SDRI and Adderall?

[thatsall]

If one does not like the way he feels on adderall and kind of gets anxious and paranoid would one also not be a good canidate for wellbutrin? They both effect dopamine so if im depressed would it be safe to say it is not dopamine related maybe another chemical in my brain?

[788.4]

Not necessarily.

Adderall increases the production of norepinephrine while Wellbutrin prevents the reuptake of norepinephinre. They work in very different ways and as a result have different effects. Wellbutrin is actually a norepinephrine and dopamine reuptake inhibitor (NDRI).

Dopaminergic agents and stimulants are usually tried when conventional antidepressants treatments fail. Dopamine may be part of the pathophysiology of depression for a subset of patients, but it's usually belived to be serotonin and/or norepinephrine.