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Various drugs not covered by other forums Discussion of Psychoactive drugs that do not have a specific forum

 
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  #1  
Old 21-01-2006, 08:38
pharmapsyche pharmapsyche is offline
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Baclofen recreational use?

Baclofen (brand name Lioresol, or something close to that) is a muscle relaxant that acts on the GABA-B receptors. From what I've read, there is abuse potential. I have never heard of this drug being sold illicitly or even heard of it being prescribed. I'm curious to know what the drug's subjective effects are exactly, whether there is abuse potential or not. Any information would be cool!
  #2  
Old 21-01-2006, 18:10
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It is a strong drug, used in the treatment of spine injury, MS, and other nerve and muscle ailments. Know several people that uses Baclofen, some by pills and others by spinal implant pumps. It does harm the liver over a course of years. I have seen people abuse it with bad results. Since it is a relaxant, heart damage is possible. I wouldn't take it!!
  #3  
Old 26-02-2006, 06:45
pharmapsyche pharmapsyche is offline
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I was searching for information on this subject and I found some interesting information that might help you understand the abuse potental of Baclofen.
Also, just for the future, the brand name is Lioresal, you were VERY close!

Baclofen, is a GABA-B receptor agonist (which you already mentioned) that is used to alleviate the signs and symptoms of muscle spasticity from Multiple Sclerosis. It is thought to inhibit transmission of reflexes at the spinal cord level. Off-label uses of Baclofen include treatment of trigeminal neuralgia, tardive dyskinesia and intractable hiccups.

...this is some information that might suprise you, or maybe not.
In alcohol and opiate withdrawal, one can see a heightened level of vital signs and a highly excitable state. With agonist properties similar to an inhibitory neurotransmitter, it is hoped that Baclofen will reverse some of the signs and symptoms of withdrawal in the alcohol and opiate dependent patient.

Initial alcohol research has found that Baclofen can reduce voluntary intake of alcohol by rats, decrease alcohol craving and alcohol withdrawal syndrome intensity in alcohol dependent patients ( Am J of Med 2002 - a small study using 10mg as an initial dose and 10mg every 8 hours for 30 days in 5 patients).

In opiate research, Baclofen was tested in comparison to Clonidine for treatment of opiate withdrawal. Presented in the J Clin Pharm Ther (2001), 62 opiate dependent patients were treated with either Baclofen or Clonidine for a 14-day, double blind trial. Maximum doses of Baclofen were 40mg per day and 0.8 mg of Clonidine per day (This appears to be a fairly low dose for opiate withdrawal treatment). The findings showed no significant difference between the two groups as to retention in treatment or side - effects, though the Clonidine group had more problems with hypotension.

There is also research using Baclofen for cocaine dependence, looking at the GABA modulation of cocaine self-administration and Baclofen's ability to reduce this. As published in the Dec. 15 edition of the peer-reviewed Journal of Clinical Psychiatry, the randomized, double-blind study, funded by the National Institute on Drug Abuse as part of a project to screen medications with potential for treating cocaine dependence, found that Baclofen used in conjunction with substance abuse counseling significantly reduced cocaine use in recovering addicts compared to placebo coupled with counseling.

I couldn't find too much information on actully abusing Baclofen itself nor could I find any experience reports, but I did notice that withdrawl from Baclofen can have extremely unpleasent and damageing effects to patients. With Abrupt Withdrawl, hallucinations and seizures have occurred. Therefore, except for serious adverse reactions, the dose should be reduced very slowly before this medication is discontinued.

Other withdrawl effects of intrathecal baclofen can Include:high fever, altered mental status, exaggerated rebound spasticity and muscle rigidity that in rare cases progressed to rhabdomyolysis, multiple organ-system failure, and death.

In the first 9 years of post-marketing experience, 27 cases of withdrawal temporally related to the cessation of baclofen therapy were reported; six patients died. In most cases, symptoms of withdrawl appeared within hours to a few days following interruption of baclofen therapy. Common reasons for abrupt interruption of intrathecal baclofen therapy included malfunction of the catheter, low volume in the pump reservoir, and end of pump battery life; also, human error may have played a causal or contributing role in some cases.

Post Quality Evaluations:
Good info

Last edited by pharmapsyche; 26-02-2006 at 10:07.
  #4  
Old 26-02-2006, 06:45
pharmapsyche pharmapsyche is offline
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This is the chemical structure of Baclofen.

Last edited by pharmapsyche; 26-02-2006 at 06:52.
  #5  
Old 04-03-2006, 14:00
pharmapsyche pharmapsyche is offline
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thanks miss methylene!
  #6  
Old 14-03-2008, 23:42
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baclofen have a question

swim has 50 mg of bablofen should he take them, is it enough to do anything and what are the effects.....swim thanks you for your time
  #7  
Old 15-03-2008, 06:56
Jatelka Jatelka is offline
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Re: baclofen have a question

Granted, there's not loads of threads on baclofen, but DID you UTFSE?

Doing so would have thrown up these...

http://www.drugs-forum.com/forum/sho...light=baclofen
http://www.drugs-forum.com/forum/sho...light=baclofen
http://www.drugs-forum.com/forum/sho...light=baclofen
http://www.drugs-forum.com/forum/sho...light=baclofen
  #8  
Old 15-03-2008, 16:16
kev152 kev152 is offline
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Re: baclofen have a question

i did search and read all of those but it never said how much will make swim feel the recreational effects, except for the one but he took like 225 mgs
  #9  
Old 15-03-2008, 17:09
Dead Head Altair Dead Head Altair is offline
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Re: baclofen have a question

As far as SWIM knows, baclofen doesn't have any recreational potential. However, as baclofen is a GABA receptor agonist, SWIM is curious about the effects of higher doses of baclofen. This deserves more research, and SWIM will try to find out what he can and experiment with larger (albeit safe) doses and see what happens.
  #10  
Old 21-07-2008, 20:48
Nate1123 Nate1123 is offline
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Baclofen

SWIM wants to know if baclofen 10mg can be used to get high
  #11  
Old 21-07-2008, 21:54
old hippie 56 old hippie 56 is offline
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Re: Baclofen

Naw, they are used mostly for people with MS. Wife takes them.
  #12  
Old 22-07-2008, 17:05
Politicalchalk Politicalchalk is offline
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Re: Baclofen

baclofen is, however, a GABA-related compound. Not sure if there's a subjective euphoria with it, but it would likely increase depressant effects of other drugs. Careful!
  #13  
Old 22-07-2008, 17:35
Kernacktur Kernacktur is offline
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Re: Baclofen

SWIM took 12 one time. Before takign this many he had experimented with taking 5-6 at a time with little effect/
He felt sick and dis-oriented for over 12 hours (10 of which were spent passed out cold)
Everything was spinning and it was hard to balance. SWIM tried drinking a cup of juice but ended up vomiting that back up 20 minutes later
Also one of his friends took 30, turned blue and was in a coma for 2 days.
  #14  
Old 22-07-2008, 20:30
astenu astenu is offline
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Re: baclofen

I've read some reports claiming it is similar to GHB but not nearly as good.
  #15  
Old 23-07-2008, 00:59
Orchid_Suspiria Orchid_Suspiria is offline
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Re: baclofen

Swim has tried this drug and was not impressed at all.He just simply got very drowsy and woke up finding it difficult to get out of bed and with a pretty bad headache and nausea.
  #16  
Old 26-01-2011, 02:58
DiabolicScheme DiabolicScheme is nu online
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Re: Baclofen recreational use?

First I'd like to say that my hamster is pretty big, he is an astonishing 5'10", 165lbs pounds! You can't imagine how large the cage is that I have to keep him in, never mind the cost of food.

My hamster Ralph believes that Baclofen recreational use would be an improper term, off-label use for anxiety? It works for Ralph.

If other hamsters like phenibut then they will most likely like Baclofen in 25mg-50mg doses. Baclofen seems a bit more consistent than phenibut too, Ralph had a lot of inconsistencies with Phenibut, sometimes it'd work sometimes it wouldn't, whereas the same dose seems to work consistently with Baclofen.

Though it makes comparison to GHB in the wiki article, It far better matches phenibut..in fact so much so Ralph would consider it its pharmaceutical twin.

Nausea and headaches are common, something Ralph has experienced..vitamin B complex taken with it seems to counter the nausea and so does cutting the dose down. The headache is relieved by OTC pain relievers.

Do NOT re-dose if other hamsters feel like the effects have worn off, Baclofen like phenibut has a tendency to fade in and out as far as effects go, making it sometimes hard to tell if your hamster actually needs to re-dose.

Start slow with this stuff and don't start high (something that should be applied to every drug anyway) otherwise the only thing other hamsters are going to get is "the spins" as if they drank too much, which is miserable.

Ralph ideal experience was with 50mg..which was split into 25mg x2 a day about 6 hours apart. Ralph has tried 75MG in one day before and ended with Ralph getting really queezy and dizzy.

Post Quality Evaluations:
very good advice on dosing
  #17  
Old 26-07-2013, 20:58
mygreenbic mygreenbic is offline
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Re: Baclofen recreational use?

The one thing the dog want to mention about baclofen is make sure you START LOW.. Titration and Titrition are both equally important with this one. The instructions on the bottle of baclofen are always very complicated because it is important that you start at a small dose and work your way up. I used to be on baclofen up to 80 mgs then stopped. Didnt know shit about it and went through rancid withdrawal for a long time )this was all legal(. My dog was recently prescribed it again, and was prescribed to take 10mg 3 times a day. Thinking that was way too small of a dose took 80 mgs. The dog was found passed out on the floor with the phone in his paw. The dog was awoken and then I found the dog holding a muffin to his mouth biting it just sitting there on the couch not moving. The next day the dog figured he would cut down to just a 50 mg dose. Similar things occured again. So be careful and follow your doctors instructions with this one.
Also my dog told me this is very recreational. He loves it and he uses it often to help with withdrawal from almost anything.

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adderall, adderall experience, baclofen, clonidine, drug, drugs, mylan, opiate, phenibut, recreational use, snorting, taper, trip report, tripping

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