Drug info - Amitryptiline: Recreational Effects?

[Insane Asian]

i have 5 little green pills with M51 on them. i want to know if this is valium. also if it is valium what will taking 1 do, i know i should take 2 but i have 5 and thats an odd number. how long does valium take to kick in and how long does it last. also what is the high like

[str8ballin]

I don't think that pill is valium.I looked it up on drugs.com and M 51 comes up as amitriptyline hydrochloride,an anti-depressant.I'm not sure about the recommended dosage maybe somebody else can help you with that.

[Insane Asian]

i couldnt find anything on it on drugs.com i was told it was valium how sure are you its not valium

[Hydrocodone]

Ive taken amitriptyline before, its not fun. Though I did take 8 of them at the time. I was f**ked up beyond taking 3 zanbars for too damn long and couldnt hardly walk or talk right. Be careful

[ShadyMilkman]

Yes, the pill is definitely Amitriptyline Hydrochloride 25mg. Might want to google that.

[ShadyMilkman]

Update:



Uses



Indication



Symptomatic treatment of depressive illness especially where sedation

is required. Nocturnal enuresis in children.



Therapeutic dosage



in adults

In depression

by mouth: 75-150 mg daily in single or divided doses (lower doses in

elderly and adolescents).

by IM or IV injection: 10-20 mg four times daily.



in children

For nocturnal enuresis:

6-10 years: 10-20 mg daily by mouth.

11-16 years: 25-50 mg daily by mouth.

Modified release preparations are not licensed for use in children.



Contra-indications



Recent myocardial infarction or coronary artery insufficiency. Heart

block or other cardiac arrhythmia. Mania. Severe liver disease.

Co-administration with monoamine oxidase inhibitors. Hypersensitivity

to amitriptyline. Lactation. Children under 6 years of age.

[VIKETIME]

i got prescribed some of this..can i use it recreationally at all? i got it for migranes/insomnia so im guessin it might be fun? any help would be appreciated.


-VIKETIME

[OneDiaDem]

I have grips of it, all it does is make me tired.</font>

[aMorphius]

Some friends of mine who tried this as a recreational drug told me that all
that happened was that they were too tired to move and could hardly stay
awake or focus their eyes. Sounds like a good sleeping pill to me.

[Micklemouse]

Amitrypiline isn't a Benzo, it's a Tricyclic Antidepressant, sometimes used as a sleeping aid because of it's sedating qualities. Little or no recreational value, but quite risky in high doses. Quite popular with overdosers looking fir a way out...

From the BNF...

AMITRIPTYLINE HYDROCHLORIDE
Additional information: interactions (Amitriptyline).
Indications: depressive illness, particularly where sedation is required; nocturnal enuresis in children (section 7.4.2)
Cautions: cardiac disease (particularly with arrhythmias, see Contra-indications below), history of epilepsy, pregnancy and breast-feeding (Appendixes 4 and 5), elderly, hepatic impairment (avoid if severe), thyroid disease, phaeochromocytoma, history of mania, psychoses (may aggravate psychotic symptoms), angle-closure glaucoma, history of urinary retention, concurrent electroconvulsive therapy; if possible avoid abrupt withdrawal; anaesthesia (increased risk of arrhythmias and hypotension, see surgery section 15.1); porphyria (section 9.8.2); see section 7.4.2 for additional nocturnal enuresis warnings; interactions: Appendix 1 (antidepressants, tricyclic)
DRIVING. Drowsiness may affect performance of skilled tasks (e.g. driving); effects of alcohol enhanced
Contra-indications: recent myocardial infarction, arrhythmias (particularly heart block), not indicated in manic phase, severe liver disease
Side-effects: dry mouth, sedation, blurred vision (disturbance of accommodation, increased intra-ocular pressure), constipation, nausea, difficulty with micturition; cardiovascular side-effects (such as ECG changes, arrhythmias, postural hypotension, tachycardia, syncope, particularly with high doses); sweating, tremor, rashes and hypersensitivity reactions (including urticaria, photosensitivity), behavioural disturbances (particularly children), hypomania or mania, confusion (particularly elderly), interference with sexual function, blood sugar changes; increased appetite and weight gain (occasionally weight loss); endocrine side-effects such as testicular enlargement, gynaecomastia, galactorrhoea; also convulsions (see also Cautions), movement disorders and dyskinesias, fever, agranulocytosis, leucopenia, eosinophilia, purpura, thrombocytopenia, hyponatraemia (may be due to inappropriate antidiuretic hormone secretion) see CSM advicesection 4.3, abnormal liver function tests (jaundice); for a general outline of side-effects see also notes above; overdosage: see Emergency Treatment of Poisoning
Dose: depression, initially 75 mg (elderly and adolescents 30–75 mg) daily in divided doses or as a single dose at bedtime increased gradually as necessary to 150–200 mg; child under 16 years not recommended for depression
Nocturnal enuresis, child 7–10 years 10–20 mg, 11–16 years 25–50 mg at night; max. period of treatment (including gradual withdrawal) 3 months—full physical examination before further course

Amitriptyline

Amitriptyline has the following interaction information:
Cimetidinemetabolism of amitriptyline inhibited by cimetidine (increased plasma concentration)
Disulfiramconcomitant amitriptyline reported to increase disulfiram reaction with alcohol
St John's Wortplasma concentration of amitriptyline reduced by St John's wort
Thyroid Hormoneseffects of amitriptyline enhanced by thyroid hormones

Amitriptyline belongs to Antidepressants, Tricyclic and will have the following interactions:
Adrenaline (epinephrine) increased risk of hypertension and arrhythmias when tricyclics given with adrenaline (epinephrine) (but local anaesthetics with adrenaline appear to be safe)
Adrenergic Neurone Blockers tricyclics antagonise hypotensive effect of adrenergic neurone blockers
Alcohol increased sedative effect when tricyclics given with alcohol
Amiodarone increased risk of ventricular arrhythmias when tricyclics given with amiodarone —avoid concomitant use

Amiodarone has a long half-life; there is a potential for drug interactions to occur for several weeks (or even months) after treatment with it has been stopped
Anaesthetics, General increased risk of arrhythmias and hypotension when tricyclics given with general anaesthetics

See also Surgery and Long-term Medication, section 15.1
Antidepressants, SSRI plasma concentration of some tricyclics increased by SSRIs
Antiepileptics tricyclics antagonise anticonvulsant effect of antiepileptics (convulsive threshold lowered)
Antihistamines increased antimuscarinic and sedative effects when tricyclics given with antihistamines

Sedative interactions apply to a lesser extent to the non-sedating antihistamines. Interactions do not generally apply to antihistamines used for topical action (including inhalation)
Antimuscarinics increased risk of antimuscarinic side-effects when tricyclics given with antimuscarinics

Many drugs have antimuscarinic effects; concomitant use of two or more such drugs can increase side-effects such as dry mouth, urine retention, and constipation; concomitant use can also lead to confusion in the elderly. Interactions do not generally apply to antimuscarinics used by inhalation
Antipsychotics plasma concentration of tricyclics increased by antipsychotics —possibly increased risk of ventricular arrhythmias

Increased risk of toxicity with myelosuppressive drugs
Anxiolytics and Hypnotics increased sedative effect when tricyclics given with anxiolytics and hypnotics
Apraclonidine avoidance of tricyclics advised by manufacturer of apraclonidine
Baclofen tricyclics enhance muscle relaxant effect of baclofen
Barbiturates tricyclics antagonises anticonvulsant effect of barbiturates (convulsive threshold lowered), also metabolism of tricyclics possibly accelerated (reduced plasma concentration)
Brimonidine avoidance of tricyclics advised by manufacturer of brimonidine
Carbamazepine metabolism of tricyclics accelerated by carbamazepine (reduced plasma concentration and reduced effect)
Cimetidine plasma concentration of tricyclics possibly increased by cimetidine
Clonidine tricyclics antagonise hypotensive effect of clonidine , also increased risk of hypertension on clonidine withdrawal
Clozapine possibly increased antimuscarinic side-effects when tricyclics given with clozapine

Avoid concomitant use of clozapine with drugs that have a substantial potential for causing agranulocytosis
Diltiazem plasma concentration of tricyclics possibly increased by diltiazem
Disopyramide increased risk of ventricular arrhythmias when tricyclics given with disopyramide
Disulfiram metabolism of tricyclics inhibited by disulfiram (increased plasma concentration)
Diuretics increased risk of postural hypotension when tricyclics given with diuretics
Entacapone caution with tricyclics advised by manufacturer of entacapone
Flecainide increased risk of ventricular arrhythmias when tricyclics given with flecainide
MAOIs increased risk of hypertension and CNS excitation when tricyclics given with MAOIs , tricyclics should not be started until 2 weeks after stopping MAOIs (3 weeks if starting clomipramine or imipramine), also MAOIs should not be started for at least 1–2 weeks after stopping tricyclics (3 weeks in the case of clomipramine or imipramine)

For interactions of reversible MAO-A inhibitors (RIMAs) see Moclobemide, and for interactions of MAO-B inhibitors see Selegiline; the antibacterial linezolid is a reversible, non-selective MAO inhibitor
Methylphenidate metabolism of tricyclics possibly inhibited by methylphenidate
Moclobemide after stopping tricyclics do not start moclobemide for at least 1 week
Moxifloxacin increased risk of ventricular arrhythmias when tricyclics given with moxifloxacin —avoid concomitant use
Nefopam side-effects possibly increased when tricyclics given with nefopam
Nicorandil tricyclics possibly enhance hypotensive effect of nicorandil
Nitrates tricyclics reduce effects of sublingual tablets of nitrates (failure to dissolve under tongue owing to dry mouth)
Noradrenaline (norepinephrine) increased risk of hypertension and arrhythmias when tricyclics given with noradrenaline (norepinephrine)
Oestrogens antidepressant effect of tricyclics antagonised by oestrogens (but side-effects of tricyclics possibly increased due to increased plasma concentration)

Interactions of combined oral contraceptives may also apply to combined contraceptive patches; in case of hormone replacement therapy low dose unlikely to induce interactions
Opioid Analgesics sedative effects possibly increased when tricyclics given with opioid analgesics
Phenothiazines increased risk of antimuscarinic side-effects when tricyclics given with phenothiazines
Phenytoin plasma concentration of tricyclics possibly reduced by phenytoin
Pimozide increased risk of ventricular arrhythmias when tricyclics given with pimozide —avoid concomitant use
Primidone tricyclics antagonises anticonvulsant effect of primidone (convulsive threshold lowered), also metabolism of tricyclics possibly accelerated (reduced plasma concentration)
Procainamide increased risk of ventricular arrhythmias when tricyclics given with procainamide
Propafenone increased risk of arrhythmias when tricyclics given with propafenone
Quinidine increased risk of ventricular arrhythmias when tricyclics given with quinidine
Rifampicin plasma concentration of tricyclics possibly reduced by rifampicin
Ritonavir plasma concentration of tricyclics possibly increased by ritonavir
Selegiline CNS toxicity reported when tricyclics given with selegiline

Selegiline is a MAO-B inhibitor
Sibutramine increased risk of CNS toxicity when tricyclics given with sibutramine (manufacturer of sibutramine advises avoid concomitant use)
Sotalol increased risk of ventricular arrhythmias when tricyclics given with sotalol
Terfenadine increased risk of ventricular arrhythmias when tricyclics given with terfenadine —avoid concomitant use
Thioridazine increased risk of ventricular arrhythmias when tricyclics given with thioridazine —avoid concomitant use
Thyroid Hormones effects of tricyclics possibly enhanced by thyroid hormones
Tramadol increased risk of CNS toxicity when tricyclics given with tramadol
Verapamil plasma concentration of tricyclics possibly increased by verapamil

Amitriptyline belongs to Antidepressants and will have the following interactions:
Artemether with Lumefantrine avoidance of antidepressants advised by manufacturer of artemether/lumefantrine

[Doparius]

Fuck yea! Hppy pills kick ass I got mine for insomnia and iI sleep so good,I take 2 25mg pills,! I haenrt slept as good untill I got my amitrptyline.

[aMorphius]

Another RX sleep aid is the anti-depressant, Trazodone. 50 to 100 mg
will give you a good night's sleep and there seems to be no tolerence
problems like you might find with benzos or Ambien.

[mark_v]

Originally Posted by aMorphius

Another RX sleep aid is the anti-depressant, Trazodone. 50 to 100 mg

will give you a good night's sleep and there seems to be no tolerence

problems like you might find with benzos or Ambien.

I got Trazodone few months back, great sleeping pill !

I also got some sort of painkiller called Nozinan (Levomepromazine), and works very well as a sleeping aid.

[Shadow_Addict]

well I was on amatrytiline for about 6months and it did NOTHING whatsoever for me atall....=/ didn't help with the depression/anxiety as it was meant to just no effects..but thats me, everyone is dif I guess

[peanut butter]

I take amitriptline to help me when I have several nights of poor sleep, which seems to happen quite a bit, and it helps my jaw not hurt, (but since taking these beta blockers my jaw is much better without the elavil) it has however cardiac affects (some people who have it use it to commit suicide by overdosing) when you take to much.





I beleive it suppresses your breathing and heart, for occassional use it is a great sedative, but for it's antidepressant affects you have to take it for several weeks, I took it for five years for chronic headaches and I never did get used to the sedative affects, spent alot of the five years sleep walking so to speak.


I would however say there is no recreational use for it.

[BlueMystic]

Anitriptalline (Elavil) is an evil drug. Unless it is prescribed to you and works for whatever condition. I would advise anyone against taking it. It has absolutely no recreational value.