The metabolites are active too though, i am really not sure but a demethylated oxycodone
looks to me alot like oxymorphone
, and wikipedia says oxymorphone is one of the metabolites. This would be one of the good ones and inhibiting this process may not be desirable. (Moreso with codeine
than oxy, because codeine is not active until it is demethylated to morphine
On the flip side, slowing destruction of oxy via inhibiting metabolic process should positively affect duration, and this will occur no matter what the original ROA (but effects more pronounced for oral intake, because of first pass metabolism).
...IDrK though, whatever floats your boat I guess. + im really tired so probably missed something