Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 2.9 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. We just need 1% of our readers to donate. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
Baclofen (brand name Lioresol, or something close to that) is a muscle relaxant that acts on the GABA-B receptors. From what I've read, there is abuse potential. I have never heard of this drug being sold illicitly or even heard of it being prescribed. I'm curious to know what the drug's subjective effects are exactly, whether there is abuse potential or not. Any information would be cool!
It is a strong drug, used in the treatment of spine injury, MS, and other nerve and muscle ailments. Know several people that uses Baclofen, some by pills and others by spinal implant pumps. It does harm the liver over a course of years. I have seen people abuse it with bad results. Since it is a relaxant, heart damage is possible. I wouldn't take it!!
I was searching for information on this subject and I found some interesting information that might help you understand the abuse potental of Baclofen.
Also, just for the future, the brand name is Lioresal, you were VERY close!
Baclofen, is a GABA-B receptor agonist (which you already mentioned) that is used to alleviate the signs and symptoms of muscle spasticity from Multiple Sclerosis. It is thought to inhibit transmission of reflexes at the spinal cord level. Off-label uses of Baclofen include treatment of trigeminal neuralgia, tardive dyskinesia and intractable hiccups.
...this is some information that might suprise you, or maybe not.
In alcohol and opiate withdrawal, one can see a heightened level of vital signs and a highly excitable state. With agonist properties similar to an inhibitory neurotransmitter, it is hoped that Baclofen will reverse some of the signs and symptoms of withdrawal in the alcohol and opiate dependent patient.
Initial alcohol research has found that Baclofen can reduce voluntary intake of alcohol by rats, decrease alcohol craving and alcohol withdrawal syndrome intensity in alcohol dependent patients ( Am J of Med 2002 - a small study using 10mg as an initial dose and 10mg every 8 hours for 30 days in 5 patients).
In opiate research, Baclofen was tested in comparison to Clonidine for treatment of opiate withdrawal. Presented in the J Clin Pharm Ther (2001), 62 opiate dependent patients were treated with either Baclofen or Clonidine for a 14-day, double blind trial. Maximum doses of Baclofen were 40mg per day and 0.8 mg of Clonidine per day (This appears to be a fairly low dose for opiate withdrawal treatment). The findings showed no significant difference between the two groups as to retention in treatment or side - effects, though the Clonidine group had more problems with hypotension.
There is also research using Baclofen for cocaine dependence, looking at the GABA modulation of cocaine self-administration and Baclofen's ability to reduce this. As published in the Dec. 15 edition of the peer-reviewed Journal of Clinical Psychiatry, the randomized, double-blind study, funded by the National Institute on Drug Abuse as part of a project to screen medications with potential for treating cocaine dependence, found that Baclofen used in conjunction with substance abuse counseling significantly reduced cocaine use in recovering addicts compared to placebo coupled with counseling.
I couldn't find too much information on actully abusing Baclofen itself nor could I find any experience reports, but I did notice that withdrawl from Baclofen can have extremely unpleasent and damageing effects to patients. With Abrupt Withdrawl, hallucinations and seizures have occurred. Therefore, except for serious adverse reactions, the dose should be reduced very slowly before this medication is discontinued.
Other withdrawl effects of intrathecal baclofen can Include:high fever, altered mental status, exaggerated rebound spasticity and muscle rigidity that in rare cases progressed to rhabdomyolysis, multiple organ-system failure, and death.
In the first 9 years of post-marketing experience, 27 cases of withdrawal temporally related to the cessation of baclofen therapy were reported; six patients died. In most cases, symptoms of withdrawl appeared within hours to a few days following interruption of baclofen therapy. Common reasons for abrupt interruption of intrathecal baclofen therapy included malfunction of the catheter, low volume in the pump reservoir, and end of pump battery life; also, human error may have played a causal or contributing role in some cases.
As far as SWIM knows, baclofen doesn't have any recreational potential. However, as baclofen is a GABA receptor agonist, SWIM is curious about the effects of higher doses of baclofen. This deserves more research, and SWIM will try to find out what he can and experiment with larger (albeit safe) doses and see what happens.
SWIM took 12 one time. Before takign this many he had experimented with taking 5-6 at a time with little effect/
He felt sick and dis-oriented for over 12 hours (10 of which were spent passed out cold)
Everything was spinning and it was hard to balance. SWIM tried drinking a cup of juice but ended up vomiting that back up 20 minutes later
Also one of his friends took 30, turned blue and was in a coma for 2 days.
First I'd like to say that my hamster is pretty big, he is an astonishing 5'10", 165lbs pounds! You can't imagine how large the cage is that I have to keep him in, never mind the cost of food.
My hamster Ralph believes that Baclofen recreational use would be an improper term, off-label use for anxiety? It works for Ralph.
If other hamsters like phenibut then they will most likely like Baclofen in 25mg-50mg doses. Baclofen seems a bit more consistent than phenibut too, Ralph had a lot of inconsistencies with Phenibut, sometimes it'd work sometimes it wouldn't, whereas the same dose seems to work consistently with Baclofen.
Though it makes comparison to GHB in the wiki article, It far better matches phenibut..in fact so much so Ralph would consider it its pharmaceutical twin.
Nausea and headaches are common, something Ralph has experienced..vitamin B complex taken with it seems to counter the nausea and so does cutting the dose down. The headache is relieved by OTC pain relievers.
Do NOT re-dose if other hamsters feel like the effects have worn off, Baclofen like phenibut has a tendency to fade in and out as far as effects go, making it sometimes hard to tell if your hamster actually needs to re-dose.
Start slow with this stuff and don't start high (something that should be applied to every drug anyway) otherwise the only thing other hamsters are going to get is "the spins" as if they drank too much, which is miserable.
Ralph ideal experience was with 50mg..which was split into 25mg x2 a day about 6 hours apart. Ralph has tried 75MG in one day before and ended with Ralph getting really queezy and dizzy.
The one thing the dog want to mention about baclofen is make sure you START LOW.. Titration and Titrition are both equally important with this one. The instructions on the bottle of baclofen are always very complicated because it is important that you start at a small dose and work your way up. I used to be on baclofen up to 80 mgs then stopped. Didnt know shit about it and went through rancid withdrawal for a long time )this was all legal(. My dog was recently prescribed it again, and was prescribed to take 10mg 3 times a day. Thinking that was way too small of a dose took 80 mgs. The dog was found passed out on the floor with the phone in his paw. The dog was awoken and then I found the dog holding a muffin to his mouth biting it just sitting there on the couch not moving. The next day the dog figured he would cut down to just a 50 mg dose. Similar things occured again. So be careful and follow your doctors instructions with this one.
Also my dog told me this is very recreational. He loves it and he uses it often to help with withdrawal from almost anything.