let it sit for a while and the hypromellose should rise to the top and dissolve; what damage this would do to the Alprazolam molecules is unfortunately unknown, and it may in fact deteriorate or destroy them in the process; rendering the entire endeavor useless.

Unfortunately there is no surefire way of defeating this matrix that the panda knows of, however from everything the panda has studied on defeating time release matrices based on cellulose derivatives, 2 facts the panda has gathered that need to happen if you want to try.

1. The pill has to be cut up, then crushed entirely into a powder. There is a reason the print on the back of your Xanax XR bottle says "Do not chew or crush before swallowing". By simply separating the actual physical body of the pill, you are already bypassing the matrix partially.
2. Hypromellose dissolves faster in acidic solutions.

This is why you're attempted lemon juice extraction worked to some degree: because of citric acid. Lemon juice has a particularly high level of acidity and ranks in at a 2.3 on the PH scale.

So what, can we use that's even more powerful; barring hydrochloric acid of course, - lime juice. Lime juice is usually around a 1.8 to a 2.0 on the ph scale and is probably one of the most acidic substances you could get your hands on and still be able to ingest. In comparison, gastric acid has a ph of 1.

The panda would suggest a lime juice extraction next time over lemon juice due to its greater acidity. Also, filling the stomach with as much acid as possible before ingestion will further help the process of degrading the hypromellose. So yes, chugging lime juice, lemon juice, orange juice and some kind of soda or coca cola in theory may help the process along - possibly all four; why the hell not? Any chemical that increases gastric acid production (caffeine being the most obvious choice), will also help this process.

This is just theory unfortunately, and there is literally no consensus anywhere on the internet about how to successfully defeat celluloid based time release matrices; regardless of what drug they are bound to.

Try the lime juice though. More than 12 hours may be needed for a succesful extraction; maybe give it a full day.

edit: Unless your colon is made out of hydrochloric acid, plugging Xanax XR powder would merely result in a giant blob of gel stuck to the inside of your ass cavity, with very little actual xanax absorption, as the digestive juices are primarily what degrades the preparation. Plugging: not a good idea.

Feel free to send hate mail to Dow Chemicals for their extensive efforts in proliferating this ridiculously annoying polymer; truly a giant cockblock to the drug using community, and not just with Xanax XR but with a number of opioid time release preparations among others.

source: "Direct Compression of Sustained-Release Hydrophilic Matrix Tablets Containing Hypromellose and MCC"
Tim D. Cabelka and Paul J. Shesky, Larkin Laboratory, Dow Chemical Company. 1999
I see this user is banned so could anyone else answer this please? If SWIM were to use this lemon/lime juice method and let the crushed pill settle in the juice for 12-24 hours what would be next?

Would SWIM then drink everything in the glass? extract the liquid out that contains the extracted cellulose and to see the alprazoloam powder and other pill ingredients sitting at the bottom of the glass; then fill up this glass with water to drink the seperated alprazolam?

Cheers.

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anxiolytic, benzodiazepine, downer, extended release, hypnotic, muscle relaxant, sedative, xanax

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